2025
Ketamine for Depression, but at What Cost? A Review of Ketamine's Neurotoxic Effects From Preclinical and Human Studies.
Li S, Kumpf K, Urrutia J, Krystal J, Sanacora G, Wilkinson S. Ketamine for Depression, but at What Cost? A Review of Ketamine's Neurotoxic Effects From Preclinical and Human Studies. American Journal Of Psychiatry 2025, appiajp20250276. PMID: 40926573, DOI: 10.1176/appi.ajp.20250276.Peer-Reviewed Original ResearchCognitive functionExecutive function impairmentNeurotoxic effectsLower cognitive functionHuman clinical trialsIntranasal esketamineClinical trialsCognitive deficitsSubanesthetic dosesKetamine administrationKetamine usersCognitive AssessmentRobust longitudinal researchEsketamineLongitudinal researchRacemic ketamineNonhuman primate modelRecreational usersObservational studyExcitotoxic neuronal damageFunctional impairmentKetamineDirect comparisonIntegrated findingsPreclinical researchPsychological Distress and Cognitive Function in Women: Exploring Potential Mediation by Use of Opiates, Sleep Aids, or Minor Tranquilizers
Sampson L, Lawn R, Murchland A, Liu J, Marquez C, Scoglio A, Jha S, Sumner J, Roberts A, Kang J, Chibnik L, Koenen K, Kubzansky L. Psychological Distress and Cognitive Function in Women: Exploring Potential Mediation by Use of Opiates, Sleep Aids, or Minor Tranquilizers. Journal Of Women's Health 2025, 34: 924-936. PMID: 40336460, PMCID: PMC12241842, DOI: 10.1089/jwh.2024.0991.Peer-Reviewed Original ResearchPosttraumatic stress disorderCognitive functionMedication useMinor tranquilizersMeasures of posttraumatic stress disorderNurses' Health Study IIAssociated with lower cognitive functionCogstate Brief BatterySleep aidsEvidence of mediationLower cognitive functionLearning/working memoryBrief batteryStress disorderPsychomotor speed/attentionAssociated with useDistress scoresHigh distressMediation analysisPsychological distressLinear regression modelsPotential mediatorsSelf-ReportAssessed associationsDepressionMultimorbidity patterns and cognitive change among Mexican older adults: findings from the Mexican Health and Aging Study
Bishop N, Botoseneanu A, Newsom J, Allore H, Nagel C, Markwardt S, Samper-Ternent R, Quiñones A. Multimorbidity patterns and cognitive change among Mexican older adults: findings from the Mexican Health and Aging Study. Journal Of Global Ageing 2025, 2: 65-97. DOI: 10.1332/29767202y2024d000000019.Peer-Reviewed Original ResearchMexican Health and Aging StudyHealth and Aging StudyMultimorbidity patternsMexican adultsChronic conditionsOlder adultsIncreasing burden of chronic conditionsDepressive symptomsBurden of chronic conditionsCo-occurring chronic conditionsCognitive declineCognitive functionAssociated with lower cognitive functionOlder Mexican adultsMexican Older AdultsRisk of cognitive declineAging StudyLower cognitive functionCognitive changesManagement of diabetesMultimorbidityIncreasing burdenCognitive trajectoriesLatent growth modelingOlder adulthood
2024
Enlarged pituitary gland volume: a possible state rather than trait marker of psychotic disorders
Guimond S, Alftieh A, Devenyi G, Mike L, Chakravarty M, Shah J, Parker D, Sweeney J, Pearlson G, Clementz B, Tamminga C, Keshavan M. Enlarged pituitary gland volume: a possible state rather than trait marker of psychotic disorders. Psychological Medicine 2024, 54: 1835-1843. PMID: 38357733, PMCID: PMC11132920, DOI: 10.1017/s003329172300380x.Peer-Reviewed Original ResearchPituitary gland volumePsychotic disordersSymptom severityAntipsychotic doseIllness durationCognitive functionAssociated with greater symptom severitySignificant effect of diagnosisAssociated with symptom severityHigher antipsychotic dosePituitary volumeBipolar-Schizophrenia NetworkIntermediate Phenotypes consortiumStructural magnetic resonance imagingProgression of psychosisGreater symptom severityEffect of diagnosisLower cognitive functionMore severe symptomsSample of individualsTransdiagnostic sampleMAGeT Brain algorithmGland volumeTrait markerBetween-group differencesAmyloid deposition and small vessel disease are associated with cognitive function in older adults with type 2 diabetes
Lesman-Segev O, Golan Shekhtman S, Springer R, Livny A, Lin H, Yuxia O, Zadok M, Ganmore I, Heymann A, Hoffmann C, Domachevsky L, Schnaider Beeri M. Amyloid deposition and small vessel disease are associated with cognitive function in older adults with type 2 diabetes. Scientific Reports 2024, 14: 2741. PMID: 38302529, PMCID: PMC10834442, DOI: 10.1038/s41598-024-53043-x.Peer-Reviewed Original ResearchConceptsNon-demented older adultsCognitive functionLower cognitive functionAmyloid burdenCognitive declineOlder adultsAssociations of small vessel diseaseAssociated with cognitive functionCognitive Decline studyAssociated with lower cognitive functionTreating cognitive declineAssociated with cognitive declineType 2 diabetesGray matterAssociation of amyloidIsrael DiabetesGM volumeAssess cognitionMeasures of small vessel diseaseWhite matter hyperintensitiesAlzheimer's disease biomarkersCognitionDecline studiesSmall vessel diseaseDiabetes-related characteristics
2022
Cardiometabolic measures and cognition in early menopause - Analysis of baseline data from a randomized controlled trial
Pal L, Morgan K, Santoro NF, Manson JE, Taylor HS, Miller VM, Brinton EA, Lobo R, Neal-Perry G, Cedars MI, Harman SM, James TT, Gleason CE. Cardiometabolic measures and cognition in early menopause - Analysis of baseline data from a randomized controlled trial. Maturitas 2022, 162: 58-65. PMID: 35617770, PMCID: PMC10089771, DOI: 10.1016/j.maturitas.2022.04.004.Peer-Reviewed Original ResearchConceptsBody mass indexWaist circumferenceCentral adiposityCardiometabolic indicesBlood pressureTotal cholesterolMenopausal womenHigh-sensitivity C-reactive proteinSocio-demographic variablesSensitivity C-reactive proteinMini-mental status scoreStepwise multivariable analysisC-reactive proteinBaseline dataMental status scoresHigh-density lipoproteinLow-density lipoproteinFinal multivariable modelLower cognitive functionWarrants further studyCross-sectional analysisRace/ethnicityCardiometabolic measuresEstrogen preventionHs-CRP
2019
Late-life depression and cognitive function among older adults in the U.S.: The National Health and Nutrition Examination Survey, 2011–2014
Wei J, Ying M, Xie L, Chandrasekar E, Lu H, Wang T, Li C. Late-life depression and cognitive function among older adults in the U.S.: The National Health and Nutrition Examination Survey, 2011–2014. Journal Of Psychiatric Research 2019, 111: 30-35. PMID: 30660811, DOI: 10.1016/j.jpsychires.2019.01.012.Peer-Reviewed Original ResearchConceptsCognitive functionOlder adultsLate-life depressionExecutive function/processing speedLower cognitionDepressive symptomsDomain-specific cognitive functionDigit Symbol Substitution TestAnimal Fluency TestWord recall testDelayed Word Recall TestLower cognitive functionRecall testOverall cognitionFluency testProcessing speedCognitionCognitive depressive symptomsSubstitution TestNational HealthZ-scoreSpecific domainsDepressionMultivariable linear regression modelsPatient Health Questionnaire
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