Novak Yang
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About
Departments & Organizations
Education & Training
- MS
- Emory University, Cancer Biology and Translational Oncology (2019)
- BS
- Emory University, Biology (2018)
- AA
- Emory University, Liberal Arts and Sciences (2016)
Research
Overview
Medical Research Interests
Drug Development; Drug Discovery; Drug Screening Assays, Antitumor; High-Throughput Screening Assays; Immunotherapy; Therapeutics; Tumor Microenvironment
Publications
2022
Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.
Mo X, Niu Q, Ivanov AA, Tsang YH, Tang C, Shu C, Li Q, Qian K, Wahafu A, Doyle SP, Cicka D, Yang X, Fan D, Reyna MA, Cooper LAD, Moreno CS, Zhou W, Owonikoko TK, Lonial S, Khuri FR, Du Y, Ramalingam SS, Mills GB, Fu H. Systematic discovery of mutation-directed neo-protein-protein interactions in cancer. Cell 2022, 185: 1974-1985.e12. PMID: 35512704, DOI: 10.1016/j.cell.2022.04.014.Peer-Reviewed Original Research
2021
Discovery of the first chemical tools to regulate MKK3-mediated MYC activation in cancer.
Yang X, Fan D, Troha AH, Ahn HM, Qian K, Liang B, Du Y, Fu H, Ivanov AA. Discovery of the first chemical tools to regulate MKK3-mediated MYC activation in cancer. Bioorganic & Medicinal Chemistry 2021, 45: 116324. PMID: 34333394, PMCID: PMC8456368, DOI: 10.1016/j.bmc.2021.116324.Peer-Reviewed Original ResearchHypomorph mutation-directed small-molecule protein-protein interaction inducers to restore mutant SMAD4-suppressed TGF-β signaling.
Tang C, Mo X, Niu Q, Wahafu A, Yang X, Qui M, Ivanov AA, Du Y, Fu H. Hypomorph mutation-directed small-molecule protein-protein interaction inducers to restore mutant SMAD4-suppressed TGF-β signaling. Cell Chemical Biology 2021, 28: 636-647.e5. PMID: 33326750, DOI: 10.1016/j.chembiol.2020.11.010.Peer-Reviewed Original Research
2020
High expression of MKK3 is associated with worse clinical outcomes in African American breast cancer patients.
Yang X, Amgad M, Cooper LAD, Du Y, Fu H, Ivanov AA. High expression of MKK3 is associated with worse clinical outcomes in African American breast cancer patients. Journal Of Translational Medicine 2020, 18: 334. PMID: 32873298, PMCID: PMC7465409, DOI: 10.1186/s12967-020-02502-w.Peer-Reviewed Original ResearchOnline informatics resources to facilitate cancer target and chemical probe discovery.
Yang X, Fu H, Ivanov AA. Online informatics resources to facilitate cancer target and chemical probe discovery. RSC Medicinal Chemistry 2020, 11: 611-624. PMID: 33479663, PMCID: PMC7429978, DOI: 10.1039/d0md00012d.Peer-Reviewed Original ResearchComputational structural modeling to discover PPI modulators
Yang X, Ivanov AA. Computational structural modeling to discover PPI modulators. Protein-protein interaction regulators, 87-108, Roy, S. & Fu, H. (Eds.) Royal Society of Chemistry.Chapters
Academic Achievements & Community Involvement
honor Gruber Science Fellowship
Yale University AwardYale UniversityDetails08/30/2021United Stateshonor SLAS Tony B. Academic Travel Award
National AwardSociety for Laboratory Automation and ScreeningDetails01/25/2020United Stateshonor ASPET Travel Award
National AwardAmerican Society for Pharmacology and Experimental TherapeuticsDetails04/06/2019United Stateshonor ASPET Program Committee Blue Ribbon Pick
National AwardAmerican Society for Pharmacology and Experimental TherapeuticsDetails04/06/2019United States