2025
Early Blood Pressure Targets in Acute Spinal Cord Injury
Sajdeya R, Yanez N, Kampp M, Goodman M, Zonies D, Togioka B, Nunn A, Winfield R, Martin N, Kohli A, Huynh T, Okonkwo D, Poblete R, Gilmore E, Chesnut R, Bunnell A, Ohnuma T, Hashemaghaie M, Treggiari M. Early Blood Pressure Targets in Acute Spinal Cord Injury. JAMA Network Open 2025, 8: e2525364. PMID: 40965887, PMCID: PMC12447234, DOI: 10.1001/jamanetworkopen.2025.25364.Peer-Reviewed Original ResearchConceptsAcute spinal cord injurySpinal cord injuryRandomized clinical trialsConventional blood pressureBlood pressureCord injuryNeurological resuscitationConventional groupEarly blood pressure managementAmerican Spinal Injury Association Impairment Scale scoreSequential Organ Failure Assessment scoreEnd pointsOrgan Failure Assessment scoreClinical trials of patientsRandomized clinical trial of patientsBaseline to 6 monthsMotor scoresPrimary end pointMulticenter Randomized Clinical TrialSafety end pointTrial of patientsMechanical ventilatory supportAugmented blood pressureBlood pressure targetsIntensive care unit dischargeEarly Vasopressor Utilization in Critically Ill Patients With Acute Traumatic Spinal Cord Injury: A Retrospective Cohort Study.
Hashemaghaie M, Ohnuma T, Sajdeya R, Khandelwal S, Yanez N, Krishnamoorthy V, Raghunathan K, Devinney M, Depuru A, Treggiari M. Early Vasopressor Utilization in Critically Ill Patients With Acute Traumatic Spinal Cord Injury: A Retrospective Cohort Study. Critical Care Medicine 2025 PMID: 40693862, DOI: 10.1097/ccm.0000000000006791.Peer-Reviewed Original ResearchSpinal cord injuryAcute traumatic spinal cord injuryTraumatic spinal cord injuryLonger hospital lengthSkilled nursing facilityCord injuryCervical spinal cord injuryHigher injury severitySpinal cord injury patientsHospital length of stayNursing facilitiesLonger hospital length-of-stayInjury Severity ScoreResidual confoundingRetrospective cohort studyLength of stayU.S. hospitalsHealthcare databasesCohort studyDischarge dispositionHospital outcomesPremier Healthcare DatabasePrimary outcomeAcute spinal cord injuryInjury severity[18F]SynVesT-1 PET Detects SV2A Changes in the Spinal Cord and Brain of Rats with Spinal Cord Injury
Chen B, Zheng C, Balayeva T, Toyonaga T, Wang X, Tong J, Mennie W, Mihailovic J, Coman D, Hyder F, Strittmatter S, Carson R, Huang Y, Cai Z. [18F]SynVesT-1 PET Detects SV2A Changes in the Spinal Cord and Brain of Rats with Spinal Cord Injury. Journal Of Nuclear Medicine 2025, 66: 1440-1448. PMID: 40675757, PMCID: PMC12410297, DOI: 10.2967/jnumed.124.269291.Peer-Reviewed Original ResearchConceptsSpinal cord injuryDistribution volume ratioDiffusion tensor imagingSpinal cordRat modelDay 1SUV ratioImmunohistochemical stainingSham controlsDay 9PET imagingRat model of spinal cord injuryContusion SCI rat modelSpinal cord injury ratsModel of spinal cord injuryCord injuryWestern blottingModerate contusion injuryBrain of ratsDiffusion tensor imaging analysisPost-mortem spinal cordTraumatic spinal cord injurySCI rat modelSynaptic vesicle glycoprotein 2ACervical cordThe incidence and trends of diving-related spine injuries in the United States and risk factors associated with spinal cord injury
Seddio A, Jabbouri S, Vasudevan R, Gouzoulis M, Day W, Maloy G, Varthi A, Rubio D, Grauer J. The incidence and trends of diving-related spine injuries in the United States and risk factors associated with spinal cord injury. Spinal Cord 2025, 63: 352-358. PMID: 40490487, DOI: 10.1038/s41393-025-01098-6.Peer-Reviewed Original ResearchEstimated annual percentage changeSpine injuriesSpinal cord injuryRisk factorsLumbar spineInjury prevention programsAnnual percentage changePublic health initiativesCord injuryCervical spine surgeryMultivariate logistic regressionLog-linear regressionUnique risk factorsHealth initiativesUnited StatesCervical spondylolisthesisElixhauser Comorbidity IndexCervical spinePrevention programsAdministrative datasetsLogistic regressionSpine surgeryPercentage changeCervical stenosisOlder ageExtracellular Vesicle (EV) Targeted Cells Release Secondary Effector EVs: Indication of How To Account for Histocompatibility and Disease Specificity of EV Treatments
Askenase P. Extracellular Vesicle (EV) Targeted Cells Release Secondary Effector EVs: Indication of How To Account for Histocompatibility and Disease Specificity of EV Treatments. Journal Of Extracellular Vesicles 2025, 14: e70076. PMID: 40415199, PMCID: PMC12104073, DOI: 10.1002/jev2.70076.Peer-Reviewed Original ResearchConceptsMesenchymal stromal cellsSpinal cord injuryT cellsExtracellular vesiclesEffector T cellsSuppressor T cellsDisease specificityTreating spinal cord injuryImmune toleranceHistocompatibility barriersRecipient macrophagesEV treatmentStromal cellsTarget cellsCord injuryMSC-derivedPathological conditionsDiverse injuriesCellsInjuryDiseasePer treatmentTreatmentHealingHealing effectSpinal Cord Protection for Open Descending Thoracic and Thoracoabdominal Aorta Surgery: Analysis of The Society of Thoracic Surgeons Adult Cardiac Surgery Database
Amabile A, Bonnell L, Del Vecchio A, Basciano A, Antonios J, Kaneko T, Habib R, Di Luozzo G. Spinal Cord Protection for Open Descending Thoracic and Thoracoabdominal Aorta Surgery: Analysis of The Society of Thoracic Surgeons Adult Cardiac Surgery Database. The Annals Of Thoracic Surgery 2025, 120: 302-310. PMID: 40389192, DOI: 10.1016/j.athoracsur.2025.05.002.Peer-Reviewed Original ResearchThoracoabdominal aortic aneurysmsThoracoabdominal aortic aneurysm repairSpinal cord injuryDrain placementDTAA/TAAA repairDrain useThe Society of Thoracic Surgeons Adult Cardiac Surgery DatabaseSociety of Thoracic Surgeons Adult Cardiac Surgery DatabaseAdult Cardiac Surgery DatabaseOpen descending thoracicCardiac Surgery DatabaseSpinal cord protectionMultivariate logistic regression modelRate of spinal cord injuryArch involvementDescending ThoracicPreoperative paralysisSurgery DatabaseSpinal drainAdult patientsAortic rootAortic aneurysmLogistic regression modelsSpinal injuryStudy populationTraumatic Vertebral Artery Injury: Diagnosis, Natural History, and Key Considerations for Management
Teasdale B, Owolo E, Padmanaban V, Elsamadicy A, Amllay A, Shankar G, Krieger P, Regenhardt R, Hebert R, Stapleton C, Rabinov J, Matouk C, Patel A, Sujijantarat N. Traumatic Vertebral Artery Injury: Diagnosis, Natural History, and Key Considerations for Management. Journal Of Clinical Medicine 2025, 14: 3159. PMID: 40364191, PMCID: PMC12072270, DOI: 10.3390/jcm14093159.Peer-Reviewed Original ResearchVertebral artery injuryBlunt cervical spine traumaRisk of vertebral artery injuryNatural historyCervical spine traumaVertebral artery occlusionPotential risk of strokeRisk of strokeComprehensive narrative reviewCo-existing injuriesCervical traumaSpine traumaSpinal cord injuryIntracranial hemorrhageIschemic sequelaeEndovascular managementAntiplatelet therapySurgical interventionRecanalization rateArterial injuryArtery occlusionIncreased riskTherapeutic strategiesDiagnostic approachBony injuriesIntravenous infusion of mesenchymal stem cells increased axonal signal intensity in the rubrospinal tract in spinal cord injury
Hirota R, Sasaki M, Teramoto A, Yamashita T, Kocsis J, Honmou O. Intravenous infusion of mesenchymal stem cells increased axonal signal intensity in the rubrospinal tract in spinal cord injury. Molecular Brain 2025, 18: 35. PMID: 40241097, PMCID: PMC12004759, DOI: 10.1186/s13041-025-01210-0.Peer-Reviewed Original ResearchConceptsIntravenous infusion of mesenchymal stem cellsInfusion of mesenchymal stem cellsSpinal cord injuryIntravenous infusionMesenchymal stem cellsRubrospinal tractCircuit reorganizationInfused mesenchymal stem cellsCord injuryNeural circuit reorganizationNeuronal tracing techniquesSignal intensityInjury siteFunctional improvementSpontaneous recoveryStem cellsDescending tractsAxonal connectionsInjuryAxonal growthTractAxonal networkCrossing the Valley of Death in Spinal Cord Injury: Learning from Successful Translators
Failli V, Strittmatter S, Schwab M, Anderson A, Ruban A, Al-Ali H, Curt A, Cohen A, Hsieh J. Crossing the Valley of Death in Spinal Cord Injury: Learning from Successful Translators. Neurotrauma Reports 2025, 6: 298-310. PMID: 40309162, PMCID: PMC12040567, DOI: 10.1089/neur.2025.0029.Peer-Reviewed Original ResearchMultifaceted challenges of deep venous thrombosis in the setting tetraplegia and ulcerative colitis: case report
Mapelli P, Wright M, Hrdlicka H, Rosenblum D. Multifaceted challenges of deep venous thrombosis in the setting tetraplegia and ulcerative colitis: case report. Spinal Cord Series And Cases 2025, 11: 8. PMID: 40169539, PMCID: PMC11961597, DOI: 10.1038/s41394-025-00703-3.Peer-Reviewed Original ResearchConceptsDeep venous thrombosisClostridium difficile infectionSpinal cord injuryUlcerative colitisUC exacerbationVenous thrombosisDifficile infectionCase reportIncreased risk of deep venous thrombosisPotential risk of progressionCase presentationA 53-year-old maleTreatment of deep venous thrombosisRisk of deep venous thrombosisBowel programKnee deep venous thrombosisDeep venous thrombosis prophylaxisRisk of progressionBilateral lower extremitiesRisk of thrombosisInflammatory bowel diseaseRisk of diarrheaBleeding complicationsDiscontinuing anticoagulationBleeding riskIVC filtersTraumatic vertebral artery occlusion is associated with high rates of recanalization: insights from a systematic review and meta-analysis
Sujijantarat N, Fathima B, Padmanaban V, Kosyakovsky J, Elsamadicy A, Haynes J, Koo A, Shankar G, Regenhardt R, Stapleton C, Rabinov J, Hebert R, Matouk C, Patel A. Traumatic vertebral artery occlusion is associated with high rates of recanalization: insights from a systematic review and meta-analysis. Neurosurgical Review 2025, 48: 306. PMID: 40097874, DOI: 10.1007/s10143-025-03460-x.Peer-Reviewed Original ResearchConceptsSpine interventionsSpinal cord injuryCervical deformityMeta-analysisSystematic reviewCord injuryRandom-effects meta-analysisAssociated with spinal cord injuryManual citation searchingEffects meta-analysisMeta-analysis of literaturePost-interventionFollow-upIncidence of strokeCitation searchingCervical injuryArtery occlusionAssociated with higher ratesNon-embolized patientsFollow-up periodVertebral artery occlusionInterventionInitial admissionClinical practicePatient populationImaging Demyelinated Axons After Spinal Cord Injuries with PET Tracer [18F]3F4AP
Ramos-Torres K, Conti S, Zhou Y, Tiss A, Caravagna C, Takahashi K, He M, Wilks M, Eckl S, Sun Y, Biundo J, Gong K, He Z, Linnman C, Brugarolas P. Imaging Demyelinated Axons After Spinal Cord Injuries with PET Tracer [18F]3F4AP. Journal Of Nuclear Medicine 2025, 66: jnumed.124.268242. PMID: 39819685, PMCID: PMC11800733, DOI: 10.2967/jnumed.124.268242.Peer-Reviewed Original ResearchSpinal cord injuryDemyelinated axonsIncomplete injuryPostmortem spinal cord tissueSpinal cord blood flowSpinal cord injury ratsResponse to therapyCord injuryCord blood flowManagement of spinal cord injurySpinal cord tissuePET imaging resultsSensitive to injuryInjured segmentContusion injuryAxonal lossCord tissueDemyelinating changesAnimal modelsDemyelinationPET imagingBlood flowPET tracersWorsening disabilityTracer binding
2024
Mesenchymal Stem Cells and Their Extracellular Vesicles: Therapeutic Mechanisms for Blood–Spinal Cord Barrier Repair Following Spinal Cord Injury
Nakazaki M, Yokoyama T, Lankford K, Hirota R, Kocsis J, Honmou O. Mesenchymal Stem Cells and Their Extracellular Vesicles: Therapeutic Mechanisms for Blood–Spinal Cord Barrier Repair Following Spinal Cord Injury. International Journal Of Molecular Sciences 2024, 25: 13460. PMID: 39769223, PMCID: PMC11677717, DOI: 10.3390/ijms252413460.Peer-Reviewed Original ResearchConceptsBlood-spinal cord barrierBSCB repairMesenchymal stromal/stem cellsSpinal cord injuryMSC-EVsMesenchymal stromal/stem cell therapyBlood-spinal cord barrier integritySpinal cord homeostasisBlood-spinal cord barrier permeabilityCord injuryImpaired axonal regenerationTreating spinal cord injuryCell-free alternativeExtracellular vesiclesTight junction proteinsSpinal neural tissueBlood-brain barrierImprove patient outcomesAnti-inflammatory propertiesImmune cellsPreclinical studiesJunction proteinsSecreted extracellular vesiclesClinical trialsReduce inflammationIntravenous Infusion of Autologous Mesenchymal Stem Cells Expanded in Auto Serum for Chronic Spinal Cord Injury Patients: A Case Series
Hirota R, Sasaki M, Iyama S, Kurihara K, Fukushi R, Obara H, Oshigiri T, Morita T, Nakazaki M, Namioka T, Namioka A, Onodera R, Kataoka-Sasaki Y, Oka S, Takemura M, Ukai R, Yokoyama T, Sasaki Y, Yamashita T, Kobayashi M, Okuma Y, Kondo R, Aichi R, Ohmatsu S, Kawashima N, Ito Y, Kobune M, Takada K, Ishiai S, Ogata T, Teramoto A, Yamashita T, Kocsis J, Honmou O. Intravenous Infusion of Autologous Mesenchymal Stem Cells Expanded in Auto Serum for Chronic Spinal Cord Injury Patients: A Case Series. Journal Of Clinical Medicine 2024, 13: 6072. PMID: 39458022, PMCID: PMC11509003, DOI: 10.3390/jcm13206072.Peer-Reviewed Original ResearchAmerican Spinal Injury Association Impairment ScaleSevere spinal cord injuryMesenchymal stem cell infusionAutologous mesenchymal stem cellsIntravenous infusionCase seriesMesenchymal stem cellsQuality of lifeAuto-serumSpinal cord injuryFunctional improvementChronic spinal cord injury patientsIntravenous infusion of mesenchymal stem cellsInfusion of mesenchymal stem cellsStem cellsCord injurySpinal Cord Independence Measure IIIAmerican Spinal Injury Association Impairment Scale grades CSpinal cord injury patientsChronic SCI patientsClassification of Spinal Cord InjuryNeurological Classification of Spinal Cord InjurySignificant functional improvementAssociation Impairment ScaleInternational Standards for Neurological Classification of Spinal Cord InjuryThere Is More to Life Than Walking: A Qualitative Study of Survivorship Among Peer Mentors in the Spinal Cord Injury Community
Kayani T, Cotter R, Sigworth J, Doolittle B. There Is More to Life Than Walking: A Qualitative Study of Survivorship Among Peer Mentors in the Spinal Cord Injury Community. The Yale Journal Of Biology And Medicine 2024, 97: 271-280. PMID: 39351326, PMCID: PMC11426298, DOI: 10.59249/yxeb6783.Peer-Reviewed Original ResearchConceptsPeer mentorship programSpinal cord injuryMentorship programSurvivorship journeySpinal cord injury survivorsPeer mentoringSpinal cord injury communityPost-injuryPost-injury rehabilitationPromote independent livingSemi-structured interviewsCommunity integrationStudies of survivorshipThematic analysisFamily supportQualitative studyEmotional copingIndependent livingTwenty-eight membersCord injuryLongitudinal effectsLife satisfactionAccessibility challengesSurvivorshipPost-SCIPAK1 inhibition with Romidepsin attenuates H‐reflex hyperexcitability after spinal cord injury
Kauer S, Benson C, Carrara J, Tarafder A, Ibrahim Y, Estacion M, Waxman S, Tan A. PAK1 inhibition with Romidepsin attenuates H‐reflex hyperexcitability after spinal cord injury. The Journal Of Physiology 2024, 602: 5061-5081. PMID: 39231098, DOI: 10.1113/jp284976.Peer-Reviewed Original ResearchDendritic spine dysgenesisSpinal cord injurySCI-induced spasticityRomidepsin treatmentSpine dysgenesisLoss of rate-dependent depressionCutaneous T-cell lymphomaTreatment of cutaneous T-cell lymphomaContusive spinal cord injuryT-cell lymphomaSpinal cord injury animalsCord injuryRate-dependent depressionExaggerated reflex responsesH-reflex changesSpinal cord injury mouse modelManaging spasticityReduce spasticityReporter micePreclinical utilityDrug responseRomidepsinControl cohortIntervention effectsSpinal hyperreflexiaFACTFINDERS FOR PATIENT SAFETY: Minimizing risks with cervical epidural injections
Holder E, Lee H, Raghunandan A, Marshall B, Michalik A, Nguyen M, Saffarian M, Schneider B, Smith C, Tiegs-Heiden C, Zheng P, Patel J, Levi D, Committee I. FACTFINDERS FOR PATIENT SAFETY: Minimizing risks with cervical epidural injections. Interventional Pain Medicine 2024, 3: 100430. PMID: 39502902, PMCID: PMC11536293, DOI: 10.1016/j.inpm.2024.100430.Peer-Reviewed Original ResearchEpidural steroid injectionsCervical transforaminal epidural steroid injectionsTransforaminal epidural steroid injectionCervical epidural injectionsSpinal cord injurySteroid injectionContralateral obliqueDural punctureEpidural hematomaCervical interlaminar epidural steroid injectionCord injuryEpidural injectionEpidural spaceCatastrophic neurologic injuryLoss of resistanceInterlaminar epidural steroid injectionsComplication of dural punctureComplication of spinal cord injuryNeedle placementCase reports of patientsReview of cross-sectional imagingSevere systemic complicationsInadvertent dural puncturePatient safetyReports of patientsUtilization and timing of surgical intervention for central cord syndrome in the United States
Dhodapkar M, Halperin S, Seddio A, Dahodwala T, Rubio D, Grauer J. Utilization and timing of surgical intervention for central cord syndrome in the United States. European Spine Journal 2024, 33: 3645-3651. PMID: 39103615, DOI: 10.1007/s00586-024-08431-2.Peer-Reviewed Original ResearchCentral cord syndromeSurgical interventionAbsence of bony injuryOperative interventionCord syndromeBony injuriesPredictors of operative managementAbsence of vertebral fracturesTiming of surgical interventionTiming of operative interventionCohort of patientsProportion of patientsDays of diagnosisHigher comorbidity burdenVertebral fracturesSpinal cord injuryMethodsAdult patientsNon-operativelyNonsurgical interventionsMultivariate analysisStudy assessed utilizationComorbidity burdenIncomplete spinal cord injuryPatientsInclusion criteriaSelf-Assembled Fibroblast Growth Factor Nanoparticles as a Therapeutic for Oxidant-Induced Neuronal and Skin Cell Injury
Kumar S, Chu A, Theis T, Rastogi S, Costea D, Banerjee R, Das B, Yarmush M, Hsia H, Cohen R, Schachner M, Berthiaume F. Self-Assembled Fibroblast Growth Factor Nanoparticles as a Therapeutic for Oxidant-Induced Neuronal and Skin Cell Injury. ACS Applied Bio Materials 2024, 7: 5158-5170. PMID: 39038169, DOI: 10.1021/acsabm.4c00135.Peer-Reviewed Original ResearchSpinal cord injuryFGF-2Cell injuryTraumatic brain injurySkin wound healingResponses in vivoInflammatory response in vivoWound healingPressure woundsOxidant-mediated injuryFibroblast growth factor-2Growth factor 2Delayed injuryLocal inflammationNanoparticle sizeChronic skin woundsSecondary complicationsCultured neuronal cellsEndothelial cellsGrowth factorPromote neurite outgrowthCord injuryNeurological sensationsRecombinant fusion proteinNanoparticlesScreening and Prophylaxis for Venous Thromboembolism in Pediatric Surgery: A Systematic Review
Kelley-Quon L, Acker S, St Peter S, Goldin A, Yousef Y, Ricca R, Mansfield S, Sulkowski J, Huerta C, Lucas D, Rialon K, Christison-Lagay E, Ham P, Rentea R, Beres A, Kulaylat A, Chang H, Polites S, Diesen D, Gonzalez K, Wakeman D, Baird R. Screening and Prophylaxis for Venous Thromboembolism in Pediatric Surgery: A Systematic Review. Journal Of Pediatric Surgery 2024, 59: 161585. PMID: 38964986, DOI: 10.1016/j.jpedsurg.2024.05.015.Peer-Reviewed Original ResearchIncidence of venous thromboembolismVenous thromboembolismPharmacological prophylaxisSystematic reviewUltrasound screeningEpidemiology of venous thromboembolismAmerican Pediatric Surgical Association OutcomesPreferred Reporting ItemsStudy systematically reviewsLow-molecular-weight heparinRoutine ultrasound screeningCongenital heart diseasePediatric trauma populationPediatric surgical populationBody mass indexPediatric surgical patientsMolecular weight heparinSequential compression devicesInjury Severity ScoreCentral line placementSpinal cord injuryInflammatory bowel diseaseWeb of Science databasesLength of stayReporting Items
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