2017
Progesterone-Mediated Non-Classical Signaling
Garg D, Ng S, Baig K, Driggers P, Segars J. Progesterone-Mediated Non-Classical Signaling. Trends In Endocrinology And Metabolism 2017, 28: 656-668. PMID: 28651856, DOI: 10.1016/j.tem.2017.05.006.Peer-Reviewed Original ResearchConceptsProgesterone response elementGrowth factor signalingNon-genomic signalingNon-classical signaling pathwaysNon-classical signalingCycle regulationFactor signalingSignaling pathwaysResponse elementProgesterone signalingCell growthSignalingProgesterone receptorSubsequent activationNovel therapeutic strategiesHormone actionProgesterone actionPathwayGrowth factorImportant physiological actionsPhysiological actionsMenstrual cycle regulationNuclear progesterone receptorRecent studiesActivation
2016
Relationship between Advanced Glycation End Products and Steroidogenesis in PCOS
Garg D, Merhi Z. Relationship between Advanced Glycation End Products and Steroidogenesis in PCOS. Reproductive Biology And Endocrinology 2016, 14: 71. PMID: 27769286, PMCID: PMC5073880, DOI: 10.1186/s12958-016-0205-6.Peer-Reviewed Original ResearchMeSH Keywords3-Hydroxysteroid DehydrogenasesAnimalsCholesterol Side-Chain Cleavage EnzymeFemaleGlycation End Products, AdvancedGonadal Steroid HormonesGranulosa CellsHumansOvaryPhosphoproteinsPolycystic Ovary SyndromeReceptors, LHReceptors, PeptideReceptors, Transforming Growth Factor betaSteroid 17-alpha-HydroxylaseTheca CellsConceptsAdvanced glycation end productsOvaries of womenTheca cell functionGlycation end productsCell functionHormone receptor expressionSteroidogenic enzyme activitiesSteroidogenic acute regulatory proteinAbnormal steroidogenesisPCOS modelOvarian dysfunctionAcute regulatory proteinReceptor expressionPCOSFollicular developmentTheca cellsGranulosa cellsSystematic reviewNew interventionsHormone receptorsEnzyme cytochrome P450SteroidogenesisEnd productsGranulosaCytochrome P450The role of AMH in the pathophysiology of polycystic ovarian syndrome
Garg D, Tal R. The role of AMH in the pathophysiology of polycystic ovarian syndrome. Reproductive BioMedicine Online 2016, 33: 15-28. PMID: 27174394, DOI: 10.1016/j.rbmo.2016.04.007.Peer-Reviewed Original ResearchConceptsPolycystic ovarian syndromeAnti-Müllerian hormoneOvarian syndromePathophysiology of PCOSTreatment of PCOSRole of AMHLaparoscopic ovarian drillingReproductive-age womenSerum AMH concentrationsNew treatment modalitiesFollicular arrestOvarian drillingOvulation inductionClinical parametersInsulin resistanceAMH concentrationsTreatment modalitiesAge womenEndocrine alterationsPoor responseAromatase productionAMH declinePCOS pathogenesisFollicular developmentHelp clinicians