2024
The brain structure, inflammatory, and genetic mechanisms mediate the association between physical frailty and depression
Jiang R, Noble S, Rosenblatt M, Dai W, Ye J, Liu S, Qi S, Calhoun V, Sui J, Scheinost D. The brain structure, inflammatory, and genetic mechanisms mediate the association between physical frailty and depression. Nature Communications 2024, 15: 4411. PMID: 38782943, PMCID: PMC11116547, DOI: 10.1038/s41467-024-48827-8.Peer-Reviewed Original ResearchConceptsIncident depressionPre-frailPhysical frailtyFrail individualsPopulation attributable fraction analysisRisk factors of depressionMendelian randomization analysisFactors of depressionPotential causal effectModifiable risk factorsNon-frail individualsCross-sectional studyEffect of frailtyHigher disease burdenUK BiobankRandomization analysisBrain volumeDepression casesDisease burdenFrailtyRegional brain volumesIncreased riskDepressionHigh riskFollow-up
2018
Maternal Immune Activation During the Third Trimester Is Associated with Neonatal Functional Connectivity of the Salience Network and Fetal to Toddler Behavior
Spann MN, Monk C, Scheinost D, Peterson BS. Maternal Immune Activation During the Third Trimester Is Associated with Neonatal Functional Connectivity of the Salience Network and Fetal to Toddler Behavior. Journal Of Neuroscience 2018, 38: 2877-2886. PMID: 29487127, PMCID: PMC5852665, DOI: 10.1523/jneurosci.2272-17.2018.Peer-Reviewed Original ResearchConceptsMaternal immune activationC-reactive proteinFetal heart rate variabilityNeonatal functional connectivityInterleukin-6Postmenstrual ageImmune activationSalience networkFunctional connectivityPsychiatric disordersCRP levelsEpidemiological studiesMaternal C-reactive proteinResting-state imaging dataC-reactive protein levelsMaternal CRP levelsMaternal IL-6Months postmenstrual agePrenatal maternal immune activationSame psychiatric disordersWeeks postmenstrual ageIL-6 levelsAlters functional connectivityAltered brain developmentSame gestational age