Gail D'Onofrio, MD, MS
Research & Publications
Biography
News
Research Summary
Gail D’Onofrio, MD, MS is internationally known for her work in substance use disorders, women’s cardiovascular health, and mentoring physician scientists in developing independent research careers. For the past 25 years she has developed and tested interventions for alcohol, opioids and other substance use disorders, serving as PI on several large NIH, SAMSHA, and CDC studies that have changed clinical practice. She is currently an MPI on the New England Consortium Node as part of the NIDA’s Clinical Trials Network. She as serves as MPI on two large multisite grants including the recently funded ED-INNOVATION, testing the implementation of ED-initiated buprenorphine in 30 diverse ED across the US; and a randomized control trial comparing a long acting 7 day injection with the traditional sublingual formation of buprenorphine in engaging patients in treatment.
In addition has completed on currently is the PI on 3 large SAMHSA grants. This included a UO1 that trains residents in all primary care specialties including Emergency Medicine Primary Care, Internal Medicine, Med/Peds, Pediatrics, OB/GYN and Psychiatry on Screening, Brief Intervention and Referral for substance use and substance use disorders. She is currently the PI on a training grant that provides medical, PA and nursing students and other MD/APP providers with the education required to obtain a the DATA 2000 Waiver to prescribe buprenorphine to individuals with an opioid use disorder. Finally she is the PI on a large service grant that provides Project ASSERT, health promotion advocates to the Yale New Haven Health System EDs, Addiction Services and Primary Care that offers SBIRT and provides medications for individuals with substance use disorders.
Along with Dr. Melnick she is the MPI on a EMBED: Pragmatic trial of user-centered clinical decision support to implement EMergency department-initiated BuprenorphinE for opioid use Disorder.
A national expert in Women and Heart Disease, Dr. D’Onofrio has been an integral part of the Yale New Haven Hospital Women’s Heart Program. She was the PI on a Department of Health and Human Services (DHHS) grant evaluating targeted interventions for women with cardiac risk factors in the ED Chest Pain Center. She was also a senior investigator on a large NHLBI grant studying young women with acute MI, enrolling at over 100 sites nationally. VIRGO (Variation in Recovery: Role of Gender on Outcomes of Young AM Patients. (PI: Krumholz). She published multiple papers documenting the disparities in reperfusion of patients with ST Elevation Myocardial Infarctions, and differences in symptom presentation and classification of disease among young women and men with acute myocardial infarction.
Dr. D’Onofrio is committed to training the next generation of physician scientists. She is the MPI of a NIDA-funded K12 establishing the Yale Drug use, Addiction and HIV Research Scholars (Yale-DAHRS) program, a three-year post-doctoral, interdisciplinary, Mentored Career Development Program with focused training in prevention and treatment of drug use, addiction, and HIV in general medical settings.
Finally, she is a founding Board member of Addiction Medicine, now recognized as a new specialty, subspecialty by the ABMS. She is an advocate for individuals with addictions and helped craft the CT's Governor's Strategic Plan to Reduce Opioid Deaths.
Coauthors
Research Interests
Pharmaceutical Preparations; Chemicals and Drugs
Research Image
SAEM Pulse Cover article: "Physician at the Forefront" an interview with Gail D'Onofrio
Selected Publications
- A brief intervention reduces hazardous and harmful drinking in emergency department patients.D'Onofrio G, Fiellin DA, Pantalon MV, Chawarski MC, Owens PH, Degutis LC, Busch SH, Bernstein SL, O'Connor PG. A brief intervention reduces hazardous and harmful drinking in emergency department patients. Annals Of Emergency Medicine 2012, 60:181-92.
- Simulation training in central venous catheter insertion: improved performance in clinical practice.Evans LV, Dodge KL, Shah TD, Kaplan LJ, Siegel MD, Moore CL, Hamann CJ, Lin Z, D'Onofrio G. Simulation training in central venous catheter insertion: improved performance in clinical practice. Academic Medicine : Journal Of The Association Of American Medical Colleges 2010, 85:1462-9.
- Addiction medicine: the birth of a new discipline.O'Connor PG, Sokol RJ, D'Onofrio G. Addiction medicine: the birth of a new discipline. JAMA Internal Medicine 2014, 174:1717-8.
- NIH Roundtable on Opportunities to Advance Research on Neurologic and Psychiatric Emergencies.D'Onofrio G, Jauch E, Jagoda A, Allen MH, Anglin D, Barsan WG, Berger RP, Bobrow BJ, Boudreaux ED, Bushnell C, Chan YF, Currier G, Eggly S, Ichord R, Larkin GL, Laskowitz D, Neumar RW, Newman-Toker DE, Quinn J, Shear K, Todd KH, Zatzick D. NIH Roundtable on Opportunities to Advance Research on Neurologic and Psychiatric Emergencies. Annals Of Emergency Medicine 2010, 56:551-64.
- Emergency department-initiated buprenorphine/naloxone treatment for opioid dependence: a randomized clinical trial.D'Onofrio G, O'Connor PG, Pantalon MV, Chawarski MC, Busch SH, Owens PH, Bernstein SL, Fiellin DA. Emergency department-initiated buprenorphine/naloxone treatment for opioid dependence: a randomized clinical trial. JAMA 2015, 313:1636-44.
- Emergency Department-Initiated Buprenorphine for Opioid Dependence with Continuation in Primary Care: Outcomes During and After Intervention.D'Onofrio G, Chawarski MC, O'Connor PG, Pantalon MV, Busch SH, Owens PH, Hawk K, Bernstein SL, Fiellin DA. Emergency Department-Initiated Buprenorphine for Opioid Dependence with Continuation in Primary Care: Outcomes During and After Intervention. Journal Of General Internal Medicine 2017, 32:660-666.
- Sex Differences in the Presentation and Perception of Symptoms Among Young Patients With Myocardial Infarction: Evidence from the VIRGO Study (Variation in Recovery: Role of Gender on Outcomes of Young AMI Patients).Lichtman JH, Leifheit EC, Safdar B, Bao H, Krumholz HM, Lorenze NP, Daneshvar M, Spertus JA, D'Onofrio G. Sex Differences in the Presentation and Perception of Symptoms Among Young Patients With Myocardial Infarction: Evidence from the VIRGO Study (Variation in Recovery: Role of Gender on Outcomes of Young AMI Patients). Circulation 2018, 137:781-790.
- Sex differences in reperfusion in young patients with ST-segment-elevation myocardial infarction: results from the VIRGO study.D'Onofrio G, Safdar B, Lichtman JH, Strait KM, Dreyer RP, Geda M, Spertus JA, Krumholz HM. Sex differences in reperfusion in young patients with ST-segment-elevation myocardial infarction: results from the VIRGO study. Circulation 2015, 131:1324-32.
- Cost-effectiveness of emergency department-initiated treatment for opioid dependence.Busch SH, Fiellin DA, Chawarski MC, Owens PH, Pantalon MV, Hawk K, Bernstein SL, O'Connor PG, D'Onofrio G. Cost-effectiveness of emergency department-initiated treatment for opioid dependence. Addiction (Abingdon, England) 2017, 112:2002-2010.
- Presentation, Clinical Profile, and Prognosis of Young Patients With Myocardial Infarction With Nonobstructive Coronary Arteries (MINOCA): Results From the VIRGO Study.Safdar B, Spatz ES, Dreyer RP, Beltrame JF, Lichtman JH, Spertus JA, Reynolds HR, Geda M, Bueno H, Dziura JD, Krumholz HM, D'Onofrio G. Presentation, Clinical Profile, and Prognosis of Young Patients With Myocardial Infarction With Nonobstructive Coronary Arteries (MINOCA): Results From the VIRGO Study. Journal Of The American Heart Association 2018, 7.
- Lorazepam for the prevention of recurrent seizures related to alcohol.D'Onofrio G, Rathlev NK, Ulrich AS, Fish SS, Freedland ES. Lorazepam for the prevention of recurrent seizures related to alcohol. The New England Journal Of Medicine 1999, 340:915-9.