Anthony Enzo Seddio, MD
Hospital ResidentCards
About
Research
Publications
Featured Publications
Semaglutide utilization associated with reduced 90-day postoperative complications following single-level posterior lumbar fusion for patients with type II diabetes
Seddio A, Gouzoulis M, Vasudevan R, Dhodapkar M, Jabbouri S, Varthi A, Rubio D, Grauer J. Semaglutide utilization associated with reduced 90-day postoperative complications following single-level posterior lumbar fusion for patients with type II diabetes. The Spine Journal 2024, 25: 485-493. PMID: 39491749, DOI: 10.1016/j.spinee.2024.10.011.Peer-Reviewed Original ResearchSingle-level posterior lumbar fusionPosterior lumbar fusionSodium-glucose transport protein 2 inhibitorsAdverse eventsPostoperative complicationsT2DM patientsCurrent Procedural TerminologyElixhauser Comorbidity IndexED visitsLumbar fusionHospital readmissionEmergency departmentOdds of postoperative complicationsNinety-day postoperative complicationsImpact of semaglutideOdds of hospital readmissionMonths of surgeryRetrospective cohort studyPostoperative adverse eventsMinor adverse eventsType II diabetes mellitusRisk of type I errorDiagnosis of T2DMII diabetes mellitusYears of ageThe incidence and trends of diving-related spine injuries in the United States and risk factors associated with spinal cord injury
Seddio A, Jabbouri S, Vasudevan R, Gouzoulis M, Day W, Maloy G, Varthi A, Rubio D, Grauer J. The incidence and trends of diving-related spine injuries in the United States and risk factors associated with spinal cord injury. Spinal Cord 2025, 63: 352-358. PMID: 40490487, DOI: 10.1038/s41393-025-01098-6.Peer-Reviewed Original ResearchEstimated annual percentage changeSpine injuriesSpinal cord injuryRisk factorsLumbar spineInjury prevention programsAnnual percentage changePublic health initiativesCord injuryCervical spine surgeryMultivariate logistic regressionLog-linear regressionUnique risk factorsHealth initiativesUnited StatesCervical spondylolisthesisElixhauser Comorbidity IndexCervical spinePrevention programsAdministrative datasetsLogistic regressionSpine surgeryPercentage changeCervical stenosisOlder ageRobotic-Assisted Versus Navigation-Assisted Posterior Lumbar Fusion
Gouzoulis M, Seddio A, Winter A, Jabbouri S, Zhu J, Rubio D, Varthi A, Grauer J. Robotic-Assisted Versus Navigation-Assisted Posterior Lumbar Fusion. Spine 2024, 49: 1483-1487. PMID: 38717329, DOI: 10.1097/brs.0000000000005032.Peer-Reviewed Original ResearchPosterior lumbar fusionLumbar fusionAdverse eventsLevel posterior lumbar fusionsCPT codesKaplan-Meier survival analysisRate of reoperationNavigation-assisted surgeryRobotic-assisted casesNavigation-assistedMinor adverse eventsPerioperative adverse eventsMultivariate logistic regressionICD-10 procedure codeRobotic cohortRobotic assistanceSpinal navigationReoperation rateAnterior fusionElixhauser Comorbidity IndexPearlDiver databaseNo significant differenceIncremental advantageAdverse outcomesComorbidity indexComparable Overall Risk of Neurological Adverse Events Following Cervicothoracic Interlaminar and Transforaminal Epidural Injections
Seddio A, McNamara K, Gouzoulis M, Jabbouri S, Vasudevan R, Day W, Ratnasamy P, Rubio D, Grauer J. Comparable Overall Risk of Neurological Adverse Events Following Cervicothoracic Interlaminar and Transforaminal Epidural Injections. Spine 2024, 50: 1273-1277. PMID: 39394649, DOI: 10.1097/brs.0000000000005181.Peer-Reviewed Original ResearchNeurological adverse eventsAdverse eventsElixhauser Comorbidity IndexNeurological complicationsOdds ratioEpidural spinal injectionsInterlaminar (ILTransforaminal epidural injectionsAssociated with specific complicationsTransforaminal (TFNerve root injuryRisk of complicationsAssociated with higher odds ratiosMultivariate logistic regressionRisk of neurological adverse eventsHigher odds ratioCervical pathologyEpidural hematomaTF injectionSpinal injectionEpidural injectionSpecific complicationsAdult patientsCase reportComorbidity indexTrends in management of odontoid fractures 2010–2021
Gouzoulis M, Seddio A, Rancu A, Jabbouri S, Moran J, Varthi A, Rubio D, Grauer J. Trends in management of odontoid fractures 2010–2021. North American Spine Society Journal (NASSJ) 2024, 20: 100553. PMID: 39381260, PMCID: PMC11459689, DOI: 10.1016/j.xnsj.2024.100553.Peer-Reviewed Original ResearchOdontoid fracturesSurgical interventionPredictive factorsAdult patientsManagement of odontoid fracturesPosterior stabilizationMethods Adult patientsNon-clinical factorsRate of surgerySampled adult patientsYearly rateAnterior surgeryPosterior surgeryNonoperative careSurgical managementNonsurgical treatmentClinical factorsMale sexPosterior approachMultivariate analysisMedicare insuranceFracture managementSurgeryPatientsMidwest United StatesLower Risk of Postoperative Complications and Rotator Cuff Retear Associated With Semaglutide Use in Patients with Type II Diabetes Mellitus Undergoing Arthroscopic Rotator Cuff Repair
Seddio A, Moran J, Gouzoulis M, Garbis N, Salazar D, Grauer J, Jimenez A. Lower Risk of Postoperative Complications and Rotator Cuff Retear Associated With Semaglutide Use in Patients with Type II Diabetes Mellitus Undergoing Arthroscopic Rotator Cuff Repair. Arthroscopy The Journal Of Arthroscopic And Related Surgery 2024, 41: 199-206. PMID: 39490542, DOI: 10.1016/j.arthro.2024.09.057.Peer-Reviewed Original ResearchArthroscopic rotator cuff repairT2DM patientsRotator cuff retearRotator cuff repairElixhauser Comorbidity IndexAdverse eventsLow risk of postoperative complicationsOdds ratioRisk of postoperative complicationsKaplan-Meier survival analysisUrinary tract infectionSurgical-site infectionCuff repairLog-rank testRetrospective comparative studyAcute kidney injuryMinor adverse eventsType II diabetes mellitusAssociated with decreased oddsMultivariate logistic regressionArthroscopic shoulder proceduresII diabetes mellitusAdministrative billing codesPostoperative complicationsTract infectionsRate and risk factors for inpatient falls following single-level posterior lumbar fusion: A national registry study
Gouzoulis M, Jabbouri S, Seddio A, Moran J, Day W, Ratnasamy P, Grauer J. Rate and risk factors for inpatient falls following single-level posterior lumbar fusion: A national registry study. North American Spine Society Journal (NASSJ) 2024, 20: 100549. PMID: 39318705, PMCID: PMC11417567, DOI: 10.1016/j.xnsj.2024.100549.Peer-Reviewed Original ResearchPosterior lumbar fusionSingle-level posterior lumbar fusionInpatient fallsOdds ratioLumbar fusionFall prevention programsIncidence of secondary injuryNational sample of patientsRisk factorsDecreased odds ratioPatient variablesPotential patient outcomesMultivariate logistic regressionNational registry studySample of patientsPrevention programsInpatient costsMedicaid insuranceActive deliriumAlcohol use disorderMethods Adult patientsSpinal pathologyOutcome metricsCommercial insuranceNational sample
2025
Endoscopic and Open Carpal Tunnel Release in Patients With Type II Diabetes Mellitus: Influence of Preoperative Semaglutide Use on Postoperative Outcomes.
Seddio AE, Day W, Rancu AL, Modrak M, Joo PY, Grauer JN. Endoscopic and Open Carpal Tunnel Release in Patients With Type II Diabetes Mellitus: Influence of Preoperative Semaglutide Use on Postoperative Outcomes. J Hand Surg Am 2025 PMID: 41105066, DOI: 10.1016/j.jhsa.2025.09.003.Peer-Reviewed Original ResearchThe Correlation of Surgeon Subspecialty With Outcomes Following Surgery for Geriatric Femoral Neck Fracture
Zhu J, Ajjawi I, Day W, Gouzoulis M, Seddio A, Grauer J. The Correlation of Surgeon Subspecialty With Outcomes Following Surgery for Geriatric Femoral Neck Fracture. JAAOS Global Research And Reviews 2025, 9: e25.00103. PMID: 40972509, PMCID: PMC12448162, DOI: 10.5435/jaaosglobal-d-25-00103.Peer-Reviewed Original ResearchConceptsGeriatric femoral neck fracturesFemoral neck fracturesFive-year ratesNeck fracturesPercutaneous pinningSurgeon subspecialtyRevision rateTotal hip arthroplastyPerioperative adverse eventsMultivariate logistic regressionNinety-day outcomesSurgeon specialtyLonger-term outcomesSurgeon cohortSurgery typeAdverse eventsNinety-dayDislocation rateAdverse outcomesOn-call physicianAdministrative data setsExclusion criteriaSurgerySurgeonsHemiarthroplastyAs Few as Three Months of Preoperative Semaglutide Exposure Prior to Total Knee Arthroplasty Is Associated With Reduced Postoperative Adverse Events in Patients With Type II Diabetes
Seddio A, Vasudevan R, Gouzoulis M, Ansah-Twum J, Grauer J, Rubin L. As Few as Three Months of Preoperative Semaglutide Exposure Prior to Total Knee Arthroplasty Is Associated With Reduced Postoperative Adverse Events in Patients With Type II Diabetes. The Journal Of Arthroplasty 2025 PMID: 40784425, DOI: 10.1016/j.arth.2025.08.003.Peer-Reviewed Original ResearchMinor adverse eventsSemaglutide exposureSevere adverse eventsPostoperative adverse eventsAdverse eventsTotal knee arthroplastyRetrospective cohortGlucagon-like peptide-1 receptor agonistsRetrospective cohort of patientsPeptide-1 receptor agonistsSevere postoperative adverse eventsUrinary tract infectionSurgical site infectionCohort of patientsAcute kidney injuryType II diabetes mellitusMultivariate logistic regressionPreoperative care pathwaysII diabetes mellitusKnee arthroplastyPreoperative exposurePostoperative total knee arthroplastyReceptor agonistsTract infectionsSite infection