2025
Polygenic risks for depression and neural responses to reward and punishment in young adults
Chen Y, Li H, Luo X, Li G, Ide J, Li C. Polygenic risks for depression and neural responses to reward and punishment in young adults. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2025 PMID: 40412620, DOI: 10.1016/j.bpsc.2025.05.008.Peer-Reviewed Original ResearchPolygenic risk scoresPunishment processingNeural responsesAchenbach Adult Self-ReportInfluence of genetic riskCortical activityAdult Self-ReportYoung adultsGenetic riskRisk of depressionGambling TaskAberrant rewardDrinking severityHuman Connectome ProjectDepression severityPublished routinesBrain responsesPolygenic riskDepression scoresSelf-ReportDepressionConnectome ProjectRewardBrain imagingPunishmentBrain connectivity correlates of the impact of a digital intervention for individuals with subjective cognitive decline on depression and IL-18
Catalogna M, Somerville Y, Saporta N, Nathansohn-Levi B, Shelly S, Edry L, Zagoory-Sharon O, Feldman R, Amedi A. Brain connectivity correlates of the impact of a digital intervention for individuals with subjective cognitive decline on depression and IL-18. Scientific Reports 2025, 15: 6863. PMID: 40011544, PMCID: PMC11865443, DOI: 10.1038/s41598-025-91457-3.Peer-Reviewed Original ResearchConceptsBrain connectivityCognitive declineResting-state functional connectivityEffect sizeCognitive behavioral therapyLate-life depressionSelf-reported depressionMedium effect sizeDigital interventionsInterventions targeting mental healthMood regulationBehavioral therapyDepressive symptomsDecreased connectivityPost-intervention changesFunctional connectivityTwo-week interventionCognitive functionSpatial cognitionDepression scoresBrain healthBehavioral outcomesBrain functionPsychological techniquesPsychological health
2024
MULTIMORBIDITY COMBINATIONS AND DEPRESSIVE SYMPTOM TRAJECTORIES AMONG US OLDER ADULTS
Bishop N, Walker K, Nagel C, Newsom J, Botoseneanu A, Allore H, Quiñones A. MULTIMORBIDITY COMBINATIONS AND DEPRESSIVE SYMPTOM TRAJECTORIES AMONG US OLDER ADULTS. Innovation In Aging 2024, 8: 356-356. PMCID: PMC11690501, DOI: 10.1093/geroni/igae098.1161.Peer-Reviewed Original ResearchHealth and Retirement StudyMultimorbidity combinationsTrajectories of depressive symptomsDepressive symptomsOlder adultsIncreased risk of depressionPhysician-diagnosed conditionsAverage depression scoreRisk of depressionComplex sampling designIncreased patient burdenMultimorbidity patternsRetirement StudyBaseline depressive symptomatologyMultimorbidityDepression scoresPatient burdenDepressive symptomatologyIncreased riskChildhood characteristicsLatent growth trajectoriesAdultsSampling designSymptomsHeart conditionsMaternal mind-mindedness and infant oxytocin are interrelated and negatively associated with postnatal depression.
Lindley Baron-Cohen K, Fearon P, Meins E, Feldman R, Hardiman P, Rosan C, Fonagy P. Maternal mind-mindedness and infant oxytocin are interrelated and negatively associated with postnatal depression. Development And Psychopathology 2024, 1-12. PMID: 39363731, DOI: 10.1017/s0954579424001585.Peer-Reviewed Original ResearchMaternal mind-mindednessMind-mindednessMind-related commentsStudy 1Study 2Mothers' appropriate mind-related commentsLevels of mind-mindednessMothers' caregiving representationsPostnatal depressionSymptoms of depressionParent-child interactionsChildren's social developmentEffects of OTParent-child relationshipMaternal depression scoresChildren's early developmentSample of mothersCaregiving representationsChild OT levelsSalivary OTDepression scoresOT levelsMaternal-infant attachmentPlacebo-ControlledDepressionEnhanced classification and severity prediction of major depressive disorder using acoustic features and machine learning
Liang L, Wang Y, Ma H, Zhang R, Liu R, Zhu R, Zheng Z, Zhang X, Wang F. Enhanced classification and severity prediction of major depressive disorder using acoustic features and machine learning. Frontiers In Psychiatry 2024, 15: 1422020. PMID: 39355380, PMCID: PMC11442283, DOI: 10.3389/fpsyt.2024.1422020.Peer-Reviewed Original ResearchVocal acoustic featuresHealthy control groupSeverity of depressive symptomsTotal depression scoreAcoustic featuresClassification accuracyMDD groupDepressive disorderAnxiety comorbiditiesDepression prediction modelDeep learning methodsDepressive symptomsDepression scoresHC groupSpeech characteristicsMean Absolute Error(MAEDepressionNeural networkEnhanced classificationControl groupLearning methodsMachine learningClassification modelOpen-source algorithmAbsolute error(MAEMedial Amygdalar Tau Is Associated With Mood Symptoms in Preclinical Alzheimer’s Disease
Li J, Tun S, Ficek-Tani B, Xu W, Wang S, Horien C, Toyonaga T, Nuli S, Zeiss C, Powers A, Zhao Y, Mormino E, Fredericks C. Medial Amygdalar Tau Is Associated With Mood Symptoms in Preclinical Alzheimer’s Disease. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2024, 9: 1301-1311. PMID: 39059466, PMCID: PMC11625605, DOI: 10.1016/j.bpsc.2024.07.012.Peer-Reviewed Original ResearchAssociated with mood symptomsMood symptomsAmyloid-positive individualsMedial amygdalaSeed-based functional connectivity analysisAssociated with anxiety symptomsSelf-reported mood symptomsPost hoc correlation analysisAlzheimer's diseaseFunctional connectivity analysisPreclinical Alzheimer's diseaseTau bindingOrbitofrontal cortexTau depositionAmygdalar connectivityEmotional processingAnxiety symptomsRetrosplenial cortexBetween-group differencesAmygdalaFunctional connectivityLateral amygdalaConnectivity analysisDepression scoresNeuropsychiatric symptomsOvervaluation of shape/weight at posttreatment predicts relapse at 12‐month follow‐up after successful behaviorally‐based treatment of binge‐eating disorder
Grilo C, Ivezaj V, Gueorguieva R. Overvaluation of shape/weight at posttreatment predicts relapse at 12‐month follow‐up after successful behaviorally‐based treatment of binge‐eating disorder. International Journal Of Eating Disorders 2024, 57: 1268-1273. PMID: 38321617, PMCID: PMC11093697, DOI: 10.1002/eat.24141.Peer-Reviewed Original ResearchOvervaluation of shape/weightEating-disorder psychopathologyBinge-eating disorderEating Disorder Examination interviewBeck Depression InventoryWeight loss treatmentClinical overvaluationBinge-eating frequencyDiagnostic specifierBinge eatingNon-abstinenceExamination interviewDepression InventoryShape/weightDepression scoresFollow-upPsychopathologyAbstinenceBingeDepressionClinical implicationsDepression 1PosttreatmentDisordersOvervaluationPsychosocial and socioeconomic factors are most predictive of health status in patients with claudication
Scierka L, Peri-Okonny P, Romain G, Cleman J, Spertus J, Fitridge R, Secemsky E, Patel M, Gosch K, Mena-Hurtado C, Smolderen K. Psychosocial and socioeconomic factors are most predictive of health status in patients with claudication. Journal Of Vascular Surgery 2024, 79: 1473-1482.e5. PMID: 38266885, PMCID: PMC11180544, DOI: 10.1016/j.jvs.2024.01.021.Peer-Reviewed Original ResearchPeripheral Artery QuestionnairePeripheral Artery Questionnaire summary scoresPeripheral arterial diseaseHealth statusSummary scoreSymptomatic peripheral arterial diseaseSocial supportInsurance statusPAD-specific health statusHierarchical multivariable linear regression modelSocioeconomic patient characteristicsLow social supportPeripheral artery disease cohortPeripheral artery questionnaire scoresImprove health statusComparative effectiveness researchDiagnosis of depressionPatient characteristicsMultivariate linear regression modelPrediction of health statusDepression scoresLinear regression modelsAge of patientsDuration of symptomsAnxiety scoresEffect of Dancing Interventions on Depression and Anxiety Symptoms in Older Adults: A Systematic Review and Meta-Analysis
Prudente T, Mezaiko E, Silveira E, Nogueira T. Effect of Dancing Interventions on Depression and Anxiety Symptoms in Older Adults: A Systematic Review and Meta-Analysis. Behavioral Sciences 2024, 14: 43. PMID: 38247695, PMCID: PMC10813489, DOI: 10.3390/bs14010043.Peer-Reviewed Original ResearchOlder adultsDance interventionAnxiety symptomsMeta-analysisEffects of dance interventionsSystematic reviewMental health interventionsEffects of danceMental Well-BeingRisk of biasRandomized trialsMild cognitive impairmentHealth interventionsAnxiety outcomesDepression scoresDepressive symptomsGrey literatureCochrane toolCognitive impairmentAnxietyDepressionDance classesInterventionWell-beingStatistically significant reductionThe effect of ABM on attentional networks and stress-induced emotional reactivity in a mixed clinical sample with depression: A randomized sham-controlled trial
Bø R, Kraft B, Jonassen R, Joormann J, Harmer C, Landrø N. The effect of ABM on attentional networks and stress-induced emotional reactivity in a mixed clinical sample with depression: A randomized sham-controlled trial. Neuroscience Applied 2024, 3: 104091. DOI: 10.1016/j.nsa.2024.104091.Peer-Reviewed Original ResearchAttention Network TaskEmotional reactivityAttention networkEfficacy of attentional bias modificationAttentional bias modificationExecutive attention networkEffect of AbMBias modificationComorbid anxietyLab stressorDepressive disorderAttentional processesDepressive symptomsMinimal effect sizeDepression scoresNetwork tasksEffect sizeSham-controlled trialRandomized sham-controlled trialClinical samplesSham comparatorTwo-weekRandomized Controlled TrialsParticipantsAnxiety
2023
Update on long-term mental health outcomes in eight face transplant recipients from a single center
Huelsboemer L, Stögner V, Hosseini H, Hauc S, Boroumand S, Parikh N, Blood A, Mookerjee V, Kauke-Navarro M, Nizzi M, Pomahac B. Update on long-term mental health outcomes in eight face transplant recipients from a single center. The International Journal Of Psychiatry In Medicine 2023, 59: 583-594. PMID: 38152028, DOI: 10.1177/00912174231225764.Peer-Reviewed Original ResearchFace transplant recipientsSelf-reported qualityLong-term psychosocial outcomesMental healthMental health dynamicsLong-term mental healthOngoing psychological supportBetter mental healthBrief COPEPsychological dimensionsPsychological benefitsPsychosocial outcomesLong-term journeyPsychological supportInstrumental supportMixed-method approachDepression scoresFacial disfigurementHealth DynamicsFace transplantationTransplant recipientsOlder ageScoresSupportLast followRacial differences after bariatric surgery: 24-month follow-up of a randomized, controlled trial for postoperative loss-of-control eating
Ivezaj V, Dilip A, Duffy A, Grilo C. Racial differences after bariatric surgery: 24-month follow-up of a randomized, controlled trial for postoperative loss-of-control eating. Surgery For Obesity And Related Diseases 2023, 20: 261-266. PMID: 37949690, PMCID: PMC10922356, DOI: 10.1016/j.soard.2023.09.017.Peer-Reviewed Original ResearchEating-disorder psychopathologyPercent excess weight lossExcess weight lossPost-bariatric surgeryNon-white patientsWhite patientsEating Disorder Examination-Bariatric Surgery Version interviewGreater percent excess weight lossGreater eating-disorder psychopathologyMonths post-bariatric surgeryWeight lossBDI-II depression scoreLong-term outcomesPost-operative lossRacial differencesAcademic medical centerBeck Depression InventoryBariatric surgeryShort-term findingsControlled TrialsProspective studyMedical CenterDepression scoresBetter outcomesPatientsMultiple trajectories of depressive symptoms among Chinese in middle and late life: Characterization and risk factors
Li C, Liu J, Ju Y, Liu B, Zhang Y. Multiple trajectories of depressive symptoms among Chinese in middle and late life: Characterization and risk factors. International Journal Of Social Psychiatry 2023, 69: 1462-1471. PMID: 37081758, DOI: 10.1177/00207640231164020.Peer-Reviewed Original ResearchConceptsDepressive symptom trajectoriesDepressive symptomsSymptom trajectoriesDepression burdenCenter for Epidemiologic Studies Depression scoreHealth statusLongitudinal associationsEpidemiological Studies Depression scoreSelf-reported health statusDevelopment of targeted prevention strategiesTrajectories of depressive symptomsRisk of mental disordersParticipants' depressive symptomsRisk factorsAssociations of baseline covariatesGeneralized Estimating EquationsAt-risk populationsAssociated with trajectoriesManifestations of depressionGrowth mixture modelingStable-lowChinese adultsStable-highDepression scoresMultinomial logistic model
2022
Longitudinal alterations in mRNA expression of the BDNF neurotrophin signaling cascade in blood correlate with changes in depression scores in patients undergoing electroconvulsive therapy
Schurgers G, Walter S, Pishva E, Guloksuz S, Peerbooms O, Incio L, Arts B, Kenis G, Rutten B. Longitudinal alterations in mRNA expression of the BDNF neurotrophin signaling cascade in blood correlate with changes in depression scores in patients undergoing electroconvulsive therapy. European Neuropsychopharmacology 2022, 63: 60-70. PMID: 36067540, DOI: 10.1016/j.euroneuro.2022.07.183.Peer-Reviewed Original ResearchConceptsBrain-derived neurotrophic factorBDNF/TrkBExpression of BDNFSerum BDNF protein levelsBDNF protein levelsElectroconvulsive therapyDepression scoresMRNA expressionPeripheral bloodTreatment-resistant depressed patientsProtein levelsMechanism of actionAntidepressant effectsNeurotrophic factorDepressed patientsLongitudinal alterationsSevere depressionBlood correlatesEffective treatmentLongitudinal changesTrkBStudy periodNR3C1PatientsTherapyWorsening physical functioning in patients with neuroinflammatory disease during the COVID-19 pandemic
Levit E, Cohen I, Dahl M, Edwards K, Weinstock-Guttman B, Ishikawa T, Kavak K, Leavitt V, Nelson K, Onomichi K, Bar-Or A, Perrone C, Riley C, Venkatesh S, De Jager PL, Xia Z, Longbrake EE, Collaborative M. Worsening physical functioning in patients with neuroinflammatory disease during the COVID-19 pandemic. Multiple Sclerosis And Related Disorders 2022, 58: 103482. PMID: 35016114, PMCID: PMC8742609, DOI: 10.1016/j.msard.2021.103482.Peer-Reviewed Original ResearchConceptsPhysical functionDepression scoresCOVID-19 pandemicPhysical disabilityNeurological inflammatory diseasesMajor academic medical centerAcademic medical centerHigher baseline levelsLack of diseaseDisease durationStudy entryTherapy useNeuroinflammatory diseasesMale genderInflammatory diseasesPhysical functioningMedical CenterMood symptomsDepressive symptomsSmall cohortBaseline levelsSerial surveysSignificant depressionOlder ageWorse depression
2021
Change in impulsivity is prospectively associated with treatment outcomes for binge-eating disorder
Boswell RG, Gueorguieva R, Grilo CM. Change in impulsivity is prospectively associated with treatment outcomes for binge-eating disorder. Psychological Medicine 2021, 53: 2789-2797. PMID: 34812713, PMCID: PMC9124732, DOI: 10.1017/s003329172100475x.Peer-Reviewed Original ResearchConceptsEating-disorder psychopathologyCognitive behavioral therapyTreatment outcomesDepression scoresPharmacological treatmentRandomized placebo-controlled clinical trialPlacebo-controlled clinical trialEfficacy of CBTBinge-eating disorderBaseline impulsivityAssociation of rapidClinical trialsTreatment groupsOverall changeDisorder psychopathologyMixed effects modelsOutcomesTreatmentBMIPatientsMeasures of impulsivityScoresPsychopathologyGeneral outcomeImpulsivityA graph theory‐based whole brain approach to assess mood state differences in adolescents and young adults with bipolar disorder
Goldman DA, Sankar A, Colic L, Villa L, Kim JA, Pittman B, Constable RT, Scheinost D, Blumberg HP. A graph theory‐based whole brain approach to assess mood state differences in adolescents and young adults with bipolar disorder. Bipolar Disorders 2021, 24: 412-423. PMID: 34665907, PMCID: PMC9016085, DOI: 10.1111/bdi.13144.Peer-Reviewed Original ResearchConceptsLenticular nucleusFunctional connectivityPrefrontal cortexMood statesYoung adultsLimited brain regionsAcute mood statesRight lenticular nucleusBipolar I disorderDorsal prefrontal cortexPrevious neuroimaging studiesWhole-brain approachTemporal functional connectivityFunctional magnetic resonanceLeft prefrontal cortexBrain dysfunctionContralateral homologuesHealthy controlsI disordersDepression scoresICD increasesRight cerebellumBipolar disorderEarly interventionBrain regionsIntensive Dialectical Behavior Treatment for Individuals With Borderline Personality Disorder With and Without Substance Use Disorders
Buono FD, Larkin K, Rowe D, Perez-Rodriguez MM, Sprong ME, Garakani A. Intensive Dialectical Behavior Treatment for Individuals With Borderline Personality Disorder With and Without Substance Use Disorders. Frontiers In Psychology 2021, 12: 629842. PMID: 34497550, PMCID: PMC8419465, DOI: 10.3389/fpsyg.2021.629842.Peer-Reviewed Original ResearchSubstance use disordersBorderline personality disorderComorbid substance use disorderUse disordersDialectical behavioral therapyTreatment programComorbid borderline personality disorderPersonality disorderDepression symptom scaleModerate depression scoresDepressive symptomsGroup 2Depression scoresGroup 1Symptom ScaleDBT treatmentSymptom overlapUnivariate general linear modelBehavioral therapyDisordersSignificant decreaseBehavior treatmentGeneral linear modelSignificant differencesPatientsDouble trouble? Associations of parental substance use and eating behaviors with pediatric disordered eating
Boswell RG, Lydecker JA. Double trouble? Associations of parental substance use and eating behaviors with pediatric disordered eating. Addictive Behaviors 2021, 123: 107089. PMID: 34450350, PMCID: PMC8506907, DOI: 10.1016/j.addbeh.2021.107089.Peer-Reviewed Original ResearchConceptsCo-occurring substance useEating-disorder psychopathologySubstance use disordersParental substance useSubstance useUse disordersChild's ageSeverity of psychopathologyOnline cross-sectional surveyCross-sectional surveyEating-related psychopathologyParental SUDEating Disorder PsychopathologyEating-related problemsChild weightDisorder behaviorsDepression scoresGreater severityDouble troublePersonal substance useTreatment effortsEating Disorder BehaviorsDisordersParent psychopathologyParents' ageDo mothers and fathers agree? Examining interparental ratings of youth externalizing behaviors among ethnically diverse families
Vassilopoulos A, DeLucia C, Torres C. Do mothers and fathers agree? Examining interparental ratings of youth externalizing behaviors among ethnically diverse families. Journal Of Clinical Psychology 2021, 77: 2653-2667. PMID: 34214193, DOI: 10.1002/jclp.23200.Peer-Reviewed Original ResearchConceptsYouth externalizing behaviorsParent reportExternalizing behaviorsChild psychological assessmentChild symptom severityMother-father agreementSymptom severityMothers' depression scoresYouth behavior problemsMother-father dyadsSmall literature baseDepression scoresPsychological assessmentPaternal caregiversBehavior problemsPsychosocial screeningYouths' parentsMinority youthFamily characteristicsDifference scoresYouth AssessmentYouth 6Stress scoresMinimal researchLiterature base
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