2025
10 Dysmenorrhea and endometriosis in the adolescent female
Davis-Kankanamge C, Vash-Margita A. 10 Dysmenorrhea and endometriosis in the adolescent female. 2025, 86-98. DOI: 10.1016/b978-0-443-10512-8.00019-9.Peer-Reviewed Original ResearchPelvic painCause of secondary dysmenorrheaTreatment of pelvic painGonadotropin-releasing hormone agonistQuality of lifeCombination of estrogenDevelopment of treatment modalitiesDiagnosis of endometriosisDevelopment of noninvasive biomarkersTreatment of endometriosisNonsteroidal antiinflammatory drugsImpaired quality of lifeRetrograde blood flowMedical treatment regimensNeuropathic medicationsOvarian pathologySecondary dysmenorrheaHistological diagnosisHormone agonistSurgical treatmentImprove quality of lifeTreatment modalitiesTreatment regimensAdolescent patientsAntiinflammatory drugs
2024
Patient Views and Values Placed on the Uterus
Chang O, Huynh A, Ringel N, Hudson P, Halder G, Winkleman W, Ton J, Davidson E, Meriwether K. Patient Views and Values Placed on the Uterus. O&G Open 2024, 1: 048. DOI: 10.1097/og9.0000000000000048.Peer-Reviewed Original ResearchGynecologic conditionsHysterectomy proceduresBenign gynecologic conditionsPelvic organ prolapseProspective cohort studyTreatment of gynecological disordersUterine preservationPelvic painOrgan prolapseMedian agePatient ageUrinary incontinenceChart reviewGynecological disordersCohort studyUterusPatient questionnaireWhite racePatientsMedical CenterHysterectomyPerson-centered careMulticenterGrounded theory approachPhysiological roleImpact of Treatment of Pudendal Neuralgia on Pain: A Systematic Review and Meta-Analysis
Andiman S, Maron J, Dandolu V, Drugge E, Cosgro R, Vasey M, Spaulding G, Ricciardi F, Yaskhi G, Toal C, Shatkin J, Loike-Weinstein D, Mahmood S, Glass M, Phillips D, Sciarrino M, Sacks A, Baruch D, Cohen M, Huang A, Pollack B, Grimes C. Impact of Treatment of Pudendal Neuralgia on Pain: A Systematic Review and Meta-Analysis. International Urogynecology Journal 2024, 36: 35-58. PMID: 39607531, DOI: 10.1007/s00192-024-06004-x.Peer-Reviewed Original ResearchPulsed radiofrequency treatmentPudendal neuralgiaPost-intervention pain scoresSystematic reviewPain measurement instrumentsPreferred Reporting ItemsRadiofrequency treatmentAdverse eventsPoor-quality studiesTreatment of pudendal neuralgiaMethodsFollowing Preferred Reporting ItemsShort-term follow-upTreatment approachesChronic pelvic painReporting ItemsAssess qualityHeterogeneous patient populationMeta-analysesEligibility criteriaConfidence intervalsStatistically significant differenceNon-standard treatmentMeta-analysisPelvic painPain scoresIs There an Association Between Endometriosis, Early Menopause, and Cardiovascular Disease?
Younis J, Taylor H. Is There an Association Between Endometriosis, Early Menopause, and Cardiovascular Disease? The Journal Of Clinical Endocrinology & Metabolism 2024, 109: e1946-e1949. PMID: 39083665, DOI: 10.1210/clinem/dgae508.Peer-Reviewed Original ResearchEarly menopauseEndometriotic cystectomyNatural menopauseCardiovascular riskCardiovascular diseaseEndometriosis-associated pelvic painIncreased risk of cardiovascular diseaseLaparoscopically diagnosed endometriosisRisk of cardiovascular diseaseEarly natural menopauseLarge-scale cohort studyPelvic painOvarian reserveBilateral casesMenopause onsetMultiple surgeriesEndometriosisCohort studyHazard ratioIncreased riskMenopauseCystectomyRisk factorsEstimates of associationConfounding factorsEndometriosis in a 22-Year-Old with Premature Ovarian Insufficiency Secondary to Pre-Pubertal Bone Marrow Transplant: a Case Report
Liao C, Ramani S, Parkash V, Kodaman P. Endometriosis in a 22-Year-Old with Premature Ovarian Insufficiency Secondary to Pre-Pubertal Bone Marrow Transplant: a Case Report. Reproductive Sciences 2024, 31: 2700-2705. PMID: 38806998, DOI: 10.1007/s43032-024-01601-z.Peer-Reviewed Original ResearchPremature ovarian insufficiencyBone marrow transplantationProgressive dysmenorrheaPelvic painMarrow transplantationContraceptive pillsInherited bone marrow failure syndromeBone marrow failure syndromesSuperficial endometriotic lesionsChronic pelvic painMarrow failure syndromesOral contraceptive pillsCases of endometriosisDiamond-Blackfan anemiaReproductive age womenSpontaneous ovarian activityCyclic progestinNulligravid femaleWorsening arthralgiasTransdermal estrogenDiagnostic laparoscopyGonadotoxic chemotherapyOral estradiolHormone therapyOvarian insufficiencyMedical Management of Endometriosis in Adolescent and Young Adult Women: A Review of 91 Cases of Biopsy-Confirmed Endometriosis
Li H, Esencan E, Song Y, Taylor H, Cho Y, Vash-Margita A. Medical Management of Endometriosis in Adolescent and Young Adult Women: A Review of 91 Cases of Biopsy-Confirmed Endometriosis. Journal Of Obstetrics And Gynaecology Canada 2024, 46: 102562. PMID: 38759792, DOI: 10.1016/j.jogc.2024.102562.Peer-Reviewed Original ResearchCombined oral contraceptivesBiopsy-proven endometriosisLNG-IUDManagement of endometriosisOral progestinInitial treatmentRetrospective chart review of womenChart review of womenMedical management of endometriosisProgestin-only formulationsLevonorgestrel intrauterine deviceReview of womenRetrospective chart reviewYoung adult patientsTertiary hospital systemPelvic painIntrauterine deviceOral contraceptivesTreatment regimensYounger patientsAdult patientsHormonal managementEndometriosisTreatment planningCurrent treatmentLinzagolix therapy versus a placebo in patients with endometriosis-associated pain: a prospective, randomized, double-blind, Phase 3 study (EDELWEISS 3)
Donnez J, Becker C, Taylor H, Herrera F, Donnez O, Horne A, Paszkowski M, Petraglia F, Renner S, Patel A, Boolell M, Bestel E, Dolmans M. Linzagolix therapy versus a placebo in patients with endometriosis-associated pain: a prospective, randomized, double-blind, Phase 3 study (EDELWEISS 3). Human Reproduction 2024, 39: 1208-1221. PMID: 38648863, PMCID: PMC11144970, DOI: 10.1093/humrep/deae076.Peer-Reviewed Original ResearchNon-menstrual pelvic painAdd-back therapyEndometriosis-associated painPelvic painMonths of therapyPhase 3 studyGedeon RichterData Monitoring BoardDaily doseStatistically significant reductionPlacebo groupDouble-blindRoche DiagnosticsTreatment of endometriosis-associated painHormonal add-back therapyRates of hot flushesReduce dysmenorrheaGonadotropin-releasing hormone antagonistRisk of bone lossDATE OF FIRST PATIENT’S ENROLMENT:Overall pelvic painPublished phase 2Hypoestrogenic side effectsMonitoring boardCompared to placeboVilaprisan for the treatment of symptomatic endometriosis: results from a terminated phase 2b randomized controlled trial
Taylor H, Dong L, Haikonen J, Oppelt P, Tamussino K, Wenzl R, Faustmann T, Groettrup-Wolfers E, Ren X, Seitz C. Vilaprisan for the treatment of symptomatic endometriosis: results from a terminated phase 2b randomized controlled trial. F&S Reports 2024, 5: 189-196. PMID: 38983729, PMCID: PMC11228778, DOI: 10.1016/j.xfre.2024.03.002.Peer-Reviewed Original ResearchPelvic painSymptomatic endometriosisTreatment of symptomatic endometriosisEndometriosis-associated pelvic painBaseline to month 3Use of pain medicationAverage pain scoreMonths of treatmentPhase 2b randomized controlled trialAssess treatment effectsOutcome measures Primary outcomesPlacebo recipientsRandomized Controlled TrialsPain scoresMonth 3Pain medicationIncreased painVilaprisanPlaceboPrimary outcomeEndometriosisToxicity findingsIntervention participantsClinical relevanceBleeding intensityInterventional Therapy of Pelvic Venous Disorders (PeVD)
Dewald C, Becker L, Meyer B. Interventional Therapy of Pelvic Venous Disorders (PeVD). RöFo 2024, 196: 921-927. PMID: 38373714, DOI: 10.1055/a-2229-4100.Peer-Reviewed Original ResearchConceptsPelvic venous disordersInterventional therapyVenous disordersTreatment optionsMinimally invasive treatment optionChronic pelvic painInterventional treatment optionsInvasive treatment optionLack of standardized nomenclatureSystematic disease managementRandomized Controlled TrialsPelvic painOvarian veinMay-ThurnerProgressive diseaseDelayed DiagnosisClinical successEndovascular therapyUnderdiagnosed conditionUnderdiagnosed causeVenous insufficiencyClinical trialsPathophysiological backgroundControlled TrialsDiagnostic criteriaDispensing patterns of antidepressant and antianxiety medications for psychiatric disorders after benign hysterectomy in reproductive-age women: Results from group-based trajectory modeling
Ishiwata R, AlAshqar A, Miyashita-Ishiwata M, Borahay M. Dispensing patterns of antidepressant and antianxiety medications for psychiatric disorders after benign hysterectomy in reproductive-age women: Results from group-based trajectory modeling. Women's Health 2024, 20: 17455057241272218. PMID: 39165003, PMCID: PMC11339748, DOI: 10.1177/17455057241272218.Peer-Reviewed Original ResearchConceptsGroup-based-trajectory modellingBenign hysterectomyReproductive-age womenUterine fibroidsAA medicationsTime of hysterectomyPatterns of antidepressantsPsychiatric disordersDispensing patternsCo-existing psychiatric diagnosisStudy periodStudy of womenClusters of patientsPelvic painAbnormal bleedingDiscontinuation ratesClinical predictorsHysterectomyGynecological symptomsGynecological disordersTrajectory groupsPerioperative periodAntidepressantsInclusion criteriaAnxiety disorders
2023
15. The Association of Polycystic Ovarian Syndrome and Adnexal Pathologies in Adolescents
Lynn A, Lepore C, Solomon N, Sailer A, Rowe E, Vash-Margita A, Zamani M. 15. The Association of Polycystic Ovarian Syndrome and Adnexal Pathologies in Adolescents. Journal Of Pediatric And Adolescent Gynecology 2023, 36: 180. DOI: 10.1016/j.jpag.2023.01.103.Peer-Reviewed Original ResearchPolycystic ovarian syndromeAdnexal pathologyPCOS groupOvarian syndromePelvic ultrasoundCystic teratomaControl groupBackground Polycystic ovarian syndromeRetrospective case-control studySertoli-Leydig cell tumorNon-PCOS counterpartsTransabdominal pelvic ultrasoundFunctional ovarian cystsTertiary children's hospitalMature cystic teratomaCase-control studyRisk of torsionControl group subjectsFemales ages 12Chronic anovulationPelvic painRotterdam criteriaOvarian volumeEndocrinology clinicOvarian cystsComplex pathologies in a patient referred for varicose veins
Ali S, Pinto P, Huber S, Perez-Lozada J, Attaran R, Chaar C. Complex pathologies in a patient referred for varicose veins. Journal Of Vascular Surgery Cases And Innovative Techniques 2023, 9: 101107. PMID: 36852313, PMCID: PMC9958068, DOI: 10.1016/j.jvscit.2023.101107.Peer-Reviewed Original ResearchVenous pathologyVaricose veinsOvarian vein embolizationSuperficial venous refluxSaphenous vein refluxIliac vein compressionCross-sectional imagingVenous ablationPelvic painVenous refluxLeg symptomsOvarian veinVein embolizationVein refluxPelvic symptomsVein compressionDuplex examinationIliac veinLeg varicositiesSuccessful treatmentComplex pathologyPathologyVeinSymptomsRefluxOvarian absence: a systematic literature review and case series report
Chen H, Grimshaw A, Taylor-Giorlando M, Vijayakumar P, Li D, Margetts M, Pelosi E, Vash-Margita A. Ovarian absence: a systematic literature review and case series report. Journal Of Ovarian Research 2023, 16: 13. PMID: 36642704, PMCID: PMC9841619, DOI: 10.1186/s13048-022-01090-1.Peer-Reviewed Original ResearchConceptsOvarian absenceUterine abnormalitiesVascular accidentRenal abnormalitiesInfertility/subfertilityCase series reportWeb of SciencePelvic painDiagnostic laparoscopyClinical presentationVascular etiologyOvid EmbaseCochrane LibraryFrequent presentationUncommon conditionSeries reportCongenital anomaliesOvid MEDLINEOvarian abnormalitiesFertility considerationsGenitourinary anatomyExclusion criteriaEmbryological defectUnpublished casesSystematic review
2022
Evaluation of the Association of Endometrial Thickness, Insulin Resistance, and Menstrual Patterns in Adolescent Females with Polycystic Ovarian Syndrome
Lynn A, Solomon N, Zamani M, Rowe E, Seifer D, Vash-Margita A. Evaluation of the Association of Endometrial Thickness, Insulin Resistance, and Menstrual Patterns in Adolescent Females with Polycystic Ovarian Syndrome. Journal Of Pediatric And Adolescent Gynecology 2022, 36: 134-139. PMID: 36403727, DOI: 10.1016/j.jpag.2022.11.005.Peer-Reviewed Original ResearchConceptsPCOS groupInsulin resistanceMenstrual patternAdolescent femalesControl groupRetrospective case-control studyLarge-scale prospective studiesAcute pelvic painEndometrial stripe thicknessTransabdominal pelvic ultrasoundTertiary children's hospitalPolycystic ovarian syndromeBody mass indexCase-control studyInstitutional review boardAdolescent PCOSEndometrial thicknessPelvic painOvarian syndromePCOS diagnosisPelvic ultrasoundUnique pathophysiologyEndocrinology clinicChildren's HospitalMass index
2021
A Rare Case of Large Left Lateral Wall Vaginal Myoma
Shrestha A, Mudbari J, Tamrakar S, Pradhan N, Makaju R, Karki S. A Rare Case of Large Left Lateral Wall Vaginal Myoma. Kathmandu University Medical Journal 2021, 19: 396-398. PMID: 36254433, DOI: 10.3126/kumj.v19i3.49748.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingVaginal wallClinical findingsLeft vaginal wallChronic pelvic painSmooth muscle tumorsVariable clinical presentationBulky uterusVaginal myomaVaginal myomectomyPelvic painMuscle tumorsVaginal leiomyomaGuided biopsyBenign tumorsClinical presentationPressure symptomsYears ladyMass lesionRare caseLeiomyomaCervixUltrasonographyResonance imagingVaginumReductions in endometriosis-associated pain among women treated with elagolix are consistent across a range of baseline characteristics reflective of real-world patients
Abrao MS, Surrey E, Gordon K, Snabes MC, Wang H, Ijacu H, Taylor HS. Reductions in endometriosis-associated pain among women treated with elagolix are consistent across a range of baseline characteristics reflective of real-world patients. BMC Women's Health 2021, 21: 246. PMID: 34134684, PMCID: PMC8210385, DOI: 10.1186/s12905-021-01385-3.Peer-Reviewed Original ResearchConceptsNon-menstrual pelvic painEndometriosis-associated painBaseline characteristicsSubgroup interactionsEndometriosis Health Profile-30Severe endometriosis-associated painGonadotropin-releasing hormone receptor antagonistEfficacy of elagolixPatient-reported reductionsPhase 3 studyHealth-related qualityReal-world patientsHormone receptor antagonistSubgroup of womenSignificant treatmentPercentage of womenAnalgesic usePelvic painMonth 3Receptor antagonistPrevious historyMost subgroupsPainPatient typesEndometriosis disease6. Time elapsed from initial presentation to diagnostic laparoscopy: factors affecting diagnostic delay in adolescents with biopsy-confirmed endometriosis
Li H, Cho Y, Taylor H, Vash-Margita A. 6. Time elapsed from initial presentation to diagnostic laparoscopy: factors affecting diagnostic delay in adolescents with biopsy-confirmed endometriosis. Journal Of Pediatric And Adolescent Gynecology 2021, 34: 241-242. DOI: 10.1016/j.jpag.2021.02.010.Peer-Reviewed Original ResearchBiopsy-proven endometriosisShorter diagnostic delayAdnexal massesDiagnostic delayMedian delayDiagnostic laparoscopyInitial presentationInitial imagingOB/GYN providersTertiary hospital systemChronic pelvic painMultiple regression analysisRegression analysisInstitutional review boardPelvic painSubspecialty referralConclusions PatientsYounger patientsMajor surgeryBackground EndometriosisMedian timeRetrospective reviewED visitationOutpatient settingDefinitive diagnosis86. Unilateral Ovarian Agenesis: A Systematic Review of the Literature and Report of Two Cases
Chen H, Vijayakumar P, Taylor-Giorlando M, Grimshaw A, Li D, Vash-Margita A. 86. Unilateral Ovarian Agenesis: A Systematic Review of the Literature and Report of Two Cases. Journal Of Pediatric And Adolescent Gynecology 2021, 34: 273-274. DOI: 10.1016/j.jpag.2021.02.090.Peer-Reviewed Original ResearchOvarian agenesisDistal fallopian tubeFallopian tubeUnilateral OAEctopic pregnancyPelvic painParatubal cystRound ligamentSystematic reviewRight tubal ectopic pregnancyMultiple peritoneal biopsiesNormal bilateral ovariesNormal-appearing ovariesRight paratubal cystUnilateral ovarian agenesisCommon presenting symptomHistory of nephrolithiasisRight fallopian tubeSevere abdominal painTubal ectopic pregnancyPositive pregnancy testCorpus luteum cystInfertility/subfertilityMajority of casesGenital chlamydia81. Medical management of endometriosis in adolescent women: a review of 91 cases of biopsy-confirmed endometriosis
Li H, Cho Y, Taylor H, Vash-Margita A. 81. Medical management of endometriosis in adolescent women: a review of 91 cases of biopsy-confirmed endometriosis. Journal Of Pediatric And Adolescent Gynecology 2021, 34: 271-272. DOI: 10.1016/j.jpag.2021.02.085.Peer-Reviewed Original ResearchBiopsy-proven endometriosisOral contraceptivesLNG-IUDOral progestinCurrent treatmentYounger patientsInitial treatmentRetrospective medical record reviewCurrent hormonal treatmentsTertiary hospital systemICD-9/10 codesCommon initial treatmentMedical record reviewReproductive-aged womenCommon treatment modalityInstitutional review boardYoung adult femalesPelvic painEndometriosis treatmentInitial presentationOptimal regimensBackground EndometriosisMedical managementRecord reviewTreatment course
2020
Responsiveness and thresholds for clinically meaningful changes in worst pain numerical rating scale for dysmenorrhea and nonmenstrual pelvic pain in women with moderate to severe endometriosis
Pokrzywinski RM, Soliman AM, Snabes MC, Chen J, Taylor HS, Coyne KS. Responsiveness and thresholds for clinically meaningful changes in worst pain numerical rating scale for dysmenorrhea and nonmenstrual pelvic pain in women with moderate to severe endometriosis. Fertility And Sterility 2020, 115: 423-430. PMID: 33066973, DOI: 10.1016/j.fertnstert.2020.07.013.Peer-Reviewed Original ResearchConceptsSevere endometriosis-associated painEndometriosis-associated painNumerical rating scaleNonmenstrual pelvic painPelvic painWorst painMonth 3Rating ScalePain numerical rating scaleMeaningful changePremenopausal womenSevere endometriosisGlobal ImpressionClinical trialsMAIN OUTCOMEPainDysmenorrheaPhase IIIWomenElagolixResponsivenessTrialsPlaceboEndometriosisPatients
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