2025
DLG2 rs11607886 polymorphism associated with schizophrenia and precuneus functional changes
Zhu H, Wu Z, Wang J, Zhang E, Zhang S, Yang Y, Li W, Shi H, Yang G, Lv L, Zhang Y. DLG2 rs11607886 polymorphism associated with schizophrenia and precuneus functional changes. Schizophrenia Research 2025, 280: 50-58. PMID: 40220608, DOI: 10.1016/j.schres.2025.04.004.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingSZ patientsPrecuneus gyrusRight middle temporal gyrusHealthy controlsMiddle temporal gyrusIncreased risk of SZSevere mental disordersRisk of SZPathogenesis of SZAssociated with SZClinical symptom assessmentSignificant main effectLeft precuneus gyrusTemporal gyrusBrain regionsMental disordersSchizophreniaCognitive functionBrain functionSZ susceptibilityMain effectGyrusMagnetic resonance imagingSingle nucleotide polymorphisms
2024
Stability and Reliability of Repeated Plasma Pregnenolone Levels After Oral Pregnenolone Dosing in Individuals with Cocaine Use Disorder: Pilot Findings
Gao H, Magin Z, Fogelman N, Sinha R, Angarita G, Milivojevic V. Stability and Reliability of Repeated Plasma Pregnenolone Levels After Oral Pregnenolone Dosing in Individuals with Cocaine Use Disorder: Pilot Findings. Life 2024, 14: 1483. PMID: 39598281, PMCID: PMC11595496, DOI: 10.3390/life14111483.Peer-Reviewed Original ResearchCocaine use disorderSubstance use disordersUse disorderPregnenolone levelsTreatment of cocaine use disorderReduce alcohol cravingTreatment-seeking individualsAssociated across timeAdministration of pregnenoloneEight-week trialSignificant main effectAlcohol cravingPregnenolone administrationNegative health risksDouble-blind clinical trialMain effectPilot findingsLevels of pregnenoloneChronic dosingStudy medication doseMedication dosesDisordersCocainePilot studyStress biologyF18. ROLE OF PSYCHIATRIC-ASSOCIATED SNVS IN THE EARLY ADULTHOOD: INSIGHTS FROM LONGITUDINAL NEUROIMAGING
Ito L, Ota V, Fernandes D, Martins A, Carvalho C, Zugman A, Sato J, Bressan R, Miguel E, Pan P, Salum G, Belangero S, Santoro M. F18. ROLE OF PSYCHIATRIC-ASSOCIATED SNVS IN THE EARLY ADULTHOOD: INSIGHTS FROM LONGITUDINAL NEUROIMAGING. European Neuropsychopharmacology 2024, 87: 214-215. DOI: 10.1016/j.euroneuro.2024.08.429.Peer-Reviewed Original ResearchPost-traumatic stress disorderAttention deficit/hyperactivity disorderBrain regionsBipolar disorderMental conditionBrain structuresBrazilian High-Risk Cohort StudyPrefrontal cortex regionsFrontal pole regionsHigh Risk Cohort StudyLateral orbitofrontal regionGenome-wide association studiesSignificant main effectDepressive disorderMixed-effects modelsStress disorderDeficit/hyperactivity disorderFrontal cortexOrbitofrontal regionsBiological underpinningsGenetic influencesCortex regionsLongitudinal relationshipIntracranial volumeEarly adulthoodRandomized controlled trial of two internet-based written therapies for world trade center workers and survivors with persistent PTSD symptoms
Feder A, Kowalchyk M, Brinkman H, Cahn L, Aaronson C, Böttche M, Presseau C, Fred-Torres S, Markowitz J, Litz B, Yehuda R, Knaevelsrud C, Pietrzak R. Randomized controlled trial of two internet-based written therapies for world trade center workers and survivors with persistent PTSD symptoms. Psychiatry Research 2024, 336: 115885. PMID: 38603979, DOI: 10.1016/j.psychres.2024.115885.Peer-Reviewed Original ResearchPosttraumatic stress disorderPosttraumatic stress disorder symptom clustersWTC-related PTSD symptomsMental health-related functioningPTSD symptomsSymptom clustersHealth-related functioningPosttraumatic stress disorder's avoidancePosttraumatic stress disorder symptomsPosttraumatic Stress Disorder ChecklistPresent-centered therapyAssociated with significantly greater reductionsPersistent PTSD symptomsActive control interventionModerate-to-largeQuality of lifeSignificant main effectTreatment-by-time interactionWorld Trade Center survivorDSM-5PCL-5Stress disorderDepressive/anxiety symptomsWorld Trade CenterDepressive symptoms
2023
Firearm Ownership Among a Nationally Representative Sample of U.S. Veterans
Fischer I, Aunon F, Nichter B, Hill M, Panza K, Kline A, Na P, Tsai J, Harpaz-Rotem I, Pietrzak R. Firearm Ownership Among a Nationally Representative Sample of U.S. Veterans. American Journal Of Preventive Medicine 2023, 65: 1129-1133. PMID: 37354925, DOI: 10.1016/j.amepre.2023.06.013.Peer-Reviewed Original ResearchConceptsU.S. veteransMultivariable logistic regression analysisLogistic regression analysisAlcohol use disorderSuicide prevention effortsU.S. military veteransNationally Representative SampleMale sexTrauma burdenNational HealthRepresentative sampleFirearm ownershipChi-square analysisUse disordersFirearm safetyIndependent sample t-testLifetime historyVeterans StudyPrevention effortsPsychiatric variablesMilitary veteransVeteransRegression analysisT-testSignificant main effect
2022
Cumulative risk exposure and child cellular aging in a Dutch low‐risk community sample
Beijers R, Thije I, Bolhuis E, O'Donnell K, Tollenaar M, Shalev I, Hastings W, MacIsaac J, Lin D, Meaney M, Kobor M, Belsky J, de Weerth C. Cumulative risk exposure and child cellular aging in a Dutch low‐risk community sample. Psychophysiology 2022, 60: e14205. PMID: 36323627, DOI: 10.1111/psyp.14205.Peer-Reviewed Original ResearchConceptsChildhood risk exposuresLow-risk community sampleAge 6Cortisol reactivityAge 10Cumulative risk exposureCommunity sampleCellular agingPhysical health outcomesHealth outcomesStressor exposureTelomere lengthSecondary findingsLater lifeChild cortisol reactivityRegression analysisSignificant main effectFurther investigationExposurePositive correlationMore researchStrong conclusionsAgingBiomarkersThe association between hormonal contraceptive use and smoking, negative affect, and cessation attempts in college females
Stewart S, Peltier M, Roys M, Copeland A. The association between hormonal contraceptive use and smoking, negative affect, and cessation attempts in college females. Drug And Alcohol Dependence Reports 2022, 3: 100063. PMID: 36845992, PMCID: PMC9948877, DOI: 10.1016/j.dadr.2022.100063.Peer-Reviewed Original ResearchHormonal contraceptivesHC useCurrent smokingCessation attemptsCombination hormonal contraceptivesHormonal contraceptive useEndogenous female hormonesSmoking status interactionFemale hormonesContraceptive useQuit attemptsLower anxiety levelsNicotine useTreatment targetsPast cessation attemptsSmokingCurrent HC useProgestinsExogenous hormonesAdditional studiesWomenStatus interactionAnxiety levelsSignificant differencesSignificant main effectSex differences in the acute effects of intravenous (IV) delta-9 tetrahydrocannabinol (THC)
Bassir Nia A, Orejarena MJ, Flynn L, Luddy C, D’Souza D, Skosnik PD, Pittman B, Ranganathan M. Sex differences in the acute effects of intravenous (IV) delta-9 tetrahydrocannabinol (THC). Psychopharmacology 2022, 239: 1621-1628. PMID: 35438304, PMCID: PMC11215802, DOI: 10.1007/s00213-022-06135-3.Peer-Reviewed Original ResearchConceptsRey Auditory Verbal Learning TaskPsychotomimetic States InventoryCognitive effectsAuditory Verbal Learning TaskSubjective effectsDelta-9-TetrahydrocannabinolSex differencesVerbal learning taskDissociative Symptoms ScaleFemale participantsMain psychoactive constituentSignificant main effectPerceptual alterationsLearning taskStates InventoryPsychoactive constituentSignificant sex differencesMain effectMale participantsVisual analog scaleSymptom ScaleTest dayEffects of cannabinoidsParticipantsPsychotomimetic effectsmTORC1 inhibitor effects on rapid ketamine-induced reductions in suicidal ideation in patients with treatment-resistant depression
Averill LA, Averill CL, Gueorguieva R, Fouda S, Sherif M, Ahn KH, Ranganathan M, D'Souza DC, Southwick SM, Sanacora G, Duman RS, Krystal JH, Abdallah CG. mTORC1 inhibitor effects on rapid ketamine-induced reductions in suicidal ideation in patients with treatment-resistant depression. Journal Of Affective Disorders 2022, 303: 91-97. PMID: 35101523, DOI: 10.1016/j.jad.2022.01.104.Peer-Reviewed Original ResearchConceptsAntisuicidal effectsAntidepressant effectsSuicidal ideationKetamine-induced reductionTreatment-resistant depressionLimited treatment optionsCross-over trialMajor depressive episodeOral rapamycinPublic health crisisKetamine administrationTreatment optionsDepressive episodeParent studyOverall severityKetamineTwo weeksBeck ScaleRapamycin complex 1Mechanistic targetPatientsSignificant main effectHealth crisisRobust improvementFuture studiesSubjective Happiness Interrupts the Association Between Alcohol Expectancies and Alcohol Consumption Among Reserve-Dwelling First Nation Adolescents
Schick M, Todi A, Spillane N. Subjective Happiness Interrupts the Association Between Alcohol Expectancies and Alcohol Consumption Among Reserve-Dwelling First Nation Adolescents. American Journal Of Orthopsychiatry 2022, 92: 497-504. PMID: 35389745, PMCID: PMC12123477, DOI: 10.1037/ort0000607.Peer-Reviewed Original ResearchConceptsAlcohol expectanciesPositive alcohol expectanciesNorth American IndigenousSubjective happinessFirst Nation adolescentsAlcohol consumptionEffects of alcohol expectanciesInteraction of alcohol expectanciesNorth American Indigenous youthNation adolescentsPositive psychology interventionsAssociated with concurrent changesTarget alcohol consumptionLevels of subjective happinessInfluence of happinessSignificant main effectPreliminary supportPsychological interventionsModeration analysisAlcohol useMain effectPencil-and-paper surveyHappinessAlcoholAdolescents
2021
Cannabinoid Receptor 1 rs1049353 Variant, Childhood Abuse, and the Heterogeneity of PTSD Symptoms: Results From the National Health and Resilience in Veterans Study
Korem N, Duek O, Xu K, Harpaz-Rotem I, Pietrzak RH. Cannabinoid Receptor 1 rs1049353 Variant, Childhood Abuse, and the Heterogeneity of PTSD Symptoms: Results From the National Health and Resilience in Veterans Study. Chronic Stress 2021, 5: 24705470211011075. PMID: 33997583, PMCID: PMC8107935, DOI: 10.1177/24705470211011075.Peer-Reviewed Original ResearchPosttraumatic stress disorderOverall PTSD symptomsAnxious arousal symptomsPTSD symptomsNational HealthChildhood abuseVeterans StudySymptom clustersArousal symptomsAllele carrier statusArousal symptom clustersMultivariable analysisEndocannabinoid systemAllele carriersPTSD symptom clustersGene-environment studiesGreater severityG homozygotesU.S. veteransSymptomsStress disorderCarrier statusReceptor geneDisordersSignificant main effect
2019
Neural correlates of reward-directed action and inhibition of action
Le TM, Zhang S, Zhornitsky S, Wang W, Li CR. Neural correlates of reward-directed action and inhibition of action. Cortex 2019, 123: 42-56. PMID: 31747630, DOI: 10.1016/j.cortex.2019.10.007.Peer-Reviewed Original ResearchConceptsRostral anterior cingulate cortexInhibition of actionGo trialsReward-directed actionGoal-directed actionsInferior parietal cortexMiddle frontal cortexAnterior cingulate cortexMain effectSignificant main effectVisual attentionNeural correlatesGo taskResponse executionReward valuationNeural processesBrain activationHealthy human adultsNeural responsesReward magnitudeConjunction analysisLarge rewardDorsal ACCCingulate cortexParietal cortexFeasibility and effects of galantamine on cognition in humans with cannabis use disorder
Sugarman DE, De Aquino JP, Poling J, Sofuoglu M. Feasibility and effects of galantamine on cognition in humans with cannabis use disorder. Pharmacology Biochemistry And Behavior 2019, 181: 86-92. PMID: 31082417, PMCID: PMC6545124, DOI: 10.1016/j.pbb.2019.05.004.Peer-Reviewed Original ResearchConceptsCannabis use disorderEffects of galantamineMeasures of attentionSelf-report measuresAdministration of galantamineOutpatient treatment periodPlacebo-controlled trialParallel-group trialTime pointsAcute cannabis intoxicationSignificant adverse effectsLong-term useSignificant main effectResponse inhibitionCognitive effectsCognitive performanceCognitive outcomesBaseline variablesCognitive AssessmentCognitive deficitsCannabis withdrawalTreatment periodProcognitive effectsGalantamine administrationBaseline sessions
2018
The moderating role of attachment on the association between childhood maltreatment and adolescent dating violence
Stover CS, Choi MJ, Mayes LC. The moderating role of attachment on the association between childhood maltreatment and adolescent dating violence. Children And Youth Services Review 2018, 94: 679-688. PMID: 31680710, PMCID: PMC6824549, DOI: 10.1016/j.childyouth.2018.09.011.Peer-Reviewed Original ResearchChildhood maltreatmentPrenatal drug exposureIntimate partner violenceChildhood abuse exposureLarger longitudinal studyStandard followDrug exposurePercent of femalesHigh riskSignificant associationAbuse exposureChildhood maltreatment experiencesPrevention effortsEarly exposureIdentification of factorsLongitudinal studyRegression modelingChildhood abuseSignificant main effectMale adolescentsAdolescentsHierarchical regression modelingAssociationIntervention effortsSelf-report measuresO4.4. DOES POLYGENIC RISK SCORE FOR SCHIZOPHRENIA MODERATE THE MOMENTARY AFFECTIVE AND PSYCHOTIC REACTIONS TO DAILY-LIFE STRESSORS?
Pries L, Guloksuz S, Menne-Lothmann C, Decoster J, van Winkel R, Collip D, Delespaul P, De Hert M, Derom C, Thiery E, Jacobs N, Wichers M, Klingenberg B, Cinar O, Lin B, Luykx J, Rutten B, van Os J. O4.4. DOES POLYGENIC RISK SCORE FOR SCHIZOPHRENIA MODERATE THE MOMENTARY AFFECTIVE AND PSYCHOTIC REACTIONS TO DAILY-LIFE STRESSORS? Schizophrenia Bulletin 2018, 44: s84-s84. PMCID: PMC5887471, DOI: 10.1093/schbul/sby015.210.Peer-Reviewed Original ResearchEvent-related stressMomentary stressStress reactivityMain effectSocial stressPsychotic experiencesYoung adult twin sampleEffect of PRSHeightened emotional reactivityAdditional explorative analysesAdult twin sampleEmotion regulationSignificant main effectEmotion reactivityNeuropsychological mechanismsEmotional reactivityMultilevel regression analysisEmotional fluctuationsMinor stressorsLife stressorsSubjective experiencePolygenic risk scoresDiary techniqueDiary methodTwin sampleT22. PITUITARY GLAND VOLUME DIFFERENCES IN INDIVIDUALS WITH PSYCHOSIS: RESULTS FROM THE BIPOLAR-SCHIZOPHRENIA NETWORK ON INTERMEDIATE PHENOTYPES (B-SNIP) STUDY
Guimond S, Tingue S, Devenyi G, Tang Y, Mike L, Chakravarty M, Sweeney J, Pearlson G, Clementz B, Tamminga C, Keshavan M. T22. PITUITARY GLAND VOLUME DIFFERENCES IN INDIVIDUALS WITH PSYCHOSIS: RESULTS FROM THE BIPOLAR-SCHIZOPHRENIA NETWORK ON INTERMEDIATE PHENOTYPES (B-SNIP) STUDY. Schizophrenia Bulletin 2018, 44: s121-s121. PMCID: PMC5888564, DOI: 10.1093/schbul/sby016.298.Peer-Reviewed Original ResearchPituitary gland volumeLarger pituitary glandsDuration of illnessHealthy controlsGland volumePituitary glandPsychotic bipolar disorderSymptom severityBipolar-Schizophrenia NetworkPituitary volumeSchizoaffective disorderLarger pituitary gland volumesClinical diagnosisLarger pituitary volumeSubgroup of patientsSignificant main effectGreater symptom severitySignificant subgroup differencesIndependent t-testAdrenal axisPatient groupIntermediate Phenotypes (B-SNIP) consortiumMAGeT Brain algorithmStructural magnetic resonance imagesIntermediate Phenotypes (B-SNIP) study
2016
OCD is associated with an altered association between sensorimotor gating and cortical and subcortical 5-HT1b receptor binding
Pittenger C, Adams TG, Gallezot JD, Crowley MJ, Nabulsi N, Ropchan J, Gao H, Kichuk SA, Simpson R, Billingslea E, Hannestad J, Bloch M, Mayes L, Bhagwagar Z, Carson RE. OCD is associated with an altered association between sensorimotor gating and cortical and subcortical 5-HT1b receptor binding. Journal Of Affective Disorders 2016, 196: 87-96. PMID: 26919057, PMCID: PMC4808438, DOI: 10.1016/j.jad.2016.02.021.Peer-Reviewed Original ResearchConceptsPrepulse inhibitionObsessive-compulsive disorderReceptor availabilitySensorimotor gatingOCD patientsImpaired sensorimotor gatingOCD-like behaviorNon-depressed OCD patientsPositron emission tomographyBasal gangliaSerotonergic regulationHealthy controlsSerotonin systemPositive correlationWidespread positive correlationsDiagnostic groupsCortical regionsEmission tomographyOrbitofrontal cortexPatientsReceptor bindingOCD diagnosisSignificant correlationSignificant main effectImportant alterations
2014
The Joint Effects of ADH1B Variants and Childhood Adversity on Alcohol Related Phenotypes in African‐American and European‐American Women and Men
Sartor CE, Wang Z, Xu K, Kranzler HR, Gelernter J. The Joint Effects of ADH1B Variants and Childhood Adversity on Alcohol Related Phenotypes in African‐American and European‐American Women and Men. Alcohol Clinical And Experimental Research 2014, 38: 2907-2914. PMID: 25410943, PMCID: PMC4445128, DOI: 10.1111/acer.12572.Peer-Reviewed Original ResearchConceptsChildhood adversityAllele carriersEA menAlcohol use disorder symptomsAlcohol phenotypesRisk factorsAA womenProtective effectADH1B rs1229984Psychiatric outcomesEA womenEuropean American womenOrdinal regression analysisProtective allelesAlcohol dependenceAUD symptomsSubstance dependenceSingle nucleotide polymorphismsDisorder symptomsADH1B variantsAlcohol problemsWomenMenRegression analysisSignificant main effect
2013
Rumination Moderates the Effects of Cognitive Bias Modification of Attention
Arditte K, Joormann J. Rumination Moderates the Effects of Cognitive Bias Modification of Attention. Cognitive Therapy And Research 2013, 38: 189-199. DOI: 10.1007/s10608-013-9581-9.Peer-Reviewed Original ResearchCognitive bias modificationAttention biasAttention biasesBias modificationDot-probe taskPositive attention biasNegative attention biasGreater positive affectSubsequent stress reactivityBiased attentionSignificant main effectPositive affectTrait ruminationEmotional reactivityTraining tasksTraining efficacyStress reactivityEye trackingRuminationAcute stressorMain effectParticipantsClinical implicationsTaskBiasesThe moderating effect of family involvement on substance use risk factors in adolescents with severe emotional and behavioral challenges
Schlauch RC, Levitt A, Connell CM, Kaufman JS. The moderating effect of family involvement on substance use risk factors in adolescents with severe emotional and behavioral challenges. Addictive Behaviors 2013, 38: 2333-2342. PMID: 23584195, PMCID: PMC3634886, DOI: 10.1016/j.addbeh.2013.02.010.Peer-Reviewed Original ResearchConceptsSubstance use involvementExternalizing problemsHierarchical linear modelingBehavioral problemsFamily involvementMarijuana useOnly internalizing problemsHigher externalizing problemsMultilevel growth curve modelsCommunity mental health initiativesSubstance use problemsGrowth curve modelsSignificant main effectInternalizing problemsAdolescent substanceMental health initiativesAdolescents' experiencesBehavioral challengesInternalizingUse problemsSubstance useAdolescents' usesAlcohol useLinear modelingRisk factors
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply