2025
The anesthetic management of a patient with stiff person syndrome undergoing ambulatory endoscopic sinus surgery: A case report
Veira J, Manes R, Cormier N. The anesthetic management of a patient with stiff person syndrome undergoing ambulatory endoscopic sinus surgery: A case report. JCA Advances 2025, 2: 100157. DOI: 10.1016/j.jcadva.2025.100157.Peer-Reviewed Original ResearchStiff-person syndromeGamma-amino butyric acidAnesthetic managementAmbulatory endoscopic sinus surgeryRare autoimmune neurological disorderEndoscopic sinus surgerySensitivity to neuromuscular blocking agentsBilateral maxillary antrostomiesAutoimmune neurological disordersPerson syndromeProgressive muscle spasmsTotal ethmoidectomyAmino butyric acidMaxillary antrostomyNasal endoscopySinus surgeryCase reportNeuromuscular blocking agentsGeneral anesthesiaMuscle spasmBlocking agentsNeurological disordersPatientsSyndromeAntrostomyManagement of the Disconnected Pancreatic Duct in Pancreatic Necrosis
Wilcox C, Bang J, Asombang A, Bennett C, Bi Y, Blogowski W, Buxbaum J, Chandrasekhara V, Chin W, Conwell D, Coté G, Gardner T, Garg P, Guda N, Hawes R, Hernandez-Barco Y, Jonica E, Kedia P, Kowalski T, Kumbhari V, Lee L, Machicado J, Mardini S, Morgan D, Muniraj T, Navaneethan U, Oza V, Parekh P, Pawa S, Puri R, Rastogi A, Reddy D, Saumoy M, Sawhney M, Vege S, Talukdar R, Tarnasky P, Tellez-Avila F, Thakkar S, Thiruvengadam N, Vivian E, Waxman I, Willingham F, Varadarajulu S, Group U. Management of the Disconnected Pancreatic Duct in Pancreatic Necrosis. Clinical Gastroenterology And Hepatology 2025, 23: 1878-1887.e3. PMID: 40680906, DOI: 10.1016/j.cgh.2025.05.024.Peer-Reviewed Original ResearchConceptsPancreatic ductComplications of severe pancreatitisPancreatic duct stentingEndoscopic transmural drainageSurgical therapySevere pancreatitisDuct stentingEndoscopic treatmentNecrotizing pancreatitisAssociated syndromesPlastic stentsPancreatic necrosisTransmural drainageStudy groupTherapeutic questionsSyndromeRadiographic definitionDiagnostic methodsDiagnosisPancreatitisStentTreatmentDuctTriglycerides/HDL ratio and HbA1c to discriminate metabolic syndrome and insulin resistance in adults with T1D
Nolasco-Rosales G, Cruz-Castillo J, Rodríguez-Sánchez E, Jiménez-López K, Martínez-Magaña J, Villar-Juárez G, Hernández-Díaz Y, Tovilla-Zárate C, Guzmán-Priego C, Marín-Medina A, Juárez-Rojo I. Triglycerides/HDL ratio and HbA1c to discriminate metabolic syndrome and insulin resistance in adults with T1D. Revista Mexicana De Endocrinología Metabolismo Y Nutrición 2025, 12: 59-67. DOI: 10.24875/rme.24000026.Peer-Reviewed Original ResearchPresence of MSMetabolic syndromeInsulin resistanceReceiver operating curveTriglycerides/HDL ratioClinical featuresAdult patientsRatio of triglycerides to HDL cholesterolRecognition of metabolic syndromeTriglycerides to HDL cholesterolClinical features of MSHemoglobin level >Levels of glycosylated hemoglobinPhenotype of patientsFeatures of MSType 1 diabetesHDL cholesterolHDL-CPatientsTriglycerides/HDLOperating curveT1DSyndromeInsulinPart II. Dermatologic Manifestations Associated with Treatment of Patients with Kidney Disease
Singal A, Cowper S, Ko C, Kroshinsky D, Lipner H, Robinson-Bostom L, Yosipovitch G, Lipner S. Part II. Dermatologic Manifestations Associated with Treatment of Patients with Kidney Disease. Journal Of The American Academy Of Dermatology 2025 PMID: 40543663, DOI: 10.1016/j.jaad.2025.06.034.Peer-Reviewed Original ResearchEnd stage kidney diseaseKidney diseaseMultidisciplinary team-based approachTreatment of patientsNephrogenic systemic fibrosisStage kidney diseaseClinical presentationSteal syndromeAffected patientsDermatological manifestationsSystemic fibrosisPatientsDialysis-related amyloidosisTeam-based approachUnique treatmentDiseaseCalciphylaxisFibrosisSyndromeDermatosesDermatologistsKidneyAmyloidosisSicca Syndrome Induced by Immune Checkpoint Inhibitor Therapy
Li Y, Kim S, Tannir N, Lu H. Sicca Syndrome Induced by Immune Checkpoint Inhibitor Therapy. 2025, 425-431. DOI: 10.1007/978-3-031-83533-9_53.Peer-Reviewed Original ResearchSicca syndromeImmune related adverse eventsImmune checkpoint inhibitor therapyCheckpoint inhibitor therapyCombination of prednisoneRelated adverse eventsKidney carcinoma patientsNivolumab treatmentInhibitor therapyCarcinoma patientsAdverse eventsSyndromeNivolumabPrednisoneRemissionImmunosuppressionHydroxychloroquineTherapyPatientsCancerICIPolymyalgia Rheumatica-Like Syndrome Post Immune Checkpoint Inhibitor Therapy
Lu H, Bowman S, Linda Bobby N, Kim S, Msaouel P, Tayar J. Polymyalgia Rheumatica-Like Syndrome Post Immune Checkpoint Inhibitor Therapy. 2025, 433-438. DOI: 10.1007/978-3-031-83533-9_54.Peer-Reviewed Original ResearchMetastatic clear cell renal cell carcinomaClear cell renal cell carcinomaPMR-like syndromeProximal muscle painCell renal cell carcinomaRenal cell carcinomaMaintenance prednisoneTapering prednisoneClinical remissionCell carcinomaMuscle painInflammation markersPrednisoneSarilumabIpilimumabNivolumabRemissionCarcinomaPainSyndromeInflammationNeckIncretin Hormones Predict Response to Enteral Nutrition Dosing Strategies in Acute Respiratory Distress Syndrome
Hansell C, Yang Z, Yende S, Aneis H, Kitsios G, Bain W, Zhao Y, Sharma L, Petro N, Patel J, Mcverry B, Talisa V, Shah F. Incretin Hormones Predict Response to Enteral Nutrition Dosing Strategies in Acute Respiratory Distress Syndrome. American Journal Of Respiratory And Critical Care Medicine 2025, 211: a1214-a1214. DOI: 10.1164/ajrccm.2025.211.abstracts.a1214.Peer-Reviewed Original ResearchHealthy ageing in older adults with cardiovascular disease
Schmanske N, Ngo J, Kalra K, Nanna M, Damluji A. Healthy ageing in older adults with cardiovascular disease. European Heart Journal 2025, 46: 2536-2551. PMID: 40296653, PMCID: PMC12233012, DOI: 10.1093/eurheartj/ehaf231.Peer-Reviewed Original ResearchHealthy agingOlder adultsGeriatric syndromesCardiovascular diseasePrevalence of chronic diseasesPopulation of older adultsDevelopment of geriatric syndromesImpact of geriatric syndromesPromote healthy agingAccelerated biological agingBiological ageUS populationChronic diseasesPotential interventionsLife expectancyPublic healthOlder patientsEuropean populationsMedical technologyAgeAdultsPopulationDiseaseSyndromeSocioeconomic progressSex differences in cerebrospinal fluid proteomics of patients with restless legs syndrome
Mogavero M, Peng G, Marchese G, Lanza G, Ferini-Strambi L, Ferri R, Koo B. Sex differences in cerebrospinal fluid proteomics of patients with restless legs syndrome. Sleep 2025, 48: zsaf112. PMID: 40289925, DOI: 10.1093/sleep/zsaf112.Peer-Reviewed Original ResearchRestless legs syndromeProteomic signatureCerebrospinal fluid proteomeUntreated RLS patientsObservational cross-sectional studyBody mass indexProteome of patientsCerebrospinal fluid samplesSex-specific mechanismsCross-sectional studyRLS patientsSex-specific analysesMass indexSex differencesTherapeutic strategiesImmune responseInflammatory pathwaysEffective treatmentCerebrospinal fluid proteome of patientsDisease pathophysiologyPatientsSyndromeProtein levelsFluid samplesProteomic alterationsA Challenging Case of Guillain-Barré Syndrome Presenting with Hyperreflexia, Severe Back Pain and Dysautonomia (P10-11.003)
Veloso V, Lambert C, Ali A, Koutsioumpa C, Sanamandra S. A Challenging Case of Guillain-Barré Syndrome Presenting with Hyperreflexia, Severe Back Pain and Dysautonomia (P10-11.003). Neurology 2025, 104 DOI: 10.1212/wnl.0000000000212333.Peer-Reviewed Original ResearchData analysis strategies for the Accelerating Medicines Partnership® Schizophrenia Program
Penzel N, Polosecki P, Addington J, Arango C, Asgari-Targhi A, Billah T, Bouix S, Calkins M, Campbell D, Cannon T, Castro E, Cho K, Coleman M, Corcoran C, Dwyer D, Frangou S, Fusar-Poli P, Glynn R, Haidar A, Harms M, Jacobs G, Kambeitz J, Kapur T, Kelly S, Koutsouleris N, Abhinandan K, Kucukemiroglu S, Kwon J, Lewandowski K, Li Q, Mantua V, Mathalon D, Mittal V, Nicholas S, Pandina G, Perkins D, Potter A, Reichenberg A, Reinen J, Sand M, Seitz-Holland J, Shah J, Srinivasan V, Srivastava A, Stone W, Torous J, Vangel M, Wang J, Wolff P, Yao B, Anticevic A, Wolf D, Zhu H, Bearden C, McGorry P, Nelson B, Kane J, Woods S, Kahn R, Shenton M, Cecchi G, Pasternak O. Data analysis strategies for the Accelerating Medicines Partnership® Schizophrenia Program. Schizophrenia 2025, 11: 53. PMID: 40180950, PMCID: PMC11968818, DOI: 10.1038/s41537-025-00561-w.Peer-Reviewed Original ResearchCHR syndromeClinical assessmentCHR individualsClinical high riskTransition to psychosisBaseline clinical assessmentClinical endpointsMultidisciplinary team of expertsAnalysis planHigh riskSample of individualsMultimodal biomarkersLongitudinal clinical assessmentsClinical trajectorySchizophrenia ProgramMultidisciplinary teamBaseline assessmentSyndromeDifferentiate subgroupsCommunity controlsBiomarkersPsychosisAMPBaselineTeam of expertsANTITHROMBOTIC STRATEGY FOR PATIENTS WITH CONCOMITANT CHRONIC CORONARY SYNDROME AND ATRIAL FIBRILLATION: A POOLED ANALYSIS OF 3 RANDOMIZED-CONTROLLED TRIALS
Chi K, Lee P, Pazooki P, Kumar S, Borkowski P, Hussain A, Nanna M. ANTITHROMBOTIC STRATEGY FOR PATIENTS WITH CONCOMITANT CHRONIC CORONARY SYNDROME AND ATRIAL FIBRILLATION: A POOLED ANALYSIS OF 3 RANDOMIZED-CONTROLLED TRIALS. Journal Of The American College Of Cardiology 2025, 85: 1904. DOI: 10.1016/s0735-1097(25)02388-5.Peer-Reviewed Original ResearchThe Molecular Basis of Polycystic Ovary Syndrome and Its Cardiometabolic Correlates: Exploring the Intersection and Its Clinical Implications—A Narrative Review
Mahabamunuge J, Sekula N, Lepore C, Kudrimoti M, Upadhyay A, Alshowaikh K, Li H, Seifer D, AlAshqar A. The Molecular Basis of Polycystic Ovary Syndrome and Its Cardiometabolic Correlates: Exploring the Intersection and Its Clinical Implications—A Narrative Review. Biomedicines 2025, 13: 709. PMID: 40149685, PMCID: PMC11940587, DOI: 10.3390/biomedicines13030709.Peer-Reviewed Original ResearchPolycystic ovary syndromeType 2 diabetes mellitusCardiometabolic morbidityIncreased cardiovascular riskDevelopment of hypertensionCardiovascular risk factorsNarrative reviewPotential clinical implicationsAndrogen excessEndothelial dysfunctionCardiovascular riskClinical conditionsPredisposed individualsTherapeutic strategiesAdipokine secretionRisk factorsInsulin resistanceCardiometabolic diseasesCardiovascular diseaseClinical implicationsMorbidityMellitusSyndromeMolecular mechanismsDiseaseMake It Happen NOW: Barriers and Inequities in Eat, Sleep, Console Implementation for Neonatal Opioid Withdrawal Syndrome.
Chaudhury N, Zhao S, Ostfeld-Johns S. Make It Happen NOW: Barriers and Inequities in Eat, Sleep, Console Implementation for Neonatal Opioid Withdrawal Syndrome. Hospital Pediatrics 2025, 15: e99-e101. PMID: 39894048, DOI: 10.1542/hpeds.2025-008332.Peer-Reviewed Original ResearchInsights into treatment of patients with mycosis fungoides or Sézary syndrome using mogamulizumab
Foss F, Kim Y, Scarisbrick J, Akilov O, Ristuccia R, Dwyer K, Wu W, Bagot M. Insights into treatment of patients with mycosis fungoides or Sézary syndrome using mogamulizumab. Journal Of Dermatological Treatment 2025, 36: 2438794. PMID: 39894454, DOI: 10.1080/09546634.2024.2438794.Peer-Reviewed Original ResearchConceptsMogamulizumab-associated rashConcomitant steroid useSezary syndromeAdvanced diseaseMycosis fungoidesSteroid useResponse to mogamulizumabProportion of patientsPercentage of patientsTreatment of patientsConcomitant steroidsRelapsed/refractory patientsLong-term responseMogamulizumabNext treatmentPatient characteristicsPatientsLymphopeniaVorinostatPatient responseFungoidesPFSMycosisSyndromeTreatmentSalivary gland stem/progenitor cells: advancing from basic science to clinical applications
Langthasa J, Guan L, Jinagal S, Le Q. Salivary gland stem/progenitor cells: advancing from basic science to clinical applications. Cell Regeneration 2025, 14: 4. PMID: 39856475, PMCID: PMC11759724, DOI: 10.1186/s13619-025-00221-5.Peer-Reviewed Original ResearchSalivary gland stem/progenitor cellsBioengineered organ replacementTissue-based therapiesEffective clinical therapiesRadiation therapySjogren's syndromeStem/progenitor cellsClinical therapyTherapyDifferentiation pathwayClinical applicationRegenerative medicineSyndromeTissue regenerationOrgan replacementCulture techniquesSjogrenTransplantationPatients16 Metabolic Syndrome and Obesity
Alonso W, Canapari C. 16 Metabolic Syndrome and Obesity. 2025, 175-184. DOI: 10.1016/b978-0-323-75566-5.00016-2.Peer-Reviewed Original ResearchMetabolic syndromeComponents of metabolic syndromeInvolvement of adipocytokinesSleep-disordered breathingIncreased sympathetic activityElevated blood pressureCardiovascular risk factorsRates of obesityIntermittent hypoxemiaTruncal obesityDysregulation of glucose metabolismSleep fragmentationSympathetic activityBlood pressureSleep curtailmentRisk factorsSyndromeObesityShort sleepGlucose metabolismCircadian factorsSleepHypoxemiaDyslipidemiaAdipocytokines
2024
Untargeted metabolomics analysis as a potential screening tool for 3-methylglutaconic aciduria syndromes
DiFalco C, Gijavanekar C, Wang Y, Grace A, Machol K, Emrick L, Liu N, Mizerik E, Mackay L, Dai H, Vossaert L, Xia F, Elsea S, Scaglia F. Untargeted metabolomics analysis as a potential screening tool for 3-methylglutaconic aciduria syndromes. Molecular Genetics And Metabolism 2024, 144: 109009. PMID: 39787888, DOI: 10.1016/j.ymgme.2024.109009.Peer-Reviewed Original ResearchConceptsUrine organic acid analysisUntargeted metabolomic profilingInborn errors of metabolismErrors of metabolismMetabolomic profilesMetabolomic analysisHeterogeneous group of inborn errors of metabolismGroup of inborn errors of metabolismUntargeted metabolomics analysisDegree of clinical sensitivityBiochemical screening toolScreening toolOrganic acid analysisClinical sensitivityBiochemical abnormalitiesDistal defectsInborn errorsSyndromeHeterogeneous groupPlasma samplesDetectable elevationImpaired functionClinical modalityBiochemical phenotypeUrineComparisons of management approaches in neonatal opioid withdrawal syndrome: The eat, sleep, console approach vs. the Finnegan approach
Johnson K, Berkwitt A, Yankova L, Osborn R. Comparisons of management approaches in neonatal opioid withdrawal syndrome: The eat, sleep, console approach vs. the Finnegan approach. Seminars In Perinatology 2024, 49: 152021. PMID: 39736490, DOI: 10.1016/j.semperi.2024.152021.Peer-Reviewed Original ResearchA Yale Dermatology perspective on cutaneous T cell lymphoma: Historic reflection to emerging therapies
Swallow M, Edelson R, Girardi M. A Yale Dermatology perspective on cutaneous T cell lymphoma: Historic reflection to emerging therapies. Clinics In Dermatology 2024, 43: 170-176. PMID: 39694197, DOI: 10.1016/j.clindermatol.2024.12.006.Peer-Reviewed Original ResearchCutaneous T-cell lymphomaT-cell lymphomaMycosis fungoidesSubtype of cutaneous T-cell lymphomaPathogenesis of cutaneous T-cell lymphomaNon-Hodgkin's lymphomaEvolving treatment landscapeSezary syndromeHistological variantsTreatment landscapeLymph nodesSchool of MedicineLymphomaYale School of MedicineFungoidesClinical careMalignancyLymphMycosisSyndromeSubtypesPathogenesis
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