Inhibition of the Akt1-mTORC1 Axis Alters Venous Remodeling to Improve Arteriovenous Fistula Patency
Guo X, Fereydooni A, Isaji T, Gorecka J, Liu S, Hu H, Ono S, Alozie M, Lee SR, Taniguchi R, Yatsula B, Nassiri N, Zhang L, Dardik A. Inhibition of the Akt1-mTORC1 Axis Alters Venous Remodeling to Improve Arteriovenous Fistula Patency. Scientific Reports 2019, 9: 11046. PMID: 31363142, PMCID: PMC6667481, DOI: 10.1038/s41598-019-47542-5.Peer-Reviewed Original ResearchConceptsM2-type macrophagesSmooth muscle cellsAVF patencyArteriovenous fistulaAVF maturationImproved long-term patencyPotential translational strategyArteriovenous fistula patencyDaily intraperitoneal injectionsClodronate-containing liposomesDepletion of macrophagesLong-term patencyAVF remodelingFistula patencyIntraperitoneal injectionEarly inflammationSustained reductionType macrophagesPatencyWall thicknessSMC proliferationWall thickeningAVF modelMuscle cellsMacrophages