Developmental loss of MeCP2 from VIP interneurons impairs cortical function and behavior
Mossner JM, Batista-Brito R, Pant R, Cardin JA. Developmental loss of MeCP2 from VIP interneurons impairs cortical function and behavior. ELife 2020, 9: e55639. PMID: 32343226, PMCID: PMC7213975, DOI: 10.7554/elife.55639.Peer-Reviewed Original ResearchConceptsVIP interneuronsRett syndromeVasoactive intestinal peptide-expressing (VIP) interneuronsLoss of MeCP2Neurodevelopmental disordersGABAergic cell typesDevastating neurodevelopmental disorderBehavioral phenotypesInhibitory interneuronsPathophysiological roleCortical functionMouse modelCortical circuitsLoss of functionInterneuronsSyndromeDevelopmental lossCell typesDisordersCritical rolePotential key pointsMeCP2PhenotypeMutationsProper development