2024
Succinate dehydrogenase–complex II regulates skeletal muscle cellular respiration and contractility but not muscle mass in genetically induced pulmonary emphysema
Balnis J, Tufts A, Jackson E, Drake L, Singer D, Lacomis D, Lee C, Elias J, Doles J, Maher L, Jen A, Coon J, Jourd’heuil D, Singer H, Vincent C, Jaitovich A. Succinate dehydrogenase–complex II regulates skeletal muscle cellular respiration and contractility but not muscle mass in genetically induced pulmonary emphysema. Science Advances 2024, 10: eado8549. PMID: 39167644, PMCID: PMC11338223, DOI: 10.1126/sciadv.ado8549.Peer-Reviewed Original ResearchConceptsPulmonary emphysemaMuscle massSuccinate dehydrogenaseReduced skeletal muscle massAssociated with high mortalityCellular respirationSkeletal muscle massReduced cellular respirationKnockout miceMuscle dysfunctionActivity of succinate dehydrogenaseComplex I respirationMitochondrial oxygen consumptionMyopathic changesTransgenic miceSubunit cMuscle atrophyProteomic effectsMyofiber contractilityRespirometry analysisSuccinate accumulationMuscle mitochondriaEmphysemaHigher mortalityAnimal data
2022
Renewing the Call for Reforms to Medical Device Safety—The Case of Penumbra
Kadakia KT, Beckman AL, Ross JS, Krumholz HM. Renewing the Call for Reforms to Medical Device Safety—The Case of Penumbra. JAMA Internal Medicine 2022, 182: 59-65. PMID: 34842892, DOI: 10.1001/jamainternmed.2021.6626.Commentaries, Editorials and LettersConceptsReperfusion catheterClinical evidenceClass IPenumbra reperfusion catheterSingle-arm trialUser Facility Device Experience (MAUDE) databaseAdverse event reportsPostmarket surveillanceHealth policy makersMedical device reportsPenumbra deviceClinical evaluationPatient deathDevice safetyMedicine recommendationsAnimal dataCatheterFDA databaseFDA medical device regulationsClinical literatureSmall sample sizeDevice reportsEvent reportsPublic healthExperience database
2020
The use of resuscitative endovascular balloon occlusion of the aorta (REBOA) for non‐traumatic cardiac arrest: A review
Nowadly CD, Johnson MA, Hoareau GL, Manning JE, Daley JI. The use of resuscitative endovascular balloon occlusion of the aorta (REBOA) for non‐traumatic cardiac arrest: A review. Journal Of The American College Of Emergency Physicians Open 2020, 1: 737-743. PMID: 33145513, PMCID: PMC7593442, DOI: 10.1002/emp2.12241.Peer-Reviewed Original ResearchNon-traumatic cardiac arrestResuscitative endovascular balloon occlusionEndovascular balloon occlusionCardiac arrestCardiopulmonary resuscitationBalloon occlusionAnimal studiesAdvanced cardiac life support measuresBalloon-tipped catheterCerebral perfusion pressureCardiac arrest resuscitationLife support measuresQuality of lifeAortic occlusionSpontaneous circulationPerfusion pressureFeasibility trialCase reportFemoral arteryKey physiologic parametersREBOARetrograde mannerVital organsAortaAnimal data
2018
Cannabinoid receptor-mediated disruption of sensory gating and neural oscillations: A translational study in rats and humans
Skosnik PD, Hajós M, Cortes-Briones JA, Edwards CR, Pittman BP, Hoffmann WE, Sewell AR, D'Souza DC, Ranganathan M. Cannabinoid receptor-mediated disruption of sensory gating and neural oscillations: A translational study in rats and humans. Neuropharmacology 2018, 135: 412-423. PMID: 29604295, PMCID: PMC6091633, DOI: 10.1016/j.neuropharm.2018.03.036.Peer-Reviewed Original ResearchConceptsLocal field potentialsSensory gatingCP 55940AM 251Dual-click paradigmNeural oscillationsCannabinoid receptor 1P50 gating ratioGating ratioCannabinoid administrationCB1R agonistEndocannabinoid systemOutcome measuresTranslational studiesReceptor 1Brain regionsAnimal dataCannabis useRatsCannabidiolPlaceboTHC conditionsField potentialsTest dayHuman subjects
2015
Treatment of Chronic Migraine with Focus on Botulinum Neurotoxins
Schaefer SM, Gottschalk CH, Jabbari B. Treatment of Chronic Migraine with Focus on Botulinum Neurotoxins. Toxins 2015, 7: 2615-2628. PMID: 26184313, PMCID: PMC4516932, DOI: 10.3390/toxins7072615.Peer-Reviewed Original ResearchConceptsChronic migraineBotulinum toxin injection therapyLarge healthcare costsBotulinum toxin therapyTreatment of migraineCommon neurological disorderToxin therapyInjection therapyPathophysiological mechanismsMigraine pathophysiologyHealthcare costsMigraineNeurological disordersAnimal dataBotulinum neurotoxinTherapyTreatmentInjection techniqueCurrent understandingMedicationsPathophysiology
2014
Red Blood Cell Alloimmunization Mitigation Strategies
Hendrickson JE, Tormey CA, Shaz BH. Red Blood Cell Alloimmunization Mitigation Strategies. Transfusion Medicine Reviews 2014, 28: 137-144. PMID: 24928468, DOI: 10.1016/j.tmrv.2014.04.008.Peer-Reviewed Original ResearchConceptsHemolytic transfusion reactionsRBC alloantibodiesRBC alloimmunizationTransfusion reactionsImmune systemRed blood cell alloantibodiesCompatible RBC unitsRBC alloimmunization rateTransfusion-associated morbidityRecipient's immune systemTransfusion-associated deathForms of anemiaAlloimmunization rateAntigen exposureSignificant morbidityTransfusion recipientsHemolytic diseaseAlloantibodiesHuman studiesAnimal studiesDanger signalsAnimal dataMorbidityAlloimmunizationRBC units
2012
Breathing motion compensated reconstruction for C-arm cone beam CT imaging: initial experience based on animal data
Schäfer D, Lin M, Rao P, Loffroy R, Liapi E, Noordhoek N, Eshuis P, Radaelli A, Grass M, Geschwind J. Breathing motion compensated reconstruction for C-arm cone beam CT imaging: initial experience based on animal data. Proceedings Of SPIE--the International Society For Optical Engineering 2012, 8313: 83131d-83131d-6. DOI: 10.1117/12.909914.Peer-Reviewed Original Research
2004
Pathophysiology and pharmacologic treatment of acute spinal cord injury
Kwon BK, Tetzlaff W, Grauer JN, Beiner J, Vaccaro AR. Pathophysiology and pharmacologic treatment of acute spinal cord injury. The Spine Journal 2004, 4: 451-464. PMID: 15246307, DOI: 10.1016/j.spinee.2003.07.007.Peer-Reviewed Original ResearchConceptsAcute spinal cord injurySpinal cord injuryCord injuryPathophysiologic processesPharmacologic treatmentNeuroprotective agentsSecondary damageImportant pathophysiologic processSecondary injury cascadePharmacologic therapyAcute treatmentInjury cascadeNeurologic functionNeuroprotective strategiesDevastating injuriesPathophysiologic mechanismsSpecific therapyPathophysiologic eventsSpinal cordHuman trialsPotential therapyInjuryAnimal dataLiterature reviewTherapyAsthma: Mechanisms of Disease Persistence and Progression
Cohn L, Elias JA, Chupp GL. Asthma: Mechanisms of Disease Persistence and Progression. Annual Review Of Immunology 2004, 22: 789-815. PMID: 15032597, DOI: 10.1146/annurev.immunol.22.012703.104716.BooksConceptsIL-13Key effector cytokineAnti-inflammatory therapyIL-13 productionProduction of chemokinesProgression of diseaseAirway fibrosisAllergic asthmaAirway remodelingEffector cytokinesEosinophilic inflammationPersistent diseaseTh2 cytokinesEpithelial damageDisease progressionInflammatory responseTh2 cellsMucus productionSmooth muscleBronchial airwaysMatrix metalloproteinasesAnimal dataAsthmaDisease persistenceInflammation
1989
Cochlear Nerve Conduction Block: An Explanation for Spontaneous Hearing Return after Acoustic Tumor Surgery
Kveton J, Tarlov E, Drumheller G, Katcher F, Abbott C. Cochlear Nerve Conduction Block: An Explanation for Spontaneous Hearing Return after Acoustic Tumor Surgery. Otolaryngology 1989, 100: 594-601. PMID: 2501735, DOI: 10.1177/019459988910000613.Peer-Reviewed Original ResearchConceptsCochlear nerveAcoustic tumor resectionIntact cochlear nerveInternal auditory arteryPertinent animal dataDirect mechanical traumaAcoustic tumor surgeryPosterior fossa surgeryReversible conduction blockIntraoperative auditoryNerve injuryTumor resectionFossa surgeryTumor manipulationElectrophysiologic dataHearing lossTumor surgeryConduction blockMechanical traumaSpontaneous recoveryAnimal dataNervePreservation proceduresHuman subjectsSurgery
1987
The Biochemistry of Fetal Lung Development
Kresch M, Gross I. The Biochemistry of Fetal Lung Development. Clinics In Perinatology 1987, 14: 481-507. PMID: 3311536, DOI: 10.1016/s0095-5108(18)30747-4.ChaptersConceptsSurfactant therapyLung complianceLung maturationAdministration of betamethasoneEffects of glucocorticoidsFetal lung developmentNumber of alveoliGlucocorticoid therapyFetal rabbitsLung developmentTherapyAnimal dataTissue complianceHormonal enhancementAdditive effectAdministrationComplianceMaturationRDSMorbidityBetamethasoneGlucocorticoidsLungMortalitySteroids
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