2025
Identifying individuals at clinical high risk for psychosis using a battery of tasks sensitive to symptom mechanisms
Williams T, Gold J, Waltz J, Schiffman J, Ellman L, Strauss G, Walker E, Woods S, Powers A, Kenney J, Pappu M, Corlett P, Tran T, Silverstein S, Zinbarg R, Mittal V. Identifying individuals at clinical high risk for psychosis using a battery of tasks sensitive to symptom mechanisms. Translational Psychiatry 2025, 15: 311. PMID: 40849429, PMCID: PMC12375010, DOI: 10.1038/s41398-025-03539-5.Peer-Reviewed Original ResearchConceptsCHR-P individualsClinical high riskCHR-PClinical InterviewComputerized assessmentAssessment of psychosis riskStructured Clinical InterviewRisk calculator scoresNeurocognitive mechanismsPsychosis symptomsPsychosis riskBehavioral tasksUnique predictorsMental disordersTask batteryPsychosisTask variablesComparison groupHealthy controlsRisk severityUpdate beliefsTaskMultinomial logistic regressionConsortium studyIndividualsCannabinoid 1 receptor availability in posttraumatic stress disorder: A positron emission tomography study
Korem N, Bassir Nia A, Hillmer A, D’Souza D, Nabulsi N, Ropchan J, Huang Y, Cosgrove K, Levy I, Pietrzak R, Harpaz-Rotem I. Cannabinoid 1 receptor availability in posttraumatic stress disorder: A positron emission tomography study. Translational Psychiatry 2025, 15: 310. PMID: 40846835, PMCID: PMC12373994, DOI: 10.1038/s41398-025-03519-9.BooksPathophysiology of posttraumatic stress disorderEmotional numbing symptomsCB1R availabilityPosttraumatic stress disorderEndocannabinoid systemStress disorderPositron emission tomographyTrauma-exposed participantsEndocannabinoid system's rolePositron emission tomography studiesCannabinoid receptor 1Emission tomography studiesMulti-faceted disorderFear learningCB1RSymptom expressionHealthy controlsCannabinoidDisordersTomography studiesEmission tomographyPreclinical studiesSymptomsHigher levelsReceptor 1Synaptic Density in Multiple Sclerosis
Luoma A, Matilainen M, Tuisku J, Aarnio R, Nikkilä T, Laaksonen S, Koivumäki M, Honkonen E, Nylund M, Wahlroos S, Solin O, Chen M, Toyonaga T, Lehto J, Snellman A, Rinne J, Airas L. Synaptic Density in Multiple Sclerosis. Neurology Neuroimmunology & Neuroinflammation 2025, 12: e200435. PMID: 40609051, PMCID: PMC12227148, DOI: 10.1212/nxi.0000000000200435.Peer-Reviewed Original ResearchConceptsCognitive measuresHealthy controlsSynaptic densityMultiple sclerosisTissue-to-plasma concentration ratioCortical GMPET imagingGray matterSynaptic vesicle glycoprotein 2ATissue-to-plasmaChronic inflammatory diseaseLoss in vivoClinically relevant aspectsPET imaging resultsSubcortical regionsCognitive impairmentInflammatory diseasesPathological featuresHistopathological studiesGM pathologyWhite matterNeurodegenerative processesPhysical disabilitySynaptic lossSV2ACentral Pathophysiology and Brain Network Changes Related to Camptocormia in Parkinson's Disease
Anjum T, Raethjen J, Ding H, Koirala N, Pryss R, Wolke R, Ip C, Deuschl G, Volkmann J, Margraf N, Muthuraman M. Central Pathophysiology and Brain Network Changes Related to Camptocormia in Parkinson's Disease. Movement Disorders 2025 PMID: 40583364, DOI: 10.1002/mds.30278.Peer-Reviewed Original ResearchCamptocormia patientsParavertebral musclesPartial directed coherence analysisParkinson's diseaseEEG-EMG coherenceBrainstem involvementCentral pathophysiologyHealthy controlsBrainstem activityDirectional coherence analysisPatientsAdvanced PDAbnormal flexionCamptocormiaCoherent sourcesCentral motor networkSubcortical regionsDiseaseMuscleTomographic mapsStooped postureBrain network changesCentral musclesBrainInteraction strengthSerum kynurenine metabolites and cytokine levels: diagnostic and predictive implications in acute manic episodes of bipolar disorder
Li W, Liu Z, Wang J, Wang X, Chen W, Li N, Huang J, Gou M, Zhang P, Liu R, Deng H, Yang K, Chen S, Xie T, Tian L, Yang F, Tian B, Li C, Li Y, Tan Y. Serum kynurenine metabolites and cytokine levels: diagnostic and predictive implications in acute manic episodes of bipolar disorder. Brain Behavior And Immunity 2025, 129: 485-493. PMID: 40578536, DOI: 10.1016/j.bbi.2025.06.033.Peer-Reviewed Original ResearchYoung Mania Rating ScaleKynurenine metabolitesHealthy controlsTreatment outcomesCytokine levelsKynurenine metabolite levelsManic episodes of bipolar disorderBipolar disorderAcute manic episodeMania Rating ScaleEpisodes of bipolar disorderWeeks of treatmentInterleukin (IL)-10Predicting Treatment OutcomePredictors of treatment outcomeManic symptom severitySerum cytokinesSerum levelsTreatment responseIL-4Diagnostic accuracyIL-10Cytokine systemManic episodesIL-8Phenotyping extracellular vesicles and their serotonin transporter cargo in major depressive disorder
Zadka Ł, Eggerstorfer B, Buzalewicz I, Vraka C, Rusak A, Godbersen G, Opalińska A, Unterholzner J, Ulatowska-Jarża A, Philippe C, Haczkiewicz-Leśniak K, Silberbauer L, Murgaš M, Nics L, Hahn A, Hacker M, Gomułkiewicz A, Rujescu D, Podhorska-Okołów M, Lanzenberger R, Gryglewski G. Phenotyping extracellular vesicles and their serotonin transporter cargo in major depressive disorder. Journal Of Affective Disorders 2025, 389: 119740. PMID: 40550277, DOI: 10.1016/j.jad.2025.119740.Peer-Reviewed Original ResearchSerotonin transporterDepressive disorderPresence of serotonin transporterAntidepressant treatment responseSerotonin transporter levelsMDD patientsNanoparticle tracking analysisMood disordersPsychiatric disordersMDDBinding potentialExtracellular vesiclesTreatment response predictionPositron emission tomographyTreatment responseDisordersHealthy controlsExosome markers CD63Blood-brain barrierEmission tomographyStudy intercellular communicationPrognostic valueConcentration of extracellular vesiclesPatient stratificationExosomal markersNetwork-wide aberrancies in neuronal activity during working memory in a large cohort of patients with mood disorders: associations with cognitive impairment and functional disability
Damgaard V, Schandorff J, Macoveanu J, Sankar A, Zarp J, Fisher P, Jørgensen M, Kessing L, Knudsen G, Frokjaer V, Miskowiak K. Network-wide aberrancies in neuronal activity during working memory in a large cohort of patients with mood disorders: associations with cognitive impairment and functional disability. Molecular Psychiatry 2025, 1-9. PMID: 40527901, DOI: 10.1038/s41380-025-03078-x.Peer-Reviewed Original ResearchCognitive control networkFunctional magnetic resonance imagingMood disordersCognitive performanceHypo-activityCross-sectional functional magnetic resonance imagingWorking memory n-back taskCognitive impairmentHyper-activityRight middle frontal gyrusLeft dorsolateral prefrontal cortexDaily functioningHealthy controlsDorsolateral prefrontal cortexFrontal medial cortexN-back taskMiddle frontal gyrusAssociated with cognitive impairmentAssociated with cognitionComprehensive neurocognitive testingAssessment of daily functionCognitive controlDMN abnormalitiesPrefrontal cortexFrontal gyrusCommon neural patterns of substance use disorder: a seed-based resting-state functional connectivity meta-analysis
Zhang X, Zhang H, Shao Y, Li Y, Zhang F, Zhang H. Common neural patterns of substance use disorder: a seed-based resting-state functional connectivity meta-analysis. Translational Psychiatry 2025, 15: 190. PMID: 40467551, PMCID: PMC12137653, DOI: 10.1038/s41398-025-03396-2.Peer-Reviewed Original ResearchConceptsAnterior cingulate cortexSuperior frontal gyrusMedian cingulate gyrusInferior frontal gyrusResting-state functional connectivityBrain reward circuitsReward circuitSUD patientsPrefrontal cortexFamily-wise errorFrontal gyrusUse disorderCortical-striatal-thalamic-cortical circuitWhole-brain rs-fMRI studiesReduced resting-state functional connectivityDorsal anterior cingulate cortexResting-state functional magnetic resonance imagingFunctional magnetic resonance imagingHealthy controlsPatterns of substance use disordersAssociated with impulsivityStages of addictionSubstance use disordersRs-fMRI studiesBackgroundSubstance use disordersCognitive–Emotional Impairments in Euthymic Bipolar Disorder—New Insights Into Emotion Regulation and Cognitive Control Deficits
Seelig E, Joormann J, Wolkenstein L. Cognitive–Emotional Impairments in Euthymic Bipolar Disorder—New Insights Into Emotion Regulation and Cognitive Control Deficits. Emotion 2025, 25: 1044-1059. PMID: 40402635, DOI: 10.1037/emo0001479.Peer-Reviewed Original ResearchBipolar disorderCognitive controlER strategiesCC deficitsStrategy useResponse to negative affectSelf-reported habitual useHabitual useDown-regulate positive emotionsHealthy controlsDeficient cognitive controlCognitive control deficitsER strategy useMaladaptive ER strategiesSpontaneous strategy useNo group differencesEuthymic patientsMood inductionER deficitsEmotion regulationNegative affectImpaired CCPositive affectControl deficitsCompetence deficitsImproved detection of circulating tumor DNA in patients with leiomyosarcoma with fragment size restriction.
Ruzgar N, Klega K, Ricker C, Tanhaemami M, Shafer A, Reinke D, Siontis B, Schuetze S, Crompton B. Improved detection of circulating tumor DNA in patients with leiomyosarcoma with fragment size restriction. Journal Of Clinical Oncology 2025, 43: 3046-3046. DOI: 10.1200/jco.2025.43.16_suppl.3046.Peer-Reviewed Original ResearchCell-free DNADetection of ctDNADetection of circulating tumor DNACycles of chemotherapyShort fragmentsDetectable ctDNACtDNA detectionTumor DNAHealthy controlsWhole-genome sequencingCopy number alterationsDiagnosis of leiomyosarcomaCell-free DNA samplesLiquid biopsy assayFragments of cell-free DNASequence dataRestriction analysisCtDNA levelsLeiomyosarcoma samplesNon-tumor originAssociated with lower likelihoodDNA samplesPrognostic valueFragment lengthBiopsy assayBrain Age Disparities in Psychosis Across DSM Diagnoses and B-SNIP Biotypes
Promet L, Meda S, Alliey-Rodriguez N, Clementz B, Gershon E, Hill S, Ivleva E, Keedy S, Keshavan M, McDowell J, Parker D, Tamminga C, Pearlson G. Brain Age Disparities in Psychosis Across DSM Diagnoses and B-SNIP Biotypes. Schizophrenia Bulletin 2025, sbaf022. PMID: 40448350, DOI: 10.1093/schbul/sbaf022.Peer-Reviewed Original ResearchBrain age gapBipolar-Schizophrenia NetworkDSM diagnosesBrain agingPRS-SZComorbid disordersNon-psychotic first-degree relativesHealthy controlsAssociated with symptom severityPsychotic bipolar disorderSubtypes of psychosisStructural T1-weighted imagesBrain structural differencesPsychotropic medication useSchizoaffective disorderPsychosis probandsPsychotic disordersBipolar disorderPolygenic risk scoresSymptom severityFirst-degree relativesPsychosisAge gapDSMIntermediate phenotypesPrediction of longitudinal synaptic loss in Alzheimer's disease using tau PET and plasma biomarkers
Wang J, Huang Q, Chen X, You Z, He K, Mao X, Huang Y, Franzmeier N, Schöll M, Guo T, Zhao J, Guan Y, Ni R, Li B, Xie F. Prediction of longitudinal synaptic loss in Alzheimer's disease using tau PET and plasma biomarkers. Alzheimer's & Dementia 2025, 21: e70333. PMID: 40432308, PMCID: PMC12117192, DOI: 10.1002/alz.70333.Peer-Reviewed Original ResearchConceptsAssociated with longitudinal cognitive declineLongitudinal cognitive declineSynaptic lossCognitive declineSynapse lossPositron emission tomographyTau depositionTau positron emission tomographyTau burdenHealthy controlsAlzheimer's diseaseSynaptic densityMedial temporal lobePlasma glial fibrillary acidic proteinIncreased tau burdenPhosphorylated tau181Longitudinal changesCognitively impaired individualsAcidic proteinTau pathologyTemporal lobeAmyloid positron emission tomographyGlial fibrillary acidic proteinPlasma phosphorylated tau181CI groupChanges in the FXR-cistrome and alterations in bile acid physiology in Wilson disease
Wooton-Kee C, Yalamanchili H, Mohamed I, Hassan M, Setchell K, Rivas M, Coskun A, Putluri V, Putluri N, Jalal P, Schilsky M, Moore D. Changes in the FXR-cistrome and alterations in bile acid physiology in Wilson disease. Hepatology Communications 2025, 9: e0707. PMID: 40408300, PMCID: PMC12106221, DOI: 10.1097/hc9.0000000000000707.Peer-Reviewed Original ResearchConceptsWild-type miceFarnesoid X receptorWilson's diseaseNon-parenchymal cellsDistal intergenic regionsLiver bile acid concentrationWD patientsHealthy controlsMetabolic target genesFarnesoid X Receptor RegulationBile salt export pumpIntergenic regionFXR activationAutosomal recessive disorderBile acid homeostasisBile acid physiologyFarnesoid X receptor activationPromoter regionHomeostasis pathwaysBile acid metabolismDecreasing FXR activityTarget genesBile acid profilesMarker genesStress pathwaysSex differences in event-related potentials and their clinical predictive value in first-episode antipsychotic-naïve schizophrenia
Qin Q, Lu C, Li S, Liu N, Li Y, Li T, Dong Y, Wang X, Li S, Li J, Zhang X. Sex differences in event-related potentials and their clinical predictive value in first-episode antipsychotic-naïve schizophrenia. European Archives Of Psychiatry And Clinical Neuroscience 2025, 1-10. PMID: 40397181, DOI: 10.1007/s00406-025-02020-0.Peer-Reviewed Original ResearchPositive and Negative Syndrome ScaleHamilton Depression ScaleHamilton Anxiety ScaleReduced P3 amplitudeHamilton Anxiety Scale scoresEvent-related potentialsSex differencesP3 amplitudeP3a latencyHealthy controlsN1 amplitudeAntipsychotic-naive schizophreniaGeneral psychopathology scoreNegative Syndrome ScaleHamilton Depression Scale scoresAuditory oddball paradigmSyndrome ScaleCompare sex differencesProlonged latencyPsychopathology scoresP3 componentN100 amplitudeAnxiety ScaleOddball paradigmCognitive impairmentHippocampal and amygdala subfield volumes in obsessive–compulsive disorder by medication status
Ntwatwa Z, Lochner C, Roos A, Sevenoaks T, van Honk J, Batistuzzo M, Choi S, Hoexter M, Kim M, Kwon J, Mataix-Cols D, Menchón J, Miguel E, Nakamae T, Soriano-Mas C, Veltman D, Groenewold N, van den Heuvel O, Stein D, Ipser J. Hippocampal and amygdala subfield volumes in obsessive–compulsive disorder by medication status. Journal Of Psychiatry And Neuroscience 2025, 50: e170-e180. PMID: 40398928, PMCID: PMC12114122, DOI: 10.1503/jpn.230119.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderSubfield volumesMedical statusSymptom severityNeuroimaging studies of obsessive-compulsive disorderObsessive-compulsive disorder symptom severityStudies of obsessive-compulsive disorderNeurobiology of obsessive-compulsive disorderHealthy controlsObsessive-compulsive disorder severityBrain volumetric alterationsPsychotropic medication useHippocampal dentate gyrusQuadratic effects of ageAssess between-group differencesComorbid anxietyUnmedicated peopleNeuroimaging studiesPsychotropic medicationsVolumetric findingsBetween-group differencesVolumetric alterationsHippocampal subfieldsAmygdalaBrain volumePlasma CHI3L1 associates with brain volume loss and glial activation in multiple sclerosis
Ahola V, Saraste M, Nylund M, Matilainen M, Luoma A, Vuorimaa A, Lehto J, Laaksonen S, Brockmann E, Kuhle J, Leppert D, Soukka T, Lamminmäki U, Airas L. Plasma CHI3L1 associates with brain volume loss and glial activation in multiple sclerosis. Journal Of Neurology Neurosurgery & Psychiatry 2025, jnnp-2025-336063. PMID: 40379482, DOI: 10.1136/jnnp-2025-336063.Peer-Reviewed Original ResearchDistribution volume ratioBrain volume lossHealthy controlsPositron emission tomographyPlasma CHI3L1Smoldering inflammationMultiple sclerosisGlial activationInnate immune cell activationAssociated with Expanded Disability Status ScaleImmune cell activationChitinase-3-like protein 1Expanded Disability Status ScaleAssociated with smaller brain volumesDisability Status ScaleCHI3L1 concentrationsIndependent of relapsesVolume lossStudy cohortCell activationImaging outcomesTSPO-PETCHI3L1Emission tomographyStatus ScaleImpact of COVID‐19 Vaccination and Infection on Anti‐Triple‐Knockout (TKO) Pig Antibody Production: A Study in Patients With End‐Stage Liver Disease and Liver Transplant Recipients
Wang L, Zhuang L, Li T, Hara H, Cooper D, Leng J, Pan D, Zheng S, Wang Y, Xu X, Wei Q. Impact of COVID‐19 Vaccination and Infection on Anti‐Triple‐Knockout (TKO) Pig Antibody Production: A Study in Patients With End‐Stage Liver Disease and Liver Transplant Recipients. Xenotransplantation 2025, 32: e70050. PMID: 40375623, DOI: 10.1111/xen.70050.Peer-Reviewed Original ResearchConceptsEnd-stage liver diseaseEnd-stage liver disease patientsLT recipientsLiver transplantationCOVID-19 vaccineAntibody productionLiver diseaseAntibody levelsImpact of COVID-19 vaccinationTKO pig cellsLiver transplant recipientsAnti-pig antibody levelsActive COVID-19 infectionSARS-CoV-2 IgGTransplant recipientsCOVID-19 infectionEffectiveness of COVID-19 vaccinesHealthy controlsIgG levelsXenotransplant recipientsPig cellsHealthy individualsIgG antibodiesPatientsEnd-stageHigh rates of suicidality and parasuicidal behavior in individuals at clinical high-risk for psychosis: Implications for suicide risk assessment and suicide prevention
Trujillo T, Mirzakhanian H, Addington J, Bearden C, Cannon T, Cornblatt B, Keshavan M, Mathalon D, Perkins D, Stone W, Walker E, Woods S, Cadenhead K. High rates of suicidality and parasuicidal behavior in individuals at clinical high-risk for psychosis: Implications for suicide risk assessment and suicide prevention. Schizophrenia Research 2025, 281: 1-9. PMID: 40300257, DOI: 10.1016/j.schres.2025.04.030.Peer-Reviewed Original ResearchConceptsClinical high riskCalgary Depression Scale for SchizophreniaClinical high-risk youthSuicide risk assessmentParasuicidal behaviorSuicidal ideationLife eventsSelf-harmNorth American Prodrome Longitudinal StudyClinical high-risk participantsStructured Assessment of Violence RiskAssessment of Violence RiskClinical high-risk groupHealthy controlsRates of suicidal ideationHistory of self-harmHistory of SILevels of suicidalityStressful life eventsPredictors of SIRates of suicideAssociated with worse symptomsCHR participantsPsychotic conversionDSM diagnosesCerebral perfusion differences in the visual cortex and fusiform subregions across the psychosis spectrum
Sritharan J, Zeng V, Petr J, Mutsaerts H, Hoang D, Bolo N, Ivleva E, Dai W, Gershon E, Keedy S, Parker D, Trotti R, McDowell J, Clementz B, Tamminga C, Pearlson G, Keshavan M, Lizano P. Cerebral perfusion differences in the visual cortex and fusiform subregions across the psychosis spectrum. Frontiers In Psychiatry 2025, 16: 1566184. PMID: 40365009, PMCID: PMC12069394, DOI: 10.3389/fpsyt.2025.1566184.Peer-Reviewed Original ResearchPsychosis spectrum disordersFusiform gyrusSchizoaffective disorderPseudo-continuous arterial spin-labeling scansCerebral blood flowOccipital lobeOverall cognitive performanceArterial spin labeling scansGray matter cerebral blood flowPsychosis spectrumBipolar disorderCognitive measuresCognitive performancePsychosisSpectrum disorderDiagnostic groupsPerfusion differencesVisual processingCognitive impairmentVisual hallucinationsCytoarchitectonic subregionsPerfusion alterationsLabeling scansSchizophreniaHealthy controlsDifferential patterns of executive dysfunction across depressive phenotype in schizophrenia and major depressive disorder
Ping Y, Liu N, Li T, Lu C, Zeng M, Zhang X, Wang L, Liu J, Li S, Li J. Differential patterns of executive dysfunction across depressive phenotype in schizophrenia and major depressive disorder. Journal Of Neural Transmission 2025, 132: 1075-1084. PMID: 40289028, DOI: 10.1007/s00702-025-02929-9.Peer-Reviewed Original ResearchConceptsMajor depressive disorderMore-odd shifting taskNegative symptomsDepressive symptomsExecutive functionSZ patientsEF dysfunctionEF subdomainsDepressive disorderPsychopathological symptomsShift taskPositive and Negative Syndrome ScaleHealthy controlsPattern of executive dysfunctionMajor depressive disorder patientsNegative Syndrome ScaleStroop Color-WordHamilton Anxiety ScaleHamilton Depression ScaleMore-oddDifferential patternSyndrome ScaleColor wordsDepressive phenotypeEF performance
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply