2021
Cellular and Extracellular White Matter Abnormalities in Obsessive-Compulsive Disorder: A Diffusion Magnetic Resonance Imaging Study
Maziero M, Seitz-Holland J, Cho K, Goldenberg J, Tanamatis T, Diniz J, Cappi C, Alice de Mathis M, Otaduy M, da Graça Morais Martin M, de Melo Felipe da Silva R, Shavitt R, Batistuzzo M, Lopes A, Miguel E, Pasternak O, Hoexter M. Cellular and Extracellular White Matter Abnormalities in Obsessive-Compulsive Disorder: A Diffusion Magnetic Resonance Imaging Study. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2021, 6: 983-991. PMID: 33862255, PMCID: PMC8502196, DOI: 10.1016/j.bpsc.2021.04.001.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderClinical variablesControl subjectsLower fractional anisotropyFractional anisotropyWhite matterDiffusion-weighted magnetic resonance imagingMagnetic resonance imaging studyDiffusion measuresDiffusion magnetic resonance imaging studyWhite matter abnormalitiesTract-based spatial statisticsResonance imaging studyMagnetic resonance imagingFree-water imagingExtracellular abnormalities
2020
Toward identifying reproducible brain signatures of obsessive-compulsive profiles: rationale and methods for a new global initiative
Simpson H, van den Heuvel O, Miguel E, Reddy Y, Stein D, Lewis-Fernández R, Shavitt R, Lochner C, Pouwels P, Narayanawamy J, Venkatasubramanian G, Hezel D, Vriend C, Batistuzzo M, Hoexter M, de Joode N, Costa D, de Mathis M, Sheshachala K, Narayan M, van Balkom A, Batelaan N, Venkataram S, Cherian A, Marincowitz C, Pannekoek N, Stovezky Y, Mare K, Liu F, Otaduy M, Pastorello B, Rao R, Katechis M, Van Meter P, Wall M. Toward identifying reproducible brain signatures of obsessive-compulsive profiles: rationale and methods for a new global initiative. BMC Psychiatry 2020, 20: 68. PMID: 32059696, PMCID: PMC7023814, DOI: 10.1186/s12888-020-2439-2.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingCircuit abnormalitiesNew global initiativesBrain signaturesGlobal InitiativeHealthy control subjectsMedication-free adultsMultiple brain circuitsMedication-free subjectsBackgroundObsessive–compulsive disorderClinical profileClinical symptomsControl subjectsClinical evaluationHealthy controlsLeading causeGlobal disabilityLifetime prevalenceResonance imagingNeurocognitive assessmentBrain circuitsImaging signaturesFunctional connectivityBrain-behavior associationsDisease dimensions
2016
Distinct Subcortical Volume Alterations in Pediatric and Adult OCD: A Worldwide Meta- and Mega-Analysis
Boedhoe PS, Schmaal L, Abe Y, Ameis SH, Arnold PD, Batistuzzo MC, Benedetti F, Beucke JC, Bollettini I, Bose A, Brem S, Calvo A, Cheng Y, Cho KI, Dallaspezia S, Denys D, Fitzgerald KD, Fouche JP, Giménez M, Gruner P, Hanna GL, Hibar DP, Hoexter MQ, Hu H, Huyser C, Ikari K, Jahanshad N, Kathmann N, Kaufmann C, Koch K, Kwon JS, Lazaro L, Liu Y, Lochner C, Marsh R, Martínez-Zalacaín I, Mataix-Cols D, Menchón JM, Minuzzi L, Nakamae T, Nakao T, Narayanaswamy JC, Piras F, Piras F, Pittenger C, Reddy YC, Sato JR, Simpson HB, Soreni N, Soriano-Mas C, Spalletta G, Stevens MC, Szeszko PR, Tolin DF, Venkatasubramanian G, Walitza S, Wang Z, van Wingen GA, Xu J, Xu X, Yun JY, Zhao Q, Thompson P, Stein D, van den Heuvel O, Abe Y, Alonso P, Ameis S, Arnold P, Bargalló N, Batistuzzo M, Benedetti F, Beucke J, Boedhoe P, Bollettini I, Bose A, Brem S, Busatto G, Calvo A, Calvo R, Cath D, Cheng Y, Cho K, Dallaspezia S, de Vries F, de Wit S, Denys D, Fang Y, Fitzgerald K, Fontaine M, Fouche J, Giménez M, Gruner P, Hanna G, Hibar D, Hoexter M, Hu H, Huyser C, Ikari K, Jahanshad N, Kathmann N, Kaufmann C, Khadka S, Koch K, Kwon J, Lazaro L, Liu Y, Lochner C, Marsh R, Martínez-Zalacaín I, Mataix-Cols D, Menchón J, Miguel E, Minuzzii L, Morer A, Nakamae T, Nakao T, Narayanaswamy J, Piras F, Piras F, Pittenger C, Reddy Y, Sato J, Simpson H, Schmaal L, Soreni N, Soriano-Mas C, Spalletta G, Stein D, Stevens M, Szeszko P, Thompson P, Tolin D, Veltman D, Venkatasubramanian G, van den Heuvel O, van der Werf Y, van Wingen G, Walitza S, Wang Z, Xu J, Xu X, Yun J, Zhao Q. Distinct Subcortical Volume Alterations in Pediatric and Adult OCD: A Worldwide Meta- and Mega-Analysis. American Journal Of Psychiatry 2016, 174: 60-69. PMID: 27609241, PMCID: PMC5344782, DOI: 10.1176/appi.ajp.2016.16020201.Peer-Reviewed Original ResearchConceptsAdult obsessive-compulsive disorderObsessive-compulsive disorderOCD patientsLarger thalamic volumesSubcortical volume alterationsSmaller hippocampal volumesAdult OCD patientsPediatric obsessive-compulsive disorderPotential modulating effectSubcortical brain volumesLimited statistical powerPallidum volumeClinical characteristicsAdult patientsPediatric patientsMean ageThalamic volumeControl subjectsPediatric controlsSubcortical abnormalitiesIllness profileHippocampal volumeHealthy subjectsNeurodevelopmental alterationsPatients
2010
Body dysmorphic disorder among dermatologic patients: Prevalence and clinical features
Conrado L, Hounie A, Diniz J, Fossaluza V, Torres A, Miguel E, Rivitti E. Body dysmorphic disorder among dermatologic patients: Prevalence and clinical features. Journal Of The American Academy Of Dermatology 2010, 63: 235-243. PMID: 20561712, DOI: 10.1016/j.jaad.2009.09.017.Peer-Reviewed Original ResearchConceptsBody dysmorphic disorderCosmetic groupClinical characteristicsDermatologic patientsDermatologic treatmentPrevalence of BDDDysmorphic disorderGeneral dermatology patientsCross-sectional studyMental health professionalsCosmetic settingsDermatology settingsClinical featuresPrevious diagnosisDermatology patientsControl subjectsUniversity HospitalDermatologic settingDermatology groupCurrent prevalencePatientsControl groupHealth professionalsPsychiatric conditionsRetrospective data
2009
Association between symptom severity and internal capsule volume in obsessive-compulsive disorder
de Souza Duran F, Hoexter M, Valente A, Miguel E, Busatto G. Association between symptom severity and internal capsule volume in obsessive-compulsive disorder. Neuroscience Letters 2009, 452: 68-71. PMID: 19150484, DOI: 10.1016/j.neulet.2009.01.007.Peer-Reviewed Original ResearchConceptsWhite matter volumeObsessive-compulsive disorderMagnetic resonance imagingMatter volumeCingulum bundleWhite matter volume deficitsPathophysiology of OCDOCD patientsAsymptomatic control subjectsWhite matter reductionThalamic-cortical circuitWhite matter alterationsVoxel-based morphometryWhite matter tractsRegional white matter volumeSymptom severity ratingsInternal capsuleNeurosurgical treatmentSeverity scoreControl subjectsAnterior limbConnectivity dysfunctionT MRI scannerOCD severity scoresVolume deficits
2006
Prenatal, Perinatal, and Postnatal Risk Factors in Obsessive–Compulsive Disorder
Vasconcelos M, Sampaio A, Hounie A, Akkerman F, Curi M, Lopes A, Miguel E. Prenatal, Perinatal, and Postnatal Risk Factors in Obsessive–Compulsive Disorder. Biological Psychiatry 2006, 61: 301-307. PMID: 17123475, DOI: 10.1016/j.biopsych.2006.07.014.Peer-Reviewed Original ResearchConceptsPostnatal risk factorsObsessive-compulsive disorderRisk factorsProlonged laborOCD patientsExcessive weight gainLogistic regression analysisEarly risk factorsHyperemesis gravidarumPreterm birthPrenatal careControl subjectsStandardized questionnaireControl groupWeight gainEdemaSocioeconomic classCompulsive disorderPregnancyPatientsRegression analysisGestationPerinatalGreater frequencyEnvironmental factors
2003
Association analysis of the catechol‐o‐methyltransferase (COMT ), serotonin transporter (5‐HTT ) and serotonin 2A receptor (5HT2A) gene polymorphisms with obsessive‐compulsive disorder
Meira‐Lima I, Shavitt R, Miguita K, Ikenaga E, Miguel E, Vallada H. Association analysis of the catechol‐o‐methyltransferase (COMT ), serotonin transporter (5‐HTT ) and serotonin 2A receptor (5HT2A) gene polymorphisms with obsessive‐compulsive disorder. Genes Brain & Behavior 2003, 3: 75-79. PMID: 15005715, DOI: 10.1046/j.1601-1848.2003.0042.x.Peer-Reviewed Original ResearchMeSH KeywordsAdultAmino Acid SubstitutionCarrier ProteinsCase-Control StudiesCatechol O-MethyltransferaseFemaleGene FrequencyHumansMaleMembrane GlycoproteinsMembrane Transport ProteinsNerve Tissue ProteinsObsessive-Compulsive DisorderPolymorphism, GeneticReceptor, Serotonin, 5-HT2AReference ValuesRegulatory Sequences, Nucleic AcidSerotonin Plasma Membrane Transport ProteinsConceptsObsessive-compulsive disorderGene polymorphismsT variantOCD patientsSerotonin receptor type 2A geneSerotonin-2A receptor gene polymorphismCross-sectional studyReceptor gene polymorphismsStrong genetic factorGenetic risk factorsControl subjectsRisk factorsDopaminergic systemDisease pathogenesisControl groupSerotonin transporter genePharmacological studiesPatientsGenetic factorsGenotypic distributionPrecise mechanismSignificant differencesFurther studiesCOMT geneFrequency of alleles
2000
A voxel-based investigation of regional cerebral blood flow abnormalities in obsessive–compulsive disorder using single photon emission computed tomography (SPECT)
Busatto G, Zamignani D, Buchpiguel C, Garrido G, Glabus M, Rocha E, Maia A, Rosario-Campos M, Castro C, Furuie S, Gutierrez M, McGuire P, Miguel E. A voxel-based investigation of regional cerebral blood flow abnormalities in obsessive–compulsive disorder using single photon emission computed tomography (SPECT). Psychiatry Research 2000, 99: 15-27. PMID: 10891646, DOI: 10.1016/s0925-4927(00)00050-0.Peer-Reviewed Original ResearchConceptsAnterior cingulate cortexECD uptakeObsessive-compulsive disorderCingulate cortexLateral orbitofrontal cortexObsessive-compulsive symptomsOrbitofrontal cortexControl subjectsOCD patientsLeft dorsal anterior cingulate cortexRegional cerebral blood flow abnormalitiesImaging studiesCerebral blood flow abnormalitiesRight medial orbitofrontal cortexPatient samplesRegional cerebral blood flowPathophysiology of OCDRight lateral orbitofrontal cortexRCBF SPECT studiesHealthy control subjectsBlood flow abnormalitiesCerebral blood flowLarger patient samplesSmall patient sampleLeft lateral orbitofrontal cortex
1996
Recall and recognition memory in obsessive-compulsive disorder
Savage C, Keuthen N, Jenike M, Brown H, Baer L, Kendrick A, Miguel E, Rauch S, Albert M. Recall and recognition memory in obsessive-compulsive disorder. Journal Of Neuropsychiatry 1996, 8: 99-103. PMID: 8845711, DOI: 10.1176/jnp.8.1.99.Peer-Reviewed Original Research