2023
Two‐Year Outcomes After Pediatric In‐Office Tympanostomy Using Lidocaine/Epinephrine Iontophoresis and an Automated Tube Delivery System
Waldman E, Ingram A, Vidrine D, Gould A, Zeiders J, Ow R, Thompson C, Moss J, Mehta R, McClay J, Brenski A, Gavin J, Ansley J, Yen D, Chadha N, Murray M, Kozak F, York C, Brown D, Grunstein E, Sprecher R, Sherman D, Schoem S, Puchalski R, Hills S, Harfe D, England L, Syms C, Lustig L. Two‐Year Outcomes After Pediatric In‐Office Tympanostomy Using Lidocaine/Epinephrine Iontophoresis and an Automated Tube Delivery System. Otolaryngology 2023, 169: 692-700. PMID: 37003297, DOI: 10.1002/ohn.336.Peer-Reviewed Original ResearchConceptsEpinephrine iontophoresisTube placementTube retentionOperating roomChildren ages 6 monthsCohort of patientsTwo-Year OutcomesAge 6 monthsDelivery systemComplication rateGeneral anesthesiaLocal anesthesiaOtolaryngology practiceTympanostomyPatientsMonthsIontophoresisTympanic membraneAnesthesiaTube displacementAdditional leadsCohortDelivery resultsOutcomesEar
2020
In‐Office Tympanostomy Tube Placement in Children Using Iontophoresis and Automated Tube Delivery
Lustig LR, Ingram A, Vidrine DM, Gould AR, Zeiders JW, Ow RA, Thompson CR, Moss JR, Mehta R, McClay JE, Brenski A, Gavin J, Waldman EH, Ansley J, Yen DM, Chadha NK, Murray MT, Kozak FK, York C, Brown DM, Grunstein E, Sprecher RC, Sherman DA, Schoem SR, Puchalski R, Hills S, Calzada A, Harfe D, England LJ, Syms CA. In‐Office Tympanostomy Tube Placement in Children Using Iontophoresis and Automated Tube Delivery. The Laryngoscope 2020, 130: s1-s9. PMID: 32160320, PMCID: PMC7187287, DOI: 10.1002/lary.28612.Peer-Reviewed Original ResearchConceptsTympanostomy tube placementTube placementPivotal cohortAdverse eventsTechnical successChildren 5Mean FPS-R scoresIndividual cohort studiesSerious adverse eventsNonserious adverse eventsProspective multicenter studyYears of ageLead-InChildren ages 6Lidocaine iontophoresisMinutes postprocedureCohort studyPatients 5Epinephrine iontophoresisMulticenter studyLocal anesthesiaMean agePapoose boardTube deliveryAge groups
2013
Nicotinic α7 receptors enhance NMDA cognitive circuits in dorsolateral prefrontal cortex
Yang Y, Paspalas CD, Jin LE, Picciotto MR, Arnsten AF, Wang M. Nicotinic α7 receptors enhance NMDA cognitive circuits in dorsolateral prefrontal cortex. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 12078-12083. PMID: 23818597, PMCID: PMC3718126, DOI: 10.1073/pnas.1307849110.Peer-Reviewed Original ResearchMeSH KeywordsAcetylcholineAconitinealpha7 Nicotinic Acetylcholine ReceptorAnalysis of VarianceAnimalsBridged Bicyclo Compounds, HeterocyclicCholinergic AgonistsCholinergic AntagonistsCognitionFemaleIontophoresisMacaca mulattaMaleMecamylamineMicroscopy, ImmunoelectronN-MethylaspartatePhenolsPiperidinesPrefrontal CortexQuinuclidinesReceptors, NicotinicSpatial BehaviorSynapsesVisual PerceptionConceptsDorsolateral prefrontal cortexΑ7 nAChRsPrefrontal cortexΑ7 nicotinic acetylcholine receptorGlutamatergic NMDA receptorsCognitive circuitsNicotinic α7 receptorsPrimary visual cortexNMDA receptor actionGenetic insultsNicotinic acetylcholine receptorsDlPFC circuitsPrimate dlPFCACh depletionNMDA actionNMDA receptorsPyramidal cellsΑ7 receptorsNeuronal firingNAChR blockadeAcetylcholine receptorsVisual cortexPersistent firingCognitive functionLow-dose stimulationHyperhidrosis: Anatomy, Pathophysiology and Treatment with Emphasis on the Role of Botulinum Toxins
Lakraj AA, Moghimi N, Jabbari B. Hyperhidrosis: Anatomy, Pathophysiology and Treatment with Emphasis on the Role of Botulinum Toxins. Toxins 2013, 5: 821-840. PMID: 23612753, PMCID: PMC3705293, DOI: 10.3390/toxins5040821.Peer-Reviewed Original ResearchConceptsClass II studiesII studyAxillary hyperhidrosisPalmar hyperhidrosisComparator studiesBotulinum toxinClass IEvidence level BLevel of evidenceClass III studiesOral agentsIII studyClinical featuresTopical agentsComparable efficacyLong lasting effectInjection sessionsBlinded studyAmerican AcademyDrug efficacyClass IIHyperhidrosisEfficacyWorld literatureToxin
2012
Local inhibition modulates learning-dependent song encoding in the songbird auditory cortex
Thompson JV, Jeanne JM, Gentner TQ. Local inhibition modulates learning-dependent song encoding in the songbird auditory cortex. Journal Of Neurophysiology 2012, 109: 721-733. PMID: 23155175, PMCID: PMC3567384, DOI: 10.1152/jn.00262.2012.Peer-Reviewed Original ResearchConceptsLocal inhibitionInhibitory modulationAuditory cortexMammalian secondary auditory cortexMasking of responsesSecondary auditory cortexResponses of neuronsLearning-related plasticityIontophoretic applicationRole of inhibitionCaudomedial nidopalliumAuditory forebrainInhibitionCortexSpectrotemporal tuningResponse patternsNeural representationResponseGabazineCentral roleForebrainNeurons
2007
Inverted-U dopamine D1 receptor actions on prefrontal neurons engaged in working memory
Vijayraghavan S, Wang M, Birnbaum SG, Williams GV, Arnsten AF. Inverted-U dopamine D1 receptor actions on prefrontal neurons engaged in working memory. Nature Neuroscience 2007, 10: 376-384. PMID: 17277774, DOI: 10.1038/nn1846.Peer-Reviewed Original ResearchAction PotentialsAnalysis of VarianceAnimalsBehavior, AnimalCyclic AMPDopamine AgentsDose-Response Relationship, DrugDrug InteractionsIontophoresisMacaca mulattaMaleMaze LearningMemory, Short-TermNeuronsNeuropsychological TestsPrefrontal CortexRatsRats, Sprague-DawleyReceptors, Dopamine D1Sensitivity and SpecificityThionucleotides
2006
Topical non-iontophoretic application of acetylcholine and nitroglycerin via a translucent patch: a new means for assessing microvascular reactivity.
Schonberger RB, Worden WS, Shahmohammadi K, Menn K, Silverman TJ, Stout RG, Shelley KH, Silverman DG. Topical non-iontophoretic application of acetylcholine and nitroglycerin via a translucent patch: a new means for assessing microvascular reactivity. The Yale Journal Of Biology And Medicine 2006, 79: 1-7. PMID: 17876370, PMCID: PMC1942174.Peer-Reviewed Original ResearchConceptsTransdermal deliveryLocal vasodilatory responseLaser Doppler flowmetry probeEndothelial cell functionTopical nitroglycerinMicrovascular reactivityVasodilatory responseLocal vasodilationMicrocirculatory changesVascular diseaseHealthy volunteersPlacebo sitesLDF monitoringLDF probeTranslucent patchesTherapeutic interventionsAcetylcholineNitroglycerinLDF readingsCell functionDrug applicationIontophoretic deliveryDrug preparationSuch dilationAcetylcholine chloride
2000
EEG Correlation of the Discharge Properties of Identified Neurons in the Basal Forebrain
Duque A, Balatoni B, Detari L, Zaborszky L. EEG Correlation of the Discharge Properties of Identified Neurons in the Basal Forebrain. Journal Of Neurophysiology 2000, 84: 1627-1635. PMID: 10980032, DOI: 10.1152/jn.2000.84.3.1627.Peer-Reviewed Original ResearchConceptsLow-voltage fast activityBasal forebrainCortical slow wavesDistinct temporal relationshipsDifferent EEG patternsBF neuronsCortical circuitryCerebral hemispheresFast activityIdentified neuronsVentral aspectPeptidergic cellsCortical releaseFiring rateNeuron firingEEG patternsNeurons increasesNeuronsNeurotransmitter acetylcholineSlow wavesEEG correlationForebrainTemporal relationshipCell typesSpecific role
1999
Waglerin-1 Selectively Blocks the Epsilon Form of the Muscle Nicotinic Acetylcholine Receptor 1
McArdle J, Lentz T, Witzemann V, Schwarz H, Weinstein S, Schmidt J. Waglerin-1 Selectively Blocks the Epsilon Form of the Muscle Nicotinic Acetylcholine Receptor 1. Journal Of Pharmacology And Experimental Therapeutics 1999, 289: 543-550. PMID: 10087048, DOI: 10.1016/s0022-3565(24)38167-4.Peer-Reviewed Original ResearchConceptsWild-type miceEnd-plate potentialsAdult wild-type miceNicotinic acetylcholine receptorsWaglerin-1Miniature end-plate potentialsKO miceMuscle nicotinic acetylcholine receptorACh responseAcetylcholine receptorsEnd-plate responsesHeterozygous KO miceHomozygous KO miceNeonatal wild-type miceSpontaneous miniature end-plate potentialsMouse muscle nicotinic acetylcholine receptorHeterozygous litter matesAdult knockout miceLethal effectsNeonatal miceSuppressant effectKnockout miceLitter matesMiceAcetylcholineRole of the medial prefrontal cortex in 5‐HT1A receptor‐induced inhibition of 5‐HT neuronal activity in the rat
Hajós M, Hajós‐Korcsok É, Sharp T. Role of the medial prefrontal cortex in 5‐HT1A receptor‐induced inhibition of 5‐HT neuronal activity in the rat. British Journal Of Pharmacology 1999, 126: 1741-1750. PMID: 10372816, PMCID: PMC1565963, DOI: 10.1038/sj.bjp.0702510.Peer-Reviewed Original ResearchMeSH Keywords8-Hydroxy-2-(di-n-propylamino)tetralinAnimalsElectrophysiologyImmunohistochemistryIontophoresisMaleMicroinjectionsNeuronsOncogene Proteins v-fosParoxetinePiperazinesPrefrontal CortexPutamenPyridinesRaphe NucleiRatsRats, Sprague-DawleyReceptors, SerotoninReceptors, Serotonin, 5-HT1Selective Serotonin Reuptake InhibitorsSerotoninSerotonin AntagonistsSerotonin Receptor AgonistsConceptsDorsal raphe nucleusReceptor-induced inhibitionCortical transectionWAY-100635Receptor agonistSystemic administrationFos expressionFrontal cortexMPFC neuronesPrefrontal cortexInhibitory effectSingle-unit recordingsMedial prefrontal cortexReuptake inhibitorsFos immunocytochemistryRaphe nucleusAnaesthetized ratsIontophoretic applicationReceptor antagonistNeuronal excitationDPATNeuronal activityHigh dosesFiring activityParietal cortex
1998
Electrophysiological and neurochemical evidence that pindolol has agonist properties at the 5‐HT1A autoreceptor in vivo
Clifford E, Gartside S, Umbers V, Cowen P, Hajós M, Sharp T. Electrophysiological and neurochemical evidence that pindolol has agonist properties at the 5‐HT1A autoreceptor in vivo. British Journal Of Pharmacology 1998, 124: 206-212. PMID: 9630361, PMCID: PMC1565357, DOI: 10.1038/sj.bjp.0701796.Peer-Reviewed Original ResearchConceptsDorsal raphe nucleusWAY-100635Clinical trialsAutoreceptor antagonistNeuronal activityAnaesthetized rat. 2Actions of pindololEffect of pindololOngoing clinical trialsEarly clinical trialsRat. 2Majority of neuronesNeurochemical evidenceRaphe nucleusReceptor antagonistFrontal cortexAgonist propertiesMicrodialysis experimentsTherapeutic efficacyPindololAutoreceptorsAntagonistElectrical activityNeuronesTrials
1997
Localized delivery of heparin to angioplasty sites with iontophoresis
Mitchel J, Azrin M, Fram D, Bow L, McKay R. Localized delivery of heparin to angioplasty sites with iontophoresis. Catheterization And Cardiovascular Interventions 1997, 41: 315-323. PMID: 9213031, DOI: 10.1002/(sici)1097-0304(199707)41:3<315::aid-ccd13>3.0.co;2-m.Peer-Reviewed Original ResearchMeSH KeywordsAngioplasty, BalloonAngioplasty, Balloon, CoronaryAnimalsAnticoagulantsAortaCoronary VesselsDose-Response Relationship, DrugDrug Delivery SystemsElastic TissueEquipment DesignHeparinIontophoresisMaleMuscle, Smooth, VascularPlatelet AggregationRatsRats, Sprague-DawleySwineTunica IntimaTunica MediaConceptsPorcine coronary arteriesBalloon injuryPlatelet depositionDrug depositionCoronary arteryIontophoretic catheterHeparin deliveryControl vesselsLocal deliveryContralateral control vesselsIontophoresis of salineEarly platelet depositionFluorescent heparinBalloon inflation pressureInternal elastic laminaIntramural localizationAngioplasty siteBalloon angioplastyCoronary studiesHemodynamic sequelaeIliac vesselsIntramural depositionImmediate drug deliveryPlatelet studiesArtery
1991
Neurotensin modulates autoreceptor mediated dopamine effects on midbrain dopamine cell activity
Shi W, Bunney B. Neurotensin modulates autoreceptor mediated dopamine effects on midbrain dopamine cell activity. Brain Research 1991, 543: 315-321. PMID: 1676331, DOI: 10.1016/0006-8993(91)90043-u.Peer-Reviewed Original ResearchConceptsDA cellsCell activityFiring rateDA cell activityInteraction of neurotensinGlutamate-induced excitationEffects of neurotensinMidbrain dopamine cell activityDopamine cell activityMidbrain dopamine neuronsSpecific D2 agonistMicroiontophoretic techniquesD2 agonistDopamine neuronsD2 receptorsDopamine effectsSpontaneous activityNeurotensinNT effectsLocal ejectionInhibitionSignificant changesCellsCell levelSame cells
1990
A simple and effective method for preventing the formation of salt bridges between barrels of a multibarrel microiontophoresis electrode
Shi W, Bunney B. A simple and effective method for preventing the formation of salt bridges between barrels of a multibarrel microiontophoresis electrode. Journal Of Neuroscience Methods 1990, 35: 89-91. PMID: 2277537, DOI: 10.1016/0165-0270(90)90098-z.Peer-Reviewed Original Research
1989
Pharmacological characterization of the receptor mediating electrophysiological responses to dopamine in the rat medial prefrontal cortex: a microiontophoretic study.
Sesack S, Bunney B. Pharmacological characterization of the receptor mediating electrophysiological responses to dopamine in the rat medial prefrontal cortex: a microiontophoretic study. Journal Of Pharmacology And Experimental Therapeutics 1989, 248: 1323-1333. PMID: 2564893, DOI: 10.1016/s0022-3565(25)24159-3.Peer-Reviewed Original ResearchConceptsRat medial prefrontal cortexMedial prefrontal cortexGamma-aminobutyric acidD2-selective agonistsSelective agonistPrefrontal cortexPFC neuronsInhibitory effectSelective antagonistExtracellular single-unit recordingsD1-selective agonistsSingle-unit recordingsD1-selective antagonistD2-selective antagonistWeak antagonist activityMicroiontophoretic studyMicroiontophoretic techniquesSuperficial laminaeIontophoretic applicationLY171555Pharmacological characterizationInhibitory responsesMajority of cellsPharmacological characteristicsPharmacological profile
1985
An electrophysiological analysis of the actions of the 3-PPP enantiomers on the nigrostriatal dopamine system
Clark D, Engberg G, Pileblad E, Svensson T, Carlsson A, Freeman A, Bunney B. An electrophysiological analysis of the actions of the 3-PPP enantiomers on the nigrostriatal dopamine system. Naunyn-Schmiedeberg's Archives Of Pharmacology 1985, 329: 344-354. PMID: 4033804, DOI: 10.1007/bf00496366.Peer-Reviewed Original ResearchConceptsPostsynaptic DA receptorsInhibitory actionDA autoreceptorsDA receptorsNeuronal activityDA cell firing rateExtracellular single-unit recordingsCaudate neuronal activityDA neuronal activityGallamine-paralyzed ratsNigrostriatal DA systemNigrostriatal dopamine systemSingle-unit recordingsCell firing rateReticulata neuronsDA agonistsDA cellsIntravenous administrationMajority of cellsDopamine systemN-propylpiperidineUnit recordingsPartial agonistCell activityFiring rateThe effects of cytoplasmic acidification upon electrical coupling in the organ of Corti
Santos-Sacchi J. The effects of cytoplasmic acidification upon electrical coupling in the organ of Corti. Hearing Research 1985, 19: 207-215. PMID: 3934121, DOI: 10.1016/0378-5955(85)90140-6.Peer-Reviewed Original Research
1984
The control of firing pattern in nigral dopamine neurons: single spike firing
Grace A, Bunney B. The control of firing pattern in nigral dopamine neurons: single spike firing. Journal Of Neuroscience 1984, 4: 2866-2876. PMID: 6150070, PMCID: PMC6564731, DOI: 10.1523/jneurosci.04-11-02866.1984.Peer-Reviewed Original ResearchConceptsSingle-spike firingDA cellsSlow depolarizationCalcium chelator EGTADopamine neuronsSpike firingCalcium-activated potassium conductanceActive DA cellsNigral dopamine neuronsChelator EGTAVivo intracellular recordingsDA neuronsDepolarization inactivationMembrane potentialIontophoretic applicationTrain of spikesIntracellular recordingsExcitatory substancesIntracellular injectionCalcium entryAction potentialsAfterhyperpolarizationPotassium conductanceRate of riseNeuronsThe control of firing pattern in nigral dopamine neurons: burst firing
Grace A, Bunney B. The control of firing pattern in nigral dopamine neurons: burst firing. Journal Of Neuroscience 1984, 4: 2877-2890. PMID: 6150071, PMCID: PMC6564720, DOI: 10.1523/jneurosci.04-11-02877.1984.Peer-Reviewed Original ResearchConceptsDA cellsIntracellular injectionBase-line firing rateFiring ratePotassium conductanceIntracellular calcium injectionNigral dopamine neuronsStriatal DA releaseVivo intracellular recordingsBurst-firing modeDegree of burstDA releaseDopamine neuronsExtracellular iontophoresisBurst firingIntracellular recordingsCalcium injectionDopamine cellsCalcium influxCalcium involvementBursting patternInjectionCellsConsecutive spikesBlockadeThe effects of phencyclidine and N-allylnormetazocine on midbrain dopamine neuronal activity
Freeman A, Bunney B. The effects of phencyclidine and N-allylnormetazocine on midbrain dopamine neuronal activity. European Journal Of Pharmacology 1984, 104: 287-293. PMID: 6094217, DOI: 10.1016/0014-2999(84)90404-7.Peer-Reviewed Original ResearchConceptsDA neuronsNeuronal activityN-allylnormetazocineMidbrain dopamine neuronal activitySingle-unit recording techniquesSubstantia nigra zona compactaFiring rateA10 DA neuronsDopamine neuronal activitySigma receptor agonistsMidbrain dopamine neuronsBaseline firing rateEffects of phencyclidineWeak inhibitory actionExcitatory effectsZona compactaHaloperidol pretreatmentDopamine neuronsReceptor agonistBiphasic effectInhibitory actionNeuronsRecording techniquesPhencyclidineDrugs
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