2025
Clinical Evidence of Mesenchymal Stromal Cells for Cerebral Palsy: Scoping Review with Meta-Analysis of Efficacy in Gross Motor Outcomes
Paton M, Griffin A, Blatch-Williams R, Webb A, Verter F, Couto P, Bersenev A, Dale R, Popat H, Novak I, Finch-Edmondson M. Clinical Evidence of Mesenchymal Stromal Cells for Cerebral Palsy: Scoping Review with Meta-Analysis of Efficacy in Gross Motor Outcomes. Cells 2025, 14: 700. PMID: 40422203, PMCID: PMC12110704, DOI: 10.3390/cells14100700.Peer-Reviewed Original ResearchConceptsGross Motor Function MeasureCerebral palsyIPD meta-analysisTreatment of cerebral palsyMeta-analysisMotor Function MeasureGross motor outcomesData Meta-AnalysisScoping ReviewWell-designed trialsStudy heterogeneityMeta-analysesEffect sizeMotor outcomeFunction measurementsParticipation variablesSubgroup analysisMeta-analysis of efficacyRegistered trialsPalsyOutcomesVariable reportingReports of efficacyTrialsPublished reportsFrequency, characteristics, and reasons for termination of cerebral palsy clinical trials
Gouzoulis M, Caruana D, Yang A, Seddio A, Grauer J, Frumberg D. Frequency, characteristics, and reasons for termination of cerebral palsy clinical trials. PM&R 2025 PMID: 40278003, DOI: 10.1002/pmrj.13398.Peer-Reviewed Original ResearchCerebral palsyIndustry sponsorshipImprove careClinical trialsRisk of premature terminationTrial characteristicsMultivariate analysisRecruitment/retentionPalsyTrial terminationTrialsPredictive factorsAssociated with terminationCareNeurodevelopmental diseasesFactorsPotential riskPremature terminationReasonsSponsorshipScientific dataDatabase
2024
Improvement in cranial nerve palsies following treatment of intracranial aneurysms with flow diverters: Institutional outcomes, systematic review and study-level meta-analysis
Sujijantarat N, Antonios J, Renedo D, Koo A, Haynes J, Fathima B, Jiang J, Hengartner A, Shekhar A, Amllay A, Nowicki K, Hebert R, Gilmore E, Sheth K, King J, Matouk C. Improvement in cranial nerve palsies following treatment of intracranial aneurysms with flow diverters: Institutional outcomes, systematic review and study-level meta-analysis. Clinical Neurology And Neurosurgery 2024, 246: 108555. PMID: 39357321, DOI: 10.1016/j.clineuro.2024.108555.Peer-Reviewed Original ResearchStudy-level meta-analysisRate of improvementCN deficitsMeta-analysisIntracranial aneurysmsCN palsySystematic reviewFactors associated with recoveryPooled rateRandom-effects meta-analysisCranial nervesManual citation searchingEffects meta-analysisRate of clinical improvementCranial nerve palsyMechanism of injuryIncreased rate of improvementFlow diversionRare presenting symptomSymptomatic intracranial aneurysmsTreatment of intracranial aneurysmsCitation searchingPalsyNerve palsyRetrospective review
2023
Association between lower limb spasticity and cryptorchidism in males with cerebral palsy
Bortnick E, Logvinenko T, Wang H, Fogelman D, Shore B, Nelson C, Kurtz M. Association between lower limb spasticity and cryptorchidism in males with cerebral palsy. Developmental Medicine & Child Neurology 2023, 66: 82-86. PMID: 37282840, DOI: 10.1111/dmcn.15644.Peer-Reviewed Original ResearchConceptsLower limb spasticityCerebral palsyLimb spasticityOrchidopexy ratesSevere lower limb spasticityPediatric Health Information System databaseHealth Information System databaseSpastic typeInformation System databaseSpasticityLogistic regressionMann-Whitney U testPalsyComparative statisticsSystem databaseCompare groupsContinuous variablesAssociationMann-WhitneyU testRiskPatientsPeopleMaleProviders
2022
Catatonia and Neuroleptic Malignant Syndrome in Patients With Cerebral Palsy: Two Case Reports and a Systematic Review of the Literature
Barnett B, Balaji D, Weleff J, Carroll B. Catatonia and Neuroleptic Malignant Syndrome in Patients With Cerebral Palsy: Two Case Reports and a Systematic Review of the Literature. Journal Of The Academy Of Consultation-Liaison Psychiatry 2022, 64: 277-293. PMID: 36586471, DOI: 10.1016/j.jaclp.2022.12.008.Peer-Reviewed Original ResearchConceptsCerebral palsyBaclofen withdrawalIntrathecal baclofen withdrawalAllied Health LiteraturePrevalence of catatoniaSpasticity managementIntrathecal baclofenCumulative IndexHealth LiteratureReports of catatoniaRecurrent self-limiting feverGroup of movement disordersService databasePalsyLifetime prevalenceOvid MEDLINESystematic reviewNeuroleptic malignant syndromePatient populationCase reportMovement disordersPsychotic disordersRoutine treatmentInduced neuroleptic malignant syndromeMalignant syndromePituitary Apoplexy
Hong C, Omay S. Pituitary Apoplexy. New England Journal Of Medicine 2022, 387: 2366-2366. PMID: 36547664, DOI: 10.1056/nejmicm2204942.Peer-Reviewed Original ResearchCommentary on “Predictors of postoperative systemic inflammatory response syndrome after scoliosis surgery in adolescents with cerebral palsy: A retrospective analysis”
Oghenesume O, Grauer J. Commentary on “Predictors of postoperative systemic inflammatory response syndrome after scoliosis surgery in adolescents with cerebral palsy: A retrospective analysis”. North American Spine Society Journal (NASSJ) 2022, 12: 100173. PMID: 36589691, PMCID: PMC9797607, DOI: 10.1016/j.xnsj.2022.100173.Commentaries, Editorials and Letters
2021
Real-Time Imaging of Aneurysmal Rupture Causing an Isolated Acute Subdural Hematoma
Hong C, Renedo D, Sujijantarat N, Koo A, Falcone GJ, Malhotra A, Petersen NH, Matouk C. Real-Time Imaging of Aneurysmal Rupture Causing an Isolated Acute Subdural Hematoma. Neurology 2021, 98: 373-374. PMID: 34937782, PMCID: PMC10508646, DOI: 10.1212/wnl.0000000000013251.Peer-Reviewed Original ResearchConceptsAcute subdural hematomaSubdural hematomaRight cranial nerve III palsyCranial nerve III palsyIsolated Acute Subdural HematomaEmergent decompressive craniectomyEmergency department evaluationDecompressive craniectomyDepartment evaluationArtery aneurysmPostoperative imagingAneurysmal ruptureHematomaMRI scannerImagingHypertensionPalsyHeadacheCraniectomyAneurysmsReal-time imagingMRIWomenMutation in ZDHHC15 Leads to Hypotonic Cerebral Palsy, Autism, Epilepsy, and Intellectual Disability
Lewis SA, Bakhtiari S, Heim J, Cornejo P, Liu J, Huang A, Musmacker A, Jin SC, Bilguvar K, Padilla-Lopez SR, Kruer MC. Mutation in ZDHHC15 Leads to Hypotonic Cerebral Palsy, Autism, Epilepsy, and Intellectual Disability. Neurology Genetics 2021, 7: e602. PMID: 34345675, PMCID: PMC8323736, DOI: 10.1212/nxg.0000000000000602.Peer-Reviewed Original ResearchHypotonic cerebral palsyCerebral palsyIntellectual disabilityOvoid lesionsMotor dysfunctionRare causeCerebral volumeTall foreheadDental crowdingMuscle hypotoniaNeurodevelopmental disabilitiesArched palateAnimal modelsPalpebral fissuresMild brachycephalyFunction genotypeNeurodevelopmental disordersPatient variantsPalsyPatientsEpilepsyLocomotor defectsFunction mutationsCandidate variantsDisabilityFoot and ankle somatosensory deficits in children with cerebral palsy: A pilot study
Zarkou A, Lee S, Prosser L, Hwang S, Franklin C, Jeka J. Foot and ankle somatosensory deficits in children with cerebral palsy: A pilot study. Journal Of Pediatric Rehabilitation Medicine 2021, 14: 247-255. PMID: 33896853, DOI: 10.3233/prm-190643.Peer-Reviewed Original ResearchConceptsLight touch-pressureCerebral palsyAnkle jointJoint position senseDuration of vibration sensationImproving functional performanceFirst metatarsal headTwo-point discrimination thresholdSomatosensory functionInvestigate footTouch pressureSpastic diplegiaMetatarsal headMedial malleolusProprioceptive deficitsPlantar sideAnkleFunctional performancePosition senseTwo-point discriminationPilot studyClinical practiceFootPalsyKinesthesiaChildren with Cerebral Palsy Have Similar Walking and Running Quality Assessed by an Overall Kinematic Index
Kelly D, McMulkin M, Franklin C, Cooney K. Children with Cerebral Palsy Have Similar Walking and Running Quality Assessed by an Overall Kinematic Index. International Journal Of Environmental Research And Public Health 2021, 18: 4683. PMID: 33924873, PMCID: PMC8124669, DOI: 10.3390/ijerph18094683.Peer-Reviewed Original ResearchConceptsGait Deviation IndexDiplegic cerebral palsyCerebral palsyMotion analysis centersDiplegic CPRunning kinematicsGDI scoreDeviation indexSeparate walkingRunning abilityWalking dataKinematic indicesPalsyRetrospective comparative studyWalkingAnalysis of varianceActive participationParticipantsChildrenOverall indexEffects of activationQualityRunningCerebralIndexRecessive COL4A2 Mutation Leads to Intellectual Disability, Epilepsy, and Spastic Cerebral Palsy
Bakhtiari S, Tafakhori A, Jin SC, Guida BS, Alehabib E, Firouzbadi S, Bilguvar K, Fahey MC, Darvish H, Kruer MC. Recessive COL4A2 Mutation Leads to Intellectual Disability, Epilepsy, and Spastic Cerebral Palsy. Neurology Genetics 2021, 7: e583. PMID: 33912663, PMCID: PMC8077768, DOI: 10.1212/nxg.0000000000000583.Peer-Reviewed Original ResearchCerebral palsySpastic cerebral palsyCortical visual impairmentBasement membrane thickeningStroke-related complicationsWhite matter diseaseIntellectual disabilityEarly fetal developmentCerebral calcificationsHemorrhagic strokeAutosomal dominant fashionMembrane thickeningPostnatal periodFunction effectsCOL4A2 mutationsFetal developmentClinical diagnosisVisual impairmentPalsyEpilepsyDiseaseDominant fashionGenes COL4A1Muscular systemDisabilityAuthor Correction: Mutations disrupting neuritogenesis genes confer risk for cerebral palsy
Jin SC, Lewis SA, Bakhtiari S, Zeng X, Sierant MC, Shetty S, Nordlie SM, Elie A, Corbett MA, Norton BY, van Eyk CL, Haider S, Guida BS, Magee H, Liu J, Pastore S, Vincent JB, Brunstrom-Hernandez J, Papavasileiou A, Fahey MC, Berry JG, Harper K, Zhou C, Zhang J, Li B, Zhao H, Heim J, Webber DL, Frank MSB, Xia L, Xu Y, Zhu D, Zhang B, Sheth AH, Knight JR, Castaldi C, Tikhonova IR, López-Giráldez F, Keren B, Whalen S, Buratti J, Doummar D, Cho M, Retterer K, Millan F, Wang Y, Waugh JL, Rodan L, Cohen JS, Fatemi A, Lin AE, Phillips JP, Feyma T, MacLennan SC, Vaughan S, Crompton KE, Reid SM, Reddihough DS, Shang Q, Gao C, Novak I, Badawi N, Wilson YA, McIntyre SJ, Mane SM, Wang X, Amor DJ, Zarnescu DC, Lu Q, Xing Q, Zhu C, Bilguvar K, Padilla-Lopez S, Lifton RP, Gecz J, MacLennan AH, Kruer MC. Author Correction: Mutations disrupting neuritogenesis genes confer risk for cerebral palsy. Nature Genetics 2021, 53: 412-412. PMID: 33432185, DOI: 10.1038/s41588-021-00780-8.Peer-Reviewed Original Research
2020
Clinical Therapy Services for Adults with Cerebral Palsy
Gannotti M, Frumberg D. Clinical Therapy Services for Adults with Cerebral Palsy. 2020, 2519-2541. DOI: 10.1007/978-3-319-74558-9_158.ChaptersCerebral palsyMeasures of healthEffective rehabilitation techniqueChronic disabilityClinical managementPhysical activityNeeds of adultsClinical practiceMetabolic consequencesTherapy servicesRehabilitation needsEvidence-based techniquesPalsyAdultsCritical periodRehabilitation techniquesHealthLife spanPainDosingMutations disrupting neuritogenesis genes confer risk for cerebral palsy
Jin SC, Lewis SA, Bakhtiari S, Zeng X, Sierant MC, Shetty S, Nordlie SM, Elie A, Corbett MA, Norton BY, van Eyk CL, Haider S, Guida BS, Magee H, Liu J, Pastore S, Vincent JB, Brunstrom-Hernandez J, Papavasileiou A, Fahey MC, Berry JG, Harper K, Zhou C, Zhang J, Li B, Zhao H, Heim J, Webber DL, Frank MSB, Xia L, Xu Y, Zhu D, Zhang B, Sheth AH, Knight JR, Castaldi C, Tikhonova IR, López-Giráldez F, Keren B, Whalen S, Buratti J, Doummar D, Cho M, Retterer K, Millan F, Wang Y, Waugh JL, Rodan L, Cohen JS, Fatemi A, Lin AE, Phillips JP, Feyma T, MacLennan SC, Vaughan S, Crompton KE, Reid SM, Reddihough DS, Shang Q, Gao C, Novak I, Badawi N, Wilson YA, McIntyre SJ, Mane SM, Wang X, Amor DJ, Zarnescu DC, Lu Q, Xing Q, Zhu C, Bilguvar K, Padilla-Lopez S, Lifton RP, Gecz J, MacLennan AH, Kruer MC. Mutations disrupting neuritogenesis genes confer risk for cerebral palsy. Nature Genetics 2020, 52: 1046-1056. PMID: 32989326, PMCID: PMC9148538, DOI: 10.1038/s41588-020-0695-1.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsbeta CateninCerebral PalsyCyclin DCytoskeletonDrosophilaExomeExome SequencingExtracellular MatrixF-Box ProteinsFemaleFocal AdhesionsGenetic Predisposition to DiseaseGenome, HumanHumansMaleMutationNeuritesrhoB GTP-Binding ProteinRisk FactorsSequence Analysis, DNASignal TransductionTubulinTumor Suppressor ProteinsConceptsDamaging de novo mutationsCerebral palsyDe novo mutationsCerebral palsy casesRisk genesDamaging de novoNovo mutationsWhole-exome sequencingPalsy casesNeuromotor functionD levelsMonogenic etiologyCyclin D levelsNeuronal connectivityPalsyGene confer riskConfer riskRecessive variantsNeurodevelopmental disorder genesReverse genetic screenDisorder genesParent-offspring triosGenome-wide significanceGenomic factorsCytoskeleton pathwayMorphea after Borrelia-induced facial nerve palsy
Xie CB, Cowper S, Odell ID. Morphea after Borrelia-induced facial nerve palsy. Journal Of Scleroderma And Related Disorders 2020, 6: 111-113. PMID: 35382252, PMCID: PMC8922639, DOI: 10.1177/2397198320956892.Peer-Reviewed Case Reports and Technical NotesFacial nerve palsyNerve palsyDevelopment of morpheaLocal immune toleranceFacial nerve paralysisAutoimmune phenomenaMost patientsNerve paralysisExact pathogenesisImmune toleranceAutoimmune diseasesHost antigensLocalized sclerodermaCommon causeFamily historyMorpheaEndemic areasGenetic predispositionPrevious episodesPalsyYoung menPrevious casesEnvironmental insultsInfectionBorreliaMolecular Diagnosis and Extracranial Extension in Cushing Disease
Hong CS, Murari K, Gossmann M, Mahajan A, Erson-Omay Z, Manes RP, Omay SB. Molecular Diagnosis and Extracranial Extension in Cushing Disease. JAMA Otolaryngology - Head & Neck Surgery 2020, 146: 865-867. PMID: 32644156, DOI: 10.1001/jamaoto.2020.1471.Peer-Reviewed Original ResearchAdaptive Activities for Patients with Cerebral Palsy
Trionfo A, Franklin C. Adaptive Activities for Patients with Cerebral Palsy. 2020, 251-256. DOI: 10.1007/978-3-030-46574-2_12.Peer-Reviewed Original ResearchMotor and sensory rehabilitation of the lower lip
Mohan S, Jowett N. Motor and sensory rehabilitation of the lower lip. Operative Techniques In Otolaryngology-Head And Neck Surgery 2020, 31: 45-54. DOI: 10.1016/j.otot.2019.12.010.Peer-Reviewed Original ResearchNeurodevelopmental outcome descriptions in cohorts of extremely preterm children
Ding S, Mew E, Chee-A-Tow A, Offringa M, Butcher N, Moore G. Neurodevelopmental outcome descriptions in cohorts of extremely preterm children. Archives Of Disease In Childhood Fetal & Neonatal 2020, 105: 510-519. PMID: 31932362, DOI: 10.1136/archdischild-2019-318144.Peer-Reviewed Original ResearchConceptsCohort studyCerebral palsyCognitive functionNeurodevelopmental outcomesOutcome selectionProspective cohort studyLong-term followOutcome descriptionsCompleteness of outcomeCompleteness of reportingOutcome assessorsPreterm infantsPreterm birthOutcome definitionsPreterm childrenOutcome reportingPalsyOutcomesInfantsChildrenReportingPretermStudy resultsCohortFollow
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