2025
Botulinum toxin treatment of lingual dystonia, oromandibular dystonia and bruxism-A review and update
Comtesse S, Tavassoli F, Jabbari B. Botulinum toxin treatment of lingual dystonia, oromandibular dystonia and bruxism-A review and update. Toxicon 2025, 266: 108503. PMID: 40714113, DOI: 10.1016/j.toxicon.2025.108503.Peer-Reviewed Original ResearchConceptsLingual dystoniaOromandibular dystoniaSide effectsBotulinum toxin treatmentLong-term side effectsBotulinum neurotoxin therapyAbsence of side effectsEfficacy of botulinum toxin therapyBotulinum toxin therapyBotulinum neurotoxin injectionsClinical trialsNeurotoxin therapyClinical reportsBlind studyNeurotoxin injectionBruxismQuality of lifeToxin therapyTherapyInvoluntary movementsPost-injectionDystoniaTrialsBotulinumScopus search enginesIncidence of Dysphagia and Comorbidities in Patients with Cervical Dystonia, Analyzed by Botulinum Neurotoxin Treatment Exposure
Barbano R, Jabbari B, Sadeghi M, Ukah A, Yue E, Ifantides K, Huang N, Swope D. Incidence of Dysphagia and Comorbidities in Patients with Cervical Dystonia, Analyzed by Botulinum Neurotoxin Treatment Exposure. Toxins 2025, 17: 148. PMID: 40137921, PMCID: PMC11945862, DOI: 10.3390/toxins17030148.Peer-Reviewed Original ResearchConceptsIncidence of dysphagiaCervical dystoniaComorbid conditionsContinuous health plan enrollmentCohort entry dateRate of dysphagiaRetrospective cohort studyPre-existing dysphagiaHealth plan enrollmentRisk factors of dysphagiaFactors of dysphagiaReal-world studyPotential adverse eventsPotential risk factorsPatient-level dataReal-world analysisAdverse eventsCD patientsCohort studyComorbid neurological conditionsLongitudinal patient-level dataCD diagnosisDysphagiaDysphagia riskPatientsAn update on botulinum toxin treatment of painful diabetic neuropathy, post-traumatic painful neuropathy/neuralgia, post-herpetic neuralgia and occipital neuralgia
Jabbari B, Tohidian A. An update on botulinum toxin treatment of painful diabetic neuropathy, post-traumatic painful neuropathy/neuralgia, post-herpetic neuralgia and occipital neuralgia. Toxicon 2025, 255: 108237. PMID: 39798899, DOI: 10.1016/j.toxicon.2025.108237.Peer-Reviewed Original ResearchConceptsPainful diabetic neuropathyPost-traumatic neuralgiaOccipital neuralgiaPostherpetic neuralgiaMode of treatmentBotulinum toxin treatmentDiabetic neuropathyTreatment of painful diabetic neuropathyPost-herpetic neuralgiaCohort of patientsPain disordersEfficacy criteriaNeuralgiaAmerican Academy of NeurologyLevel of efficacyToxin treatmentAmerican AcademyNeuropathyBotulinum therapyEfficacyPatientsTreatment
2024
Botulinum Toxin Treatment of Psoriasis—A Comprehensive Review
Ghaseminejad-Bandpey A, Etemadmoghadam S, Jabbari B. Botulinum Toxin Treatment of Psoriasis—A Comprehensive Review. Toxins 2024, 16: 449. PMID: 39453225, PMCID: PMC11510791, DOI: 10.3390/toxins16100449.Peer-Reviewed Original ResearchConceptsOpen-label studyClinical trialsAnimal studiesPlacebo-controlled studyInjection of botulinum toxinPsoriatic skin lesionsLevels of interleukinsBotulinum toxin injectionOpen-labelDouble-blindBotulinum toxin treatmentCase reportInflammatory cellsPsoriatic plaquesSkin lesionsSmall dosesToxin injectionToxin treatmentLiterature searchBotulinum toxinRelevant articlesPsoriasisInterleukinHuman dataDose
2021
Development of Objective Structured Assessment of Technical Skills in facial cosmetic procedures: Botulinum toxin neuromodulator and soft-tissue filler injection
Suozzi KC, Kibbi N, Lee KC, Worley B, Furlan KC, Kang BY, Ibrahim SA, Poon E, Alam M, Group C. Development of Objective Structured Assessment of Technical Skills in facial cosmetic procedures: Botulinum toxin neuromodulator and soft-tissue filler injection. Journal Of The American Academy Of Dermatology 2021, 86: 463-467. PMID: 34499988, DOI: 10.1016/j.jaad.2021.08.063.Peer-Reviewed Original Research
2018
Botulinum toxin treatment of pain syndromes –an evidence based review
Safarpour Y, Jabbari B. Botulinum toxin treatment of pain syndromes –an evidence based review. Toxicon 2018, 147: 120-128. PMID: 29409817, DOI: 10.1016/j.toxicon.2018.01.017.Peer-Reviewed Original ResearchConceptsLevel B evidencePain syndromeLevel of evidencePelvic painB evidenceMale pelvic pain syndromeChronic low back painTraumatic spinal cord injuryEfficacy of BoNTFemale pelvic painMale pelvic painVastus lateralis imbalanceMyofascial pain syndromePelvic pain syndromePost-herpetic neuralgiaAnterior knee painBotulinum toxin treatmentPainful knee osteoarthritisPost-operative painDifferent pain syndromesLow back painSpinal cord injuryCarpal tunnel syndromeTotal knee arthroplastyRole of BoNT
2016
Grey Matter Microstructural Integrity Alterations in Blepharospasm Are Partially Reversed by Botulinum Neurotoxin Therapy
Alexandru H, Muthuraman M, Chirumamilla V, Koirala N, Paktas B, Deuschl G, Zeuner K, Groppa S. Grey Matter Microstructural Integrity Alterations in Blepharospasm Are Partially Reversed by Botulinum Neurotoxin Therapy. PLOS ONE 2016, 11: e0168652. PMID: 27992533, PMCID: PMC5161386, DOI: 10.1371/journal.pone.0168652.Peer-Reviewed Original ResearchConceptsBenign essential blepharospasmHemifacial spasmBoNT therapyCortical thicknessBEB patientsHealthy controlsTemporal poleCommon hyperkinetic movement disordersStandard evidence-based treatmentGroup of patientsBotulinum neurotoxin therapyHyperkinetic movement disordersPrimary motor cortexDifferent pathophysiological mechanismsLower cortical thicknessEvidence-based treatmentsFacial musclesPre-supplementary motor areaRight superior frontal regionsGroup of ageLeft lingual gyrusSuperior frontal regionsGray matter integrityContrary patientsNeurotoxin therapyBotulinum Toxin Treatment in Neurology
Jabbari B. Botulinum Toxin Treatment in Neurology. Seminars In Neurology 2016, 36: 003-004. PMID: 26866489, DOI: 10.1055/s-0036-1571849.Peer-Reviewed Original ResearchBotulinum Toxin Treatment of Neuropathic Pain
Mittal SO, Safarpour D, Jabbari B. Botulinum Toxin Treatment of Neuropathic Pain. Seminars In Neurology 2016, 36: 073-083. PMID: 26866499, DOI: 10.1055/s-0036-1571953.Peer-Reviewed Original ResearchConceptsNeuropathic painBoNT treatmentComplex regional pain syndromeBotulinum toxin treatmentPainful diabetic neuropathyRegional pain syndromeCarpal tunnel syndromePhantom limb painEvidence-based statementsForm of painTechnique of injectionPosttraumatic neuralgiaAnalgesic medicationPain syndromePostherpetic neuralgiaDiabetic neuropathyOccipital neuralgiaLevel of efficacyLimb painTrigeminal neuralgiaTunnel syndromeClinical trialsToxin treatmentPainNeuralgiaBotulinum Toxin Treatment of Spasticity in Adults and Children
Moeini-Naghani I, Hashemi-Zonouz T, Jabbari B. Botulinum Toxin Treatment of Spasticity in Adults and Children. Seminars In Neurology 2016, 36: 064-072. PMID: 26866498, DOI: 10.1055/s-0036-1571847.Peer-Reviewed Original ResearchConceptsCerebral palsyPlacebo-controlled clinical trialDoses of BoNTSpasticity of childrenBotulinum toxin treatmentAdult spasticityTherapeutics subcommitteeBoNT treatmentPharmacologic treatmentFrequent symptomsMultiple sclerosisSpinal traumaClinical trialsToxin treatmentSpasticityAmerican AcademyPalsyBotulinum neurotoxinTreatmentChildrenWorld literatureEfficacyAdultsSclerosisPathophysiology
2015
Treatment of Chronic Migraine with Focus on Botulinum Neurotoxins
Schaefer SM, Gottschalk CH, Jabbari B. Treatment of Chronic Migraine with Focus on Botulinum Neurotoxins. Toxins 2015, 7: 2615-2628. PMID: 26184313, PMCID: PMC4516932, DOI: 10.3390/toxins7072615.Peer-Reviewed Original ResearchConceptsChronic migraineBotulinum toxin injection therapyLarge healthcare costsBotulinum toxin therapyTreatment of migraineCommon neurological disorderToxin therapyInjection therapyPathophysiological mechanismsMigraine pathophysiologyHealthcare costsMigraineNeurological disordersAnimal dataBotulinum neurotoxinTherapyTreatmentInjection techniqueCurrent understandingMedicationsPathophysiology
2013
Sialorrhea: Anatomy, Pathophysiology and Treatment with Emphasis on the Role of Botulinum Toxins
Lakraj AA, Moghimi N, Jabbari B. Sialorrhea: Anatomy, Pathophysiology and Treatment with Emphasis on the Role of Botulinum Toxins. Toxins 2013, 5: 1010-1031. PMID: 23698357, PMCID: PMC3709276, DOI: 10.3390/toxins5051010.Peer-Reviewed Original ResearchConceptsBotulinum toxinSide effectsAdministration of BoNTLevel B evidencePlacebo-controlled studyCurrent medical managementTroublesome side effectsLevel of evidenceOral agentsCerebral palsyClinical featuresExcessive droolingMedical managementTopical agentsB evidenceBlinded studyMedical treatmentAmerican AcademyClinical notesDrug efficacyNeurodegenerative disordersClinical pointB levelsSalivary glandsType BHyperhidrosis: Anatomy, Pathophysiology and Treatment with Emphasis on the Role of Botulinum Toxins
Lakraj AA, Moghimi N, Jabbari B. Hyperhidrosis: Anatomy, Pathophysiology and Treatment with Emphasis on the Role of Botulinum Toxins. Toxins 2013, 5: 821-840. PMID: 23612753, PMCID: PMC3705293, DOI: 10.3390/toxins5040821.Peer-Reviewed Original ResearchConceptsClass II studiesII studyAxillary hyperhidrosisPalmar hyperhidrosisComparator studiesBotulinum toxinClass IEvidence level BLevel of evidenceClass III studiesOral agentsIII studyClinical featuresTopical agentsComparable efficacyLong lasting effectInjection sessionsBlinded studyAmerican AcademyDrug efficacyClass IIHyperhidrosisEfficacyWorld literatureToxin
2008
Botulinum neurotoxins in the treatment of refractory pain
Jabbari B. Botulinum neurotoxins in the treatment of refractory pain. Nature Reviews Neurology 2008, 4: 676-685. PMID: 19043424, DOI: 10.1038/ncpneuro0948.Peer-Reviewed Original ResearchEmerging treatments for Tourette’s disorder
Bloch MH. Emerging treatments for Tourette’s disorder. Current Psychiatry Reports 2008, 10: 323. PMID: 18627671, DOI: 10.1007/s11920-008-0052-z.Peer-Reviewed Original ResearchConceptsTourette's disorderRepetitive transcranial magnetic stimulationChildhood-onset neuropsychiatric disorderHabit reversal therapyDeep brain stimulationTranscranial magnetic stimulationReversal therapyVocal ticsCurrent treatmentSevere symptomsMagnetic stimulationBrain stimulationSignificant disabilityNeuropsychiatric disordersEvidence baseDisordersTreatmentStimulationTherapySymptomsMultiple motors
2007
Treatment of chronic low back pain with botulinum neurotoxins
Jabbari B. Treatment of chronic low back pain with botulinum neurotoxins. Current Pain And Headache Reports 2007, 11: 352-358. PMID: 17894925, DOI: 10.1007/s11916-007-0217-1.Peer-Reviewed Original ResearchMeSH KeywordsBotulinum ToxinsClinical Trials as TopicHumansLow Back PainMuscle, SkeletalRandomized Controlled Trials as TopicConceptsLow back painChronic low back painBack painParaspinal musclesRefractory chronic low back painRefractory low back painFlu-like reactionsSignificant pain reliefOpen-label studyPlacebo-controlled studyBotulinum toxin ALumbar erector spinaeBotulinum treatmentPain reliefTechniques of treatmentLumbar levelsToxin AErector spinaePainSide effectsTrigger pointsInjection siteTotal dosePatientsEarly response
2005
Nonsynaptic GABA signaling in postnatal subventricular zone controls proliferation of GFAP-expressing progenitors
Liu X, Wang Q, Haydar TF, Bordey A. Nonsynaptic GABA signaling in postnatal subventricular zone controls proliferation of GFAP-expressing progenitors. Nature Neuroscience 2005, 8: 1179-1187. PMID: 16116450, PMCID: PMC1380263, DOI: 10.1038/nn1522.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornBotulinum ToxinsBromodeoxyuridineCadmiumCell CountCell ProliferationChelating AgentsCyclooxygenase InhibitorsDose-Response Relationship, DrugDose-Response Relationship, RadiationDrug InteractionsEgtazic AcidElectric StimulationEnzyme InhibitorsGABA Antagonistsgamma-Aminobutyric AcidGene Expression RegulationGlial Fibrillary Acidic ProteinGreen Fluorescent ProteinsImmunohistochemistryIn Vitro TechniquesLateral VentriclesMeclofenamic AcidMembrane PotentialsMiceMice, TransgenicNeuronsNickelPatch-Clamp TechniquesPotassiumSodium Channel BlockersSpider VenomsStem CellsTetrodotoxinConceptsPostnatal subventricular zoneGFAP-expressing cellsSubventricular zoneCell cycleGABAA receptorsStem cellsNeuroblastsProgenitorsGlial fibrillary acidic proteinSVZ cellsGABAA receptor currentsGABAA receptor activationFibrillary acidic proteinReceptor activationCellsProliferationGABA releaseMouse slicesLocal cuesAcidic proteinReceptor currentsSpontaneous depolarizationsGFAPGABAReceptorsBotulinum toxin: More than meets the naked eye!
Azizi S. Botulinum toxin: More than meets the naked eye! Neuroscience Letters 2005, 381: 205-206. PMID: 15896470, DOI: 10.1016/j.neulet.2005.04.008.Peer-Reviewed Original Research
2003
Rho Kinase Inhibition Enhances Axonal Regeneration in the Injured CNS
Fournier AE, Takizawa BT, Strittmatter SM. Rho Kinase Inhibition Enhances Axonal Regeneration in the Injured CNS. Journal Of Neuroscience 2003, 23: 1416-1423. PMID: 12598630, PMCID: PMC6742251, DOI: 10.1523/jneurosci.23-04-01416.2003.Peer-Reviewed Original ResearchMeSH KeywordsADP Ribose TransferasesAmidesAnimalsAxonsBotulinum ToxinsCells, CulturedChick EmbryoEnzyme InhibitorsFemaleGanglia, SpinalIntracellular Signaling Peptides and ProteinsMotor ActivityMyelin ProteinsNerve RegenerationNeuritesNogo ProteinsPC12 CellsProtein Serine-Threonine KinasesPyridinesRatsRats, Sprague-Dawleyrho GTP-Binding Proteinsrho-Associated KinasesSpinal Cord InjuriesConceptsAxonal regenerationAdult ratsNeurite outgrowthCorticospinal tract lesionsNeurite outgrowth inhibitorChick DRG neuronsRho-kinase inhibitionCST fibersDRG neuronsCST lesionLocomotor recoveryTract lesionsSpinal cordOutgrowth inhibitorInhibits neurite outgrowthNogo-66Activity levelsMyelinKinase inhibitionLesionsActivation of RhoRatsC3 transferaseInhibition of p160ROCKInhibitors
1999
Treatment of Achalasia
Seelig M, DeVault K, Seelig S, Klingler P, Branton S, Floch N, Bammer T, Hinder R. Treatment of Achalasia. Journal Of Clinical Gastroenterology 1999, 28: 202-207. PMID: 10192604, DOI: 10.1097/00004836-199904000-00004.Peer-Reviewed Original ResearchConceptsPrimary treatment optionTreatment optionsLong-term relief of symptomsMinimally invasive surgical techniquesLong-term reliefRelief of symptomsInvasive surgical techniquesLower esophageal sphincterBotulinum toxin injectionShort-term reliefPneumatic dilationHeller myotomyLaparoscopic proceduresAntireflux procedureTherapeutic optionsMotility disordersSurgical techniqueEsophageal sphincterEffective treatmentToxin injectionAchalasiaDilatationPatientsOptionsMyotomy
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