A potential role for intragenic miRNAs on their hosts' interactome
Hinske L, Galante P, Kuo W, Ohno-Machado L. A potential role for intragenic miRNAs on their hosts' interactome. BMC Genomics 2010, 11: 533. PMID: 20920310, PMCID: PMC3091682, DOI: 10.1186/1471-2164-11-533.Peer-Reviewed Original ResearchConceptsIntragenic miRNAsHost genesAdenylate/uridylate-rich elementsMiRNA targetsMRNA targetsHost interactomeGene cohortsMiRNA biogenesis pathwayNon-coding RNA moleculesHigh-confidence setMiRNA target genesProtein-coding regionsKEGG pathway analysisTight regulatory controlNegative feedback regulatorIntronic miRNAsMore intronsBiogenesis pathwayMiRNA genesNegative feedback loopUridylate-rich elementsCellular homeostasisTarget genesRNA moleculesInteractomeTGF-beta1 interactome: metastasis and beyond.
Perera M, Tsang C, Distel R, Lacy J, Ohno-Machado L, Ricchiuti V, Samaranayake L, Smejkal G, Smith M, Trachtenberg A, Kuo W. TGF-beta1 interactome: metastasis and beyond. Cancer Genomics & Proteomics 2010, 7: 217-29. PMID: 20656987.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsDifferential expression profilesCancer therapeuticsPersonalized cancer therapeuticsRegulation of tumorEffective cancer therapeuticsNovel cancer biomarkersGenomic dataExpression profilesMetastatic attributesInteractomeUbiquitous cytokineTumor progressionCancer biomarkersPolarity changeTherapeuticsValuable insightsImmense valueRegulationInsightsInducerImportant stepMappingGrowth