Meet Dr. Stephanie Halene
March 17, 2022Meet Dr. Stephanie Halene
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Information
Stephanie Halene, MD, PhD, cares for patients with hematologic malignancies, and works to bridge the gap between the clinic and the basic science laboratories.
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- 00:00I'm Stephanie Helena.
- 00:01I am associate professor of
- 00:03hematology and internal medicine.
- 00:05And I'm the chief of hematology,
- 00:08and I focus on Mallard display.
- 00:10JE and acute myeloid leukemia.
- 00:12To me, the most important thing is
- 00:15to build a team that seamlessly
- 00:17transitioned from the clinic all
- 00:20the way to basic science that
- 00:22brings questions from the clinic
- 00:24to the basic science laboratories,
- 00:27and that brings innovation from the basic
- 00:30science laboratories back to the patient.
- 00:32Advancements in in medicine.
- 00:34A general in hematology have been.
- 00:36Absolutely amazing and we are in a
- 00:39phenomenal time for for innovation.
- 00:41I think a lot of it comes from our
- 00:45deeper understanding of diseases.
- 00:47We have so many technologies at our
- 00:50fingertips to understand what causes disease,
- 00:53what drives disease,
- 00:54what results in resistance is to therapies,
- 00:57and as a result we can develop novel
- 01:01therapies that we never had the
- 01:03opportunity to do that are no longer these.
- 01:07Sledge hammer chemotherapies but very
- 01:09targeted at what drives the cancer.
- 01:12One area that my laboratory is
- 01:15particularly interested in is how
- 01:17RNA modifications and we look
- 01:20at how this RNA is altered,
- 01:22for example through mutations and so
- 01:25called splicing factors or through
- 01:28abnormalities and RNA editing.
- 01:30And we have identified a couple
- 01:33of mechanisms in that area that
- 01:35we may be able to exploit in the
- 01:38therapy of hematologic diseases.