2025
Apixaban Versus Aspirin to Reduce Cognitive Decline After Cryptogenic Stroke and Atrial Cardiopathy: ARCADIA-Cognition Study.
Lazar R, Howard G, Brewer M, Cassarly C, Pauls Q, Kemp S, Tirschwell D, Sheth K, Wintermark M, Kamel H, Longstreth W, Elkind M, Broderick J, Lansberg M. Apixaban Versus Aspirin to Reduce Cognitive Decline After Cryptogenic Stroke and Atrial Cardiopathy: ARCADIA-Cognition Study. Journal Of The American Heart Association 2025, 14: e042147. PMID: 40847528, DOI: 10.1161/jaha.125.042147.Peer-Reviewed Original ResearchConceptsCognitive declineCognitive testsBaseline dementiaStandardized cognitive testsStroke Prevention StudyPrevention StudyCognitive trajectoriesCognitive AssessmentIndividual test scoresMixed-effects modelsAspirin armCognitive examPrimary analysisAtrial cardiopathyIndex strokeMean ageScoresFollow-upBaseline characteristicsStrokeTest scoresAnnual changesArmCryptogenic strokeApixaban armCognitive subtypes in youth at clinical high risk for psychosis
Yassin W, Green J, Keshavan M, del Re E, Addington J, Bearden C, Cadenhead K, Cannon T, Cornblatt B, Mathalon D, Perkins D, Walker E, Woods S, Stone W. Cognitive subtypes in youth at clinical high risk for psychosis. Psychiatry And Clinical Neurosciences 2025 PMID: 40600477, DOI: 10.1111/pcn.13861.Peer-Reviewed Original ResearchClinical high riskCognitive subtypesWorking memoryClinical high-risk groupWorking memory domainsConversion statusPsychotic disordersCognitive clustersVerbal abilityCHR patientsCognitive measuresMemory domainCognitive domainsNAPLS-2Cognitive trajectoriesPsychosisImpairment groupIntact groupHealthy controlsFunction trajectoriesIntervention strategiesBaseline differencesMemoryHigh riskMonths of follow-upMultimorbidity patterns and cognitive change among Mexican older adults: findings from the Mexican Health and Aging Study
Bishop N, Botoseneanu A, Newsom J, Allore H, Nagel C, Markwardt S, Samper-Ternent R, Quiñones A. Multimorbidity patterns and cognitive change among Mexican older adults: findings from the Mexican Health and Aging Study. Journal Of Global Ageing 2025, 2: 65-97. DOI: 10.1332/29767202y2024d000000019.Peer-Reviewed Original ResearchMexican Health and Aging StudyHealth and Aging StudyMultimorbidity patternsMexican adultsChronic conditionsOlder adultsIncreasing burden of chronic conditionsDepressive symptomsBurden of chronic conditionsCo-occurring chronic conditionsCognitive declineCognitive functionAssociated with lower cognitive functionOlder Mexican adultsMexican Older AdultsRisk of cognitive declineAging StudyLower cognitive functionCognitive changesManagement of diabetesMultimorbidityIncreasing burdenCognitive trajectoriesLatent growth modelingOlder adulthoodEffects of exercise on cognition and Alzheimer's biomarkers in a randomized controlled trial of adults with mild cognitive impairment: The EXERT study
Baker L, Pa J, Katula J, Aslanyan V, Salmon D, Jacobs D, Chmelo E, Hodge H, Morrison R, Matthews G, Brewer J, Jung Y, Rissman R, Taylor C, Léger G, Messer K, Evans A, Okonkwo O, Shadyab A, Zou J, Jin S, Thomas R, Zhang J, La Croix A, Cotman C, Feldman H, Group F. Effects of exercise on cognition and Alzheimer's biomarkers in a randomized controlled trial of adults with mild cognitive impairment: The EXERT study. Alzheimer's & Dementia 2025, 21: e14586. PMID: 40271888, PMCID: PMC12019696, DOI: 10.1002/alz.14586.Peer-Reviewed Original ResearchConceptsSedentary older adultsAmnestic mild cognitive impairmentIntensity aerobic trainingMild cognitive impairmentEffects of exerciseRandomized Controlled TrialsIntervention deliveryAerobic trainingOlder adultsMonths of supervised exerciseCognitive impairmentMultisite Randomized Controlled TrialCognitive trajectoriesLower-intensity exerciseMeasure of global cognitive functionRandomized controlled trials of adultsTests of executive functionIntervention group differencesMeasures of brain healthAssess intervention efficacyGlobal cognitive functionGlobal cognitive compositeMild cognitive impairment groupSupervised exerciseMild memory problemsEffects of exercise versus usual care on older adults with amnestic mild cognitive impairment: EXERT versus ADNI
Shadyab A, Aslanyan V, Jacobs D, Salmon D, Morrison R, Katula J, Jin S, Thomas R, LaCroix A, Pa J, Cotman C, Feldman H, Baker L, Group F. Effects of exercise versus usual care on older adults with amnestic mild cognitive impairment: EXERT versus ADNI. Alzheimer's & Dementia 2025, 21: e70118. PMID: 40271887, PMCID: PMC12019695, DOI: 10.1002/alz.70118.Peer-Reviewed Original ResearchConceptsUsual careRandomized Controlled TrialsAmnestic mild cognitive impairmentOlder adultsMild cognitive impairmentADNI-1Multisite Randomized Controlled TrialNo interventionSedentary older adultsIntensity aerobic trainingAlzheimer's Disease Neuroimaging Initiative 1Moderate-high intensityEffects of exerciseCognitive declineCognitive impairmentFlexibility exercisesExercise armAerobic trainingAD-signature regionsExertion groupCognitive trajectoriesExertionCarePost Hoc AnalysisExerciseCare Recipients’ Cognitive Trajectories and Caregivers’ Depressive Symptoms: The Mediating Role of Caregiving Burden
Lou Y, Gong J, Zang E. Care Recipients’ Cognitive Trajectories and Caregivers’ Depressive Symptoms: The Mediating Role of Caregiving Burden. The Gerontologist 2025, 65: gnaf024. PMID: 39873410, PMCID: PMC11934274, DOI: 10.1093/geront/gnaf024.Peer-Reviewed Original ResearchConceptsCaregiver depressive symptomsCare recipientsCaregiver burdenDepressive symptomsCognitive trajectoriesCaregiving burdenNational Health and Aging Trends StudyNational Study of CaregivingFinancial caregiving burdensCaregiver mental healthStudy of CaregivingStress process modelLongitudinal cognitive courseGroup-based trajectoryCaregiving difficultiesCaregiving experienceTrajectory group membershipEmotional burdenTrends StudyMental healthCaregiversCareTrajectory groupsNational studyCognitive function
2024
Association Between Cognitive Trajectories and Subsequent Health Status, Depressive Symptoms, and Mortality Among Older Adults in the United States: Findings From a Nationally Representative Study
Zang E, Zhang Y, Wang Y, Wu B, Fried T, Becher R, Gill T. Association Between Cognitive Trajectories and Subsequent Health Status, Depressive Symptoms, and Mortality Among Older Adults in the United States: Findings From a Nationally Representative Study. The Journals Of Gerontology Series A 2024, 79: glae143. PMID: 38845419, PMCID: PMC11212484, DOI: 10.1093/gerona/glae143.Peer-Reviewed Original ResearchPoor health statusHealth statusDepressive symptomsOlder adultsHealth outcomesCognitive trajectoriesNational Health and Aging Trends StudyScreening of cognitive functionTrajectory groupsCognitive functionHigher depressive symptomsPopulation-based dataAdverse health outcomesNationally Representative CohortGroup-based trajectory modelingHigher mortality riskAssociated with higher riskNationally-representative studyLogistic regression modelsTrends StudyRepresentative cohortGlobal cognitionLiving respondentsRegular screeningMortality risk
2023
73 Identification of 24-Month Cognitive Trajectories Among Clinical High Risk for Psychosis (CHR-P) Using Latent Class Mixture Modeling
Guest R, Addington J, Bearden C, Cadenhead K, Cornblatt B, Mathalon D, Perkins D, Tsuang M, Woods S, Cannon T, Keshavan M, Stone W, Walker E. 73 Identification of 24-Month Cognitive Trajectories Among Clinical High Risk for Psychosis (CHR-P) Using Latent Class Mixture Modeling. Journal Of The International Neuropsychological Society 2023, 29: 857-858. DOI: 10.1017/s1355617723010597.Peer-Reviewed Original ResearchMATRICS Consensus Cognitive BatterySpeed of processingVerbal learningCognitive batteryCognitive trajectoriesCognitive deficitsWide Range Achievement TestDomain-specific deficitsConsensus Cognitive BatteryWechsler Abbreviated ScalePre-morbid IQHigher cognitive skillsFull Scale IQLower premorbid IQAge-based normsMild cognitive deficitsClinical high riskMCCB domainsCognitive remediationMemory domainCognitive skillsGeneral cognitionReading subtestCognitive performanceNorth American Prodromal Longitudinal StudyThe National Israel Brain Repository: Characterizing those who sign and do not sign intent to autopsy
Manzali S, Ravona‐Springer R, Ouyang Y, Lin H, Heymann A, Greenbaum L, Liraz‐Zaltsman S, Beeri M. The National Israel Brain Repository: Characterizing those who sign and do not sign intent to autopsy. Alzheimer's & Dementia 2023, 19 DOI: 10.1002/alz.064443.Peer-Reviewed Original ResearchCognitive characteristics of individualsCommunity-based study of individualsCompare cognitive functionOlder adultsOffspring of AD patientsRate of cognitive declinePostmortem human brainCognitive follow-upMiddle-aged offspringEpisodic memoryMotor functionStudy of individualsMaccabi Health ServicesCommunity-based studyMiddle-aged adultsCognitive functionBrain RepositoryCognitive trajectoriesCharacteristics of individualsCognitive characteristicsSelection biasCognitive declineDementia riskFollow-upHealth services
2022
Associations between pituitary-ovarian hormones and cognition in recently menopausal women independent of type of hormone therapy
Kling J, Dowling N, Bimonte-Nelson H, Gleason C, Kantarci K, Stonnington C, Harman S, Naftolin F, Pal L, Cedars M, Manson J, James T, Brinton E, Miller V. Associations between pituitary-ovarian hormones and cognition in recently menopausal women independent of type of hormone therapy. Maturitas 2022, 167: 113-122. PMID: 36395695, PMCID: PMC10077876, DOI: 10.1016/j.maturitas.2022.10.002.Peer-Reviewed Original ResearchConceptsComplex attention tasksLatent growth curve modelsPoor cognitive performancePoorer global cognitionGrowth curve modelsAuditory attentionAttention taskCognitive factorsMental flexibilityVisual attentionExecutive functionCognitive domainsCognitive performanceCognitive trajectoriesGlobal cognitionPituitary-ovarian hormonesHormone therapyBaseline cognitionCognitionHormone levelsNeuropsychological testingMonth 18Menopausal womenEstrone levelsMonth 48Greater intake of the MEDI diet is associated with better cognitive trajectory in older adults with type 2 diabetes
Lotan R, Ravona-Springer R, Shakked J, Lin H, Ouyang Y, Shahar D, Bezalel S, Agarwal P, Dhana K, Heymann A, Sano M, Schnaider Beeri M. Greater intake of the MEDI diet is associated with better cognitive trajectory in older adults with type 2 diabetes. Diabetes Research And Clinical Practice 2022, 190: 109989. PMID: 35820563, DOI: 10.1016/j.diabres.2022.109989.Peer-Reviewed Original ResearchConceptsDietary patternsCognitive declineCognitive trajectoriesType 2 diabetes mellitusOlder adultsMultivariable-adjusted modelsType 2 diabetesLongitudinal observational studyGreater intakeExecutive functionObservational studyIsrael DiabetesDiet intakeGlobal cognitionMultivariate modelT2DCognitionIntakeAdultsAdherenceDietStability in BMI over time is associated with a better cognitive trajectory in older adults
Beeri M, Tirosh A, Lin H, Golan S, Boccara E, Sano M, Zhu C. Stability in BMI over time is associated with a better cognitive trajectory in older adults. Alzheimer's & Dementia 2022, 18: 2131-2139. PMID: 35049119, PMCID: PMC9296696, DOI: 10.1002/alz.12525.Peer-Reviewed Original ResearchConceptsBody mass indexBMI changeCognitive trajectoriesAlzheimer's Disease CenterFollow-up body mass indexCognitive declineOlder adultsFollow-up visitHealth phenomenaMass indexNon-dementedDisease CenterLongitudinal dataBaselineOverweightNatural courseClinical valueHealthVisitsParticipantsAdultsDeclineStandard deviation
2021
Stability in BMI over time is associated with a better cognitive trajectory in older adults
Beeri M, Tirosh A, Lin H, Golan S, Boccara E, Sano M, Zhu C. Stability in BMI over time is associated with a better cognitive trajectory in older adults. Alzheimer's & Dementia 2021, 17 DOI: 10.1002/alz.057574.Peer-Reviewed Original ResearchBody mass indexRate of cognitive declineNon-demented older adultsOlder adultsCognitive trajectoriesCognitive declineBMI stabilizationRisk of incident cognitive impairmentLongitudinal associations of changesBody mass index changeAlzheimer's Disease CenterIncident cognitive impairmentFollow-up body mass indexAssociation of changesDisease CenterYears of educationRelevance of body mass indexSpecific cognitive domainsLinear mixed effects modelsBMI changeLongitudinal associationsYears of ageGlobal cognitionLongitudinal clinical dataFollow-up visitDivergent connectomic organization delineates genetic evolutionary traits in the human brain
Bueichekú E, Gonzalez-de-Echavarri J, Ortiz-Teran L, Montal V, d’Oleire Uquillas F, De Marcos L, Orwig W, Kim C, Ortiz-Teran E, Basaia S, Diez I, Sepulcre J. Divergent connectomic organization delineates genetic evolutionary traits in the human brain. Scientific Reports 2021, 11: 19692. PMID: 34608211, PMCID: PMC8490416, DOI: 10.1038/s41598-021-99082-6.Peer-Reviewed Original ResearchConceptsEvolutionary traitsHomo sapiens lineageDN/dS ratiosPositive selectionCellular functionsEvolutionary pathwaysGene expressionGenetic expressionSapiens lineageBiological dataCo-localizationDivergent pathwaysFunctional specializationTraitsBiological qualityResting-state dataPathwayHuman brain functionSimian ancestorsExpressionConnectome organizationCognitive trajectoriesAncestorLineagesBrain functionIn vivo and neuropathology data support locus coeruleus integrity as indicator of Alzheimer’s disease pathology and cognitive decline
Jacobs H, Becker J, Kwong K, Engels-Domínguez N, Prokopiou P, Papp K, Properzi M, Hampton O, d'Oleire Uquillas F, Sanchez J, Rentz D, El Fakhri G, Normandin M, Price J, Bennett D, Sperling R, Johnson K. In vivo and neuropathology data support locus coeruleus integrity as indicator of Alzheimer’s disease pathology and cognitive decline. Science Translational Medicine 2021, 13: eabj2511. PMID: 34550726, PMCID: PMC8641759, DOI: 10.1126/scitranslmed.abj2511.Peer-Reviewed Original ResearchConceptsLC integrityLongitudinal cognitive measuresCognitive measuresLocus coeruleusIndicators of Alzheimer's disease pathologyLocus coeruleus integrityMedial temporal lobeTangle densityRush Memory and Aging ProjectBraak stageMemory and Aging ProjectHyperphosphorylated tau aggregatesAlzheimer's diseaseB-amyloidAD-related processesMemory declineCognitive dysfunctionDisease pathologyCognitive trajectoriesTemporal lobeLC neuronsPostmortem correlationsCognitive declineEntorhinal cortexPreclinical ADRecruitment of a multi‐site randomized controlled trial of aerobic exercise for older adults with amnestic mild cognitive impairment: The EXERT trial
Shadyab AH, LaCroix AZ, Feldman HH, van Dyck C, Okonkwo OC, Tam SP, Fairchild JK, Welsh‐Bohmer K, Matthews G, Bennett D, Shadyab AA, Schafer KA, Morrison RH, Kipperman SA, Mason J, Tan D, Thomas RG, Cotman CW, Baker LD, Group F. Recruitment of a multi‐site randomized controlled trial of aerobic exercise for older adults with amnestic mild cognitive impairment: The EXERT trial. Alzheimer's & Dementia 2021, 17: 1808-1817. PMID: 34297895, PMCID: PMC9292825, DOI: 10.1002/alz.12401.Peer-Reviewed Original ResearchConceptsMild cognitive impairmentAmnestic mild cognitive impairmentAerobic exerciseOlder adultsCognitive impairmentMass mailingElectronic health recordsClinic rostersRandomized participantsExercise trialsIntervention trialsPublic service announcementsLocal registryTrialsHealth recordsAdultsCognitive trajectoriesCommunity presentationsImpairmentMailingAgeExerciseRecruitment rates
2017
COGNITIVE TRAJECTORY PATTERNS PREDICT INCIDENT DEMENTIA RISK IN OLDER SWEDISH ADULTS
Munoz E, Gatz M, Pedersen N, Sharp E, Reynolds C. COGNITIVE TRAJECTORY PATTERNS PREDICT INCIDENT DEMENTIA RISK IN OLDER SWEDISH ADULTS. Innovation In Aging 2017, 1: 708-708. PMCID: PMC6248351, DOI: 10.1093/geroni/igx004.2535.Peer-Reviewed Original ResearchSwedish Adoption/Twin StudyExecutive function tasksCognitive performance measuresDementia riskAverage performance levelEpisodic memoryFunction tasksVerbal domainSpatial abilityCognitive trajectoriesCognitive dataLevel of performanceAdditional tasksSwedish adultsHARMONY studyTwin studiesMemoryAge 65Dementia onsetPerformance levelTaskTotal sampleAdultsIncident dementiaLinear decline
2016
Bayesian model reveals latent atrophy factors with dissociable cognitive trajectories in Alzheimer’s disease
Zhang X, Mormino E, Sun N, Sperling R, Sabuncu M, Yeo B, Weiner M, Aisen P, Weiner M, Aisen P, Petersen R, Jack C, Jagust W, Trojanowki J, Toga A, Beckett L, Green R, Saykin A, Morris J, Shaw L, Khachaturian Z, Sorensen G, Carrillo M, Kuller L, Raichle M, Paul S, Davies P, Fillit H, Hefti F, Holtzman D, Mesulam M, Potter W, Snyder P, Schwartz A, Green R, Montine T, Petersen R, Aisen P, Thomas R, Donohue M, Walter S, Gessert D, Sather T, Jiminez G, Balasubramanian A, Mason J, Sim I, Beckett L, Harvey D, Donohue M, Jack C, Bernstein M, Fox N, Thompson P, Schuff N, DeCArli C, Borowski D, Gunter J, Senjem M, Vemuri P, Jones D, Kantarci K, Ward C, Jagust W, Koeppe R, Foster N, Reiman E, Chen K, Mathis C, Landau S, Morris J, Cairns N, Franklin E, Taylor-Reinwald L, Shaw L, Trojanowki J, Lee V, Korecka M, Figurski M, Toga A, Crawford K, Neu S, Saykin A, Foroud T, Potkin S, Shen L, Faber K, Kim S, Nho K, Weiner M, Thal L, Khachaturian Z, Thal L, Buckholtz N, Weiner M, Snyder P, Potter W, Paul S, Albert M, Frank R, Khachaturian Z, Hsiao J, Kaye J, Quinn J, Silbert L, Lind B, Carter R, Dolen S, Schneider L, Pawluczyk S, Becerra M, Teodoro L, Spann B, Brewer J, Vanderswag H, Fleisher A, Heidebrink J, Lord J, Petersen R, Mason S, Albers C, Knopman D, Johnson K, Doody R, Villanueva-Meyer J, Pavlik V, Shibley V, Chowdhury M, Rountree S, Dang M, Stern Y, Honig L, Bell K, Ances B, Morris J, Carroll M, Creech M, Franklin E, Mintun M, Schneider S, Oliver A, Marson D, Geldmacher D, Love M, Griffith R, Clark D, Brockington J, Roberson E, Grossman H, Mitsis E, Shah R, deToledo-Morrell L, Duara R, Greig-Custo M, Barker W, Albert M, Onyike C, D’Agostino D, Kielb S, Sadowski M, Sheikh M, Ulysse A, Gaikwad M, Doraiswamy P, Petrella J, Borges-Neto S, Wong T, Coleman E, Arnold S, Karlawish J, Wolk D, Clark C, Smith C, Jicha G, Hardy P, Sinha P, Oates E, Conrad G, Lopez O, Oakley M, Simpson D, Porsteinsson A, Goldstein B, Martin K, Makino K, Ismail M, Brand C, Potkin S, Preda A, Nguyen D, Womack K, Mathews D, Quiceno M, Levey A, Lah J, Cellar J, Burns J, Swerdlow R, Brooks W, Apostolova L, Tingus K, Woo E, Silverman D, Lu P, Bartzokis G, Graff-Radford N, Parfitt F, Poki-Walker K, Farlow M, Hake A, Matthews B, Brosch J, Herring S, van Dyck C, Carson R, MacAvoy M, Varma P, Chertkow H, Bergman H, Hosein C, Black S, Stefanovic B, Caldwell C, Hsiung G, Mudge B, Sossi V, Feldman H, Assaly M, Finger E, Pasternack S, Rachisky I, Trost D, Kertesz A, Bernick C, Munic D, Mesulam M, Rogalski E, Lipowski K, Weintraub S, Bonakdarpour B, Kerwin D, Wu C, Johnson N, Sadowsky C, Villena T, Turner R, Johnson K, Reynolds B, Sperling R, Johnson K, Marshall G, Yesavage J, Taylor J, Lane B, Rosen A, Tinklenberg J, Sabbagh M, Belden C, Jacobson S, Sirrel S, Kowall N, Killiany R, Budson A, Norbash A, Johnson P, Obisesan T, Wolday S, Allard J, Lerner A, Ogrocki P, Tatsuoka C, Fatica P, Fletcher E, Maillard P, Olichney J, DeCarli C, Carmichael O, Kittur S, Borrie M, Lee T, Bartha R, Johnson S, Asthana S, Carlsson C, Potkin S, Preda A, Nguyen D, Tariot P, Burke A, Milliken A, Trncic N, Fleisher A, Reeder S, Bates V, Capote H, Rainka M, Scharre D, Kataki M, Kelley B, Zimmerman E, Celmins D, Brown A, Pearlson G, Blank K, Anderson K, Flashman L, Seltzer M, Hynes M, Santulli R, Sink K, Gordineer L, Williamson J, Garg P, Watkins F, Ott B, Tremont G, Daiello L, Salloway S, Malloy P, Correia S, Rosen H, Miller B, Perry D, Mintzer J, Spicer K, Bachman D, Finger E, Pasternak S, Rachinsky I, Rogers J, Kertesz A, Drost D, Pomara N, Hernando R, Sarrael A, Schultz S, Smith K, Koleva H, Nam K, Shim H, Relkin N, Chiang G, Lin M, Ravdin L, Smith A, Raj B, Fargher K. Bayesian model reveals latent atrophy factors with dissociable cognitive trajectories in Alzheimer’s disease. Proceedings Of The National Academy Of Sciences Of The United States Of America 2016, 113: e6535-e6544. PMID: 27702899, PMCID: PMC5081632, DOI: 10.1073/pnas.1611073113.Peer-Reviewed Original ResearchConceptsAtrophy factorAtrophy patternsCortical factorsDementia patientsAlzheimer's disease dementia patientsDistinct atrophy patternsStrong associationEntire clinical spectrumAD dementia patientsExecutive function declineExecutive functionSubcortical factorsFunction declineClinical spectrumEarly ADAlzheimer's diseaseStructural MRIDisease monitoringNormal participantsMemory declineMCI participantsDifferent cognitive domainsPatientsFactor compositionCognitive trajectories
2015
Cognitive Aging Trajectories and Burdens of Disability, Hospitalization and Nursing Home Admission Among Community-living Older Persons
Han L, Gill TM, Jones BL, Allore HG. Cognitive Aging Trajectories and Burdens of Disability, Hospitalization and Nursing Home Admission Among Community-living Older Persons. The Journals Of Gerontology Series A 2015, 71: 766-771. PMID: 26511011, PMCID: PMC4888384, DOI: 10.1093/gerona/glv159.Peer-Reviewed Original ResearchConceptsNursing home admissionBurden of disabilityCommunity-living older personsHome admissionOlder personsGreater burdenCognitive trajectoriesMini-Mental State ExaminationCommunity-living personsCognitive aging trajectoriesNursing home placementPrecipitating Events ProjectLow incidence rateEquation Poisson modelsRapid cognitive declineBaseline cognitive functionAging trajectoriesGroup-based trajectory modelsThird of participantsADL disabilityHigher baseline cognitive functionInstrumental ADLIncidence rateDaily livingHospitalization
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