Role of the endolysosomal system in Parkinson’s disease
Vidyadhara DJ, Lee JE, Chandra SS. Role of the endolysosomal system in Parkinson’s disease. Journal Of Neurochemistry 2019, 150: 487-506. PMID: 31287913, PMCID: PMC6707858, DOI: 10.1111/jnc.14820.Peer-Reviewed Original ResearchConceptsHealthy mitochondrial poolParkinson's diseaseRME-8Synaptic endocytosisEndolysosomal sortingEndolysosomal systemDysfunctional mitochondriaPD geneticsMitochondrial poolKey proteinsEarly pathomechanismLysosomal functionSystem genesCell deathKey pathwaysCommon risk factorsCommon neurodegenerative disorderL pathwayMutationsPD pathogenesisL-systemsImportant pathwayAutophagyDopaminergic neuronsPathway