2024
Sacituzumab govitecan in heavily pretreated, platinum-resistant high grade serous ovarian cancer
Greenman M, Bellone S, Demirkiran C, Hartwich T, Santin A. Sacituzumab govitecan in heavily pretreated, platinum-resistant high grade serous ovarian cancer. Gynecologic Oncology Reports 2024, 54: 101459. PMID: 39108617, PMCID: PMC11300917, DOI: 10.1016/j.gore.2024.101459.Peer-Reviewed Original ResearchHigh grade serous ovarian cancerAntibody-drug conjugatesSerous ovarian cancerSacituzumab govitecanOvarian cancerTreatment optionsPlatinum-resistant ovarian cancer patientsDose-limiting toxicityOvarian cancer patientsNovel treatment optionsPartial responseRecurrent diseaseDose reductionCancer patientsClinical trialsBackground treatmentTargeted treatmentChemotherapyTreatmentCancerDoseDiseaseOptionsTrop2PatientsEmerging therapeutic options for follicular-derived thyroid cancer in the era of immunotherapy
Turner N, Hamidi S, Ouni R, Rico R, Henderson Y, Puche M, Alekseev S, Colunga-Minutti J, Zafereo M, Lai S, Kim S, Cabanillas M, Nurieva R. Emerging therapeutic options for follicular-derived thyroid cancer in the era of immunotherapy. Frontiers In Immunology 2024, 15: 1369780. PMID: 38868771, PMCID: PMC11167082, DOI: 10.3389/fimmu.2024.1369780.Peer-Reviewed Original ResearchConceptsAnaplastic thyroid cancerFollicular-derived thyroid cancersAdvanced thyroid cancerThyroid cancerFood and Drug AdministrationManagement of advanced thyroid cancerEra of immunotherapyTargeted kinase inhibitorsU.S Food and Drug AdministrationImmune milieuRefractory diseaseExcellent prognosisTherapeutic optionsTreatment optionsKinase inhibitorsDrug AdministrationGenetic driversTherapeutic avenuesCancerImmunotherapyGenetic landscapeRadioiodineTreatmentMolecular basisOptionsEyebrow and Eyelash Loss in Patients With Cancer.
Rose L, Khuhro A, Minta A, Novice M, Novice T, Lustberg M, Ruddy K, Rake E, Loprinzi C, Dulmage B. Eyebrow and Eyelash Loss in Patients With Cancer. Journal Of Drugs In Dermatology 2024, 23: 327-331. PMID: 38709698, DOI: 10.36849/jdd.8003.Peer-Reviewed Original ResearchConceptsPrevention optionsRadiation therapyTopical vasoconstrictorEndocrine therapyEyelash lossTreatment optionsPrescription medicationsCancer treatmentPatientsScalp coolingHair lossRobust researchMadarosisPermanent tattoosTherapyCancerTreatmentEyebrowsEyelash hairScalpOptionsChemotherapyCryotherapyVasoconstrictorDermatologistsNCCN Guidelines® Insights: Merkel Cell Carcinoma, Version 1.2024.
Schmults C, Blitzblau R, Aasi S, Alam M, Amini A, Bibee K, Bolotin D, Bordeaux J, Chen P, Contreras C, DiMaio D, Donigan J, Farma J, Ghosh K, Harms K, Ho A, Lukens J, Manber S, Mark L, Medina T, Nehal K, Nghiem P, Olino K, Park S, Patel T, Puzanov I, Rich J, Sekulic A, Shaha A, Srivastava D, Thomas V, Tomblinson C, Venkat P, Xu Y, Yu S, Yusuf M, McCullough B, Espinosa S. NCCN Guidelines® Insights: Merkel Cell Carcinoma, Version 1.2024. Journal Of The National Comprehensive Cancer Network 2024, 22: e240002. PMID: 38244274, DOI: 10.6004/jnccn.2024.0002.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsLocally advanced diseaseMerkel cell carcinomaAdvanced diseaseLocally advanced Merkel cell carcinomaAdvanced Merkel cell carcinomaNode negative statusSystemic therapy optionsIn-transit diseaseNCCN Guidelines InsightsCell carcinomaNCCN guidelinesClinical stageDiagnostic workupTherapy optionsTreatment optionsNegative statusInstitutional reviewNCCNDiseaseGuidelinesOptionsCarcinomaWorkupPatientsPanel members
2023
Right Heart Failure in the Intensive Care Unit: Etiology, Pathogenesis, Diagnosis, and Treatment
Tarras E, Khosla A, Heerdt P, Singh I. Right Heart Failure in the Intensive Care Unit: Etiology, Pathogenesis, Diagnosis, and Treatment. Journal Of Intensive Care Medicine 2023, 40: 119-136. PMID: 38031338, DOI: 10.1177/08850666231216889.Peer-Reviewed Original ResearchRight heart failureFailure patientsHeart failureTreatment optionsIntensive care unit settingMechanical circulatory support devicesIntensive care unitCirculatory support devicesCardio-pulmonary physiologyCare unitDifferent pharmacotherapiesUnit settingClinical guidancePathophysiological manifestationsCirculatory physiologyIntensivistsPatientsSupport devicesSupport optionsCirculatory systemHigh rateTreatmentDiagnosisFailureOptionsTreatment Considerations of Myelodysplastic Syndromes/Neoplasms for Pathologists
Madanat Y, Zeidan A. Treatment Considerations of Myelodysplastic Syndromes/Neoplasms for Pathologists. Clinics In Laboratory Medicine 2023, 43: 685-698. PMID: 37865511, DOI: 10.1016/j.cll.2023.07.003.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsBone marrow biopsy reportsAvailable treatment optionsBest therapeutic approachClinical presentationPathologic findingsRisk stratificationTherapeutic optionsTreatment optionsBiopsy reportsDisease entityTherapeutic approachesTreatment considerationsAccurate diagnosisGenetic abnormalitiesDiagnosisDisease subclassificationPatientsNeoplasmsHematopathologistsOptionsPrognosticationAbnormalitiesCliniciansSubclassificationEarly Treatment for Multiple Sclerosis
Longbrake E, Kalincik T. Early Treatment for Multiple Sclerosis. Neurology 2023, 101: 549-550. PMID: 37468283, DOI: 10.1212/wnl.0000000000207754.Peer-Reviewed Original ResearchHigh-Risk Pulmonary Embolism: Management for the Intensivist
Khosla A, Zhao Y, Mojibian H, Pollak J, Singh I. High-Risk Pulmonary Embolism: Management for the Intensivist. Journal Of Intensive Care Medicine 2023, 38: 1087-1098. PMID: 37455352, DOI: 10.1177/08850666231188290.Peer-Reviewed Original ResearchConceptsHigh-risk pulmonary embolismHigh-risk PE patientsPulmonary embolismRisk stratificationPE patientsTreatment optionsRisk pulmonary embolismMassive pulmonary embolismIntensivist’s perspectiveReperfusion therapySupportive careAcute managementPatientsIntensivistsSupport optionsEmbolismHigh rateCarePhysiological consequencesOutcomesTreatmentOptionsStratificationMorbidityTherapyAn international research agenda for clozapine-resistant schizophrenia
Luykx J, Gonzalez-Diaz J, Guu T, van der Horst M, van Dellen E, Boks M, Guloksuz S, DeLisi L, Sommer I, Cummins R, Shiers D, Lee J, Every-Palmer S, Mhalla A, Chadly Z, Chan S, Cotes R, Takahashi S, Benros M, Wagner E, Correll C, Hasan A, Siskind D, Endres D, MacCabe J, Tiihonen J. An international research agenda for clozapine-resistant schizophrenia. The Lancet Psychiatry 2023, 10: 644-652. PMID: 37329895, DOI: 10.1016/s2215-0366(23)00109-8.Peer-Reviewed Original ResearchConceptsClozapine-resistant schizophreniaQuality of lifeTreatment optionsTreatment-resistant symptomsThird of patientsNew treatment optionsHealth care providersMiddle-income countriesFunctional outcomeInterventional studyUnmet needEpidemiological researchTranslational approachDiagnostic testsPatientsSchizophreniaHealth policyEarly detectionOptionsSymptomsDiagnosisTrialsHair loss during and after breast cancer therapy
Rose L, Lustberg M, Ruddy K, Cathcart-Rake E, Loprinzi C, Dulmage B. Hair loss during and after breast cancer therapy. Supportive Care In Cancer 2023, 31: 186. PMID: 36826602, DOI: 10.1007/s00520-023-07634-5.Peer-Reviewed Original ResearchConceptsTreatment optionsHair lossDistressing side effectsChemotherapy-induced alopeciaCancer therapyBreast cancer therapyEndocrine therapyMajor surgeryPatient counselingTelogen effluviumBreast cancerBreast oncologistsSide effectsPrevention strategiesAlopeciaTherapyChemotherapyPatientsSurgeryOncologistsOptionsEtiologyCancer
2022
Endovascular Assessment of Liver Hemodynamics in Patients with Cirrhosis Complicated by Portal Hypertension
Ferral H, Schepis F, Gaba R, Garcia-Tsao G, Zanetto A, Perez-Campuzano V, Haskal Z, Garcia-Pagan J. Endovascular Assessment of Liver Hemodynamics in Patients with Cirrhosis Complicated by Portal Hypertension. Journal Of Vascular And Interventional Radiology 2022, 34: 327-336. PMID: 36516940, DOI: 10.1016/j.jvir.2022.12.014.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsHepatic venous pressure gradientPortal hypertensionPortosystemic pressure gradientTransjugular intrahepatic portosystemic shuntVenous pressure gradientIntrahepatic portosystemic shuntSurgical patientsRisk stratificationHemodynamic measurementsPortosystemic shuntLiver hemodynamicsTreatment optionsShunt diameterMeticulous techniquePatientsClinical practiceGold standardHypertensionManagement optionsPressure gradientCirrhosisComplicatedHemodynamicsOptionsShuntBreastmilk pumping experiences of physician mothers: quantitative and qualitative findings from a nationwide survey study
Jain S, Neaves S, Royston A, Huang I, Juengst S. Breastmilk pumping experiences of physician mothers: quantitative and qualitative findings from a nationwide survey study. Journal Of General Internal Medicine 2022, 37: 3411-3418. PMID: 35060006, PMCID: PMC9550890, DOI: 10.1007/s11606-021-07388-y.Peer-Reviewed Original ResearchConceptsNationwide survey studyPhysician mothersFree-text response optionsBreast milkFree-text responsesSurvey studyBreastmilkSurvey response optionsCommon barriersMothersMothers' experiencesShort durationInfantsMedical students todayResponse optionsFamily leaveOpen-ended questionMaternity leaveLack of supportQualitative findingsBackgroundNearlyResultsLackBreastfeedGreater supportOptions
2021
The Patellofemoral Joint: A Case-Based Approach
Abdelkafy A, Fulkerson J, Kuroda R. The Patellofemoral Joint: A Case-Based Approach. 2021, 111-115. DOI: 10.1007/978-3-030-81545-5_10.Peer-Reviewed Original ResearchPatellar dislocationAcute traumatic patellar dislocationsSurgical treatment optionsDifferent surgical optionsAcute patellar dislocationHigh recurrence rateTraumatic patellar dislocationConservative treatmentDefinitive managementSurgical optionsRecurrence rateTreatment optionsPatellofemoral jointArthroscopy resultsCase-based approachPainPatientsOptionsPathoanatomy
2020
Concentrating human milk: an innovative point-of-care device designed to increase human milk feeding options for preterm infants
Schinkel ER, Nelson ER, Young BE, Bernstein RM, Taylor SN, Brown LD, Hay WW, Brown KJ, Prenni J. Concentrating human milk: an innovative point-of-care device designed to increase human milk feeding options for preterm infants. Journal Of Perinatology 2020, 41: 582-589. PMID: 33060780, PMCID: PMC9848740, DOI: 10.1038/s41372-020-00820-x.Peer-Reviewed Original ResearchConceptsCertain bioactive componentsPreterm infantsHuman milk nutrientsNeonatal nutritionFeeding neonatesHuman milkFeeding optionsBaseline samplesEvidence baseHM samplesCare devicesBioactive levelsFurther studiesBioactive componentsMilk nutrientsRaw milk samplesMilk samplesOsmotic devicesNeonatesOptionsEffect of timeInfantsPromising optionArthrofibrosis of the Ankle
Velasco BT, Patel SS, Broughton KK, Frumberg DB, Kwon JY, Miller CP. Arthrofibrosis of the Ankle. Foot & Ankle Orthopaedics 2020, 5: 2473011420970463. PMID: 35097416, PMCID: PMC8564948, DOI: 10.1177/2473011420970463.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsExtensive physical therapyFuture therapeutic optionsSoft tissue traumaPathogenesis of arthrofibrosisScar tissue formationCommon etiologyInitial treatmentSignificant morbiditySurgical optionsTherapeutic optionsPhysical therapyAnkle dysfunctionTissue traumaArthrofibrosisAnkleLevel VTissue formationExpert opinionReview articleMorbidityPainSurgeryDysfunctionOptionsPathogenesisPhysicians' political party affiliation and clinical management of obesity
Zatz L, Hersh E, Gudzune K, Thorndike A, Goldenberg M, Bleich S. Physicians' political party affiliation and clinical management of obesity. Clinical Obesity 2020, 10: e12396. PMID: 32803863, DOI: 10.1111/cob.12396.Peer-Reviewed Original ResearchConceptsObesity management optionsMedical recordsPrimary care physicians' reportsEvidence-based careCross-sectional surveyObesity careClinical managementFollowing outcomesPhysician reportsProvider characteristicsClinical careObesityPatient vignettesPatientsManagement optionsSecondary analysisCareTime courseHealth risksPCPMedicationsOptionsLikelihoodShared decision-making in atrial fibrillation: patient-reported involvement in treatment decisions
Ali-Ahmed F, Pieper K, North R, Allen LA, Chan PS, Ezekowitz MD, Fonarow GC, Freeman JV, Go AS, Gersh BJ, Kowey PR, Mahaffey KW, Naccarelli GV, Pokorney SD, Reiffel JA, Singer DE, Steinberg BA, Peterson ED, Piccini JP, O’Brien E. Shared decision-making in atrial fibrillation: patient-reported involvement in treatment decisions. European Heart Journal - Quality Of Care And Clinical Outcomes 2020, 6: 263-272. PMID: 32392287, PMCID: PMC7778449, DOI: 10.1093/ehjqcco/qcaa040.Peer-Reviewed Original ResearchConceptsAtrial fibrillationTreatment decisionsHealthcare providersNew-onset atrial fibrillationHalf of patientsAvailable therapeutic optionsBetter Informed TreatmentHCP recommendationOutcomes RegistryRhythm controlTherapeutic optionsPatient understandingHigher oddsPatientsInformed TreatmentUS sitesFibrillationFuture interventionsPotential targetHigher likelihoodSelf-reported understandingTreatmentSDMSubstudyOptionsChronic Disease Decision Making and “What Matters Most”
Fried TR, Street RL, Cohen AB. Chronic Disease Decision Making and “What Matters Most”. Journal Of The American Geriatrics Society 2020, 68: 474-477. PMID: 32043559, PMCID: PMC7197748, DOI: 10.1111/jgs.16371.Commentaries, Editorials and LettersConceptsOlder patientsChronic disease careClinical practice guidelinesPlan of careRobust outcome dataDifferent treatment optionsPatient-centered careMild cognitive impairmentAdverse eventsDisease careTreatment optionsChronic conditionsPractice guidelinesOutcome dataCognitive impairmentTreatment planPatientsCareMultimorbidityDisease decisionTherapyOutcomesOptionsSyndromeFrailtyChapter 12 Prenatal testing
Copel J, Kohari K, Merriam A. Chapter 12 Prenatal testing. 2020, 201-221. DOI: 10.1016/b978-0-12-816561-4.00012-0.ChaptersPrenatal testingMaternal-fetal medicineSecond-trimester screeningFirst-trimester screeningTime of deliveryWhole-exome sequencingChorionic villus samplingCurrent pregnancyCell-free fetal DNA screeningCertain patientsMaternal ageReproductive endocrinologyGenetic testingVillus samplingDNA screeningPatientsObstetricsSitu hybridizationScreeningTest optionsMedical GeneticsRiskGeneticsOptionsPregnancy
2019
Ovarian Stimulation in Women with Breast Cancer
Turan V, Oktay K. Ovarian Stimulation in Women with Breast Cancer. 2019, 105-115. DOI: 10.1007/978-3-030-24086-8_10.Peer-Reviewed Original ResearchFertility preservation optionsOvarian stimulationBreast cancerPreservation optionsEffective fertility preservation optionsEstrogen-sensitive malignanciesReproductive-aged womenCommon cancer typesCytotoxic chemotherapyGonadal failureAged womenOocyte cryopreservationNumber of womenCancer typesCancerWomenStimulationTreatmentHigh levelsChemotherapyPatientsMalignancyOptionsRadiotherapyEstradiol
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