Preston C. Sprenkle, MD
Biography
Research & Publications
Patient Care
News
Locations
Appointments
Biography
Dr. Preston C. Sprenkle specializes in the treatment of urologic cancers, including prostate cancer, kidney cancer, bladder cancer, testicular cancer and sarcoma – a rare kind of cancer that grows in cells that connect or support other parts of the body, like bone or muscle.
Dr. Sprenkle has dedicated his career to using the latest imaging technologies to improve diagnosis. He was one of the first physicians nationwide to implement the use of the Artemis Device. This machine, introduced in 2009, allows a surgeon to use 3D ultrasound technology and merge it with even more precise magnetic resonance imaging (MRI) to accurately identify cancerous tumors.
“Skilled and experienced radiologists are rare for this relatively new technique,” Dr. Sprenkle explains. “At Yale, we are fortunate to have some of the world leaders in prostate MRI.”
Dr. Sprenkle is also a pioneer in “focal therapy,” which allows a surgeon to treat tiny prostate lesions, rather than the whole organ. This avoids many of the side effects—such as erectile dysfunction and incontinence—that may follow the removal of the whole prostate.
“Exciting technological advances are revolutionizing urology. Prostate cancer is very common and current treatments can majorly impact a man's sexual and urinary function,” Dr. Sprenkle says. “Developing ways to minimize the impact of prostate cancer diagnosis and treatment on a man's health and quality of life is tremendously rewarding.”
Dr. Sprenkle believes in working with patients to come up with individualized treatment plans. “I want my patients to feel that I hear their concerns and treat them like a person. I am pleased at the end of a long consultation when they feel like they understand their disease and their options.”
Education & Training
- Non Degree ProgramYale School of Management, Emerging Leaders Program (2018)
- FellowshipMemorial Sloan Kettering Cancer Center (2011)
- ResidencyNew York Presbyterian Hospital (2009)
- InternshipNew York Presbyterian Hospital (2005)
- MDColumbia University (2004)
- BAStanford University, Human Biology (1998)
Activities
- Prostate imaging clinical correlationNew Haven, CT, United States 2023Resident Learning Series - Radiology Conference
- Molecular Diagnostics in the VADepartment of Veterans Affairs, National Surgery Office 2023Prostate Cancer Diagnosis Symposium
- Prostate Biopsy: Transrectal vs Transperineal approachPortland, ME, United States 2022New England Section of American Urological Association Annual Meeting
- Transperineal vs. Transrectal approach to prostate biopsy, debate moderatorPortland, ME, United States 2022New England Section of American Urological Association Annual Meeting
- Update on the NCCN Early Detection of Prostate Cancer GuidelinesInternational Virtual Summit 20226th Global Summit on Precision Diagnosis and Treatment of Prostate Cancer
- The OPTIMUM Trial: Current and Emerging Evidence supporting 29Mhz High-Precision real-time Micro-ultrasoundInternational Virtual Symposium 20226th Global Summit on Precision Diagnosis and Treatment of Prostate Cancer
- Prostate Cancer Ablation: Applications and ApproachesNew Haven, CT, United States 2022Urology Grand Rounds
- Prostate Cancer Ablation: The best option for intermediate risk patientsNew Haven, CT, United States 2022Urology Grand Rounds
- New Treatments in Prostate Cancer, the TULSA ProParticipated in virtual support group for men with prostate cancer on the East Coast of the United States 2022Men Fighting Cancer Prostate Cancer support group
- Experience with PET imaginghttps://www.docwirenews.com/round-the-wire-gu/ 2022ASCO GU 2022: Key Takeaways in Prostate Cancer Imaging
- Prostate cancer outcomes, comparing surgery and radiation. Side effects of robotic prostatectomyAIS Channel Live Surgery 2022Prostate Caner Surgery versus Radiotherapy, the Current State of the Art
- Negative Multiparametric MRI of the Prostate: can biopsy be avoided?Vienna, Vienna, Austria 2021European Society of Medicine Annual Congress
- Update on NCCN Early Detection of Prostate Cancer GuidelinesBoston, MA, United States 20215th Annual Global Summit on Precision Diagnosis and Treatment of Prostate Cancer
- Roundtable discussion on PSMA PET/CT imaging in prostate cancerPresentations available online through AUA 2021 2021American Urological Association Annual Meeting
- How to: Prostate UltrasoundCreated instructional Video for AUA Educational Series 2021How to: Prostate Ultrasound
- How To: Placement of Endorectal Spacer and Fiducial MarkersCreated instructional Video for AUA Educational Series 2021How To: Placement of Endorectal Spacer and Fiducial Markers
- Negative prostate MRI, can prostate biopsy be avoided?Vienna, Vienna, Austria 2021Negative prostate MRI, can prostate biopsy be avoided?
- Diagnostic Test for Early Detection of Prostate Cancer, review of NCCN Guidelines updateFourth Global Summit on Precision Diagnosis for Prostate Cancer 2020Diagnostic Test for Early Detection of Prostate Cancer, review of NCCN Guidelines update
- Diagnostic Tests for Early Detection of Prostate Cancer, review of NCCN guidelines updatesBoston, MA, United States 2019Diagnostic Tests for Early Detection of Prostate Cancer, review of NCCN guidelines updates
- Integrating a rectal spacer procedure into urology practiceChicago, IL, United States 2019Integrating a rectal spacer procedure into urology practice
- Prostate Cancer Session ModeratorProvidence, RI, United States 2019Prostate Cancer Session Moderator
- Multimodal treatment of advanced prostate cancer, discussion panel memberProvidence, RI, United States 2019Multimodal treatment of advanced prostate cancer, discussion panel member
- Diagnostic Tests for Early Detection of Prostate Cancer, review of NCCN guidelines updatesBoston, MA, United States 2018Diagnostic Tests for Early Detection of Prostate Cancer, review of NCCN guidelines updates
- Hands On Training Course, MR-US fusion prostate biopsy tips and tricksSan Francisco, CA, United States 2018Hands On Training Course, MR-US fusion prostate biopsy tips and tricks
- Session Moderator: Prostate cancer genomics panelHartford, CT, United States 2018Session Moderator: Prostate cancer genomics panel
- Diagnostic Tests for Early Detection of Prostate Cancer, review of NCCN guidelines updatesBoston, MA, United States 2017Diagnostic Tests for Early Detection of Prostate Cancer, review of NCCN guidelines updates
- MR-US Fusion Biopsy, West Haven VA experienceBoston, MA, United States 2017MR-US Fusion Biopsy, West Haven VA experience
- Principles of Image RegistrationLinthicum Heights, MD, United States 2017Principles of Image Registration
- MR-US fusion biopsy in practice: Yale University experienceLinthicum Heights, MD, United States 2017MR-US fusion biopsy in practice: Yale University experience
- Yale experience with SpaceOAR rectal spacerMontreal, QC, Canada 2017Yale experience with SpaceOAR rectal spacer
- Outcomes of Serial MRI-Fusion Biopsy in Men with Prostate Cancer Managed with Active SurveillanceBoston, MA, United States 2017Outcomes of Serial MRI-Fusion Biopsy in Men with Prostate Cancer Managed with Active Surveillance
- Physician learning curve using MR-US fusion prostate biopsyMontreal, QC, Canada 2017Physician learning curve using MR-US fusion prostate biopsy
- Image Registration in MR-US Fusion biopsyChicago, IL, United States 2016Image Registration in MR-US Fusion biopsy
- Focal ablation for prostate cancerPortland, ME, United States 2016Focal ablation for prostate cancer
- Should we still biopsy patients with a negative MP-MRI?San Diego, CA, United States 2016Should we still biopsy patients with a negative MP-MRI?
- Emerging role of MR-US fusion prostate biopsyHartford, CT, United States 2015Emerging role of MR-US fusion prostate biopsy
- MR-US Fusion prostate biopsy: improving prostate cancer diagnosisWest Haven, CT, United States 2015MR-US Fusion prostate biopsy: improving prostate cancer diagnosis
- Prostate Cancer ScreeningWest Haven, CT, United States 2015Prostate Cancer Screening
- MRI targeted biopsy alone is inadequate to detect clinically significant prostate cancer: a meta-analysis.Nassau, New Providence, Bahamas 2015MRI targeted biopsy alone is inadequate to detect clinically significant prostate cancer: a meta-analysis.
- MRI-Fusion biopsy in a first-time biopsy cohort yields increased detection of clinically significant cancer using a simplified MRI grading scale.Orlando, FL, United States 2015MRI-Fusion biopsy in a firt-time biopsy cohort yields increased detection of clinically significant cancer using a simplified MRI grading scale.
- MRI-US fusion prostate biopsy, improving cancer detectionProvidence, RI, United States 2014MRI-US fusion prostate biopsy, improving cancer detection
- Urine Neutrophil Gelatinase-Associated Lipocalin (uNGAL) as a marker for Acute Kidney Injury in Kidney Surgery PatientsBethesda, MD, United States 2012Urine Neutrophil Gelatinase-Associated Lipocalin (uNGAL) as a marker for Acute Kidney Injury in Kidney Surgery Patients
- Grand Round Presentation "Management of T1 Bladder Cancer"Brooklyn, NY, United States 2011Grand Round Presentation "Management of T1 Bladder Cancer"
- Annual Meeting, Society of Urologic Oncology "B7x is a seum marker for prostate cancer."Bethseda, MD, United States 2009Annual Meeting, Society of Urologic Oncology "B7x is a seum marker for prostate cancer."
- B7x is a serum marker for prostate cancerBethesda, MD, United States 2009B7x is a serum marker for prostate cancer
- Annual Meeting, American Urological Association, "The bladder trigone is not a Wolffian duct remnant."San Francisco, CA, United States 2006Annual Meeting, American Urological Association, "The bladder trigone is not a Wolffian duct remnant."
- The bladder trigone is not a Wolffian duct remnantSan Francisco, CA, United States 2006The bladder trigone is not a Wolffian duct remnant
Honors & Recognition
Award | Awarding Organization | Date |
---|---|---|
2021 Thesis Reviewer, PA Master Thesis Committee, Yale School of Medicine | 2021 | |
Mentor Appreciation Award | Interprofessional Longitudinal Clinical Experience | 2017, 2018, 2019, 2020 |
Best Poster Podium Presentation | Young Urologic Oncologist dinner, Society Of Urologic Oncology Annual Meeting | 2009 |
Finalist - NY section AUA Valentine Essay Contest | NY Academy of Medicine | 2009 |
Finalist - NY section AUA Valentine Essay Contest | NY Academy of Medicine | 2007 |
First Prize - NY section AUA Valentine Essay Contest | NY Academy of Medicine | 2006 |
Arnold P. Gold Humanism in Medicine Honors Society | 2004 | |
Alpha Omega Alpha Medical School Honors Society | 2004 | |
Outstanding Member of Stanford Community | Stanford University | 1998 |
Member, Board of Directors | Stanford University Alumni Association | 1997 |
Professional Service
Organization | Role | Date |
---|---|---|
Clinical Advisory Board, Profound Medical | Board Member | 2022 - 2023 |
NCCN Prostate Cancer Early Detection Guideline Panel | Vice Chair | 2021 - Present |
Department of Urology Medical Student Thesis review committee | Member | 2021 - 2023 |
VHA National Surgery Office - Robotic Surgery Surgical Advisory Board | Member | 2021 - Present |
Robotic Credentialing and Privileging committee | Multidisciplinary committee to review and define acceptable requirements to attain and maintain robotic surgery privileges. | 2020 - 2021 |
NIH | Ad Hoc reviewer for NIH Clinical Trials Genitourinary Steering Committee | 2019 |
Scientific Advisory Board, Boston Scientific Inc. | Scientific review and advice on urologic products | 2019 - Present |
MCIC LLC | Surgeon representative on multi-institutional meetings to improve clinical outcomes | 2018 - Present |
Department of Urology Executive Committee | Member | 2016 - Present |
Urologic Oncology | Reviewer | 2016 - Present |
Oncotarget | Reviewer | 2016 - Present |
Nature Scientific Reports | Reviewer | 2016 - Present |
Department of Urology Residency Promotion Committee | Member | 2015 - 2019 |
Yale Prostate SPORE kickoff meeting | Planning Committee | 2015 |
Yale Interdisciplinary Prostate Program | Interdisciplinary group focused on collaborative research and development of clinical programs in prostate cancer | 2015 - Present |
Yale Urology Prostate Cancer Screening Clinic | Participant | 2015 - Present |
Clinical Genitourinary Cancer | Reviewer | 2015 - Present |
PLOS One | Reviewer | 2015 - Present |
Frontiers | Associate Editor | 2015 - Present |
NCCN Prostate Cancer Early Detection Guideline Panel | Board Member | 2014 - 2021 |
Urologic Clinical Cost and Value Committee | Member | 2014 - 2016 |
Interventional Radiology Purchasing Committee | Expert Panel Member | 2014 - 2016 |
Society of Urologic Oncology | Member | 2009 - Present |
Journal of Urology | Reviewer | 2009 - Present |
Frontiers in Science | Reviewer | 2009 - Present |
Urology | Reviewer | 2009 - Present |
Washington Heights free prostate cancer education and screening clinic | Participant | 2008 |
American Association of Clinical Urologists | Member | 2006 - Present |
Departments & Organizations
- Cancer Screening & Prevention Program
- Developmental Therapeutics
- Prostate & Urologic Cancers Program
- Robotic Surgery and Laparoscopy
- Urologic Oncology Program
- Urology
- Yale Cancer Center
- Yale Medicine