2023
Dopamine transporter and synaptic vesicle sorting defects underlie auxilin-associated Parkinson’s disease
Vidyadhara D, Somayaji M, Wade N, Yücel B, Zhao H, Shashaank N, Ribaudo J, Gupta J, Lam T, Sames D, Greene L, Sulzer D, Chandra S. Dopamine transporter and synaptic vesicle sorting defects underlie auxilin-associated Parkinson’s disease. Cell Reports 2023, 42: 112231. PMID: 36920906, PMCID: PMC10127800, DOI: 10.1016/j.celrep.2023.112231.Peer-Reviewed Original ResearchConceptsParkinson's diseaseMotor deficitsDopamine transporterPathogenesis of PDNigral dopaminergic lossProgressive motor deficitsΑ-synuclein pathologyEarly-onset Parkinson's diseaseDopamine sequestrationDopaminergic vulnerabilityDopaminergic lossKO micePresynaptic sitesKO brainNeurochemical analysisDorsal striatumKnockout miceCardinal featuresReuptake kineticsL-DOPADiseaseSynaptic autophagyFunction mutationsDeficitsMice
2019
Role of the endolysosomal system in Parkinson’s disease
Vidyadhara DJ, Lee JE, Chandra SS. Role of the endolysosomal system in Parkinson’s disease. Journal Of Neurochemistry 2019, 150: 487-506. PMID: 31287913, PMCID: PMC6707858, DOI: 10.1111/jnc.14820.Peer-Reviewed Original ResearchConceptsHealthy mitochondrial poolParkinson's diseaseRME-8Synaptic endocytosisEndolysosomal sortingEndolysosomal systemDysfunctional mitochondriaPD geneticsMitochondrial poolKey proteinsEarly pathomechanismLysosomal functionSystem genesCell deathKey pathwaysCommon risk factorsCommon neurodegenerative disorderL pathwayMutationsPD pathogenesisL-systemsImportant pathwayAutophagyDopaminergic neuronsPathway