2025
OnabotulinumtoxinA in the Management of Pain in Adult Patients with Spasticity: A Systematic Literature Review
Bianchi F, Nelson M, Wissel J, Kim H, Traut A, Shah D, Musacchio T, Jabbari B. OnabotulinumtoxinA in the Management of Pain in Adult Patients with Spasticity: A Systematic Literature Review. Toxins 2025, 17: 418. PMID: 40864094, PMCID: PMC12390114, DOI: 10.3390/toxins17080418.Peer-Reviewed Original ResearchConceptsManagement of painSpasticity-associated painManagement of spasticitySpasticity-related painPublished evidenceClinically meaningful reductionsReport painSpasticityPain measuresSystematic reviewSystematic literature reviewMeaningful reductionsStatistically significant reductionPainAdultsLevel of heterogeneityAdult patientsSearch strategyOnabotALiterature reviewJournal publicationsSignificant reductionPatientsBaselineOnabotulinumtoxinA
2023
Increased astrocytic GLT-1 expression in tripartite synapses is associated with SCI-induced hyperreflexia
Benson C, King J, Kauer S, Waxman S, Tan A. Increased astrocytic GLT-1 expression in tripartite synapses is associated with SCI-induced hyperreflexia. Journal Of Neurophysiology 2023, 130: 1358-1366. PMID: 37877184, PMCID: PMC10972632, DOI: 10.1152/jn.00234.2023.Peer-Reviewed Original ResearchConceptsSpinal cord injuryRate-dependent depressionTripartite synapsesGLT-1Astrocytic GLT-1 expressionChronic neurological complicationsGLT-1 expressionAstrocyte involvementChronic spasticityUninjured shamsNeurological complicationsNeuropathic painHyperexcitability disordersH-reflexPSD-95 proteinReactive astrocytesVentral hornCord injuryMuscle toneAstrocytes' roleSpinal cordSpinal circuitsSynaptic transmissionHyperreflexiaSpasticityAssociation between lower limb spasticity and cryptorchidism in males with cerebral palsy
Bortnick E, Logvinenko T, Wang H, Fogelman D, Shore B, Nelson C, Kurtz M. Association between lower limb spasticity and cryptorchidism in males with cerebral palsy. Developmental Medicine & Child Neurology 2023, 66: 82-86. PMID: 37282840, DOI: 10.1111/dmcn.15644.Peer-Reviewed Original ResearchConceptsLower limb spasticityCerebral palsyLimb spasticityOrchidopexy ratesSevere lower limb spasticityPediatric Health Information System databaseHealth Information System databaseSpastic typeInformation System databaseSpasticityLogistic regressionMann-Whitney U testPalsyComparative statisticsSystem databaseCompare groupsContinuous variablesAssociationMann-WhitneyU testRiskPatientsPeopleMaleProviders
2021
Biallelic variants in HPDL cause pure and complicated hereditary spastic paraplegia
Wiessner M, Maroofian R, Ni MY, Pedroni A, Müller JS, Stucka R, Beetz C, Efthymiou S, Santorelli FM, Alfares AA, Zhu C, Meszarosova A, Alehabib E, Bakhtiari S, Janecke AR, Otero MG, Chen JYH, Peterson JT, Strom TM, De Jonghe P, Deconinck T, De Ridder W, De Winter J, Pasquariello R, Ricca I, Alfadhel M, van de Warrenburg BP, Portier R, Bergmann C, Firouzabadi S, Jin SC, Bilguvar K, Hamed S, Abdelhameed M, Haridy NA, Maqbool S, Rahman F, Anwar N, Carmichael J, Pagnamenta A, Wood NW, Mau-Them F, Haack T, Consortium P, Di Rocco M, Ceccherini I, Iacomino M, Zara F, Salpietro V, Scala M, Rusmini M, Xu Y, Wang Y, Suzuki Y, Koh K, Nan H, Ishiura H, Tsuji S, Lambert L, Schmitt E, Lacaze E, Küpper H, Dredge D, Skraban C, Goldstein A, Willis M, Grand K, Graham J, Lewis R, Millan F, Duman Ö, Dündar N, Uyanik G, Schöls L, Nürnberg P, Nürnberg G, Bordes A, Seeman P, Kuchar M, Darvish H, Rebelo A, Bouçanova F, Medard J, Chrast R, Auer-Grumbach M, Alkuraya F, Shamseldin H, Al Tala S, Varaghchi J, Najafi M, Deschner S, Gläser D, Hüttel W, Kruer M, Kamsteeg E, Takiyama Y, Züchner S, Baets J, Synofzik M, Schüle R, Horvath R, Houlden H, Bartesaghi L, Lee H, Ampatzis K, Pierson T, Senderek J. Biallelic variants in HPDL cause pure and complicated hereditary spastic paraplegia. Brain 2021, 144: 1422-1434. PMID: 33970200, PMCID: PMC8219359, DOI: 10.1093/brain/awab041.Peer-Reviewed Original ResearchConceptsHereditary spastic paraplegiaPure hereditary spastic paraplegiaGlobal developmental delaySpastic paraplegiaNervous systemNeurological diseasesComplicated hereditary spastic paraplegiaDevelopmental delayAbnormal motor behaviorRespiratory decompensationSpastic tetraplegiaNeurological manifestationsTruncating changesMissense substitutionsBiallelic variantsParaplegiaMotor behaviorDiseaseNeural differentiationUnknown specificityHuman diseasesMitochondrial diseaseDecompensationSpasticityTetraplegia
2020
Utility of intrathecal baclofen pump in primary lateral sclerosis
Zubair AS, Raymond M, Patwa HS. Utility of intrathecal baclofen pump in primary lateral sclerosis. Journal Of The Neurological Sciences 2020, 420: 117227. PMID: 33239209, DOI: 10.1016/j.jns.2020.117227.Peer-Reviewed Original ResearchConceptsPrimary lateral sclerosisLateral sclerosisProgressive upper motor neuron dysfunctionLower motor neuron involvementUpper motor neuron dysfunctionMigration of catheterMotor neuron involvementIntrathecal baclofen pumpMotor neuron dysfunctionSpinal cord injuryLower extremity stiffnessAshworth scoreNeuron involvementBaclofen pumpIntrathecal baclofenClinical courseInsidious onsetMuscle spasticityPLS patientsNeuron dysfunctionCord injuryNeurologic conditionsClinical examinationEffective treatmentSpasticity
2017
Baclofen Pumps
Woolf SM, Baum CR. Baclofen Pumps. Pediatric Emergency Care 2017, 33: 271-275. PMID: 28353527, DOI: 10.1097/pec.0000000000001090.Peer-Reviewed Original ResearchConceptsIntrathecal baclofen therapyBaclofen therapySpinal cord conditionsMechanism of actionBaclofen pumpSignificant morbidityContinuous infusionBolus dosingPediatric cliniciansPediatric settingAbdominal wallImplanted pumpComplicationsTherapyMorbiditySpasticityBaclofenDystoniaInfusionDosingCliniciansBrain
2016
Botulinum Toxin Treatment of Spasticity in Adults and Children
Moeini-Naghani I, Hashemi-Zonouz T, Jabbari B. Botulinum Toxin Treatment of Spasticity in Adults and Children. Seminars In Neurology 2016, 36: 064-072. PMID: 26866498, DOI: 10.1055/s-0036-1571847.Peer-Reviewed Original ResearchConceptsCerebral palsyPlacebo-controlled clinical trialDoses of BoNTSpasticity of childrenBotulinum toxin treatmentAdult spasticityTherapeutics subcommitteeBoNT treatmentPharmacologic treatmentFrequent symptomsMultiple sclerosisSpinal traumaClinical trialsToxin treatmentSpasticityAmerican AcademyPalsyBotulinum neurotoxinTreatmentChildrenWorld literatureEfficacyAdultsSclerosisPathophysiology
2015
Arm Posturing in a Patient Following Stroke: Dystonia, Levitation, Synkinesis, or Spasticity?
Irmady K, Jabbari B, Louis ED. Arm Posturing in a Patient Following Stroke: Dystonia, Levitation, Synkinesis, or Spasticity? Tremor And Other Hyperkinetic Movements 2015, 5: 353. PMID: 26682091, PMCID: PMC4681881, DOI: 10.7916/d8222tbh.Peer-Reviewed Original ResearchPost-stroke movement disordersArm contralateralArm posturingInvoluntary elevationIschemic strokeStroke patientsFollowing StrokeMovement disordersAppropriate treatmentDifferential diagnosisClinical phenomenologyDiagnostic possibilitiesSpasticitySynkinesisArm levitationDystoniaStrokeUnusual movementsPatientsContralateralDiagnosisBiomechanical analysis of spasticity treatment in patients with multiple sclerosis
Wininger M, Craelius W, Settle J, Robinson S, Isaac B, Maloni H, Moradi M, Newby NA, Wallin M. Biomechanical analysis of spasticity treatment in patients with multiple sclerosis. Therapeutic Advances In Neurological Disorders 2015, 8: 203-211. PMID: 26668586, PMCID: PMC4622116, DOI: 10.1177/1756285615601390.Peer-Reviewed Original ResearchModified Ashworth ScaleAge-matched healthy controlsMultiple sclerosisTardieu ScaleMS casesHealthy controlsClinical assessmentVoluntary movementBiomechanical analysisArm spasticityBaclofen therapyOral baclofenBaclofen treatmentAshworth ScaleLimb spasticitySpasticity symptomsSpasticity treatmentClinical spasticityBaseline scoresPatientsSpasticitySimple biomechanical analysisMotor performanceSclerosisSignificant increase
2013
Recessive loss of function of the neuronal ubiquitin hydrolase UCHL1 leads to early-onset progressive neurodegeneration
Bilguvar K, Tyagi NK, Ozkara C, Tuysuz B, Bakircioglu M, Choi M, Delil S, Caglayan AO, Baranoski JF, Erturk O, Yalcinkaya C, Karacorlu M, Dincer A, Johnson MH, Mane S, Chandra SS, Louvi A, Boggon TJ, Lifton RP, Horwich AL, Gunel M. Recessive loss of function of the neuronal ubiquitin hydrolase UCHL1 leads to early-onset progressive neurodegeneration. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 3489-3494. PMID: 23359680, PMCID: PMC3587195, DOI: 10.1073/pnas.1222732110.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge of OnsetAmino Acid SequenceBase SequenceChild, PreschoolExomeFemaleGenes, RecessiveHomozygoteHumansHydrolysisMaleModels, MolecularMolecular Sequence DataMutation, MissenseNerve DegenerationNeuronsPedigreeProtein BindingSequence Analysis, DNASubstrate SpecificitySyndromeThermodynamicsUbiquitinUbiquitin ThiolesteraseConceptsUbiquitin C-terminal hydrolase L1Upper motor neuron dysfunctionMotor neuron dysfunctionProgressive neurodegenerative syndromeEarly-onset progressive neurodegenerationChildhood-onset blindnessWhole-exome sequencingNeuron dysfunctionHomozygous missense mutationIndex caseNervous systemProgressive neurodegenerationNeurodegenerative syndromeCerebellar ataxiaHydrolase activityNear complete lossComplete lossAffected individualsConsanguineous unionsMissense mutationsRecessive lossHomozygosity mappingProper positioningReduced affinitySpasticity
2011
Reaching Toward Quantitative Metrics of Spasticity
Krasner A, Wininger M, Kim N, Craelius W. Reaching Toward Quantitative Metrics of Spasticity. 2011, 1: 1-2. DOI: 10.1109/nebc.2011.5778569.Peer-Reviewed Original Research
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