2023
Child Pedestrian Safety.
Kendi S, Johnston B, Hoffman B, Agran P, Culyba A, Dodington J, Lee L, McFadden T, Monroe K, Tenenbein M, Quinlan K, Beno S, Dixon C, Dunn L, Midgett J, Miller B, Qualters J, Kozial B. Child Pedestrian Safety. 2023, 152 PMID: 37337837, DOI: 10.1542/peds.2023-062506.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsAmerican AcademyPediatrics policy statementEvidence-based adviceCommunity pediatriciansSevere injuriesPublic healthPediatriciansChild pedestriansSafety precautionsActive transportationSpecific risksSafetyRiskIndependent mobilityDistracted walkingDifferent agesPedestrian educationPedestrian safetyTraffic fatalitiesInjuryPediatricsEpidemiology and Prevention of Child Pedestrian Injury.
Kendi S, Johnston B, Hoffman B, Agran P, Culyba A, Dodington J, Lee L, McFadden T, Monroe K, Tenenbein M, Quinlan K, Beno S, Dixon C, Dunn L, Midgett J, Miller B, Qualters J, Kozial B. Epidemiology and Prevention of Child Pedestrian Injury. 2023, 152 PMID: 37337844, DOI: 10.1542/peds.2023-062508.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsPrevious policy statementChild pedestrian injuriesPublic healthChild pedestrian safetyTransportation injuriesPolicy statementsEvidence basePedestrian injuriesSafety initiativesInjuryChild pedestriansPolicy recommendationsSafety precautionsActive transportationSpecific risksSafetyRiskIndependent mobilityDistracted walkingDifferent agesHealthPedestrian safetyPedestrian educationReportUrban design
2021
Safety considerations for esophageal dilation by anesthetic type: A systematic review
Lerner MZ, Bourdillon AT, Dai F, Brackett A, Kohli N. Safety considerations for esophageal dilation by anesthetic type: A systematic review. American Journal Of Otolaryngology 2021, 42: 103128. PMID: 34216877, DOI: 10.1016/j.amjoto.2021.103128.Peer-Reviewed Original ResearchConceptsEsophageal dilationOffice-based techniqueSystematic reviewDerSimonian-Laird random-effects modelType of anesthesiaSmall case seriesOffice-based proceduresFull-text studiesUse of stentsRandom-effects modelComprehensive literature searchInverse variance weightingAdverse eventsAnesthetic typeCase seriesIntravenous sedationGeneral anesthesiaHigh morbidityAnesthesia techniquesLocal anesthesiaEmbase databasesExclusion criteriaEquivalent safetyPRISMA guidelinesRare diseaseA Broader View of Risk to Health Care Workers: Perspectives on Supporting Vulnerable Health Care Professional Households During COVID-19
Donroe JH, Rabin TL, Hsieh E, Schwartz JI. A Broader View of Risk to Health Care Workers: Perspectives on Supporting Vulnerable Health Care Professional Households During COVID-19. Academic Medicine 2021, 96: 1233-1235. PMID: 34039858, PMCID: PMC8378440, DOI: 10.1097/acm.0000000000004175.Commentaries, Editorials and LettersConceptsVulnerable householdsHigh-risk family membersCOVID-19 pandemicState of emergencyFull-time workRange of concernsFamily responsibilitiesFamily safetyFrontline workersSupport networksChallenges of planningFamily membersHealth care workersHealth care providersHouseholdsHealth care professionalsCOVID-19Health care settingsUncertain timesBroad riskPersonal hazardWorkersCare settingsThreat of illnessCare providers
2020
Effectiveness of seasonal malaria chemoprevention at scale in west and central Africa: an observational study
Partnership A, Baba E, Hamade P, Kivumbi H, Marasciulo M, Maxwell K, Moroso D, Roca-Feltrer A, Sanogo A, Johansson J, Tibenderana J, Abdoulaye R, Coulibaly P, Hubbard E, Jah H, Lama E, Razafindralambo L, Van Hulle S, Jagoe G, Tchouatieu A, Collins D, Gilmartin C, Tetteh G, Djibo Y, Ndiaye F, Kalleh M, Kandeh B, Audu B, Ntadom G, Kiba A, Savodogo Y, Boulotigam K, Sougoudi D, Guilavogui T, Keita M, Kone D, Jackou H, Ouba I, Ouedraogo E, Messan H, Jah F, Kaira M, Sano M, Traore M, Ngarnaye N, Elagbaje A, Halleux C, Merle C, Iessa N, Pal S, Sefiani H, Souleymani R, Laminou I, Doumagoum D, Kesseley H, Coldiron M, Grais R, Kana M, Ouedraogo J, Zongo I, Eloike T, Ogboi S, Achan J, Bojang K, Ceesay S, Dicko A, Djimde A, Sagara I, Diallo A, NdDiaye J, Loua K, Beshir K, Cairns M, Fernandez Y, Lal S, Mansukhani R, Muwanguzi J, Scott S, Snell P, Sutherland C, Tuta R, Milligan P. Effectiveness of seasonal malaria chemoprevention at scale in west and central Africa: an observational study. The Lancet 2020, 396: 1829-1840. PMID: 33278936, PMCID: PMC7718580, DOI: 10.1016/s0140-6736(20)32227-3.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAfrica, CentralAfrica, WesternAmodiaquineAntimalarialsCase-Control StudiesChemopreventionChildCost-Benefit AnalysisDrug CombinationsDrug ResistanceFeasibility StudiesHumansIncidenceMalariaProgram EvaluationPyrimethamineSafetySeasonsSulfadoxineSurveys and QuestionnairesYoung AdultConceptsSeasonal malaria chemopreventionCase-control studyHigh transmission periodMalaria chemopreventionObservational studyHealth-care staff timeHigh malaria transmission seasonDrug resistanceSerious adverse drug reactionsMalaria transmission seasonSerious adverse reactionsSevere skin reactionsCommunity health workersNational health management information systemAdverse drug reactionsCost-effectiveness ratioHealth Management Information SystemIndividual case safetyTarget populationMarker of resistanceSMC treatmentHospital admissionOutpatient clinicDrug reactionsSkin reactionsLearning About Safety: Conditioned Inhibition as a Novel Approach to Fear Reduction Targeting the Developing Brain
Odriozola P, Gee DG. Learning About Safety: Conditioned Inhibition as a Novel Approach to Fear Reduction Targeting the Developing Brain. American Journal Of Psychiatry 2020, 178: 136-155. PMID: 33167673, PMCID: PMC7951569, DOI: 10.1176/appi.ajp.2020.20020232.Peer-Reviewed Original ResearchConceptsSafety signal learningExtinction learningSignal learningAnxiety disordersAnxious youthSafety cuesDorsal anterior cingulate cortexInhibition of fearFronto-amygdala circuitryCross-species evidenceAnterior cingulate cortexFear responsesAnxiety-like behaviorFrontolimbic circuitryCingulate cortexNeural circuitryCore featuresPrelimbic cortexBasic neuroscienceTranslational frameworkCuesYouthFearLearningAnimal modelsNeuroprotection by remote ischemic conditioning in the setting of acute ischemic stroke: a preclinical two-centre study
Basalay M, Wiart M, Chauveau F, Dumot C, Leon C, Amaz C, Bolbos R, Cash D, Kim E, Mechtouff L, Cho T, Nighoghossian N, Davidson S, Ovize M, Yellon D. Neuroprotection by remote ischemic conditioning in the setting of acute ischemic stroke: a preclinical two-centre study. Scientific Reports 2020, 10: 16874. PMID: 33037284, PMCID: PMC7547701, DOI: 10.1038/s41598-020-74046-4.Peer-Reviewed Original ResearchConceptsRemote ischemic conditioningAcute ischemic strokeInfarct sizeIschemic strokeNeuroprotective effect of remote ischemic conditioningEffect of remote ischemic conditioningIschemic conditionsTargeting reperfusion injuryMiddle cerebral artery occlusionT2-weighted MRIImprove functional recoveryCerebral artery occlusionHind limb ischemiaReduced infarct sizeArea at riskPrimary endpointSecondary endpointsNeurofunctional outcomesInfarct growthMale ratsReperfusion injuryMultivariate analysisArtery occlusionImaging endpointsLesion sizeEvaluating and Deploying Covid-19 Vaccines — The Importance of Transparency, Scientific Integrity, and Public Trust
Schwartz JL. Evaluating and Deploying Covid-19 Vaccines — The Importance of Transparency, Scientific Integrity, and Public Trust. New England Journal Of Medicine 2020, 383: 1703-1705. PMID: 32966716, DOI: 10.1056/nejmp2026393.Peer-Reviewed Original ResearchFirst-in-Human Assessment of 11C-LSN3172176, an M1 Muscarinic Acetylcholine Receptor PET Radiotracer
Naganawa M, Nabulsi N, Henry S, Matuskey D, Lin SF, Slieker L, Schwarz AJ, Kant N, Jesudason C, Ruley K, Navarro A, Gao H, Ropchan J, Labaree D, Carson RE, Huang Y. First-in-Human Assessment of 11C-LSN3172176, an M1 Muscarinic Acetylcholine Receptor PET Radiotracer. Journal Of Nuclear Medicine 2020, 62: 553-560. PMID: 32859711, PMCID: PMC8049371, DOI: 10.2967/jnumed.120.246967.Peer-Reviewed Original ResearchConceptsSimplified reference tissue modelM1 receptorsHealthy subjectsMuscarinic acetylcholine receptor subtype M1Distribution volumePET radiotracersAbsolute test-retest variabilityExcellent test-retest reproducibilityReference tissue model 2Total distribution volumeSuitable reference regionTest-retest reproducibilityTest-retest variabilityReference regionTest-retest protocolNondisplaceable distribution volumeReference tissue modelTest-retest studySubtypes M1Preclinical studiesRegional time-activity curvesAcetylcholine concentrationHuman studiesReceptor occupancyTime-activity curvesFirst-in-Human Evaluation of 18F-SynVesT-1, a Radioligand for PET Imaging of Synaptic Vesicle Glycoprotein 2A
Naganawa M, Li S, Nabulsi N, Henry S, Zheng MQ, Pracitto R, Cai Z, Gao H, Kapinos M, Labaree D, Matuskey D, Huang Y, Carson RE. First-in-Human Evaluation of 18F-SynVesT-1, a Radioligand for PET Imaging of Synaptic Vesicle Glycoprotein 2A. Journal Of Nuclear Medicine 2020, 62: 561-567. PMID: 32859701, PMCID: PMC8049363, DOI: 10.2967/jnumed.120.249144.Peer-Reviewed Original ResearchConceptsC-UCBSynaptic densityRegional time-activity curvesTime-activity curvesDistribution volumeMetabolite-corrected arterial input functionPET imagingMultilinear analysis 1Synaptic vesicle glycoprotein 2AAntiepileptic drug levetiracetamTotal distribution volumeNondisplaceable distribution volumeCentrum semiovaleBlocking doseHealthy volunteersHuman studiesDrug levetiracetamLassen plotNeuropsychiatric disordersPET radioligandArterial input functionNonhuman primatesLevetiracetamReference regionRadioligandLeading Change to Address the Needs and Well-Being of Trainees During the COVID-19 Pandemic
Weiss PG, Li ST. Leading Change to Address the Needs and Well-Being of Trainees During the COVID-19 Pandemic. Academic Pediatrics 2020, 20: 735-741. PMID: 32512054, PMCID: PMC7273143, DOI: 10.1016/j.acap.2020.06.001.Peer-Reviewed Original ResearchBetacoronavirusChange ManagementCoronavirus InfectionsCOVID-19Education, Medical, GraduateEmpowermentFoodHealth StatusHumansInternship and ResidencyMental HealthNeeds AssessmentOrganizational PolicyPandemicsPediatricsPersonal Protective EquipmentPneumonia, ViralSafetySARS-CoV-2Self ConceptSleepSocial SupportBiodistribution and internal radiation dosimetry of a novel probe for thymidine phosphorylase imaging, [123I]IIMU, in healthy volunteers
Watanabe S, Nishijima KI, Okamoto S, Magota K, Hirata K, Toyonaga T, Shiga T, Kuge Y, Tamaki N. Biodistribution and internal radiation dosimetry of a novel probe for thymidine phosphorylase imaging, [123I]IIMU, in healthy volunteers. Annals Of Nuclear Medicine 2020, 34: 595-599. PMID: 32361818, DOI: 10.1007/s12149-020-01469-4.Peer-Reviewed Original ResearchConceptsΜSv/MBqHealthy volunteersOLINDA/EXM 1.1 softwareEffective dosesWhole-body emission scansThymidine phosphorylaseResultsNo adverse eventsHealthy male adultsHigh uptakePotential clinical useMean effective dosesHigh-uptake organsAdverse eventsSingle doseInternal radiation dosimetryBlood samplesRenal systemTime-activity curvesHealthy adultsInjected activityScreening testNew radiotracersClinical useTime pointsMale adultsSafety of oral naltrexone in HIV-positive men who have sex with men and transgender women with alcohol use disorder and initiating antiretroviral therapy
Gonzales P, Grieco A, White E, Ding R, Ignacio RB, Pinto-Santini D, Lama JR, Altice FL, Duerr A. Safety of oral naltrexone in HIV-positive men who have sex with men and transgender women with alcohol use disorder and initiating antiretroviral therapy. PLOS ONE 2020, 15: e0228433. PMID: 32134956, PMCID: PMC7058313, DOI: 10.1371/journal.pone.0228433.Peer-Reviewed Original ResearchConceptsAlcohol use disorderAntiretroviral therapyClinical adverse eventsAdverse eventsTransgender womenUse disordersDouble-blind randomized placebo-controlled trialMSM/transgender womenRandomized placebo-controlled trialART-naïve participantsPossibility of hepatotoxicityPlacebo-controlled trialSerious adverse eventsHIV-positive menMedication-Assisted TherapyProportion of subjectsAdverse event dataMultiple new medicationsOral naltrexoneStudy medicationTransaminase elevationPlacebo armNTX treatmentTreatment armsNew medicationsCharacterising near misses and injuries in the temporary agency construction workforce: qualitative study approach
Santiago K, Yang X, Ruano-Herreria EC, Chalmers J, Cavicchia P, Caban-Martinez AJ. Characterising near misses and injuries in the temporary agency construction workforce: qualitative study approach. Occupational And Environmental Medicine 2020, 77: 94-99. PMID: 31896614, DOI: 10.1136/oemed-2019-106215.Peer-Reviewed Original ResearchConceptsNon-standard workersTemporary workersConstruction industryNear missesWorker levelFocus group discussionsTemporary staffing agenciesWorkplace safety hazardsHealth priorityInjury severityInjuryGeneral inductive approachHealth concernGroup discussionsUnique barriersConvenience sampleWorkplace injuriesStaffing agenciesQualitative study approachReporting practicesOrganisational levelDemographic questionnaireHealth risksSafety concernsConstruction workforce
2019
Systematic review of child restraint system interventions (2007–2018)
Glerum K, Zonfrillo M, Fleisher L, McDonald C. Systematic review of child restraint system interventions (2007–2018). Traffic Injury Prevention 2019, 20: 866-872. PMID: 31725324, DOI: 10.1080/15389588.2019.1666372.Peer-Reviewed Original ResearchThe impact of safety‐net burden on in‐hospital outcomes after surgical aortic valve replacement
Ando T, Adegbala O, Akintoye E, Briasoulis A, Takagi H. The impact of safety‐net burden on in‐hospital outcomes after surgical aortic valve replacement. Journal Of Cardiac Surgery 2019, 34: 1178-1184. PMID: 31441545, DOI: 10.1111/jocs.14187.Peer-Reviewed Original ResearchConceptsSurgical aortic valve replacementSafety-net burdenAortic valve replacementSAVR outcomesValve replacementAcute kidney injuryMajor perioperative complicationsHospital-level characteristicsNationwide Inpatient SampleLength of staySafety-net hospitalNumber of admissionsHospital mortalityNonroutine dischargeValvular surgeryHospital outcomesHospital stayKidney injuryPerioperative complicationsDisadvantaged patientsInpatient SampleHospital costsUnadjusted modelsHospitalPatientsSerious adverse events in patients with idiopathic pulmonary fibrosis in the placebo arms of 6 clinical trials
Wuyts W, Antin-Ozerkis D, Huggins JT, LaCamera PP, Spagnolo P, Vašáková M, Wijsenbeek MS, Polman B, Kirchgaessler KU, Scholand MB. Serious adverse events in patients with idiopathic pulmonary fibrosis in the placebo arms of 6 clinical trials. Respiratory Medicine 2019, 150: 120-125. PMID: 30961937, DOI: 10.1016/j.rmed.2019.02.021.Peer-Reviewed Original ResearchConceptsSerious adverse eventsIdiopathic pulmonary fibrosisAdverse eventsPulmonary fibrosisClinical trialsCardiac disordersFatal interstitial lung diseaseInterstitial lung diseaseRespiratory failureCommon comorbiditiesPlacebo armLung functionFatal outcomeLung diseasePooled analysisMyocardial infarctionUnpredictable courseDisease progressionFatal infectionSafety dataPatientsPlaceboFibrosisInfectionTrialsCollective Efficacy as a Key Context in Neighborhood Support for Urban Youth
Prince DM, Hohl B, Hunter BA, Thompson AB, Matlin SL, Hausman AJ, Tebes JK. Collective Efficacy as a Key Context in Neighborhood Support for Urban Youth. American Journal Of Community Psychology 2019, 63: 179-189. PMID: 30843253, PMCID: PMC6676898, DOI: 10.1002/ajcp.12311.Peer-Reviewed Original ResearchConceptsAdult supportNeighborhood youthCollective efficacyAdults' perceptionsPositive youth developmentYouth antisocial behaviorYouth developmentAntisocial behaviorStigmatized groupsIndirect relationshipSense of alienationPath modelNeighborhood constructsSocial environmentTransactional approachNegative perceptionsPerceptionYouthNeighborhood contextNeighborhood supportUrban youthKey contextsYoung peopleNeighborhood physical environmentNeighborhood conditions
2018
Bleeding events and safety outcomes in persons with haemophilia A with inhibitors: A prospective, multi‐centre, non‐interventional study
Mahlangu J, Oldenburg J, Callaghan M, Shima M, Santagostino E, Moore M, Recht M, Garcia C, Yang R, Lehle M, Macharia H, Asikanius E, Levy G, Kruse‐Jarres R. Bleeding events and safety outcomes in persons with haemophilia A with inhibitors: A prospective, multi‐centre, non‐interventional study. Haemophilia 2018, 24: 921-929. PMID: 30295389, DOI: 10.1111/hae.13612.Peer-Reviewed Original ResearchConceptsActivated prothrombin complex concentrateNon-interventional studyAdverse eventsHemophilia AProphylaxis adherenceAPCC prophylaxisBleeding rateFactor VIIIViral upper respiratory tract infectionMulti-centreSafety outcomesUpper respiratory tract infectionAnnualized bleeding rateRecombinant activated FVIIProthrombin complex concentrateRespiratory tract infectionsInhibitor historyPrescribed doseBleeding eventsTract infectionsTreat bleedingStandard treatmentBleedingEffective treatmentPWHAIn utero nanoparticle delivery for site-specific genome editing
Ricciardi AS, Bahal R, Farrelly JS, Quijano E, Bianchi AH, Luks VL, Putman R, López-Giráldez F, Coşkun S, Song E, Liu Y, Hsieh WC, Ly DH, Stitelman DH, Glazer PM, Saltzman WM. In utero nanoparticle delivery for site-specific genome editing. Nature Communications 2018, 9: 2481. PMID: 29946143, PMCID: PMC6018676, DOI: 10.1038/s41467-018-04894-2.Peer-Reviewed Original ResearchConceptsSite-specific genome editingReversal of splenomegalyPeptide nucleic acidIntra-amniotic administrationBlood hemoglobin levelsMonogenic disordersNanoparticle deliveryPolymeric nanoparticlesPostnatal elevationGestational ageHemoglobin levelsImproved survivalPediatric morbidityDisease improvementHuman β-thalassemiaReticulocyte countNormal organ developmentMouse modelNormal rangeEarly interventionGenome editingOff-target mutationsPostnatal growthGene editingVersatile method
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