Adjunct Faculty
Adjunct faculty typically have an academic or research appointment at another institution and contribute or collaborate with one or more School of Medicine faculty members or programs.
Adjunct rank detailsNatalia Kunst, PhD
Assistant Professor AdjunctAbout
Research
Publications
2025
Long-Term Outcomes and Cost-Effectiveness of Artificial Intelligence for Breast Cancer Screening: A Modeling Study
Andersen M, Richman I, Kunst N. Long-Term Outcomes and Cost-Effectiveness of Artificial Intelligence for Breast Cancer Screening: A Modeling Study. Value In Health 2025 PMID: 40983310, DOI: 10.1016/j.jval.2025.09.005.Peer-Reviewed Original ResearchBreast cancer screeningQuality-adjusted life yearsBreast cancer deathsBreast cancer casesCancer screeningIncremental cost-effectiveness ratioDigital breast tomosynthesisBreast Cancer Surveillance ConsortiumCancer casesLong-term health outcomesBreast cancer mortalityCancer deathNegative screeningNationally representative dataCost-effectiveBiennial screeningAdvanced breast cancer casesHealth outcomesCancer mortalityCost-effectiveness ratioWomen ageStandardized screeningLife yearsRepresentative dataRoutine practiceModeling the Impact of Multicancer Early Detection Tests: A Review of Natural History of Disease Models.
Mandrik O, Whyte S, Kunst N, Rayner A, Harden M, Dias S, Payne K, Palmer S, Soares M. Modeling the Impact of Multicancer Early Detection Tests: A Review of Natural History of Disease Models. Medical Decision Making 2025, 272989x251351639. PMID: 40753481, DOI: 10.1177/0272989x251351639.Peer-Reviewed Original ResearchMulticancer early detectionNatural history of diseaseHistory of diseaseTrial evidenceMulticancer early detection testsAbsence of trial evidenceScreening clinical trialsCancer screening modelStage shiftEarly detection testsEarly detectionCritical appraisalNatural historyMortality impactClinical study evidenceMortality effectsTest accuracyCost-effectiveEvaluation approachClinical studiesClinical trialsPublished estimatesMortalityAppraisalStudy evidenceCost-effectiveness of ribociclib plus endocrine therapy in HR-positive, HER2-negative early breast cancer in the United States.
Potnis K, Ito S, Kunst N, Richman I, Winer E, Goshua G. Cost-effectiveness of ribociclib plus endocrine therapy in HR-positive, HER2-negative early breast cancer in the United States. Journal Of Clinical Oncology 2025, 43: 11049-11049. DOI: 10.1200/jco.2025.43.16_suppl.11049.Peer-Reviewed Original ResearchHER2- early breast cancerEarly breast cancerIncremental cost-effectiveness ratioEndocrine therapyBreast cancerQuality-adjusted life yearsDeterministic sensitivity analysisHR-positiveHER2-negative early breast cancerWTP thresholdCost-effectiveness of ribociclibInvasive disease-free survivalDisease-free survival curvesAcceptable WTP thresholdDisease-free survivalBase-caseHigher WTP thresholdNonsteroidal aromatase inhibitorBase-case analysisCyclin-dependent kinase 4Cost-effectiveness ratioHER2-negativeCDK4/6 inhibitorsAromatase inhibitorsHealth system perspectiveAdoption of Broad Genomic Profiling in Patients With Cancer
Wang X, Rothen J, Huang S, Long J, Soulos P, Goldberg S, Mamtani R, Presley C, Kunst N, Ma S, Wang S, Gross C, Dinan M. Adoption of Broad Genomic Profiling in Patients With Cancer. JAMA Oncology 2025, 11: 666-668. PMID: 40244595, PMCID: PMC12006912, DOI: 10.1001/jamaoncol.2025.0499.Peer-Reviewed Original ResearchProstate-Specific Membrane Antigen Imaging Findings and Subsequent Clinical Management Among Patients With Biochemically Recurrent Prostate Cancer
Rabil M, Ghaffar U, Long J, Westvold S, Sprenkle P, Kim I, Saperstein L, Kunst N, Wang S, Ma X, Gross C, Leapman M, Karnes R. Prostate-Specific Membrane Antigen Imaging Findings and Subsequent Clinical Management Among Patients With Biochemically Recurrent Prostate Cancer. JU Open Plus 2025, 3 DOI: 10.1097/ju9.0000000000000278.Peer-Reviewed Original ResearchMetastasis-directed therapyPSMA PET findingsPSMA-PETBiochemical recurrencePSA levelsDistant metastasisProstate cancerLocal therapyProstate-specific membrane antigen positron emission tomographyClinical managementBiochemically recurrent prostate cancerIdentification of distant metastasesNegative PSMA-PETRecurrent prostate cancerRegional nodal diseasePositron emission tomographyNodal diseaseLocal recurrenceInitial therapySystemic therapyTreatment initiationClinical outcomesImaging findingsMetastasisTreatment choiceExamining Consistency Across NICE Single Technology Appraisals: A Review of Appraisals for Paroxysmal Nocturnal Haemoglobinuria
Donoghue J, Youngs M, Reeve A, Vydyula K, Kunst N, Trikha R, Gallacher D. Examining Consistency Across NICE Single Technology Appraisals: A Review of Appraisals for Paroxysmal Nocturnal Haemoglobinuria. PharmacoEconomics 2025, 43: 499-508. PMID: 39934600, PMCID: PMC12011644, DOI: 10.1007/s40273-025-01472-5.Peer-Reviewed Original ResearchSingle Technology AppraisalNational Institute for Health and Care ExcellenceTechnology appraisalCost-effectiveness evidenceParoxysmal nocturnal haemoglobinuriaEconomic modelExamination consistAppraisalCare ExcellenceHealth technologiesFollow-up lengthImplementation of health technologyIndirect comparisonsDose escalationCost-effective healthcareEvidenceClinical evidencePositive recommendations
2024
SA49 Drug Approval Under Uncertainty Across the COVID-19 Timeline: Cumulative Evidence Versus Value of Information Analyses
Dijk S, Krijkamp E, Kunst N, Gross C, Labrecque J, Pandit A, Lu C, Visser L, Wong J, Hunink M. SA49 Drug Approval Under Uncertainty Across the COVID-19 Timeline: Cumulative Evidence Versus Value of Information Analyses. Value In Health 2024, 27: s623. DOI: 10.1016/j.jval.2024.10.3130.Peer-Reviewed Original ResearchHTA224 A Roadmap to the Use of Value of Information Analysis in Health Technology Assessment: An International Study of Barriers, Facilitators, and Potential Applications
Grimm S, Glynn D, Coyle D, Jalal H, Koffijberg E, Tuffaha H, Vervaart M, Welton N, Wilson E, Rothery C, Kunst N. HTA224 A Roadmap to the Use of Value of Information Analysis in Health Technology Assessment: An International Study of Barriers, Facilitators, and Potential Applications. Value In Health 2024, 27: s398. DOI: 10.1016/j.jval.2024.10.2049.Peer-Reviewed Original ResearchMSR67 Comparison of Multi-Cancer Early Detection Modelling Approaches: Appraisal of the Methods
Mandrik L, Whyte S, Kunst N, Palmer S, Soares M. MSR67 Comparison of Multi-Cancer Early Detection Modelling Approaches: Appraisal of the Methods. Value In Health 2024, 27: s450-s451. DOI: 10.1016/j.jval.2024.10.2301.Peer-Reviewed Original ResearchEvaluating the Health and Economic Impacts of Return-to-Work Interventions: A Modeling Study
Morgante N, Bjørnelv G, Aasdahl L, Nguyen C, Fimland M, Kunst N, Burger E. Evaluating the Health and Economic Impacts of Return-to-Work Interventions: A Modeling Study. Value In Health 2024, 28: 415-423. PMID: 39579934, DOI: 10.1016/j.jval.2024.10.3850.Peer-Reviewed Original ResearchQuality-adjusted life yearsReturn to workO-ACTReturn-to-work interventionsHealth-related quality of lifeDecision-analytic modelRates of sickness absenceHealth-related qualityCost-effectiveQuality of lifeRTW interventionsProductivity lossSickness absenceSick leaveCost-effectiveness thresholdRegistry dataHealthcare costsNorwegian guidelinesHealthcare perspectiveLife yearsSocietal perspectiveEconomic evaluationInterventionTrial outcomesPsychological disorders