2020
Preclinical insights into therapeutic targeting of KCC2 for disorders of neuronal hyperexcitability
Duy PQ, He M, He Z, Kahle KT. Preclinical insights into therapeutic targeting of KCC2 for disorders of neuronal hyperexcitability. Expert Opinion On Therapeutic Targets 2020, 24: 629-637. PMID: 32336175, PMCID: PMC8104019, DOI: 10.1080/14728222.2020.1762174.Peer-Reviewed Original ResearchConceptsNeuronal hyperexcitabilityKCC2 functionSynaptic inhibitionKCC2 activityPreclinical insightsRole of KCC2Treatment of epilepsyCommon neurological disorderNovel therapeutic strategiesPotential adverse effectsDrug targetsKCC2 dysfunctionSeizure reductionUnprovoked seizuresIntractable epilepsySeizure activityEpilepsy therapyCotransporter KCC2Clinical urgencyPreclinical proofTherapeutic benefitTherapeutic strategiesNew drug targetsTherapeutic targetingKCC2
2019
Identification of KCC2 Mutations in Human Epilepsy Suggests Strategies for Therapeutic Transporter Modulation
Duy PQ, David WB, Kahle KT. Identification of KCC2 Mutations in Human Epilepsy Suggests Strategies for Therapeutic Transporter Modulation. Frontiers In Cellular Neuroscience 2019, 13: 515. PMID: 31803025, PMCID: PMC6873151, DOI: 10.3389/fncel.2019.00515.Peer-Reviewed Original ResearchHuman epilepsySignificant drug-related adverse effectsDrug-related adverse effectsMedication-refractory epilepsyDevelopment of epilepsyCommon neurological disorderPotential therapeutic strategyKCC2 dysfunctionNeuronal hyperexcitabilityGABA inhibitionGABAergic inhibitionSeizure disorderUnprovoked seizuresImpaired balanceKCC2 activityNeuronal excitabilityNeuronal excitationTherapeutic strategiesTransporter modulationEpileptic seizuresEpilepsyNeurological disordersChloride homeostasisSatisfactory treatmentAdverse effects
2018
An Energy Efficient Epileptic Seizure Detector
Abu Saveed, Mohanty S, Kougianos E, Zaveri H. An Energy Efficient Epileptic Seizure Detector. 2018, 1-4. DOI: 10.1109/icce.2018.8326063.Peer-Reviewed Original ResearchCommon neurological disorder
2017
Animal Models of Epilepsy
Koshal P, Jamwal S, Akula K, Bansal P. Animal Models of Epilepsy. 2017, 59-78. DOI: 10.1007/978-981-10-5981-0_5.Peer-Reviewed Original ResearchCentral nervous systemAntiepileptic drugsEpileptic seizuresPrinciple inhibitory neurotransmitterDevelopment of epilepsyLong-term outcomesType of epilepsyExcessive electrical dischargesGABAergic axon terminalsTreatment of epilepsyCommon neurological disorderPopulations of neuronsAmino butyric acidFrequent seizuresGABAB receptorsSecondary complicationsInhibitory neurotransmitterGABAA receptorsMotor disordersAxon terminalsEpileptic patientsHealthcare costsAnimal modelsNervous systemNeonatal stage
2015
Treatment of Chronic Migraine with Focus on Botulinum Neurotoxins
Schaefer SM, Gottschalk CH, Jabbari B. Treatment of Chronic Migraine with Focus on Botulinum Neurotoxins. Toxins 2015, 7: 2615-2628. PMID: 26184313, PMCID: PMC4516932, DOI: 10.3390/toxins7072615.Peer-Reviewed Original ResearchConceptsChronic migraineBotulinum toxin injection therapyLarge healthcare costsBotulinum toxin therapyTreatment of migraineCommon neurological disorderToxin therapyInjection therapyPathophysiological mechanismsMigraine pathophysiologyHealthcare costsMigraineNeurological disordersAnimal dataBotulinum neurotoxinTherapyTreatmentInjection techniqueCurrent understandingMedicationsPathophysiology
2011
Environmental Risk Factors for Paediatric Multiple Sclerosis
Makhani N, Banwell B. Environmental Risk Factors for Paediatric Multiple Sclerosis. European Neurological Review 2011, 6: 175. DOI: 10.17925/enr.2011.06.03.175.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMultiple sclerosisEnvironmental risk factorsRisk factorsAberrant immune responsePediatric multiple sclerosisCommon neurological disorderChildhood environmental exposuresDisease prevention strategiesImmune responseStudy of childrenPrevention strategiesNeurological disordersPediatric researchEnvironmental exposuresSclerosisCurrent understanding
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