Adjunct Faculty
Adjunct faculty typically have an academic or research appointment at another institution and contribute or collaborate with one or more School of Medicine faculty members or programs.
Adjunct rank detailsHuabing Li, PhD
Assistant Professor AdjunctAbout
Research
Publications
2026
tRNA m1A modification orchestrates STING translation in macrophages to enhance antitumor immunity and CAR-macrophage immunotherapy
Wang X, Wang X, Li H, Liu S, Lu Y, Chen H, Cai X, Su S, Li B, Liu R, Hu W, Zhu X, Zhang J, Ye Y, Li H. tRNA m1A modification orchestrates STING translation in macrophages to enhance antitumor immunity and CAR-macrophage immunotherapy. Cellular & Molecular Immunology 2026, 23: 261-272. PMID: 41535541, PMCID: PMC12949049, DOI: 10.1038/s41423-025-01383-7.Peer-Reviewed Original ResearchConceptsTumor-associated macrophagesRegulation of tumor-associated macrophagesTherapy in vivoTumor cell growthCAR macrophagesAntitumor immunityAntitumor therapeutic potentialTumor microenvironmentTumor progressionProinflammatory macrophagesTumor growthTumorTherapeutic potentialMacrophagesRegulatory mechanismsAntitumorPosttranscriptional regulationCell growthM1A modificationImmunotherapyStingsIntrathecal CRISPR-edited allogeneic IL-13Rα2 CAR T Cells for recurrent high-grade Glioma: preclinical characterization and phase I trial
Li X, Shang X, Liu J, Zhang Y, Jia X, Li H, Wang Y, Gao J, Ma X, Zhang X, Rong X, Gan W, Zhang Y, Chen J, Wang L, Bao Z, He L, Yan X, Liu Y, Shao J, Xiao Z, Wang Z, Zhu H, Wang Z, Wu Y, Huang Y. Intrathecal CRISPR-edited allogeneic IL-13Rα2 CAR T Cells for recurrent high-grade Glioma: preclinical characterization and phase I trial. Nature Communications 2026, 17: 1362. PMID: 41495049, PMCID: PMC12877024, DOI: 10.1038/s41467-025-68112-6.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAnimalsBrain NeoplasmsCell Line, TumorCRISPR-Cas SystemsFemaleGene EditingGlioblastomaGliomaGraft vs Host DiseaseHumansImmunotherapy, AdoptiveInterleukin-13 Receptor alpha2 SubunitKiller Cells, NaturalMaleMiceMiddle AgedNeoplasm Recurrence, LocalReceptors, Chimeric AntigenT-LymphocytesTreatment OutcomeConceptsCAR-T cellsHigh-grade gliomasIntrathecal injectionUniversal CAR T-cell therapiesNK cell-mediated rejectionUniversal CAR T cellsCAR-T cell therapyChimeric antigen receptor TGraft-versus-host diseaseRecurrent high-grade gliomaHLA class I moleculesHost-versus-graft responsePreliminary clinical activityPhase I trialPreliminary clinical dataFirst-in-humanInvestigator-initiated trialClass I moleculesMedian survivalPartial responseRecurrent glioblastomaTherapy failureI trialSingle-centerT cellstRNA m1A modification is essential for gut homeostasis and function of group 3 innate lymphoid cells
Li J, Tang Z, Chen Y, Cai X, Wu L, Wang G, Kan C, Li B, Su B, Li H, Chu C, Li H. tRNA m1A modification is essential for gut homeostasis and function of group 3 innate lymphoid cells. Cell Discovery 2026, 12: 1. PMID: 41484094, PMCID: PMC12764812, DOI: 10.1038/s41421-025-00850-9.Peer-Reviewed Original ResearchGroup 3 innate lymphoid cellsM1A modificationLymphoid cellsEnteric bacterial infectionsBacterial infectionsTRNA modificationDysregulated cell cycleGut homeostasisEnteric pathogensEpigenetic mechanismsIntestinal homeostasisCell cycleIntestinal ILC3sTRMT61AExperimental intestinal inflammationILC3 responsesInnate immunityAntibiotic treatmentILC3sIntestinal inflammationCell numberHomeostasisIntestinal tissueCellsInflammationRNA epigenetic modification for immune cell reprogramming and therapeutic translation
Zhang Y, Liu A, Li H. RNA epigenetic modification for immune cell reprogramming and therapeutic translation. Fundamental Research 2026 DOI: 10.1016/j.fmre.2025.12.028.Peer-Reviewed Original ResearchRNA modificationsMulti-level regulationEpigenetic modificationsFunctions of RNA modificationsRegulation of gene expressionEpigenetic regulatory mechanismsRNA epigenetic modificationRNA metabolismGene editing toolsCellular homeostasisImmunosuppressive tumor microenvironmentCAR-T therapyT cell exhaustionImmune cell reprogrammingCell adaptationGene expressionRegulatory mechanismsRNACell reprogrammingIntricate networkCAR-TEnvironmental changesPrincipal functionEditing toolsImmunotherapeutic approaches
2025
RNA modifications in intestinal macrophages: Implications for gut immunity and inflammation
Su M, Fan J, Li H. RNA modifications in intestinal macrophages: Implications for gut immunity and inflammation. Genes & Diseases 2025, 13: 101881. PMID: 41376856, PMCID: PMC12688690, DOI: 10.1016/j.gendis.2025.101881.Peer-Reviewed Original ResearchRNA modificationsRegulatory potentialLayer of post-transcriptional regulationDiverse environmental cuesGut immune homeostasisPost-transcriptional regulationIntestinal macrophagesEpitranscriptomic regulationRegulation of mucosal immunityMicrobial signalsMicrobial surveillanceEnvironmental cuesGut immunityResponse to inflammatory stimuliRNABarrier maintenanceImmunometabolic programsMacrophage developmentImmune cellsImmune homeostasisGutRegulationInflammatory stimuliMucosal immunityImmune regulationFTO regulates ELK3-mediated metabolic rewiring and represents a unique therapeutic target in T cell leukemia
Huang H, Li X, Luo J, Gao C, Yang M, Xu J, Xie T, Chen Z, Wang D, Wang Y, Li H, Huang J, Liu Y, Zhang H, Ntziachristos P, Zhao Y, Qing G, Liu H. FTO regulates ELK3-mediated metabolic rewiring and represents a unique therapeutic target in T cell leukemia. Science Advances 2025, 11: eadq3052. PMID: 40435251, PMCID: PMC12118595, DOI: 10.1126/sciadv.adq3052.Peer-Reviewed Original ResearchConceptsT-cell leukemiaT-ALLT-cell acute lymphoblastic leukemiaAcute lymphoblastic leukemiaExpression of glycolytic genesDevelopment of potential therapeutic strategiesPotential therapeutic strategyAntileukemia efficacyLymphoblastic leukemiaLeukemia initiationLymphoid leukemiaTherapeutic strategiesGlycolytic genesPharmacological inhibitionMetabolic rewiringLeukemiaDemethylase FTOHuman cancersN6-methyladenosineMRNA stabilityTherapeutic targetCancerMechanistic analysisMRNAModel systemRNA cytidine acetyltransferase NAT10 maintains T cell pathogenicity in inflammatory bowel disease
Li H, Cai X, Xu C, Yang X, Song X, Kong Y, Yang M, Wu Q, Zheng S, Shao Y, Wang P, Zhou J, Li H. RNA cytidine acetyltransferase NAT10 maintains T cell pathogenicity in inflammatory bowel disease. Cell Discovery 2025, 11: 19. PMID: 40038243, PMCID: PMC11880361, DOI: 10.1038/s41421-025-00781-5.Peer-Reviewed Original ResearchAccelerated rate of apoptosisPost-transcriptional gene regulationBcl2-associated athanogene 3N-acetyltransferase 10Apoptosis-related genesUpregulation of apoptosis-related genesAcetyltransferase NAT10T cell developmentRate of apoptosisGene regulationApoptotic pathwayAc4C modificationN4-acetylcytidineCD4+ T cellsAcetylation modificationNAT10Inflammatory bowel diseaseMRNA stabilityNAT10 expressionDiminished stabilityT cellsN-acetyltransferaseRNAPathogensNaive CD4+ T cellsAcute inflammation induces acute megakaryopoiesis with impaired platelet production during fetal hematopoiesis.
Hu X, He Y, Li S, Jiang Y, Yu R, Wu Y, Fu X, Song Y, Lin C, Shi J, Li H, Gao Y. Acute inflammation induces acute megakaryopoiesis with impaired platelet production during fetal hematopoiesis. Development 2025, 152 PMID: 39817838, DOI: 10.1242/dev.204226.Peer-Reviewed Original ResearchFetal hematopoiesisMegakaryocyte-erythroid progenitorsAcute inflammationInterferon-stimulated genesDouble-stranded RNAMegakaryocyte maturationPlatelet productionImpaired platelet productionFormation of double-stranded RNADownstream interferon-stimulated genesCell fate determinationRNA m6A modificationPhosphorylation of STAT1Hematopoietic progenitorsMegakaryocyte progenitorsHematopoietic cellsM6A methyltransferase METTL3Hematopoietic developmentGene expression analysisImmune responseMegakaryopoiesisHematopoiesisInflammationFate determinationIGF1 expressiontRNA m1A modification regulates cholesterol biosynthesis to promote antitumor immunity of CD8+ T cells
Miao S, Li H, Song X, Liu Y, Wang G, Kan C, Ye Y, Liu R, Li H. tRNA m1A modification regulates cholesterol biosynthesis to promote antitumor immunity of CD8+ T cells. Journal Of Experimental Medicine 2025, 222: e20240559. PMID: 39873720, PMCID: PMC11774205, DOI: 10.1084/jem.20240559.Peer-Reviewed Original ResearchConceptsCD8+ T cellsT cellsTumor-killing functionTransfer RNARegulating cholesterol biosynthesisAntitumor immunityCapacity of CD8+ T cellsActivation of CD8+ T cellsCholesterol biosynthesisM1A modificationTumor-killing capacityAntitumor responseATP citrate lyaseCancer immunotherapyCD8Effector functionsMetabolic reprogrammingProtein translationBiosynthetic demandsCitrate lyaseIn vitro assaysIn vivoPosttranscriptional mechanismsRegulatory checkpointsBiosynthesisMETTL3 modulates colonic epithelium integrity via maintaining the self-renewal and differentiation of Lgr5+ stem cell
Ding C, Yang X, Liu H, Roulis M, Chen H, Chen Y, Xu H, Gao Y, Zhong J, Li H, Ye Y, Cai W, Hu W, Wang Z. METTL3 modulates colonic epithelium integrity via maintaining the self-renewal and differentiation of Lgr5+ stem cell. Journal Of Molecular Cell Biology 2025, 17: mjae060. PMID: 39762134, PMCID: PMC12309382, DOI: 10.1093/jmcb/mjae060.Peer-Reviewed Original ResearchSelf-RenewalStem cellsMaturation of goblet cellsDifferentiation of Lgr5Ulcerative colitisHomeostasis of intestinal epitheliumColonic stem cellsGoblet cellsSpontaneous inflammationIntestinal dysplasiaColonic mucosaUC treatmentLgr5Epithelium integrityDepletion of METTL3Intestinal epitheliumTherapeutic targetInflammationDifferentiation capacityMETTL3 expressionUC samplesMETTL3 levelsExpression levelsM6A methylationCells
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