2023
Effects of the HIV‐1 maturation inhibitor GSK3640254 on QT interval in healthy participants
Zhang Y, Bush M, Yazdani P, Zhan J, Wen B, Bainbridge V, Wynne B, Joshi S, Lataillade M. Effects of the HIV‐1 maturation inhibitor GSK3640254 on QT interval in healthy participants. Pharmacology Research & Perspectives 2023, 11: e01151. PMID: 37961928, PMCID: PMC10644204, DOI: 10.1002/prp2.1151.Peer-Reviewed Original ResearchConceptsConcentration-QTc analysisHealthy participantsQT intervalNovel HIV-1 maturation inhibitorsPlacebo-adjusted changeHIV-1 treatmentHIV-1 maturation inhibitorsMoxifloxacin doseSupratherapeutic dosePlasma concentrationsRelevant effectsFridericia's formulaTreatment periodCardiac repolarizationHeart rateMaturation inhibitorsCardiac conductionCardiac parametersDay 7QT studyDoseTime pointsGSK3640254ΔΔQTcFPharmacokinetics
2013
Top3β is an RNA topoisomerase that works with fragile X syndrome protein to promote synapse formation
Xu D, Shen W, Guo R, Xue Y, Peng W, Sima J, Yang J, Sharov A, Srikantan S, Yang J, Fox D, Qian Y, Martindale JL, Piao Y, Machamer J, Joshi SR, Mohanty S, Shaw AC, Lloyd TE, Brown GW, Ko MS, Gorospe M, Zou S, Wang W. Top3β is an RNA topoisomerase that works with fragile X syndrome protein to promote synapse formation. Nature Neuroscience 2013, 16: 1238-1247. PMID: 23912945, PMCID: PMC3853347, DOI: 10.1038/nn.3479.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, Genetically ModifiedCells, CulturedChickensDNA Topoisomerases, Type IDrosophilaDrosophila ProteinsEmbryo, MammalianEyeFragile X Mental Retardation ProteinGene Expression RegulationHumansMiceMice, Inbred C57BLNerve Tissue ProteinsNeurogenesisNeuromuscular JunctionNeuronsRNA-Binding ProteinsTransfection
2010
Dysregulation of human Toll-like receptor function in aging
Shaw AC, Panda A, Joshi SR, Qian F, Allore HG, Montgomery RR. Dysregulation of human Toll-like receptor function in aging. Ageing Research Reviews 2010, 10: 346-353. PMID: 21074638, PMCID: PMC3633557, DOI: 10.1016/j.arr.2010.10.007.Peer-Reviewed Original ResearchConceptsToll-like receptorsTLR functionImmune systemToll-like receptor functionPattern recognition receptor familyAge-associated dysregulationInnate immune systemGeriatric patientsTLR activationAnimal modelsContext of agingReceptor functionHuman cohortsInfectious diseasesReceptor familyInappropriate persistenceDysregulationRecent studiesOverarching themesAdaptive responseMorbidityImmunosenescencePatientsCohortInnateAging of the innate immune system
Shaw AC, Joshi S, Greenwood H, Panda A, Lord JM. Aging of the innate immune system. Current Opinion In Immunology 2010, 22: 507-513. PMID: 20667703, PMCID: PMC4034446, DOI: 10.1016/j.coi.2010.05.003.Peer-Reviewed Original ResearchConceptsInnate immune systemImmune systemPro-inflammatory environmentInnate immune activationToll-like receptorsMonocytes/macrophagesAge-associated defectsNKT cellsDendritic cellsImmune activationElderly individualsTissue damageNetwork of cellsCell typesSignal transduction pathwaysCellsActivationEarly interactionsTransduction pathwaysImmunosenescenceNeutrophilsInfectionMacrophagesNKReceptorsEmergence of Resistance to Azithromycin-Atovaquone in Immunocompromised Patients with Babesia microti Infection
Wormser GP, Prasad A, Neuhaus E, Joshi S, Nowakowski J, Nelson J, Mittleman A, Aguero-Rosenfeld M, Topal J, Krause PJ. Emergence of Resistance to Azithromycin-Atovaquone in Immunocompromised Patients with Babesia microti Infection. Clinical Infectious Diseases 2010, 50: 381-386. PMID: 20047477, DOI: 10.1086/649859.Peer-Reviewed Original ResearchConceptsDrug regimenB. microtiLevel of immunosuppressionBabesia microti infectionTreatment of babesiosisDrug-resistant strainsEmergence of resistanceActive babesiosisMicrobiologic relapseLaboratory abnormalitiesDrug regimensImmunocompromised patientsOptimal therapyTreatment failureDrug therapyMicroti infectionPatientsClinical case historiesDrug resistanceBabesia microtiInfectionRegimenMicrotiEventual developmentBabesiosis
2009
Pandemic influenza H1N1 2009, innate immunity, and the impact of immunosenescence on influenza vaccine.
Joshi SR, Shaw AC, Quagliarello VJ. Pandemic influenza H1N1 2009, innate immunity, and the impact of immunosenescence on influenza vaccine. The Yale Journal Of Biology And Medicine 2009, 82: 143-51. PMID: 20027279, PMCID: PMC2794489.Peer-Reviewed Original ResearchConceptsPandemic influenza H1N1 2009Influenza H1N1 2009Influenza vaccineEpidemiologic characteristicsH1N1 2009Innate immune system responseImpact of immunosenescenceInfluenza vaccine responsivenessPandemic influenza vaccineSeasonal influenza vaccinePrevention of morbidityInfluenza virus infectionShort narrative reviewImmune system responseSeroprotective responseVaccine responsivenessPandemic influenzaSeasonal influenzaEffective vaccineVirus infectionPandemic strainsNeuraminidase inhibitorsInnate immunityNarrative reviewVaccine