2025
Emerging Trends in Artificial Intelligence in Neuro-Oncology
Chadha S, Sritharan D, Hager T, D’Souza R, Aneja S. Emerging Trends in Artificial Intelligence in Neuro-Oncology. Current Oncology Reports 2025, 1-12. PMID: 40504358, DOI: 10.1007/s11912-025-01688-w.Peer-Reviewed Original ResearchArtificial intelligenceNeuro-oncologyLeverage natural language processingExtract actionable insightsNatural language processingTreatment response evaluationOptimal treatment planHardware efficiencyLanguage processingComputational pathologyModel generalizabilityActionable insightsAutomated tumor segmentationTumor segmentationRisk stratificationDiagnostic accuracyMolecular classificationTreatment planningClinical reportsComputational techniquesResponse evaluationReviewThis articlePatient outcomesClinical workflowAccelerating drug discovery
2024
High-throughput assays to assess variant effects on disease
Ma K, Gauthier L, Cheung F, Huang S, Lek M. High-throughput assays to assess variant effects on disease. Disease Models & Mechanisms 2024, 17: dmm050573. PMID: 38940340, PMCID: PMC11225591, DOI: 10.1242/dmm.050573.Peer-Reviewed Original ResearchConceptsDeep mutational scanningGenetic variantsRare disease diagnosticsRare genetic variantsDisease mechanismsHigh-throughput assaySequencing effortsInvestigation of variantsMutational scanningModel cell lineVariant effectsMolecular toolsCell linesCell survival rateFunctional assaysDrug resistanceDisease diagnosticsDisease-relevant assaysVariantsClinical case reportBiological mechanismsAssayCase reportClinical reportsSurvival rateThe Role of the Pediatrician in the Promotion of Healthy, Active Living.
Muth N, Bolling C, Hannon T, Sharifi M, Armstrong S, Barlow S, Fox C, Groos J, Haemer M, Stanford F, Jack J, Bremer A, Reichard K, Thapar M, Womack S, Corkins M, Blanco C, Fuchs G, Rome E, Goday P, Hannon T, Peterson A, Bremer A, Funanich C, Lotze A, Hamner H, Perrine C, Sant’Anna A, Burrowes D, Daniels P, Curtis M, Haro T. The Role of the Pediatrician in the Promotion of Healthy, Active Living. 2024, 153 PMID: 38404207, PMCID: PMC11042797, DOI: 10.1542/peds.2023-065480.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsScreen usePhysical activity recommendationsMental health risksPublic policy levelsFederal nutritionActivity recommendationsActive livingPhysical activityNegative health effectsPromote HealthLifestyle factorsClinical reportsWellness practicesInadequate sleepAdolescent HealthPolicy levelHealth effectsHealthAdolescentsHealth risksPediatriciansChildrenDomain of influenceSocial-emotional factorsScreening
2023
Protecting Children and Adolescents From Tobacco and Nicotine.
Jenssen B, Walley S, Boykan R, Little Caldwell A, Camenga D, Groner J, Marbin J, Mih B, Rabinow L, Blake G, Smith K, Baumberger J, Gonzalez L, Agarwal R, Quigley J, Zoucha K, Walker-Harding L, Kurien C, Ba’Gah R, Jarrett R. Protecting Children and Adolescents From Tobacco and Nicotine. 2023, 151 PMID: 37066668, DOI: 10.1542/peds.2023-061806.Peer-Reviewed Original ResearchConceptsPreventable causeSecondhand exposurePrenatal exposureAAP recommendationsTobacco useTobacco smokeClinical reportsTobacco epidemicNicotine useThirdhand exposureE-cigarettesEvidence baseSubstantial tollAdolescent HealthChildrenExposureChildhoodAdolescenceHealthReportPregnancyTobaccoDiseaseNicotine
2022
Asthma exacerbations during the pandemic: Time to rethink clinical markers
Ortega H, Katz L, Chupp G. Asthma exacerbations during the pandemic: Time to rethink clinical markers. Journal Of Allergy And Clinical Immunology Global 2022, 2: 97-100. PMID: 36281240, PMCID: PMC9581642, DOI: 10.1016/j.jacig.2022.09.003.Peer-Reviewed Original ResearchPrimary end pointAsthma exacerbationsClinical studiesClinical markersEnd pointCOVID-19 pandemicClinical trial enrollmentCoronavirus disease 2019 (COVID-19) pandemicNitric oxide levelsRecent clinical reportsDisease 2019 pandemicPrior exacerbationsPlacebo armFuture exacerbationsTrial enrollmentClinical trialsOxide levelsExacerbationClinical reportsClinical practiceCOVID-19Prior yearPandemicEnrollmentBest predictorEvaluation for Bleeding Disorders in Suspected Child Abuse.
Anderst J, Carpenter SL, Abshire TC, Killough E, Mendonca E, Downs S, Wetmore C, Allen C, Dickens D, Harper J, Rogers Z, Jain J, Warwick A, Yates A, Hord J, Lipton J, Wilson H, Kirkwood S, Haney S, Asnes A, Gavril A, Girardet R, Heavilin N, Gilmartin A, Laskey A, Messner S, Mohr B, Nienow S, Rosado N, Idzerda S, Legano L, Raj A, Sirotnak A, Forkey H, Keeshin B, Matjasko J, Edward H, Chavdar M, Di Paola J, Leavey P, Graham D, Hastings C, Hijiya N, Hord J, Matthews D, Pace B, Velez M, Wechsler D, Billett A, Stork L, Hooker R. Evaluation for Bleeding Disorders in Suspected Child Abuse. 2022, 150 PMID: 36180615, DOI: 10.1542/peds.2022-059276.Peer-Reviewed Original ResearchCalcifying nested stromal-epithelial tumor of the liver with recurrence in a transplanted liver – A clinical report with literature review
Kamal M, Atwi D, Gatalica Z, Luo W. Calcifying nested stromal-epithelial tumor of the liver with recurrence in a transplanted liver – A clinical report with literature review. Human Pathology Reports 2022, 28: 300620. DOI: 10.1016/j.hpr.2022.300620.Peer-Reviewed Original ResearchStromal-epithelial tumorAggressive clinical courseSmall blue cellsTERT promoter mutationsRare liver neoplasmLiver transplantationClinical courseFemale predominanceLiver failureTransplanted liverRare tumorRecurrence 3Unknown histogenesisImmunohistochemical spectrumLiver neoplasmsDiffuse positivityClinical reportsTumorsBlue cellsYoung adultsCNSETPromoter mutationsMolecular featuresPIK3CAPathologic mutations
2021
Clinical definition of acquired resistance to immunotherapy in patients with metastatic non-small-cell lung cancer
Schoenfeld A, Antonia S, Awad M, Felip E, Gainor J, Gettinger S, Hodi F, Johnson M, Leighl N, Lovly C, Mok T, Perol M, Reck M, Solomon B, Soria J, Tan D, Peters S, Hellmann M. Clinical definition of acquired resistance to immunotherapy in patients with metastatic non-small-cell lung cancer. Annals Of Oncology 2021, 32: 1597-1607. PMID: 34487855, PMCID: PMC12013006, DOI: 10.1016/j.annonc.2021.08.2151.Peer-Reviewed Original ResearchConceptsCell lung cancerClinical definitionAcquired ResistanceLung cancerClinical trialsCell death protein 1/Death protein 1/Consistent clinical definitionPersistent antitumor immunityProspective clinical trialsInvestigational immunotherapiesAntitumor immunityObjective responseProgressive diseaseAntibody treatmentNSCLC biologyInitial respondersTreatment strategiesClinical reportsPatientsBlockadeImmunotherapyTherapeutic discoveryCancerUniform criteria
2020
Overview on the use of IL-6 agents in the treatment of patients with cytokine release syndrome (CRS) and pneumonitis related to COVID-19 disease
Zhou Z, Price CC. Overview on the use of IL-6 agents in the treatment of patients with cytokine release syndrome (CRS) and pneumonitis related to COVID-19 disease. Expert Opinion On Investigational Drugs 2020, 29: 1407-1412. PMID: 33094669, DOI: 10.1080/13543784.2020.1840549.BooksConceptsCytokine release syndromeIL-6 inhibitorsRelease syndromeSafety profileInterleukin-6Mild safety profileRandomized clinical trialsTreatment of patientsAvailable clinical dataCOVID-19COVID-19 diseaseCOVID-19 managementNovel coronavirus pneumoniaHyperinflammatory stateClinical outcomesHealthcare burdenClinical trialsClinical dataObservational studyImmune responseLong-term effectsClinical reportsLiterature searchCoronavirus pneumoniaTocilizumabFertility Preservation for Pediatric and Adolescent Patients With Cancer: Medical and Ethical Considerations
Klipstein S, Fallat M, Savelli S, Katz A, Macauley R, Mercurio M, Moon M, Okun A, Weise K, Rogers Z, Allen C, Harper J, Lipton J, Wetmore C, Wilson H, Yates A, Rescorla F, Brandt M, Caty M, Heiss K, Holcomb G, Meyers R, Moss R. Fertility Preservation for Pediatric and Adolescent Patients With Cancer: Medical and Ethical Considerations. 2020, 145: e20193994. PMID: 32071259, DOI: 10.1542/peds.2019-3994.Peer-Reviewed Original ResearchConceptsFertility preservationAdolescent patientsTreatment of infertilityAdjuvant therapyPotential adverse consequencesHematologic malignanciesGonadal axisClinical reportsSolid tumorsCancerReproductive technologiesGonad removalMedical aspectsPatientsInfertilityAdverse consequencesTreatmentGerm cellsEthical considerationsDamageChemotherapySurgeryMalignancyRadiotherapySubfertility
2019
Potential for early antiretroviral therapy to reduce central nervous system HIV-1 persistence.
Spudich S, Peterson J, Fuchs D, Price RW, Gisslen M. Potential for early antiretroviral therapy to reduce central nervous system HIV-1 persistence. AIDS 2019, 33 Suppl 2: s135-s144. PMID: 31789814, DOI: 10.1097/qad.0000000000002326.Peer-Reviewed Original ResearchConceptsHIV-1 infectionCentral nervous systemEarly antiretroviral therapyAntiretroviral therapyHIV-1 persistenceEarly treatmentInitiation of ARTCentral nervous inflammationEarly-treatment cohortHIV-1 exposureHIV-1 reservoirCourse of infectionClinical neurological diseaseCNS infectionHIV reservoirTreatment cohortsImmune activationCNS compartmentViral controlHIV-1Cerebrospinal fluidClinical reportsNervous systemEarly infectionNeurological diseases
2018
The Role of Integrated Care in a Medical Home for Patients With a Fetal Alcohol Spectrum Disorder
Turchi R, Smith V, Ryan S, Camenga D, Patrick S, Plumb J, Quigley J, Walker-Harding L, Kuo D, Apkon S, Brei T, Davidson L, Davis B, Ellerbeck K, Hyman S, Leppert M, Noritz G, Stille C, Yin L. The Role of Integrated Care in a Medical Home for Patients With a Fetal Alcohol Spectrum Disorder. 2018, 142: e20182333. PMID: 30201625, DOI: 10.1542/peds.2018-2333.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsFetal alcohol spectrum disordersPrenatal alcohol exposureAlcohol spectrum disordersAlcohol exposureClinical reportsPrevious clinical reportsPreventable birth defectsMedical homeSpectrum disorderDiagnostic criteriaClinical practicePediatricians' awarenessAmerican AcademyIntegrated careBirth defectsDevelopmental disabilitiesDisordersChildrenExposureReportPatientsPediatriciansManagementPediatricsDiagnosis
2017
Sexual and Reproductive Health Care Services in the Pediatric Setting
Marcell A, Burstein G, Braverman P, Adelman W, Alderman E, Breuner C, Hornberger L, Levine D. Sexual and Reproductive Health Care Services in the Pediatric Setting. 2017, 140: e20172858. PMID: 29061870, DOI: 10.1542/peds.2017-2858.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsUnintended pregnancyHealth care servicesYoung adultsCare servicesReproductive health care servicesPreventable health outcomesSerious permanent sequelaeHealth careReproductive health careReproductive health needsHealth service deliveryReproductive health informationPermanent sequelaePediatric settingProfessional medical organizationsClinical reportsHealth outcomesHIVPregnancyAmerican AcademyHealth needsHealth informationCareAdultsPediatriciansAnimal Models of Traumatic Brain Injury
Kaur T, Jamwal S, Bansal P. Animal Models of Traumatic Brain Injury. 2017, 89-103. DOI: 10.1007/978-981-10-5981-0_7.Peer-Reviewed Original ResearchTraumatic brain injuryHead injuryBrain injuryPrimary head injurySecondary head injuryBrain contusionNeuronal damageBrain lacerationSecondary injuryPhysical functioningClinical reportsAnimal modelsCell lossInjurySharp objectsMolecular changesDistant tissuesBrainViolent blowConsciousness of personsContusionHospitalizationLacerationPeriod of hoursDamageCan Discrepancies Between Coronary Computed Tomography Angiography and Cardiac Catheterization in High-Risk Patients be Overcome With Consensus Reading?
Steinberger S, Plodkowski A, Latson L, Levsky J, Zalta B, Godelman A, Cohen H, Haramati L. Can Discrepancies Between Coronary Computed Tomography Angiography and Cardiac Catheterization in High-Risk Patients be Overcome With Consensus Reading? Journal Of Computer Assisted Tomography 2017, 41: 159-164. PMID: 27560020, DOI: 10.1097/rct.0000000000000481.Peer-Reviewed Original ResearchConceptsCoronary CTA interpretationCTA interpretationSevere stenosisCoronary CTATomography angiographyHigh-risk patientsQuarter of patientsInner-city populationCatheterization resultsCardiac catheterizationCatheterizationClinical reportsClinical practiceStenosisPatientsDiagnostic profileAngiographyPanel interpretationCTAReview panelCauses of discrepanciesCoronariesIncidence
2016
Menstrual Management for Adolescents With Disabilities
Quint E, O’Brien R, Braverman P, Adelman W, Alderman E, Breuner C, Levine D, Marcell A, O’Brien R. Menstrual Management for Adolescents With Disabilities. 2016, 138: e20160295. PMID: 27325636, DOI: 10.1542/peds.2016-0295.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsMenstrual cyclePrimary health care providersOnset of mensesSubsequent menstrual cycleUse of medicationsHealth care providersMenstrual managementIrregular bleedingCare providersPremenstrual symptomsClinical reportsPhysical disabilityAdolescent femalesPubertal transitionAbnormal cyclesIntellectual disabilityDisabilityPediatriciansAdolescentsAdditional concernsCycle regulationAmenorrheaBleedingDysmenorrheaMedicationsDevelopment and Feasibility Testing of a Critical Care EEG Monitoring Database for Standardized Clinical Reporting and Multicenter Collaborative Research
Lee JW, LaRoche S, Choi H, Ruiz A, Fertig E, Politsky JM, Herman ST, Loddenkemper T, Sansevere AJ, Korb PJ, Abend NS, Goldstein JL, Sinha SR, Dombrowski KE, Ritzl EK, Westover MB, Gavvala JR, Gerard EE, Schmitt SE, Szaflarski JP, Ding K, Haas KF, Buchsbaum R, Hirsch LJ, Wusthoff CJ, Hopp JL, Hahn CD. Development and Feasibility Testing of a Critical Care EEG Monitoring Database for Standardized Clinical Reporting and Multicenter Collaborative Research. Journal Of Clinical Neurophysiology 2016, 33: 133-140. PMID: 26943901, PMCID: PMC4878836, DOI: 10.1097/wnp.0000000000000230.Peer-Reviewed Original ResearchConceptsCritical Care EEG Monitoring Research ConsortiumAmerican Clinical Neurophysiology SocietyIncidence of seizuresMulticenter feasibility studyIntensive care unitLarge-volume centersInterictal epileptiform dischargesDaily clinical useMulticenter collaborative researchCare unitUnique patientsVolume centersElectroencephalogram monitoringDuration of recordingEpileptiform dischargesMulticenter research studiesRhythmic dischargesClinical reportsResearch DatabaseEEG monitoringClinical data repositoryClinical useConsortium databaseEEG reportsReporting toolsUreteral Stones: Implementation of a Reduced-Dose CT Protocol in Patients in the Emergency Department with Moderate to High Likelihood of Calculi on the Basis of STONE Score.
Moore CL, Daniels B, Singh D, Luty S, Gunabushanam G, Ghita M, Molinaro A, Gross CP. Ureteral Stones: Implementation of a Reduced-Dose CT Protocol in Patients in the Emergency Department with Moderate to High Likelihood of Calculi on the Basis of STONE Score. Radiology 2016, 280: 743-51. PMID: 26943230, PMCID: PMC5341691, DOI: 10.1148/radiol.2016151691.Peer-Reviewed Original ResearchConceptsReduced-dose CTEmergency departmentUrologic interventionUreteral stonesHigher likelihoodDose CTAverage dose-length productSingle-center studyClinical prediction ruleDose-length productComputed tomography protocolStandard-dose CTInstitutional review boardHIPAA authorizationNonurologic causesPrimary outcomeClinical courseClinician's discretionDose reductionClinical reportsPatientsSTONE scoreCT protocolInformed consentReview boardA painful neuropathy-associated Nav1.7 mutant leads to time-dependent degeneration of small-diameter axons associated with intracellular Ca2+ dysregulation and decrease in ATP levels
Rolyan H, Liu S, Hoeijmakers JG, Faber CG, Merkies IS, Lauria G, Black JA, Waxman SG. A painful neuropathy-associated Nav1.7 mutant leads to time-dependent degeneration of small-diameter axons associated with intracellular Ca2+ dysregulation and decrease in ATP levels. Molecular Pain 2016, 12: 1744806916674472. PMID: 27821467, PMCID: PMC5102167, DOI: 10.1177/1744806916674472.Peer-Reviewed Original ResearchConceptsSmall fiber neuropathySmall-diameter axonsTime-dependent degenerationDorsal root ganglion neuronsNerve fiber injuryNervous system disordersPrevious clinical reportsIntracellular calcium levelsMutant Nav1.7 channelsATP levelsAδ nerve fibersHigh altitude sicknessPainful neuropathyTime-dependent increaseFiber injuryClinical onsetGanglion neuronsOxygen species productionSystem disordersCalcium levelsClinical reportsDistal extremitiesIntracellular Ca2NeuropathyNav1.7 channels
2014
Improving Concordance of MRI and PET/CT Interpretations With Retrospectively Coregistered MRI and PET/CT Data Sets
Wang Y, Lim R, Khawaja R, Blake M. Improving Concordance of MRI and PET/CT Interpretations With Retrospectively Coregistered MRI and PET/CT Data Sets. Current Problems In Diagnostic Radiology 2014, 44: 232-236. PMID: 25745822, DOI: 10.1067/j.cpradiol.2014.11.004.Peer-Reviewed Original ResearchConceptsConcordance of MRIEvidence of metastatic diseaseMRI scansInstitutional review board approvalPelvic MRI scanImaging follow-upInstitutional electronic medical record systemReview board approvalInterpretation of MRIPET/CT interpretationMetastatic diseasePET/Computed TomographyDiscordant lesionsMRI findingsRetrospective studyMRI reportsBoard approvalPET/CTFollow-upDiscordant findingsLesion characterizationBone sitesClinical reportsSoftware fusionPairs of scans
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