2022
The association between beta‐blockers and outcomes in patients with heart failure and concurrent Alzheimer's disease and related dementias
Gilstrap L, Cohen A, Ouellet GM, Goyal P, Gladders B, Flint D, Skinner J. The association between beta‐blockers and outcomes in patients with heart failure and concurrent Alzheimer's disease and related dementias. Journal Of The American Geriatrics Society 2022, 71: 404-413. PMID: 36240493, DOI: 10.1111/jgs.18086.Peer-Reviewed Original ResearchConceptsHigh riskBB useHeart failureAlzheimer's diseaseLong-term mortality ratesConcurrent Alzheimer's diseaseBeta-blocker useReduced ejection fractionMedicare Part ARisk/benefitBB therapyEjection fractionContemporary patientsHFrEFHigh prevalenceSimilar riskMortality ratePatientsCognitive impairmentMortalityDiseaseADRDRiskTherapyOutcomes
2019
Challenges and strategies in patients’ health priorities-aligned decision-making for older adults with multiple chronic conditions
Tinetti M, Dindo L, Smith CD, Blaum C, Costello D, Ouellet G, Rosen J, Hernandez-Bigos K, Geda M, Naik A. Challenges and strategies in patients’ health priorities-aligned decision-making for older adults with multiple chronic conditions. PLOS ONE 2019, 14: e0218249. PMID: 31181117, PMCID: PMC6557523, DOI: 10.1371/journal.pone.0218249.Peer-Reviewed Original ResearchConceptsPatients' health prioritiesMultiple chronic conditionsHealth priorityChronic conditionsPatient prioritiesPatient Priorities CarePrimary care cliniciansCare of patientsCare cliniciansPrimary carePatient outcomesCardiology practicePatientsCare optionsCare PilotCliniciansOlder adultsSerial trialsCarePriority careImplementation teamQualitative studyMultiple conditionsAdditional settingsMultiplicity of problems
2018
Principle of rational prescribing and deprescribing in older adults with multiple chronic conditions
Ouellet GM, Ouellet JA, Tinetti ME. Principle of rational prescribing and deprescribing in older adults with multiple chronic conditions. Therapeutic Advances In Drug Safety 2018, 9: 639-652. PMID: 30479739, PMCID: PMC6243421, DOI: 10.1177/2042098618791371.Peer-Reviewed Original ResearchMultiple chronic conditionsOptimal treatment regimensTreatment regimensOlder adultsChronic conditionsClinical trajectoriesMedication-related harmPatient's own prioritiesPatient's clinical trajectoryOptimal prescribingTherapeutic trialsPrescribed medicationsClinical statusHealth outcome goalsHealthy patientsRational prescribingPatient goalsClinical trialsPatient prioritiesPatientsSignificant burdenRegimensAdverse effectsAdultsLess benefit
2017
Care Transitions Between Hospitals and Skilled Nursing Facilities: Perspectives of Sending and Receiving Providers
Britton MC, Ouellet GM, Minges KE, Gawel M, Hodshon B, Chaudhry SI. Care Transitions Between Hospitals and Skilled Nursing Facilities: Perspectives of Sending and Receiving Providers. The Joint Commission Journal On Quality And Patient Safety 2017, 43: 565-572. PMID: 29056176, PMCID: PMC5693352, DOI: 10.1016/j.jcjq.2017.06.004.Peer-Reviewed Original ResearchMeSH KeywordsAcademic Medical CentersAttitude of Health PersonnelCommunicationHospital AdministrationHumansInsurance, Health, ReimbursementInterviews as TopicPatient DischargePatient ReadmissionPatient TransferQualitative ResearchQuality ImprovementRisk FactorsSeverity of Illness IndexSkilled Nursing FacilitiesUnited StatesConceptsSkilled nursing facilitiesCare transitionsNursing facilitiesSNF providersPatient-level risk factorsOptimal care settingAcute medical illnessUnplanned hospital readmissionComprehensive care planCost of careHospital readmissionMedical illnessComplex patientsRisk factorsMedicare patientsCare settingsCare plansPatient complexityHealth care institutionsPatient transferPsychosocial issuesHospitalPatientsSeparate hospitalsCare institutions
2012
Effect of Cardiac Resynchronization Therapy on the Risk of First and Recurrent Ventricular Tachyarrhythmic Events in MADIT-CRT
Ouellet G, Huang DT, Moss AJ, Hall WJ, Barsheshet A, McNitt S, Klein H, Zareba W, Goldenberg I. Effect of Cardiac Resynchronization Therapy on the Risk of First and Recurrent Ventricular Tachyarrhythmic Events in MADIT-CRT. Journal Of The American College Of Cardiology 2012, 60: 1809-1816. PMID: 23040580, DOI: 10.1016/j.jacc.2012.05.057.Peer-Reviewed Original ResearchConceptsLeft bundle branch blockVentricular tachyarrhythmic eventsNon-LBBB patientsFirst arrhythmic eventCardiac resynchronization therapyMADIT-CRTResynchronization therapyArrhythmic riskTachyarrhythmic eventsArrhythmic eventsSubsequent heart failureCRT-D therapyBundle branch blockCox proportional hazardsRisk of FirstHeart failureActive treatmentEfficacy analysisBranch blockPatientsProportional hazardsMultivariate analysisTherapyRegression modelingRiskEffectiveness of Cardiac Resynchronization Therapy in Diabetic Patients with Ischemic and Nonischemic Cardiomyopathy
George J, Barsheshet A, Moss AJ, Martin D, Ouellet G, McNitt S, Goldenberg I. Effectiveness of Cardiac Resynchronization Therapy in Diabetic Patients with Ischemic and Nonischemic Cardiomyopathy. Annals Of Noninvasive Electrocardiology 2012, 17: 14-21. PMID: 22276624, PMCID: PMC6932461, DOI: 10.1111/j.1542-474x.2011.00476.x.Peer-Reviewed Original ResearchConceptsNonischemic cardiomyopathyDiabetes mellitusProportional hazards regression modelingCardiac resynchronization therapyMADIT-CRTClinical responseEchocardiographic responseNonischemic patientsDiabetic patientsDM patientsResynchronization therapyClinical benefitCardiomyopathyPatientsRegression modelingCRTMellitusResponseTherapyDefibrillator
2011
RESPONSE TO CARDIAC RESYNCHRONIZATION THERAPY AMONG PATIENTS WITH DIABETES MELLITUS AND ISCHEMIC AND NON-ISCHEMIC ETIOLOGY OF CARDIOMYOPATHY
George J, Ouellet G, Moss A, Martin D, Barsheshet A, McNitt S, Goldenberg I. RESPONSE TO CARDIAC RESYNCHRONIZATION THERAPY AMONG PATIENTS WITH DIABETES MELLITUS AND ISCHEMIC AND NON-ISCHEMIC ETIOLOGY OF CARDIOMYOPATHY. Journal Of The American College Of Cardiology 2011, 57: e95. DOI: 10.1016/s0735-1097(11)60095-8.Peer-Reviewed Original ResearchMutation and gender-specific risk in type 2 long QT syndrome: Implications for risk stratification for life-threatening cardiac events in patients with long QT syndrome
Migdalovich D, Moss AJ, Lopes CM, Costa J, Ouellet G, Barsheshet A, McNitt S, Polonsky S, Robinson JL, Zareba W, Ackerman MJ, Benhorin J, Kaufman ES, Platonov PG, Shimizu W, Towbin JA, Vincent GM, Wilde AA, Goldenberg I. Mutation and gender-specific risk in type 2 long QT syndrome: Implications for risk stratification for life-threatening cardiac events in patients with long QT syndrome. Heart Rhythm 2011, 8: 1537-1543. PMID: 21440677, PMCID: PMC4028036, DOI: 10.1016/j.hrthm.2011.03.049.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultChildChild, PreschoolChi-Square DistributionDeath, Sudden, CardiacERG1 Potassium ChannelEther-A-Go-Go Potassium ChannelsFemaleHeart ArrestHumansInfantInfant, NewbornLong QT SyndromeMaleMutationProbabilityProportional Hazards ModelsRegistriesRisk AssessmentSex FactorsStatistics, NonparametricSurvival AnalysisConceptsLife-threatening cardiac eventsCardiac eventsLong QT syndromeGender-specific riskRisk stratificationQT syndromeKCNH2 channelsImproved risk stratificationType 2 long QT syndromeAge 40 yearsLife-threatening eventsLQT2 womenFemale patientsHigh riskLQT2 patientsTime-dependent differencesMultivariate analysisPatientsCombined assessmentCumulative probabilityWomenDisease-causing mutationsLoop mutationsMenRisk
2009
Clinical Implications for Patients With Long QT Syndrome Who Experience a Cardiac Event During Infancy
Spazzolini C, Mullally J, Moss AJ, Schwartz PJ, McNitt S, Ouellet G, Fugate T, Goldenberg I, Jons C, Zareba W, Robinson JL, Ackerman MJ, Benhorin J, Crotti L, Kaufman ES, Locati EH, Qi M, Napolitano C, Priori SG, Towbin JA, Vincent GM. Clinical Implications for Patients With Long QT Syndrome Who Experience a Cardiac Event During Infancy. Journal Of The American College Of Cardiology 2009, 54: 832-837. PMID: 19695463, PMCID: PMC3517782, DOI: 10.1016/j.jacc.2009.05.029.Peer-Reviewed Original ResearchConceptsSudden cardiac deathLong QT syndromeCardiac eventsQT syndromeHeart rateClinical implicationsFirst yearBeta-blocker therapyHigh-risk subsetInternational LQTS RegistryBeats/minAge 1 yearYears of lifeHazard ratioCardiac deathSyncopal episodesCardiac arrestLQTS RegistryFemale sexPrognostic aspectsQT intervalStudy populationHigh riskPatientsSyndrome