Aline Herlopian, MD
Associate Professor Term; Affiliated Faculty , Yale Institute for Global Health; Medical Director, Clinical Neurophysiology/EEG lab, Neurology; Director, Clinical trials in Epilepsy , Neurology
Research & Publications
Biography
Coauthors
Selected Publications
- Epilepsy Surgery: A Practical Case-Based Approach 2024th EditionPublished by Springer International Publishing, May 2023 DOI 10.1007/978-3-031-23828-4 ISBNs 978-3-03-123827-7, 978-3-03-123828-4
- Combined neuromodulation and resection for functional cortex epilepsy: a case series.Merenzon M, Sivaraju A, Herlopian A, Gerrard J, Quraishi I, Hirsch L, Spencer D, Damisah E. Combined neuromodulation and resection for functional cortex epilepsy: a case series. Journal Of Neurosurgery 2024, 1-9. PMID: 38848588, DOI: 10.3171/2024.3.jns24122.
- Improving Clinician Performance in Classifying EEG Patterns on the Ictal-Interictal Injury Continuum Using Interpretable Machine Learning.Barnett A, Guo Z, Jing J, Ge W, Kaplan P, Kong W, Karakis I, Herlopian A, Jayagopal L, Taraschenko O, Selioutski O, Osman G, Goldenholz D, Rudin C, Westover M. Improving Clinician Performance in Classifying EEG Patterns on the Ictal-Interictal Injury Continuum Using Interpretable Machine Learning. NEJM AI 2024, 1 PMID: 38872809, PMCID: PMC11175595, DOI: 10.1056/aioa2300331.
- Semiology Consistency in Focal Epilepsy: Differences Between New-onset and Refractory Epilepsy (P3-1.007)Okafor C, Herlopian A, Gopaul M, Chen Z, Altalib H. Semiology Consistency in Focal Epilepsy: Differences Between New-onset and Refractory Epilepsy (P3-1.007). Neurology 2024, 102 DOI: 10.1212/wnl.0000000000206535.
- Non-dominant, Lesional Frontal Lobe Epilepsy Masquerading as Generalized EpilepsyHerlopian A. Non-dominant, Lesional Frontal Lobe Epilepsy Masquerading as Generalized Epilepsy. 2024, 339-359. DOI: 10.1007/978-3-031-23828-4_15.
- Dominant, Lesional Mesial Temporal Lobe EpilepsyHerlopian A. Dominant, Lesional Mesial Temporal Lobe Epilepsy. 2024, 33-45. DOI: 10.1007/978-3-031-23828-4_2.
- Non-dominant, Lesional Frontal Lobe Epilepsy in the Vicinity of Motor CortexHerlopian A. Non-dominant, Lesional Frontal Lobe Epilepsy in the Vicinity of Motor Cortex. 2024, 431-468. DOI: 10.1007/978-3-031-23828-4_19.
- Non-dominant, Non-lesional Temporal-Plus EpilepsyHerlopian A, Percy J, Mattson R. Non-dominant, Non-lesional Temporal-Plus Epilepsy. 2024, 599-631. DOI: 10.1007/978-3-031-23828-4_24.
- Dominant, Lesional Temporal Lobe EpilepsyHerlopian A. Dominant, Lesional Temporal Lobe Epilepsy. 2024, 849-888. DOI: 10.1007/978-3-031-23828-4_34.
- Epilepsy Surgery EvaluationHerlopian A. Epilepsy Surgery Evaluation. 2024, 3-28. DOI: 10.1007/978-3-031-23828-4_1.
- Non-dominant, Tumor-related Temporal Lobe EpilepsyHerlopian A. Non-dominant, Tumor-related Temporal Lobe Epilepsy. 2024, 161-174. DOI: 10.1007/978-3-031-23828-4_8.
- Rasmussen’s Encephalitis and Focal Cortical DysplasiaVadiparati A, Herlopian A. Rasmussen’s Encephalitis and Focal Cortical Dysplasia. 2024, 241-286. DOI: 10.1007/978-3-031-23828-4_12.
- Hypothalamic HamartomaHerlopian A. Hypothalamic Hamartoma. 2024, 327-338. DOI: 10.1007/978-3-031-23828-4_14.
- Non-dominant, Non-lesional Orbitofrontal-Plus EpilepsyHerlopian A. Non-dominant, Non-lesional Orbitofrontal-Plus Epilepsy. 2024, 563-598. DOI: 10.1007/978-3-031-23828-4_23.
- Multifocal Epilepsy and Non-dominant Cingulate LesionHerlopian A, Gray T, Quraishi I. Multifocal Epilepsy and Non-dominant Cingulate Lesion. 2024, 393-429. DOI: 10.1007/978-3-031-23828-4_18.
- Non-dominant, Lesional Neocortical Temporal Lobe EpilepsyHerlopian A. Non-dominant, Lesional Neocortical Temporal Lobe Epilepsy. 2024, 105-134. DOI: 10.1007/978-3-031-23828-4_6.
- Dominant, Lesional Congenital Hemispheric EpilepsyHerlopian A, Mahmud S, Mattson R. Dominant, Lesional Congenital Hemispheric Epilepsy. 2024, 699-731. DOI: 10.1007/978-3-031-23828-4_28.
- Non-dominant, Lesional Frontal Lobe Epilepsy Overlapping with Motor CortexHerlopian A. Non-dominant, Lesional Frontal Lobe Epilepsy Overlapping with Motor Cortex. 2024, 469-496. DOI: 10.1007/978-3-031-23828-4_20.
- Acquired, Lesional Lennox-Gastaut SyndromeHerlopian A. Acquired, Lesional Lennox-Gastaut Syndrome. 2024, 919-943. DOI: 10.1007/978-3-031-23828-4_37.
- Dominant, Lesional Posterior Quadrant EpilepsyHerlopian A, Tolba H, Mattson R. Dominant, Lesional Posterior Quadrant Epilepsy. 2024, 757-777. DOI: 10.1007/978-3-031-23828-4_31.
- Non-dominant, Lesional Frontal Lobe Epilepsy Involving the Prefrontal CortexHerlopian A. Non-dominant, Lesional Frontal Lobe Epilepsy Involving the Prefrontal Cortex. 2024, 189-220. DOI: 10.1007/978-3-031-23828-4_10.
- Non-dominant, Temporal Lobe Epilepsy Due to Dual PathologyHerlopian A. Non-dominant, Temporal Lobe Epilepsy Due to Dual Pathology. 2024, 175-187. DOI: 10.1007/978-3-031-23828-4_9.
- Non-dominant, Lesional Hemispheric EpilepsyHerlopian A. Non-dominant, Lesional Hemispheric Epilepsy. 2024, 653-666. DOI: 10.1007/978-3-031-23828-4_26.
- Multifocal Epilepsy Due to New-Onset Refractory Status EpilepticusHerlopian A, Gunawardane N. Multifocal Epilepsy Due to New-Onset Refractory Status Epilepticus. 2024, 497-532. DOI: 10.1007/978-3-031-23828-4_21.
- Non-lesional Bilateral Mesial Temporal Lobe EpilpesyQuraishi I, Herlopian A. Non-lesional Bilateral Mesial Temporal Lobe Epilpesy. 2024, 781-818. DOI: 10.1007/978-3-031-23828-4_32.
- Dominant, Tumor-Related Mesial Temporal Lobe EpilepsyHerlopian A. Dominant, Tumor-Related Mesial Temporal Lobe Epilepsy. 2024, 747-755. DOI: 10.1007/978-3-031-23828-4_30.
- Dominant, Lesional Post-Traumatic Temporal Lobe EpilepsyHerlopian A. Dominant, Lesional Post-Traumatic Temporal Lobe Epilepsy. 2024, 135-160. DOI: 10.1007/978-3-031-23828-4_7.
- Non-dominant, Lesional Parieto-occipital Lobe EpilepsyHerlopian A. Non-dominant, Lesional Parieto-occipital Lobe Epilepsy. 2024, 221-240. DOI: 10.1007/978-3-031-23828-4_11.
- Non-dominant, Non-lesional Insular epilepsyHerlopian A. Non-dominant, Non-lesional Insular epilepsy. 2024, 287-326. DOI: 10.1007/978-3-031-23828-4_13.
- Dominant, Non-lesional Frontal and Parietal Lobe EpilepsyHerlopian A. Dominant, Non-lesional Frontal and Parietal Lobe Epilepsy. 2024, 669-697. DOI: 10.1007/978-3-031-23828-4_27.
- Congenital, Non-lesional Lennox-Gastaut SyndromeHerlopian A. Congenital, Non-lesional Lennox-Gastaut Syndrome. 2024, 889-906. DOI: 10.1007/978-3-031-23828-4_35.
- Non-dominant, Lesional Posterior Quadrant EpilepsyHerlopian A. Non-dominant, Lesional Posterior Quadrant Epilepsy. 2024, 633-652. DOI: 10.1007/978-3-031-23828-4_25.
- Non-dominant, Lesional Temporal Lobe EpilepsyHerlopian A. Non-dominant, Lesional Temporal Lobe Epilepsy. 2024, 361-374. DOI: 10.1007/978-3-031-23828-4_16.
- Non-dominant, Non-lesional Mesial Temporal Lobe EpilepsyHerlopian A, Mattson R. Non-dominant, Non-lesional Mesial Temporal Lobe Epilepsy. 2024, 63-86. DOI: 10.1007/978-3-031-23828-4_4.
- Dominant, Lesional Pediatric-Onset Hemispheric EpilepsyKnight V, Herlopian A. Dominant, Lesional Pediatric-Onset Hemispheric Epilepsy. 2024, 533-562. DOI: 10.1007/978-3-031-23828-4_22.
- Non-dominant, Lesional Frontal and Temporal Lobe EpilepsyHerlopian A. Non-dominant, Lesional Frontal and Temporal Lobe Epilepsy. 2024, 375-391. DOI: 10.1007/978-3-031-23828-4_17.
- Dominant, Lesional Temporal Pole EpilepsyHerlopian A. Dominant, Lesional Temporal Pole Epilepsy. 2024, 87-103. DOI: 10.1007/978-3-031-23828-4_5.
- Dominant, Mesial Temporal Lobe Epilepsy Due to Hippocampal SclerosisHerlopian A. Dominant, Mesial Temporal Lobe Epilepsy Due to Hippocampal Sclerosis. 2024, 735-745. DOI: 10.1007/978-3-031-23828-4_29.
- Bilateral Lesional EpilepsyHerlopian A. Bilateral Lesional Epilepsy. 2024, 819-847. DOI: 10.1007/978-3-031-23828-4_33.
- Multifocal, Non-lesional EpilepsyHerlopian A. Multifocal, Non-lesional Epilepsy. 2024, 907-918. DOI: 10.1007/978-3-031-23828-4_36.
- Future PerspectivesHerlopian A. Future Perspectives. 2024, 947-956. DOI: 10.1007/978-3-031-23828-4_38.
- Non-dominant, Lesional Mesial Temporal Lobe EpilepsyMahmoud N, Herlopian A, Mattson R. Non-dominant, Lesional Mesial Temporal Lobe Epilepsy. 2024, 47-61. DOI: 10.1007/978-3-031-23828-4_3.
- On-demand EEG education through competition – A novel, app-based approach to learning to identify interictal epileptiform dischargesBarfuss J, Nascimento F, Duhaime E, Kapur S, Karakis I, Ng M, Herlopian A, Lam A, Maus D, Halford J, Cash S, Westover M, Jing J. On-demand EEG education through competition – A novel, app-based approach to learning to identify interictal epileptiform discharges. Clinical Neurophysiology Practice 2023, 8: 177-186. PMID: 37681118, PMCID: PMC10480673, DOI: 10.1016/j.cnp.2023.08.003.
- Ictal Thalamic Recordings in Patients with Deep Brain Stimulation Targeting Thalamic NucleiIdentify whether ictal thalamic EEG signals could be derived from ambulatory recordings in patients with pharmacoresistant epilepsy treated with deep brain stimulation (DBS) targeting either bilateral anterior thalamic nuclei (ATN) or centromedian nuclei (CMN). (P5-1.008)Saab L, Jiang J, Quraishi I, Herlopian A. Ictal Thalamic Recordings in Patients with Deep Brain Stimulation Targeting Thalamic NucleiIdentify whether ictal thalamic EEG signals could be derived from ambulatory recordings in patients with pharmacoresistant epilepsy treated with deep brain stimulation (DBS) targeting either bilateral anterior thalamic nuclei (ATN) or centromedian nuclei (CMN). (P5-1.008). Neurology 2023, 100 DOI: 10.1212/wnl.0000000000204225.
- Epileptiform Discharges in Patients with Psychogenic Non-Epileptic Attacks: A Case Series (P1-1.009)Afify M, Tolchin B, Altalib H, Hirsch L, Herlopian A. Epileptiform Discharges in Patients with Psychogenic Non-Epileptic Attacks: A Case Series (P1-1.009). Neurology 2023, 100 DOI: 10.1212/wnl.0000000000204120.
- Inter-Rater Reliability of EEG-Based Encephalopathy Grading (S30.008)Zahoor A, Banks J, Tesh R, Eckhardt C, Sun H, Greenblatt A, Herlopian A, Karakis I, Katyal R, Nayak C, Ng M, Williams J, Sheikh I, Nascimento F, Westover M. Inter-Rater Reliability of EEG-Based Encephalopathy Grading (S30.008). Neurology 2023, 100 DOI: 10.1212/wnl.0000000000202773.
- Development of Expert-Level Classification of Seizures and Rhythmic and Periodic Patterns During EEG InterpretationJing J, Ge W, Hong S, Fernandes M, Lin Z, Yang C, An S, Struck A, Herlopian A, Karakis I, Halford J, Ng M, Johnson E, Appavu B, Sarkis R, Osman G, Kaplan P, Dhakar M, Arcot Jayagopal L, Sheikh Z, Taraschenko O, Schmitt S, Haider H, Kim J, Swisher C, Gaspard N, Cervenka M, Rodriguez Ruiz A, Lee J, Tabaeizadeh M, Gilmore E, Nordstrom K, Yoo J, Holmes M, Herman S, Williams J, Pathmanathan J, Nascimento F, Fan Z, Nasiri S, Shafi M, Cash S, Hoch D, Cole A, Rosenthal E, Zafar S, Sun J, Westover M. Development of Expert-Level Classification of Seizures and Rhythmic and Periodic Patterns During EEG Interpretation. Neurology 2023, 100: e1750-e1762. PMID: 36878708, PMCID: PMC10136013, DOI: 10.1212/wnl.0000000000207127.
- Interrater Reliability of Expert Electroencephalographers Identifying Seizures and Rhythmic and Periodic Patterns in EEGsJing J, Ge W, Struck A, Fernandes M, Hong S, An S, Fatima S, Herlopian A, Karakis I, Halford J, Ng M, Johnson E, Appavu B, Sarkis R, Osman G, Kaplan P, Dhakar M, Jayagopal L, Sheikh Z, Taraschenko O, Schmitt S, Haider H, Kim J, Swisher C, Gaspard N, Cervenka M, Rodriguez Ruiz A, Lee J, Tabaeizadeh M, Gilmore E, Nordstrom K, Yoo J, Holmes M, Herman S, Williams J, Pathmanathan J, Nascimento F, Fan Z, Nasiri S, Shafi M, Cash S, Hoch D, Cole A, Rosenthal E, Zafar S, Sun J, Westover M. Interrater Reliability of Expert Electroencephalographers Identifying Seizures and Rhythmic and Periodic Patterns in EEGs. Neurology 2022, 100: e1737-e1749. PMID: 36460472, PMCID: PMC10136018, DOI: 10.1212/wnl.0000000000201670.
- Measuring expertise in identifying interictal epileptiform dischargesHarid NM, Jing J, Hogan J, Nascimento FA, Ouyang A, Zheng W, Ge W, Zafar SF, Kim JA, Alice DL, Herlopian A, Maus D, Karakis I, Ng M, Hong S, Yu Z, Kaplan PW, Cash S, Shafi M, Martz G, Halford JJ, Westover MB. Measuring expertise in identifying interictal epileptiform discharges. Epileptic Disorders 2022, 24: 496-506. PMID: 35770748, PMCID: PMC9340812, DOI: 10.1684/epd.2021.1409.
- Electroencephalographic changes in purified pharmaceutical cannabidiol therapyHerlopian A, Barnett JR, Nascimento FA, Lee H, Thiele EA. Electroencephalographic changes in purified pharmaceutical cannabidiol therapy. Epilepsy & Behavior 2022, 128: 108558. PMID: 35078115, DOI: 10.1016/j.yebeh.2022.108558.
- Deep active learning for Interictal Ictal Injury Continuum EEG patternsGe W, Jing J, An S, Herlopian A, Ng M, Struck AF, Appavu B, Johnson EL, Osman G, Haider HA, Karakis I, Kim JA, Halford JJ, Dhakar MB, Sarkis RA, Swisher CB, Schmitt S, Lee JW, Tabaeizadeh M, Rodriguez A, Gaspard N, Gilmore E, Herman ST, Kaplan PW, Pathmanathan J, Hong S, Rosenthal ES, Zafar S, Sun J, Westover M. Deep active learning for Interictal Ictal Injury Continuum EEG patterns. Journal Of Neuroscience Methods 2020, 351: 108966. PMID: 33131680, PMCID: PMC8135050, DOI: 10.1016/j.jneumeth.2020.108966.
- Comparison of Responsive Neurostimulation System Efficacy Between Different Electrographic Seizure Onset Patterns (1255)Henriquez-Rojas P, Torabi T, Farooque P, Hirsch L, Duckrow R, Herlopian A, Spencer D, Gerrard J, Quraishi I. Comparison of Responsive Neurostimulation System Efficacy Between Different Electrographic Seizure Onset Patterns (1255). Neurology 2020, 94 DOI: 10.1212/wnl.94.15_supplement.1255.
- Cannabidiol in treatment of refractory epileptic spasms: An open-label studyHerlopian A, Hess EJ, Barnett J, Geffrey AL, Pollack SF, Skirvin L, Bruno P, Sourbron J, Thiele EA. Cannabidiol in treatment of refractory epileptic spasms: An open-label study. Epilepsy & Behavior 2020, 106: 106988. PMID: 32169600, DOI: 10.1016/j.yebeh.2020.106988.
- Interrater Reliability of Experts in Identifying Interictal Epileptiform Discharges in ElectroencephalogramsJing J, Herlopian A, Karakis I, Ng M, Halford JJ, Lam A, Maus D, Chan F, Dolatshahi M, Muniz C, Chu C, Sacca V, Pathmanathan J, Ge W, Sun H, Dauwels J, Cole AJ, Hoch DB, Cash SS, Westover MB. Interrater Reliability of Experts in Identifying Interictal Epileptiform Discharges in Electroencephalograms. JAMA Neurology 2020, 77: 49-57. PMID: 31633742, PMCID: PMC6806666, DOI: 10.1001/jamaneurol.2019.3531.
- Development of Expert-Level Automated Detection of Epileptiform Discharges During Electroencephalogram InterpretationJing J, Sun H, Kim JA, Herlopian A, Karakis I, Ng M, Halford JJ, Maus D, Chan F, Dolatshahi M, Muniz C, Chu C, Sacca V, Pathmanathan J, Ge W, Dauwels J, Lam A, Cole AJ, Cash SS, Westover MB. Development of Expert-Level Automated Detection of Epileptiform Discharges During Electroencephalogram Interpretation. JAMA Neurology 2020, 77: 103-108. PMID: 31633740, PMCID: PMC6806668, DOI: 10.1001/jamaneurol.2019.3485.
- Preoperative Functional Mapping for Epilepsy SurgeryHerlopian A, Maus D. Preoperative Functional Mapping for Epilepsy Surgery. 2018 DOI: 10.1891/9781617052941.0022.
- EEG findings in CAR T-cell therapy-related encephalopathyHerlopian A, Dietrich J, Abramson JS, Cole AJ, Westover MB. EEG findings in CAR T-cell therapy-related encephalopathy. Neurology 2018, 91: 227-229. PMID: 29959264, PMCID: PMC6093761, DOI: 10.1212/wnl.0000000000005910.
- Bilateral independent periodic discharges are associated with electrographic seizures and poor outcome: a case-control study (P3.276)Osman G, Rahangdale R, Britton J, Gilmore E, Haider H, Hantus S, Herlopian A, Hocker S, Lee J, Legros B, Punia V, Rampal N, Szaflarski J, Wallace A, Westover M, Hirsch L, Gaspard N. Bilateral independent periodic discharges are associated with electrographic seizures and poor outcome: a case-control study (P3.276). Neurology 2018, 90 DOI: 10.1212/wnl.90.15_supplement.p3.276.
- Predictive Value of Electrocorticography in Patients With Mesial Temporal Lobe Epilepsy Undergoing Selective AmygdalohippocampectomyHerlopian A, Shihabuddin B. Predictive Value of Electrocorticography in Patients With Mesial Temporal Lobe Epilepsy Undergoing Selective Amygdalohippocampectomy. Journal Of Clinical Neurophysiology 2017, 34: 370-374. PMID: 28306691, DOI: 10.1097/wnp.0000000000000376.
- Extreme delta brush evolving into status epilepticus in a patient with anti-NMDA encephalitisHerlopian A, Rosenthal ES, Chu CJ, Cole AJ, Struck AF. Extreme delta brush evolving into status epilepticus in a patient with anti-NMDA encephalitis. Epilepsy & Behavior Reports 2016, 7: 69-71. PMID: 28616386, PMCID: PMC5459970, DOI: 10.1016/j.ebcr.2016.09.002.
- Chronic Severe Polyradiculoneuropathy with Ophthalmoplegia and Encephalopathy Due to Thiamine Deficiency in a Bariatric Surgery Patient (P7.088)Mehaffey C, Herlopian A, Gundogdu B. Chronic Severe Polyradiculoneuropathy with Ophthalmoplegia and Encephalopathy Due to Thiamine Deficiency in a Bariatric Surgery Patient (P7.088). Neurology 2015, 84 DOI: 10.1212/wnl.84.14_supplement.p7.088.
- The Clinical Features of Neuropathies Associated with Monoclonal Gammopathies (P7.085)Herlopian A, Al-salaimeh A, Gundogdu B, Al-Lahham T. The Clinical Features of Neuropathies Associated with Monoclonal Gammopathies (P7.085). Neurology 2015, 84 DOI: 10.1212/wnl.84.14_supplement.p7.085.
- Neurological Complications of Ipilimumab Therapy in Patients with Metastatic Melanoma (P3.136)Herlopian A, Mahmoud F, David R, Samant R, Gokden M, Hutchins L, Ong S. Neurological Complications of Ipilimumab Therapy in Patients with Metastatic Melanoma (P3.136). Neurology 2015, 84 DOI: 10.1212/wnl.84.14_supplement.p3.136.
Clinical Trials
Conditions | Study Title |
---|---|
Diseases of the Nervous System; Mental Health & Behavioral Research | Human Epilepsy Project 3: Newly Diagnosed Idiopathic Generalized Epilepsy |
Diseases of the Nervous System; Mental Health & Behavioral Research | SV2A PET Imaging in Healthy Subjects and Epilepsy Patients |