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Associate Professor Tenure
Biography
Dr. Malaker is an Assistant Professor in the Department of Chemistry at Yale University. Her laboratory is focused on establishing methods and technology to study mucins, a class of densely O-glycosylated extracellular proteins, by MS. Additionally, the laboratory studies mucins in a biological context, since these proteins play integral, yet poorly understood, roles in numerous diseases. Prior to her appointment at Yale, she received her B.S. from the University of Michigan in Biochemistry and Anthropology-Zoology. Dr. Malaker then went on to receive her PhD in Chemistry from the University of Virginia in the laboratory of Professor Donald Hunt. She continued to investigate the role of aberrant glycosylation in cancer as an NIH postdoctoral fellow in Professor Carolyn Bertozzi’s laboratory at Stanford University before starting at Yale in 2021.
Last Updated on April 07, 2025.
Appointments
Chemistry
Associate Professor TenurePrimary
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Research
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Research Projects
Developing Diagnostics for Early Detection of Ovarian Cancer
Yale School of Medicine / , parent organization of Women's Health Research at Yale
ORCID
0000-0003-2382-5067- View Lab Website
Malaker Lab
Research at a Glance
Yale Co-Authors
Frequent collaborators of Stacy Malaker's published research.
Publications Timeline
A big-picture view of Stacy Malaker's research output by year.
Carlos Fernandez-Hernando, PhD
Inmaculada Ruz-Maldonado
James Knight, PhD
Jing Yan, PhD
Kaelyn Sumigray, PhD
Kariona Grabinska, PhD
70Publications
4,706Citations
Publications
2026
Transcriptome, glycome, and mucinome analysis reveal zinc is essential for the composition of mucus in the human goblet cell model HT-29-MTX
Schüßler C, Chung N, Léonard R, Sprenger H, Rödel T, Mahoney K, Thomsen S, Ocket E, Matthaeus C, Denis J, Ebert F, Wolf M, Morelle W, Foulquier F, Braeuning A, Masselot C, Malaker S, Maares M. Transcriptome, glycome, and mucinome analysis reveal zinc is essential for the composition of mucus in the human goblet cell model HT-29-MTX. Scientific Reports 2026, 16: 24822. PMID: 42575931, PMCID: PMC13458581, DOI: 10.1038/s41598-026-66227-4.Peer-Reviewed Original ResearchO‑Glycosylation Shapes the Proteolytic Landscape of the Native Tear Peptidome
Chang V, Chen R, Lian I, Mahoney K, Malaker S. O‑Glycosylation Shapes the Proteolytic Landscape of the Native Tear Peptidome. JACS Au 2026, 6: 4321-4335. PMID: 42529429, PMCID: PMC13417242, DOI: 10.1021/jacsau.6c00834.Peer-Reviewed Original ResearchCitationsMapping galectin-3 ligands in human tear fluid establishes spliceoform-dependent lacritin binding
Chang V, Lian I, Mahoney K, Romano J, Afshari A, Chen R, Chen X, Fineide F, Khan A, Utheim T, Karlsson N, Laurie G, Malaker S. Mapping galectin-3 ligands in human tear fluid establishes spliceoform-dependent lacritin binding. Communications Biology 2026, 9: 1120. PMID: 42191868, PMCID: PMC13486718, DOI: 10.1038/s42003-026-10337-2.Peer-Reviewed Original ResearchCitationsAltmetricGlycosite mapping and in situ mass spectrometry imaging of MUC2 glycopeptides via on-slide mucinase digestion
Lowery S, Ribi M, Chongsaritsinsuk J, Tran I, Grimsley G, Stubler R, Mahoney K, Lucas T, Charkoftaki G, Santos-Neto A, Varki N, Vasiliou V, Angelo M, Drake R, Malaker S. Glycosite mapping and in situ mass spectrometry imaging of MUC2 glycopeptides via on-slide mucinase digestion. Nature Communications 2026, 17: 6125. PMID: 42098121, PMCID: PMC13357551, DOI: 10.1038/s41467-026-72853-3.Peer-Reviewed Original ResearchCitationsAltmetricEnrichment strategies for mucin-domain O-glycoproteins
Finn S, Malaker S. Enrichment strategies for mucin-domain O-glycoproteins. Methods In Enzymology 2026, 732: 1-30. PMID: 42399048, DOI: 10.1016/bs.mie.2026.03.003.BooksCharacterization of O-glycoproteases for applications in mass spectrometry
Steigmeyer A, Chongsaritsinsuk J, Malaker S. Characterization of O-glycoproteases for applications in mass spectrometry. Methods In Enzymology 2026, 732: 31-63. PMID: 42399054, DOI: 10.1016/bs.mie.2026.03.004.BooksScreening of the transcriptome, mucinome, and O‐/N‐glycans of the intestinal goblet cell model HT29‐MTX during zinc deficiency
Schüßler C, Chung N, Leonard R, Sprenger H, Braeuning A, Morelle W, Foulquier F, Malaker S, Masselot C, Maares M. Screening of the transcriptome, mucinome, and O‐/N‐glycans of the intestinal goblet cell model HT29‐MTX during zinc deficiency. Lebensmittelchemie 2026, 80: s1-113-s1-113. DOI: 10.1002/lemi.202651077.Peer-Reviewed Original ResearchImpaired glycosylation promotes rapid transition to hepatocellular carcinoma in model of diet induced steatotic liver disease
Singh A, Chaube B, Citrin K, Fowler J, Lee S, Catarino J, Knight J, Lowery S, Shree S, Mahoney K, Boutagy N, Ruz-Maldonado I, Harry K, Shanabrough M, Ross T, Malaker S, Suárez Y, Fernández-Hernando C, Grabińska K, Sessa W. Impaired glycosylation promotes rapid transition to hepatocellular carcinoma in model of diet induced steatotic liver disease. Journal Of Clinical Investigation 2026, 136: e197719. PMID: 41805633, PMCID: PMC13132402, DOI: 10.1172/jci197719.Peer-Reviewed Original ResearchCitationsAltmetricXylosyltransferase engineering to manipulate proteoglycans in mammalian cells
Li Z, Chawla H, Di Vagno L, Ní Cheallaigh A, Critcher M, Sammon D, Gonzalez-Rodriguez E, Briggs D, Chung N, Chang V, Mahoney K, Cioce A, Bineva-Todd G, Wang P, Liu Y, Murphy L, Chen Y, Narimatsu Y, Miller R, Willems L, Malaker S, Huang M, Miller G, Hohenester E, Schumann B. Xylosyltransferase engineering to manipulate proteoglycans in mammalian cells. Nature Chemical Biology 2026, 22: 612-621. PMID: 41559400, PMCID: PMC13038410, DOI: 10.1038/s41589-025-02113-w.Peer-Reviewed Original ResearchCitationsAltmetricErratum: Decoding Extracellular Protein Glycosylation in Human Health and Disease
Steigmeyer A, Lowery S, Rangel-Angarita V, Malaker S. Erratum: Decoding Extracellular Protein Glycosylation in Human Health and Disease. Annual Review Of Analytical Chemistry 2026 DOI: 10.1146/annurev-ac-18-010726-200001.Commentaries, Editorials and Letters
Academic Achievements & Community Involvement
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Honors
honor Early Career Researcher Manuscript Competition Finalist
11/17/2021Other AwardHuman Proteome OrganizationDetailsUnited Stateshonor Chemistry Biology Interface Division Horizon Prize
06/08/2021International AwardRoyal Society for ChemistryDetailsUnited Kingdomhonor Early Career Faculty Award
04/12/2021National AwardAmerican Society for Biochemistry and Molecular Biology (ASBMB)DetailsUnited Stateshonor Rising Stars in Proteomics and Metabolomics: 40 under 40
01/14/2021International AwardJournal of Proteome ResearchDetailsUnited States
News
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News
- July 17, 2026
Women’s Health Research at Yale Funds Projects on Obesity and Ovarian Aging, Diabetes, Cancers, and Autoimmunity
- October 17, 2025
Results Realized: Better Understanding the Structure of CA125
- September 08, 2023
WHRY Launches New Pilot Project Studies
- May 25, 2023Source: NBC CT
Yale Researcher Studying How to Detect Ovarian Cancer Earlier
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