2017
Correlation between follicular fluid levels of sRAGE and vitamin D in women with PCOS
Garg D, Grazi R, Lambert-Messerlian GM, Merhi Z. Correlation between follicular fluid levels of sRAGE and vitamin D in women with PCOS. Journal Of Assisted Reproduction And Genetics 2017, 34: 1507-1513. PMID: 28825156, PMCID: PMC5699991, DOI: 10.1007/s10815-017-1011-6.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntigens, NeoplasmBiomarkersFemaleFertilization in VitroFollicular FluidGlycation End Products, AdvancedHumansMitogen-Activated Protein KinasesOocytesOvaryPolycystic Ovary SyndromeVitamin DConceptsAdvanced glycation end productsFollicular fluidVitamin DPro-inflammatory advanced glycation end productsHigher anti-Mullerian hormone levelsAnti-Mullerian hormone levelsProtective anti-inflammatory roleFollicular fluid levelsLevels of sRAGEAnti-inflammatory rolePathogenesis of PCOSGlycation end productsPotential therapeutic targetDay 5 embryosConclusionsIn womenSRAGE levelsOvarian dysfunctionOvarian levelHormone levelsPCOSSRAGESoluble receptorTherapeutic targetDay 3Fluid levels
2016
Relationship between Advanced Glycation End Products and Steroidogenesis in PCOS
Garg D, Merhi Z. Relationship between Advanced Glycation End Products and Steroidogenesis in PCOS. Reproductive Biology And Endocrinology 2016, 14: 71. PMID: 27769286, PMCID: PMC5073880, DOI: 10.1186/s12958-016-0205-6.Peer-Reviewed Original ResearchMeSH Keywords3-Hydroxysteroid DehydrogenasesAnimalsCholesterol Side-Chain Cleavage EnzymeFemaleGlycation End Products, AdvancedGonadal Steroid HormonesGranulosa CellsHumansOvaryPhosphoproteinsPolycystic Ovary SyndromeReceptors, LHReceptors, PeptideReceptors, Transforming Growth Factor betaSteroid 17-alpha-HydroxylaseTheca CellsConceptsAdvanced glycation end productsOvaries of womenTheca cell functionGlycation end productsCell functionHormone receptor expressionSteroidogenic enzyme activitiesSteroidogenic acute regulatory proteinAbnormal steroidogenesisPCOS modelOvarian dysfunctionAcute regulatory proteinReceptor expressionPCOSFollicular developmentTheca cellsGranulosa cellsSystematic reviewNew interventionsHormone receptorsEnzyme cytochrome P450SteroidogenesisEnd productsGranulosaCytochrome P450
2015
Advanced Glycation End Products: Link between Diet and Ovulatory Dysfunction in PCOS?
Garg D, Merhi Z. Advanced Glycation End Products: Link between Diet and Ovulatory Dysfunction in PCOS? Nutrients 2015, 7: 10129-10144. PMID: 26690206, PMCID: PMC4690076, DOI: 10.3390/nu7125524.Peer-Reviewed Original ResearchMeSH KeywordsDietFemaleGlycation End Products, AdvancedHumansInsulin ResistanceObesityPolycystic Ovary SyndromeReceptor for Advanced Glycation End ProductsReproductionConceptsOvulatory dysfunctionAdvanced glycation end productsHigh AGE dietReproductive-aged womenPro-inflammatory receptorGlycation end productsDietary AGEsPharmacological therapyOvulatory problemsExpression of AGEsCommon causeOvarian healthPCOSOvarian tissueAnovulationModification of foodVariety of dietsWomenAgeDysfunctionDietReproductive alterationsSubsequent developmentNon-enzymatic reactionEnd products