Leonid Tyan, PhD
Associate Research ScientistCards
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Associate Research Scientist
Appointments
Pediatric Critical Care Medicine
Associate Research ScientistPrimary
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Education & Training
- PhD
- Eberhard Karls Universität Tübingen (2012)
Research
Research at a Glance
Yale Co-Authors
Frequent collaborators of Leonid Tyan's published research.
Publications Timeline
A big-picture view of Leonid Tyan's research output by year.
David Zenisek, PhD
Michael Caplan, PhD, MD
Mustafa Khokha, MD
Valentyna Kostiuk
17Publications
14Citations
Publications
2022
Membrane potential drives the exit from pluripotency and cell fate commitment via calcium and mTOR
Sempou E, Kostiuk V, Zhu J, Cecilia Guerra M, Tyan L, Hwang W, Camacho-Aguilar E, Caplan M, Zenisek D, Warmflash A, Owens N, Khokha M. Membrane potential drives the exit from pluripotency and cell fate commitment via calcium and mTOR. Nature Communications 2022, 13: 6681. PMID: 36335122, PMCID: PMC9637099, DOI: 10.1038/s41467-022-34363-w.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsPluripotent cellsAdult tissue homeostasisCell fate commitmentDifferentiated cell fatesLeft-right patterningPluripotent embryonic cellsHuman embryonic stem cellsTemporal transcriptome analysisGene regulatory networksExpense of differentiationEmbryonic stem cellsGerm layer differentiationMembrane depolarizationFate commitmentPluripotent stateCell fateTranscriptome analysisRegulatory networksMyogenic lineageEmbryonic developmentTissue homeostasisDifferentiated fateEmbryonic cellsCandidate genesPluripotencyCaveolin-3 prevents swelling-induced membrane damage via regulation of ICl,swell activity.
Turner DGP, Tyan L, DeGuire FC, Medvedev RY, Stroebel SJ, Lang D, Glukhov AV. Caveolin-3 prevents swelling-induced membrane damage via regulation of ICl,swell activity. Biophysical Journal 2022, 121: 1643-1659. PMID: 35378081, PMCID: PMC9117929, DOI: 10.1016/j.bpj.2022.04.001.Peer-Reviewed Original Research
2021
Caveolin-3 is required for regulation of transient outward potassium current by angiotensin II in mouse atrial myocytes.
Tyan L, Turner D, Komp KR, Medvedev RY, Lim E, Glukhov AV. Caveolin-3 is required for regulation of transient outward potassium current by angiotensin II in mouse atrial myocytes. American Journal Of Physiology. Heart And Circulatory Physiology 2021, 320: H787-H797. PMID: 33416459, PMCID: PMC8082791, DOI: 10.1152/ajpheart.00569.2020.Peer-Reviewed Original Research
2020
A compartmentalized mathematical model of mouse atrial myocytes.
Asfaw TN, Tyan L, Glukhov AV, Bondarenko VE. A compartmentalized mathematical model of mouse atrial myocytes. American Journal Of Physiology. Heart And Circulatory Physiology 2020, 318: H485-H507. PMID: 31951471, PMCID: PMC7099449, DOI: 10.1152/ajpheart.00460.2019.Peer-Reviewed Original Research
2019
Atrial fibrillation risk loci interact to modulate Ca2+-dependent atrial rhythm homeostasis.
Laforest B, Dai W, Tyan L, Lazarevic S, Shen KM, Gadek M, Broman MT, Weber CR, Moskowitz IP. Atrial fibrillation risk loci interact to modulate Ca2+-dependent atrial rhythm homeostasis. The Journal Of Clinical Investigation 2019, 129: 4937-4950. PMID: 31609246, PMCID: PMC6819107, DOI: 10.1172/JCI124231.Peer-Reviewed Original ResearchCaveolae-Mediated Activation of Mechanosensitive Chloride Channels in Pulmonary Veins Triggers Atrial Arrhythmogenesis.
Egorov YV, Lang D, Tyan L, Turner D, Lim E, Piro ZD, Hernandez JJ, Lodin R, Wang R, Schmuck EG, Raval AN, Ralphe CJ, Kamp TJ, Rosenshtraukh LV, Glukhov AV. Caveolae-Mediated Activation of Mechanosensitive Chloride Channels in Pulmonary Veins Triggers Atrial Arrhythmogenesis. Journal Of The American Heart Association 2019, 8: e012748. PMID: 31597508, PMCID: PMC6818041, DOI: 10.1161/JAHA.119.012748.Peer-Reviewed Original ResearchA calcium transport mechanism for atrial fibrillation in Tbx5-mutant mice.
Dai W, Laforest B, Tyan L, Shen KM, Nadadur RD, Alvarado FJ, Mazurek SR, Lazarevic S, Gadek M, Wang Y, Li Y, Valdivia HH, Shen L, Broman MT, Moskowitz IP, Weber CR. A calcium transport mechanism for atrial fibrillation in Tbx5-mutant mice. ELife 2019, 8 PMID: 30896405, PMCID: PMC6428569, DOI: 10.7554/eLife.41814.Peer-Reviewed Original ResearchLong QT syndrome caveolin-3 mutations differentially modulate Kv 4 and Cav 1.2 channels to contribute to action potential prolongation.
Tyan L, Foell JD, Vincent KP, Woon MT, Mesquitta WT, Lang D, Best JM, Ackerman MJ, McCulloch AD, Glukhov AV, Balijepalli RC, Kamp TJ. Long QT syndrome caveolin-3 mutations differentially modulate Kv 4 and Cav 1.2 channels to contribute to action potential prolongation. The Journal Of Physiology 2019, 597: 1531-1551. PMID: 30588629, PMCID: PMC6418751, DOI: 10.1113/JP276014.Peer-Reviewed Original Research
2017
Transcription-factor-dependent enhancer transcription defines a gene regulatory network for cardiac rhythm.
Yang XH, Nadadur RD, Hilvering CR, Bianchi V, Werner M, Mazurek SR, Gadek M, Shen KM, Goldman JA, Tyan L, Bekeny J, Hall JM, Lee N, Perez-Cervantes C, Burnicka-Turek O, Poss KD, Weber CR, de Laat W, Ruthenburg AJ, Moskowitz IP. Transcription-factor-dependent enhancer transcription defines a gene regulatory network for cardiac rhythm. ELife 2017, 6 PMID: 29280435, PMCID: PMC5745077, DOI: 10.7554/eLife.31683.Peer-Reviewed Original Research
2016
Electrophysiology and metabolism of caveolin-3-overexpressing mice.
Schilling JM, Horikawa YT, Zemljic-Harpf AE, Vincent KP, Tyan L, Yu JK, McCulloch AD, Balijepalli RC, Patel HH, Roth DM. Electrophysiology and metabolism of caveolin-3-overexpressing mice. Basic Research In Cardiology 2016, 111: 28. PMID: 27023865, PMCID: PMC5336321, DOI: 10.1007/s00395-016-0542-9.Peer-Reviewed Original Research
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