2025
Sedation for moderate‐to‐severe traumatic brain injury in adults
Williamson D, Dryden L, Cheng W, Hutton B, Skidmore B, Mehta S, Golan E, Turgeon A, Adhikari N, Rose L, Burry L. Sedation for moderate‐to‐severe traumatic brain injury in adults. Cochrane Database Of Systematic Reviews 2025, 2025: cd012639. PMID: 40326601, PMCID: PMC12053465, DOI: 10.1002/14651858.cd012639.pub2.Peer-Reviewed Original ResearchPain Management in the Older Adults A Narrative Review
Rajput K, Ng J, Zwolinski N, Chow R. Pain Management in the Older Adults A Narrative Review. Clinics In Geriatric Medicine 2025, 41: 131-151. PMID: 39551538, DOI: 10.1016/j.cger.2024.03.011.Peer-Reviewed Original ResearchConceptsPain managementOlder adult populationOlder adult patientsOlder adultsAdult populationMultiple medicationsLife expectancyClinical practiceAdult patientsMedical managementPreexisting comorbiditiesPainUnited StatesDegenerative processPracticeNonagenariansMedicationAdultsComorbiditiesReviewManagementOctogenariansPatientsNav1.8, an analgesic target for nonpsychotomimetic phytocannabinoids
Ghovanloo M, Tyagi S, Zhao P, Waxman S. Nav1.8, an analgesic target for nonpsychotomimetic phytocannabinoids. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2416886122. PMID: 39835903, PMCID: PMC11789019, DOI: 10.1073/pnas.2416886122.Peer-Reviewed Original ResearchConceptsExcitation of peripheral sensory neuronsTherapeutic potential of cannabinoidsPotential of cannabinoidsPeripheral sensory neuronsVoltage-gated sodiumSpectrum of adverse effectsNociceptor excitabilityPain signalsIn vivo studiesAnalgesic targetsPain treatmentAttenuate painRepetitive firingNav1.8Sensory neuronsTreatment optionsClinical studiesInhibit excitabilityAnalgesic compoundsPainTherapeutic potentialCannabigerolProof-of-principalAdverse effectsTreatment
2024
Efficacy of GABA aminotransferase inactivator OV329 in models of neuropathic and inflammatory pain without tolerance or addiction
Wirt J, Ferreira L, Jesus C, Woodward T, Oliva I, Xu Z, Crystal J, Pepin R, Silverman R, Hohmann A. Efficacy of GABA aminotransferase inactivator OV329 in models of neuropathic and inflammatory pain without tolerance or addiction. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 122: e2318833121. PMID: 39793055, PMCID: PMC11725897, DOI: 10.1073/pnas.2318833121.Peer-Reviewed Original ResearchConceptsComplete Freund's adjuvantInflammatory painMechanical hypersensitivityAntinociceptive efficacyGlutamate levelsInjection of complete Freund's adjuvantConditioned place preference assayPaclitaxel-induced mechanical hypersensitivitySpinal site of actionSide effectsEnhancement of GABAergic transmissionChemotherapeutic agent paclitaxelPaclitaxel-induced increaseCompared to morphineLumbar spinal cordIncreased endogenous GABA levelsReduced glutamate levelsNeuropathic nociceptionSite of actionGABAergic transmissionAnalgesic strategiesPathological painGABAergic inhibitionSpinal sitesAbuse liabilityReal-world impact of acupuncture on analgesics and healthcare resource utilization in breast cancer survivors with pain
Ng D, Lee S, Lee R, Wang Y, Chan A. Real-world impact of acupuncture on analgesics and healthcare resource utilization in breast cancer survivors with pain. BMC Medicine 2024, 22: 394. PMID: 39285302, PMCID: PMC11406884, DOI: 10.1186/s12916-024-03626-2.Peer-Reviewed Original ResearchConceptsBreast cancer survivorsImpact of acupunctureCancer survivorsHealthcare resource utilizationHealthcare costsAcupuncture-treated patientsHigh-utilizing patientsTotal healthcare costsShort-term opioidsCommercial health insuranceAcupuncture utilizationAcupuncture-treatedPost-acupunctureAcupuncture effectsPrevalence of opioidsMusculoskeletal painAcupunctureCancer diagnosisHealth insuranceReal-world settingsNSAID usePrescription fillsHealthcareUnited StatesResource utilizationRegional anesthesia for transplantation surgery ‐ A White Paper Part 2: Abdominal transplantation surgery
Ander M, Mugve N, Crouch C, Kassel C, Fukazawa K, Isaak R, Deshpande R, McLendon C, Huang J. Regional anesthesia for transplantation surgery ‐ A White Paper Part 2: Abdominal transplantation surgery. Clinical Transplantation 2024, 38: e15227. PMID: 38289879, DOI: 10.1111/ctr.15227.Peer-Reviewed Original ResearchMeSH KeywordsAbdominal MusclesAnalgesicsAnalgesics, OpioidAnesthesia, ConductionFemaleHumansPain, PostoperativeConceptsSociety for the Advancement of Transplant AnesthesiaTransplant surgeryRegional anesthesiaPostoperative pain controlRegional anesthetic techniquesDevelopment of enhanced recoveryAvailability of ultrasound machinesAbdominal transplantationOpioid usePain controlAnalgesic effectNeuraxial blockPerioperative culturesPatient's hemodynamicsSurgeryUterus transplantationAnesthetic techniqueTransplantationReview available literatureAdvancement of Transplant AnesthesiaSystemic reviewTransplantation techniquesAnesthesiaLiterature searchUltrasound machine
2023
Does Liposomal Bupivacaine Injectable Suspension Peripheral Nerve Block Further Aid in Decreasing At-home Narcotic Utilization in Children and Adolescents After Anterior Cruciate Ligament Reconstruction
Walls H, Thomas E, Kain Z, Schlechter J. Does Liposomal Bupivacaine Injectable Suspension Peripheral Nerve Block Further Aid in Decreasing At-home Narcotic Utilization in Children and Adolescents After Anterior Cruciate Ligament Reconstruction. Journal Of Pediatric Orthopaedics 2023, 43: 511-515. PMID: 37400092, DOI: 10.1097/bpo.0000000000002466.Peer-Reviewed Original ResearchConceptsAnterior cruciate ligament reconstructionPeripheral nerve blocksCruciate ligament reconstructionVisual analog scaleNerve blockOpioid useLigament reconstructionAnalog scaleSingle-shot peripheral nerve blockAdductor canal nerve blockAverage opioid useHome opioid useHydrocodone/acetaminophenPain treatment satisfactionTreatment satisfaction scoresPostoperative pain managementACLR patientsOral acetaminophenOpioid usageUncontrolled painControl patientsNarcotic utilizationPostoperative dayOpioid analgesicsPain managementPractice Advisory for Preoperative and Intraoperative Pain Management of Cardiac Surgical Patients: Part 2
Makkad B, Heinke T, Sheriffdeen R, Khatib D, Brodt J, Meng M, Grant M, Kachulis B, Popescu W, Wu C, Bollen B. Practice Advisory for Preoperative and Intraoperative Pain Management of Cardiac Surgical Patients: Part 2. Anesthesia & Analgesia 2023, 137: 26-47. PMID: 37326862, DOI: 10.1213/ane.0000000000006506.Peer-Reviewed Original ResearchConceptsIntraoperative pain managementCardiac surgical patientsCardiac surgeryPain managementPractice advisorySurgical patientsEffective postoperative pain controlMultimodal analgesic strategyPostoperative pain controlPain management strategiesCardiac surgical proceduresPreoperative patient evaluationMeaningful patient outcomesHealth care costsAnalgesic strategiesMultimodal analgesicsOpioid exposurePain controlPerioperative usePostoperative distressFunctional recoveryPatient evaluationPatient outcomesRegional techniquesSurgical proceduresRegional anesthesia for transplantation surgery – A white paper part 1: Thoracic transplantation surgery
Ander M, Mugve N, Crouch C, Kassel C, Fukazawa K, Izaak R, Deshpande R, McLendon C, Huang J. Regional anesthesia for transplantation surgery – A white paper part 1: Thoracic transplantation surgery. Clinical Transplantation 2023, 37: e15043. PMID: 37306898, PMCID: PMC10834230, DOI: 10.1111/ctr.15043.Peer-Reviewed Original ResearchConceptsTransplantation surgeryRegional anesthesiaOpioid usePostoperative pain controlRegional anesthetic techniquesAnalgesic modalitiesAnalgesic effectivenessPain controlSurgery protocolNeuraxial blockPatient's hemodynamicsAnesthetic techniqueAbdominal transplantationTransplant anesthesiaSurgeryAnesthesiaSystemic reviewEnhanced recoveryTransplant techniquesPerioperative culturesLiterature searchFormal guidelinesAvailable literatureUltrasound machineTask ForceHuman TRPV1 structure and inhibition by the analgesic SB-366791
Neuberger A, Oda M, Nikolaev Y, Nadezhdin K, Gracheva E, Bagriantsev S, Sobolevsky A. Human TRPV1 structure and inhibition by the analgesic SB-366791. Nature Communications 2023, 14: 2451. PMID: 37117175, PMCID: PMC10147690, DOI: 10.1038/s41467-023-38162-9.Peer-Reviewed Original ResearchMeSH KeywordsAnalgesicsCryoelectron MicroscopyHumansPainTransient Receptor Potential ChannelsTRPV Cation ChannelsConceptsSB-366791Transient receptor potential (TRP) ion channelsPotential ion channelsPain pathwaysPain therapyPain treatmentPsychiatric disordersOpioid crisisTherapy targetTRPV1 inhibitorElectrophysiological recordingsHuman TRPV1TRP channelsTRPV1New drugsDisease conditionsVanilloid subfamilyIon channelsTreatmentInhibitorsOpioidsPainTherapyDiseaseCryo-electron microscopy structurePractice Advisory for Preoperative and Intraoperative Pain Management of Thoracic Surgical Patients: Part 1
Makkad B, Heinke T, Sheriffdeen R, Khatib D, Brodt J, Meng M, Grant M, Kachulis B, Popescu W, Wu C, Bollen B. Practice Advisory for Preoperative and Intraoperative Pain Management of Thoracic Surgical Patients: Part 1. Anesthesia & Analgesia 2023, 137: 2-25. PMID: 37079466, DOI: 10.1213/ane.0000000000006441.Peer-Reviewed Original ResearchConceptsIntraoperative pain managementThoracic surgical patientsPain managementThoracic surgerySurgical patientsPractice advisoryEffective postoperative pain controlMultimodal analgesic strategyPostoperative pain controlPersistent postoperative painPain management strategiesPreoperative patient evaluationRelevant patient outcomesThoracic surgical proceduresAnalgesic strategiesMultimodal analgesicsOpioid exposurePain controlPostoperative painPerioperative usePostoperative distressFunctional recoveryPatient evaluationPatient outcomesRegional techniquesResearch objectives and general considerations for pragmatic clinical trials of pain treatments: IMMPACT statement
Hohenschurz-Schmidt D, Cherkin D, Rice A, Dworkin R, Turk D, McDermott M, Bair M, DeBar L, Edwards R, Farrar J, Kerns R, Markman J, Rowbotham M, Sherman K, Wasan A, Cowan P, Desjardins P, Ferguson M, Freeman R, Gewandter J, Gilron I, Grol-Prokopczyk H, Hertz S, Iyengar S, Kamp C, Karp B, Kleykamp B, Loeser J, Mackey S, Malamut R, McNicol E, Patel K, Sandbrink F, Schmader K, Simon L, Steiner D, Veasley C, Vollert J. Research objectives and general considerations for pragmatic clinical trials of pain treatments: IMMPACT statement. Pain 2023, 164: 1457-1472. PMID: 36943273, PMCID: PMC10281023, DOI: 10.1097/j.pain.0000000000002888.Peer-Reviewed Original ResearchMeSH KeywordsAnalgesicsConsensusHumansPainPain ManagementPragmatic Clinical Trials as TopicResearch DesignConceptsPragmatic trialPain treatmentClinical careSystematic reviewAddiction Clinical Trial TranslationsNetworks (ACTTION) public-private partnershipTraditional efficacy trialsRoutine clinical careDaily clinical carePragmatic clinical trialsEvidence-based treatmentsRelated health policiesInternal validityPain assessmentClinical managementClinical trialsEfficacy trialsConsensus meetingTrial designConsensus discussionTrial objectivesSuch trialsHealth policyTrialsExpert presentationsAnalgesic Treatment Approach for Postherpetic Neuralgia: A Narrative Review
Valero E, Mendoza W, Sarmiento D, Amaya S. Analgesic Treatment Approach for Postherpetic Neuralgia: A Narrative Review. Journal Of Pain & Palliative Care Pharmacotherapy 2023, 37: 184-193. PMID: 36731106, DOI: 10.1080/15360288.2023.2174632.Peer-Reviewed Original ResearchConceptsPost-herpetic neuralgiaVaricella zoster virusDiagnosis of post-herpetic neuralgiaPeripheral nerve damageDisease reappearanceNeuropathic characteristicsAntiviral regimensDifficult-to-manage casesPostherpetic neuralgiaZoster virusPharmacological optionsNerve damageEarly treatmentInterventional therapyEarly initiationTreatment alternativesInterventional proceduresTreatment approachesChronic stageMultimodal approachTherapeutic objectivesNeuralgiaNarrative reviewAdverse effectsPatientsAdult use of highly-potent Δ9-THC cannabis concentrate products by U.S. state cannabis legalization status, 2021
Hasin D, Borodovsky J, Shmulewitz D, Walsh C, Struble C, Livne O, Habib M, Fink D, Aharonovich E, Budney A. Adult use of highly-potent Δ9-THC cannabis concentrate products by U.S. state cannabis legalization status, 2021. Addictive Behaviors 2023, 140: 107617. PMID: 36736229, PMCID: PMC9930475, DOI: 10.1016/j.addbeh.2023.107617.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnalgesicsCannabisDronabinolHallucinogensHumansLegislation, DrugMedical MarijuanaUnited StatesConceptsCannabis concentratesCannabis lawsDelta-9-TetrahydrocannabinolCannabis-related harmsFactors associated with useCannabis legalization statusMedical cannabis lawsCannabis usersCannabis useRecreational cannabis lawsAssociated with greater likelihoodOdds ratioCannabisCannabis productsLogistic regressionAdult useGreater likelihoodPatient useConcentrate useOddsLegal statusParticipantsAverage potency
2022
Analgesic effects of main indole alkaloid of kratom, mitragynine in acute pain animal model
Mat N, Bakar S, Murugaiyah V, Chawarski M, Hassan Z. Analgesic effects of main indole alkaloid of kratom, mitragynine in acute pain animal model. Behavioural Brain Research 2022, 439: 114251. PMID: 36503042, DOI: 10.1016/j.bbr.2022.114251.Peer-Reviewed Original ResearchConceptsAnti-inflammatory propertiesAnalgesic effectTRPV1 expressionAcute pain animal modelsEffective doseFemale Sprague-Dawley ratsPain animal modelsPain-like behaviorsNon-opioid receptorsOpioid receptor activationNumber of writhesSprague-Dawley ratsInflammatory painPain pathwaysTRPV1 receptorsDawley ratsWrithing behaviorED95 valuesRat brainAnimal modelsReceptor activationReceptor pathwayRatsBehavior scoresMain indole alkaloidsMaximizing treatment efficacy through patient stratification in neuropathic pain trials
Baron R, Dickenson A, Calvo M, Dib-Hajj S, Bennett D. Maximizing treatment efficacy through patient stratification in neuropathic pain trials. Nature Reviews Neurology 2022, 19: 53-64. PMID: 36400867, DOI: 10.1038/s41582-022-00741-7.Peer-Reviewed Original ResearchConceptsNeuropathic painPain medicineOutcome measuresClinical practiceNeuropathic pain etiologyNeuropathic pain trialsPatient stratification approachesMultiple pathophysiological mechanismsSubgrouping of patientsRoutine clinical practiceNovel outcome measuresPain etiologyBaseline characteristicsPain trialsPathophysiological mechanismsClinical trialsTreatment successTherapeutic approachesAnimal modelsPatient stratificationTreatment efficacyPainHuman painTherapeutic compoundsPatientsPatient Demographics Are Associated with Differences in Prehospital Pain Management among Trauma Patients
Supples M, Vaizer J, Liao M, Arkins T, Lardaro T, Faris G, O’Donnell D, Glober N. Patient Demographics Are Associated with Differences in Prehospital Pain Management among Trauma Patients. Prehospital Emergency Care 2022, 27: 1048-1053. PMID: 36191334, DOI: 10.1080/10903127.2022.2132565.Peer-Reviewed Original ResearchConceptsEmergency medical servicesUrban EMS systemInitial pain scoreEmergency medical services agenciesEMS systemEmergency medical services patientsEmergency medical services protocolsPain scoresMedian initial pain scorePrehospital pain managementGlasgow Coma ScalePain medication administrationTransport intervalElectronic medical recordsEmergency department patientsFemale compared to male patientsFemale patientsMale patientsPatient demographicsLogistic regression modelsTraumatic injuryAfrican American patientsElectronic medical records of adult patientsMedical records of adult patientsMedication administrationZavegepant nasal spray for the acute treatment of migraine: A Phase 2/3 double‐blind, randomized, placebo‐controlled, dose‐ranging trial
Croop R, Madonia J, Stock D, Thiry A, Forshaw M, Murphy A, Coric V, Lipton R. Zavegepant nasal spray for the acute treatment of migraine: A Phase 2/3 double‐blind, randomized, placebo‐controlled, dose‐ranging trial. Headache The Journal Of Head And Face Pain 2022, 62: 1153-1163. PMID: 36239038, PMCID: PMC9827820, DOI: 10.1111/head.14389.Peer-Reviewed Original ResearchConceptsAcute treatmentNasal sprayH postdosePain freedomBothersome symptomsAdverse eventsCommon treatment-emergent adverse eventsCalcitonin gene-related peptide receptor antagonistInteractive web response systemTreatment-emergent adverse eventsCoprimary efficacy endpointsMost adverse eventsSevere pain intensityWeb response systemDose-ranging trialFavorable safety profilePeptide receptor antagonistPhase 2/3 trialUS study sitesStudy medicationNasal discomfortCoprimary endpointsEfficacy endpointPain intensityPhase 2/3The relationship between cannabis use and taurine: A MRS and metabolomics study
Newman S, Martin A, Raymond D, Cheng H, Wilson L, Barnes S, O’Donnell B. The relationship between cannabis use and taurine: A MRS and metabolomics study. PLOS ONE 2022, 17: e0269280. PMID: 35653401, PMCID: PMC9162360, DOI: 10.1371/journal.pone.0269280.Peer-Reviewed Original ResearchConceptsTaurine levelsCB useBody compositionLow-BMI individualsDorsal anterior cingulateMagnetic resonance spectroscopyNon-user groupNeuroprotective effectsBMI individualsNeurotoxic effectsMRS studiesUrine analysisAnterior cingulateCannabis useSimilar findingsUrine samplesTaurineEssential amino acidsMetabolomic analysisMetabolomics studiesGlutamateCurrent studyGroupBMILevelsMultimodal Correlates of Cannabis Use among U.S. Veterans with Bipolar Disorder: An Integrated Study of Clinical, Cognitive, and Functional Outcomes
Selloni A, Bhatia G, Ranganathan M, De Aquino JP. Multimodal Correlates of Cannabis Use among U.S. Veterans with Bipolar Disorder: An Integrated Study of Clinical, Cognitive, and Functional Outcomes. Journal Of Dual Diagnosis 2022, 18: 81-91. PMID: 35430960, PMCID: PMC9794455, DOI: 10.1080/15504263.2022.2053264.Peer-Reviewed Original ResearchConceptsBD type IPost-traumatic stress disorderBipolar disorderDrug useU.S. veteransLifetime suicidal ideationHigher functional capacityType IPoor outcomeFunctional outcomeNationwide studyFunctional capacityAnalysis of covarianceSuicidal ideationBivariate analysisCannabis useFunctional measuresStress disorderCannabis increasesDisordersVeterans
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