Sachin Haresh Bhagchandani
he/him/his
Postdoctoral AssociateAbout
Research
Publications
2026
Bioactive enhanced adjuvant chemokine oligonucleotide nanoparticles (BEACONs) for mucosal vaccination against genital herpes.
Bhagchandani SH, Ehrenzeller S, Pires IS, Chaudhary N, Booth CJ, Kwon DI, Koutsioumpa C, Baker CA, Laxton C, Santos Guedes de Sá K, Matthews C, Gill P, Li S, Olszowka A, Hudak A, Fischer S, Bayarri-Olmos R, Hooper WB, Iwasaki A. Bioactive enhanced adjuvant chemokine oligonucleotide nanoparticles (BEACONs) for mucosal vaccination against genital herpes. Sci Immunol 2026, 11: eaea6419. PMID: 42319912, DOI: 10.1126/sciimmunol.aea6419.Peer-Reviewed Original ResearchThis study investigates a novel vaccine strategy using BEACONs, a mucosal adjuvant, to enhance localized immunity and protect against genital herpes by boosting tissue-resident T cells and antibodies.A causal link between autoantibodies and neurological symptoms in long COVID
de Sá K, Silva J, Bayarri-Olmos R, Baker C, Lu Z, Gipson W, Na D, Chen B, Wenxue L, Khosroabadi D, Brinda R, Constable R, Omene B, Colom Díaz P, Kwon D, Rodrigues G, Heidecke H, Schulze-Forster K, Gross A, Shneer T, Clarke A, Linnekin T, Brate A, Brown L, Buda H, Jatiani S, Moise L, Greene K, Bhagchandani S, Bhattacharjee B, Gehlhausen J, Wood J, Tabacof L, Scheibenbogen C, Liu Y, Guan L, Schneeberger Pane M, Putrino D, Horvath T, Iwasaki A. A causal link between autoantibodies and neurological symptoms in long COVID. Cell 2026, 189: 3214-3235.e37. PMID: 42208499, DOI: 10.1016/j.cell.2026.04.042.Peer-Reviewed Original ResearchHarnessing mucosal immunity for protective vaccines
Kwon D, Bhagchandani S, Ehrenzeller S, Iwasaki A. Harnessing mucosal immunity for protective vaccines. Nature Reviews Immunology 2026, 26: 507-524. PMID: 41699393, PMCID: PMC13088808, DOI: 10.1038/s41577-026-01273-7.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2025
Antibody–bottlebrush prodrug conjugates for targeted cancer therapy
Liu B, Nguyen H, Jiang Y, Wang A, Lensch V, Sun Z, Boyer Z, Raftopoulos P, Dai Y, MacNicol P, Wang Y, Jyotsana N, Wang W, Bhagchandani S, Hemdev S, Shieh P, Kristufek S, Boucher M, Downes M, Evans R, MacMillan D, Johnson J. Antibody–bottlebrush prodrug conjugates for targeted cancer therapy. Nature Biotechnology 2025, 44: 1011-1022. PMID: 40925997, PMCID: PMC12425459, DOI: 10.1038/s41587-025-02772-z.Peer-Reviewed Original ResearchA mechanically resilient soft hydrogel improves drug delivery for treating post-traumatic osteoarthritis in physically active joints
Joshi N, Yan J, Dang M, Slaughter K, Wang Y, Wu D, Ung T, Bhingaradiya N, Pandya V, Chen M, Kaur S, Bhagchandani S, Alfassam H, Joseph J, Gao J, Dewani M, Chu R, Yip R, Weldon E, Shah P, Pisal N, Shukla C, Sherman N, Luo J, Conway T, Eickhoff J, Botelho L, Alhasan A, Karp J, Ermann J. A mechanically resilient soft hydrogel improves drug delivery for treating post-traumatic osteoarthritis in physically active joints. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2409729122. PMID: 40163719, PMCID: PMC12002200, DOI: 10.1073/pnas.2409729122.Peer-Reviewed Original Research
2024
Two-dose priming immunization amplifies humoral immunity by synchronizing vaccine delivery with the germinal center response
Bhagchandani S, Yang L, Lam J, Maiorino L, Ben-Akiva E, Rodrigues K, Romanov A, Suh H, Aung A, Wu S, Wadhera A, Chakraborty A, Irvine D. Two-dose priming immunization amplifies humoral immunity by synchronizing vaccine delivery with the germinal center response. Science Immunology 2024, 9: eadl3755-eadl3755. PMID: 39303017, PMCID: PMC11492009, DOI: 10.1126/sciimmunol.adl3755.Peer-Reviewed Original ResearchCarbohydrate-Lectin Interactions Reprogram Dendritic Cells to Promote Type 1 Anti-Tumor Immunity
Lensch V, Gabba A, Hincapie R, Bhagchandani S, Basak A, Alam M, Noble J, Irvine D, Shalek A, Johnson J, Finn M, Kiessling L. Carbohydrate-Lectin Interactions Reprogram Dendritic Cells to Promote Type 1 Anti-Tumor Immunity. ACS Nano 2024, 18: 26770-26783. PMID: 39283240, PMCID: PMC11646345, DOI: 10.1021/acsnano.4c07360.Peer-Reviewed Original Research
2023
Mixing ligands to enhance gas uptake in polyMOFs
Pearson M, Bhagchandani S, Dincă M, Johnson J. Mixing ligands to enhance gas uptake in polyMOFs. Molecular Systems Design & Engineering 2023, 8: 591-597. DOI: 10.1039/d2me00227b.Peer-Reviewed Original ResearchEngineering kinetics of TLR7/8 agonist release from bottlebrush prodrugs enables tumor-focused immune stimulation
Bhagchandani S, Vohidov F, Milling L, Tong E, Brown C, Ramseier M, Liu B, Fessenden T, Nguyen H, Kiel G, Won L, Langer R, Spranger S, Shalek A, Irvine D, Johnson J. Engineering kinetics of TLR7/8 agonist release from bottlebrush prodrugs enables tumor-focused immune stimulation. Science Advances 2023, 9: eadg2239. PMID: 37075115, PMCID: PMC10115420, DOI: 10.1126/sciadv.adg2239.Peer-Reviewed Original ResearchMolecular bottlebrush prodrugs as mono- and triplex combination therapies for multiple myeloma
Detappe A, Nguyen H, Jiang Y, Agius M, Wang W, Mathieu C, Su N, Kristufek S, Lundberg D, Bhagchandani S, Ghobrial I, Ghoroghchian P, Johnson J. Molecular bottlebrush prodrugs as mono- and triplex combination therapies for multiple myeloma. Nature Nanotechnology 2023, 18: 184-192. PMID: 36702954, PMCID: PMC10032145, DOI: 10.1038/s41565-022-01310-1.Peer-Reviewed Original Research