Peng Zhao, PhD
Associate Research Scientist in Neurology
Research & Publications
Biography
News
Coauthors
Selected Publications
- Functionally-selective inhibition of threshold sodium currents and excitability in dorsal root ganglion neurons by cannabinolGhovanloo M, Effraim P, Tyagi S, Zhao P, Dib-Hajj S, Waxman S. Functionally-selective inhibition of threshold sodium currents and excitability in dorsal root ganglion neurons by cannabinol. Communications Biology 2024, 7: 120. PMID: 38263462, PMCID: PMC10805714, DOI: 10.1038/s42003-024-05781-x.
- Compartment-specific regulation of NaV1.7 in sensory neurons after acute exposure to TNF-αTyagi S, Higerd-Rusli G, Ghovanloo M, Dib-Hajj F, Zhao P, Liu S, Kim D, Shim J, Park K, Waxman S, Choi J, Dib-Hajj S. Compartment-specific regulation of NaV1.7 in sensory neurons after acute exposure to TNF-α. Cell Reports 2024, 43: 113685. PMID: 38261513, PMCID: PMC10947185, DOI: 10.1016/j.celrep.2024.113685.
- Sodium currents in naïve mouse dorsal root ganglion neurons: No major differences between sexesGhovanloo M, Tyagi S, Zhao P, Effraim P, Dib-Hajj S, Waxman S. Sodium currents in naïve mouse dorsal root ganglion neurons: No major differences between sexes. Channels 2023, 18: 2289256. PMID: 38055732, PMCID: PMC10761158, DOI: 10.1080/19336950.2023.2289256.
- Pain-causing stinging nettle toxins target TMEM233 to modulate NaV1.7 functionJami S, Deuis J, Klasfauseweh T, Cheng X, Kurdyukov S, Chung F, Okorokov A, Li S, Zhang J, Cristofori-Armstrong B, Israel M, Ju R, Robinson S, Zhao P, Ragnarsson L, Andersson Å, Tran P, Schendel V, McMahon K, Tran H, Chin Y, Zhu Y, Liu J, Crawford T, Purushothamvasan S, Habib A, Andersson D, Rash L, Wood J, Zhao J, Stehbens S, Mobli M, Leffler A, Jiang D, Cox J, Waxman S, Dib-Hajj S, Neely G, Durek T, Vetter I. Pain-causing stinging nettle toxins target TMEM233 to modulate NaV1.7 function. Nature Communications 2023, 14: 2442. PMID: 37117223, PMCID: PMC10147923, DOI: 10.1038/s41467-023-37963-2.
- Paclitaxel effects on axonal localization and vesicular trafficking of NaV1.8Baker C, Tyagi S, Higerd-Rusli G, Liu S, Zhao P, Dib-Hajj F, Waxman S, Dib-Hajj S. Paclitaxel effects on axonal localization and vesicular trafficking of NaV1.8. Frontiers In Molecular Neuroscience 2023, 16: 1130123. PMID: 36860665, PMCID: PMC9970094, DOI: 10.3389/fnmol.2023.1130123.
- A novel high throughput combined voltage-clamp/current-clamp analysis of single primary neuronsGhovanloo M, Tyagi S, Zhao P, Kiziltug E, Estacion M, Dib-Hajj S, Waxman S. A novel high throughput combined voltage-clamp/current-clamp analysis of single primary neurons. Biophysical Journal 2023, 122: 101a. DOI: 10.1016/j.bpj.2022.11.734.
- High-throughput combined voltage-clamp/current-clamp analysis of freshly isolated neuronsGhovanloo M, Tyagi S, Zhao P, Kiziltug E, Estacion M, Dib-Hajj S, Waxman S. High-throughput combined voltage-clamp/current-clamp analysis of freshly isolated neurons. Cell Reports Methods 2023, 3: 100385. PMID: 36814833, PMCID: PMC9939380, DOI: 10.1016/j.crmeth.2022.100385.
- Fibroblast growth factor homologous factor 2 attenuates excitability of DRG neuronsEffraim PR, Estacion M, Zhao P, Sosniak D, Waxman SG, Dib-Hajj SD. Fibroblast growth factor homologous factor 2 attenuates excitability of DRG neurons. Journal Of Neurophysiology 2022, 128: 1258-1266. PMID: 36222860, PMCID: PMC9909838, DOI: 10.1152/jn.00361.2022.
- Depolarizing NaV and Hyperpolarizing KV Channels Are Co-Trafficked in Sensory Neurons.Higerd-Rusli GP, Alsaloum M, Tyagi S, Sarveswaran N, Estacion M, Akin EJ, Dib-Hajj FB, Liu S, Sosniak D, Zhao P, Dib-Hajj SD, Waxman SG. Depolarizing NaV and hyperpolarizing KV channels are co-trafficked in sensory neurons. Journal Of Neuroscience 2022, 42: 4794-4811. PMID: 35589395, PMCID: PMC9188389, DOI: 10.1523/jneurosci.0058-22.2022.
- Inhibition of sodium conductance by cannabigerol contributes to a reduction of dorsal root ganglion neuron excitabilityGhovanloo M, Estacion M, Higerd‐Rusli G, Zhao P, Dib‐Hajj S, Waxman SG. Inhibition of sodium conductance by cannabigerol contributes to a reduction of dorsal root ganglion neuron excitability. British Journal Of Pharmacology 2022, 179: 4010-4030. PMID: 35297036, DOI: 10.1111/bph.15833.
- Cannabigerol inhibits sodium conductance to reduce neuronal dorsal root ganglion excitabilityGhovanloo M, Estacion M, Zhao P, Dib-Hajj S, Waxman S. Cannabigerol inhibits sodium conductance to reduce neuronal dorsal root ganglion excitability. Biophysical Journal 2022, 121: 93a. DOI: 10.1016/j.bpj.2021.11.2240.
- Contributions of NaV1.8 and NaV1.9 to excitability in human induced pluripotent stem-cell derived somatosensory neuronsAlsaloum M, Labau JIR, Liu S, Estacion M, Zhao P, Dib-Hajj F, Waxman SG. Contributions of NaV1.8 and NaV1.9 to excitability in human induced pluripotent stem-cell derived somatosensory neurons. Scientific Reports 2021, 11: 24283. PMID: 34930944, PMCID: PMC8688473, DOI: 10.1038/s41598-021-03608-x.
- Identification of a Novel Gain-of-Function Sodium Channel B2 Subunit Mutation in Small Fiber NeuropathyAlsaloum M, Zhao P, Gerrits M, Almomani R, Hoeijmakers J, Sopacua M, Lauria G, Faber C, Dib-Hajj S, Waxman S. Identification of a Novel Gain-of-Function Sodium Channel B2 Subunit Mutation in Small Fiber Neuropathy. Biophysical Journal 2020, 118: 578a-579a. DOI: 10.1016/j.bpj.2019.11.3141.
- Dynamic-Clamp Analysis of Wild-Type Human NaV1.7 and Erythromelalgia Mutant Channel L858HVasylyev D, Han C, Zhao P, Dib-Hajj S, Waxman S. Dynamic-Clamp Analysis of Wild-Type Human NaV1.7 and Erythromelalgia Mutant Channel L858H. 2018, 109-132. DOI: 10.7551/mitpress/10310.003.0016.
- A Gain-of-Function Mutation in Nav1.6 in a Case of Trigeminal NeuralgiaTanaka BS, Zhao P, Dib-Hajj FB, Morisset V, Tate S, Waxman SG, Dib-Hajj SD. A Gain-of-Function Mutation in Nav1.6 in a Case of Trigeminal Neuralgia. Molecular Medicine 2016, 22: 338-348. PMID: 27496104, PMCID: PMC5023517, DOI: 10.2119/molmed.2016.00131.
- Dynamic-clamp analysis of wild-type human Nav1.7 and erythromelalgia mutant channel L858HVasylyev DV, Han C, Zhao P, Dib-Hajj S, Waxman SG. Dynamic-clamp analysis of wild-type human Nav1.7 and erythromelalgia mutant channel L858H. Journal Of Neurophysiology 2014, 111: 1429-1443. PMID: 24401712, DOI: 10.1152/jn.00763.2013.
- Sodium Channels Contribute to Degeneration of Dorsal Root Ganglion Neurites Induced by Mitochondrial Dysfunction in an In Vitro Model of Axonal InjuryPersson AK, Kim I, Zhao P, Estacion M, Black JA, Waxman SG. Sodium Channels Contribute to Degeneration of Dorsal Root Ganglion Neurites Induced by Mitochondrial Dysfunction in an In Vitro Model of Axonal Injury. Journal Of Neuroscience 2013, 33: 19250-19261. PMID: 24305821, PMCID: PMC6618782, DOI: 10.1523/jneurosci.2148-13.2013.
- Small-Fiber Neuropathy Nav1.8 Mutation Shifts Activation to Hyperpolarized Potentials and Increases Excitability of Dorsal Root Ganglion NeuronsHuang J, Yang Y, Zhao P, Gerrits MM, Hoeijmakers JG, Bekelaar K, Merkies IS, Faber CG, Dib-Hajj SD, Waxman SG. Small-Fiber Neuropathy Nav1.8 Mutation Shifts Activation to Hyperpolarized Potentials and Increases Excitability of Dorsal Root Ganglion Neurons. Journal Of Neuroscience 2013, 33: 14087-14097. PMID: 23986244, PMCID: PMC6618513, DOI: 10.1523/jneurosci.2710-13.2013.
- Burn injury-induced mechanical allodynia is maintained by Rac1-regulated dendritic spine dysgenesisTan AM, Samad OA, Liu S, Bandaru S, Zhao P, Waxman SG. Burn injury-induced mechanical allodynia is maintained by Rac1-regulated dendritic spine dysgenesis. Experimental Neurology 2013, 248: 509-519. PMID: 23933578, DOI: 10.1016/j.expneurol.2013.07.017.
- Maladaptive Dendritic Spine Remodeling Contributes to Diabetic Neuropathic PainTan AM, Samad OA, Fischer TZ, Zhao P, Persson AK, Waxman SG. Maladaptive Dendritic Spine Remodeling Contributes to Diabetic Neuropathic Pain. Journal Of Neuroscience 2012, 32: 6795-6807. PMID: 22593049, PMCID: PMC6622192, DOI: 10.1523/jneurosci.1017-12.2012.
- Nav1.7-related small fiber neuropathyHan C, Hoeijmakers JG, Ahn H, Zhao P, Shah P, Lauria G, Gerrits MM, te Morsche R, Dib-Hajj SD, Drenth JP, Faber CG, Merkies IS, Waxman SG. Nav1.7-related small fiber neuropathy. Neurology 2012, 78: 1635-1643. PMID: 22539570, DOI: 10.1212/wnl.0b013e3182574f12.
- Rac1-regulated dendritic spine remodeling contributes to neuropathic pain after peripheral nerve injuryTan AM, Chang YW, Zhao P, Hains BC, Waxman SG. Rac1-regulated dendritic spine remodeling contributes to neuropathic pain after peripheral nerve injury. Experimental Neurology 2011, 232: 222-233. PMID: 21963650, DOI: 10.1016/j.expneurol.2011.08.028.
- Nav1.7 is the Predominant Sodium Channel in Rodent Olfactory Sensory NeuronsAhn HS, Black JA, Zhao P, Tyrrell L, Waxman SG, Dib-Hajj SD. Nav1.7 is the Predominant Sodium Channel in Rodent Olfactory Sensory Neurons. Molecular Pain 2011, 7: 1744-8069-7-32. PMID: 21569247, PMCID: PMC3101130, DOI: 10.1186/1744-8069-7-32.
- BDNF-Hypersecreting Human Mesenchymal Stem Cells Promote Functional Recovery, Axonal Sprouting, and Protection of Corticospinal Neurons after Spinal Cord InjurySasaki M, Radtke C, Tan AM, Zhao P, Hamada H, Houkin K, Honmou O, Kocsis JD. BDNF-Hypersecreting Human Mesenchymal Stem Cells Promote Functional Recovery, Axonal Sprouting, and Protection of Corticospinal Neurons after Spinal Cord Injury. Journal Of Neuroscience 2009, 29: 14932-14941. PMID: 19940189, PMCID: PMC2825276, DOI: 10.1523/jneurosci.2769-09.2009.
- Early microglial inhibition preemptively mitigates chronic pain development after experimental spinal cord injury.Tan AM, Zhao P, Waxman SG, Hains BC. Early microglial inhibition preemptively mitigates chronic pain development after experimental spinal cord injury. The Journal Of Rehabilitation Research And Development 2009, 46: 123-33. PMID: 19533525, DOI: 10.1682/jrrd.2008.03.0048.
- Neuropathic Pain Memory Is Maintained by Rac1-Regulated Dendritic Spine Remodeling after Spinal Cord InjuryTan AM, Stamboulian S, Chang YW, Zhao P, Hains AB, Waxman SG, Hains BC. Neuropathic Pain Memory Is Maintained by Rac1-Regulated Dendritic Spine Remodeling after Spinal Cord Injury. Journal Of Neuroscience 2008, 28: 13173-13183. PMID: 19052208, PMCID: PMC6671613, DOI: 10.1523/jneurosci.3142-08.2008.
- Anisomycin protects cortical neurons from prolonged hypoxia with differential regulation of p38 and ERKHong SS, Qian H, Zhao P, Bazzy-Asaad A, Xia Y. Anisomycin protects cortical neurons from prolonged hypoxia with differential regulation of p38 and ERK. Brain Research 2007, 1149: 76-86. PMID: 17391655, PMCID: PMC1937507, DOI: 10.1016/j.brainres.2007.02.062.
- Rapid Hypoxia Preconditioning Protects Cortical Neurons From Glutamate Toxicity Through δ-Opioid ReceptorZhang J, Qian H, Zhao P, Hong SS, Xia Y. Rapid Hypoxia Preconditioning Protects Cortical Neurons From Glutamate Toxicity Through δ-Opioid Receptor. Stroke 2006, 37: 1094-1099. PMID: 16514101, DOI: 10.1161/01.str.0000206444.29930.18.
- Down-regulation of delta-opioid receptors in Na+/H+ exchanger 1 null mutant mouse brain with epilepsyZhao P, Ma M, Qian H, Xia Y. Down-regulation of delta-opioid receptors in Na+/H+ exchanger 1 null mutant mouse brain with epilepsy. Neuroscience Research 2005, 53: 442-446. PMID: 16297477, DOI: 10.1016/j.neures.2005.09.003.
- GABA and glycine are protective to mature but toxic to immature rat cortical neurons under hypoxiaZhao P, Qian H, Xia Y. GABA and glycine are protective to mature but toxic to immature rat cortical neurons under hypoxia. European Journal Of Neuroscience 2005, 22: 289-300. PMID: 16045482, DOI: 10.1111/j.1460-9568.2005.04222.x.
- Intermittent hypoxia modulates Na+ channel expression in developing mouse brainZhao P, Xue J, Gu X, Haddad G, Xia Y. Intermittent hypoxia modulates Na+ channel expression in developing mouse brain. International Journal Of Developmental Neuroscience 2005, 23: 327-333. PMID: 15927756, DOI: 10.1016/j.ijdevneu.2004.12.011.
- Oxygen-sensitive δ-Opioid Receptor-regulated Survival and Death Signals NOVEL INSIGHTS INTO NEURONAL PRECONDITIONING AND PROTECTION*Ma M, Qian H, Ghassemi F, Zhao P, Xia Y. Oxygen-sensitive δ-Opioid Receptor-regulated Survival and Death Signals NOVEL INSIGHTS INTO NEURONAL PRECONDITIONING AND PROTECTION*. Journal Of Biological Chemistry 2005, 280: 16208-16218. PMID: 15687501, DOI: 10.1074/jbc.m408055200.
- Na+ Channel Expression and Neuronal Function in the Na+/H+ Exchanger 1 Null Mutant MouseXia Y, Zhao P, Xue J, Gu X, Sun X, Yao H, Haddad G. Na+ Channel Expression and Neuronal Function in the Na+/H+ Exchanger 1 Null Mutant Mouse. Journal Of Neurophysiology 2003, 89: 229-236. PMID: 12522174, DOI: 10.1152/jn.00488.2002.
- Neuroprotective role of δ-opioid receptors in cortical neuronsZhang J, Gibney GT, Zhao P, Xia Y. Neuroprotective role of δ-opioid receptors in cortical neurons. American Journal Of Physiology - Cell Physiology 2002, 282: c1225-c1234. PMID: 11997236, DOI: 10.1152/ajpcell.00226.2001.