2025
Uptake of and Disparities in Semaglutide and Tirzepatide Prescribing for Obesity in the US
Kim C, Ross J, Jastreboff A, Meeker D, Freedman H, Krumholz H, Lu Y. Uptake of and Disparities in Semaglutide and Tirzepatide Prescribing for Obesity in the US. JAMA 2025, 333: 2203-2206. PMID: 40299371, PMCID: PMC12042086, DOI: 10.1001/jama.2025.4735.Peer-Reviewed Original ResearchAssociation of Endocrinologists in Clinical Care Team With Sodium–Glucose Cotransporter 2 Inhibitor Prescription for People With Type 2 Diabetes After Coronary Artery Bypass Grafting: A Two-Center Study
Yi Y, Kumar N, Smith M, Mueller A, Houle T, Jassar A, Cornella L, Schonberger R, Bardia A. Association of Endocrinologists in Clinical Care Team With Sodium–Glucose Cotransporter 2 Inhibitor Prescription for People With Type 2 Diabetes After Coronary Artery Bypass Grafting: A Two-Center Study. Clinical Diabetes 2025 DOI: 10.2337/cd24-0107.Peer-Reviewed Original ResearchSodium-glucose cotransporter 2Coronary Artery Bypass GraftingType 2 diabetesArtery Bypass GraftingInhibitor prescriptionBypass GraftingSodium-glucose cotransporter 2 inhibitorsTwo-center studyCotransporter 2Sodium-glucosePostoperative careEndocrinologistsClinical care teamTwo-centerPatientsTreatment teamPrescription
2024
Benzodiazepine Utilization in Ischemic Stroke Survivors: Analyzing Initial Excess Supply and Longitudinal Trends
Torres V, Brooks J, Donahue M, Sun S, Hsu J, Price M, Blacker D, Schwamm L, Newhouse J, Haneuse S, Moura L. Benzodiazepine Utilization in Ischemic Stroke Survivors: Analyzing Initial Excess Supply and Longitudinal Trends. Stroke 2024, 55: 2694-2702. PMID: 39417222, PMCID: PMC11729356, DOI: 10.1161/strokeaha.124.047257.Peer-Reviewed Original ResearchConceptsIschemic stroke dischargesSkilled nursing facilityDays supplyMonths prior enrollmentUS Medicare claimsIschemic stroke survivorsPost-acute ischemic strokeIschemic strokeNursing facilitiesStroke survivorsStroke dischargesMedicare claimsBenzodiazepine initiationTraditional Medicare coverageMedicare coverageMedical insuranceBenzodiazepine prescriptionsExamined demographicsAcute ischemic strokeInitiation rateLongitudinal trendsPrescription patternsPart AHospital insurancePrescriptionImpact of complementary health approaches on opioid prescriptions among veterans with musculoskeletal disorders – A retrospective cohort study
Han L, Goulet J, Skanderson M, Redd D, Brandt C, Zeng-Treitler Q. Impact of complementary health approaches on opioid prescriptions among veterans with musculoskeletal disorders – A retrospective cohort study. Journal Of Pain 2024, 26: 104695. PMID: 39384145, PMCID: PMC11781976, DOI: 10.1016/j.jpain.2024.104695.Peer-Reviewed Original ResearchIntegrative health approachesHealth approachOpioid prescriptionsMusculoskeletal disordersAdministration electronic health recordComplementary health approachesPrimary care visitsElectronic health recordsPharmacy dispensing recordsCIH approachesCare visitsDispensed opioid prescriptionsHealth recordsRetrospective cohort studyDispensing recordsPatient's painAnalytic sampleIndex diagnosisExposure groupCohort studyVeteransOpioid initiationQuasi-experimental investigationCIHPrescriptionPrescription Medication Use Among Older Adults in the US
Innes G, Ogden C, Crentsil V, Concato J, Fakhouri T. Prescription Medication Use Among Older Adults in the US. JAMA Internal Medicine 2024, 184: 1121-1123. PMID: 38949837, PMCID: PMC11217884, DOI: 10.1001/jamainternmed.2024.2781.Peer-Reviewed Original ResearchOver‐The‐Counter Hearing Aids: Are They Safe and Effective?
Shah R, Wilkins S, Panth N, Tyagi S, Dunn H, Bell M, Norgaard S, Guyer E, Schwartz N. Over‐The‐Counter Hearing Aids: Are They Safe and Effective? Otolaryngology 2024, 171: 1017-1026. PMID: 38769863, DOI: 10.1002/ohn.817.Peer-Reviewed Original ResearchOver-the-counter hearing aidsHearing aidsHearing lossOver-the-counterMild-to-moderate hearing lossModerate hearing lossOver-the-counter devicesEfficacy of prescriptionHearing levelPrescriptionFood and Drug AdministrationHearingStatistically significant advantageAverage differenceSafety profileAIDSDrug AdministrationAudioscanEfficacySafetyLoss patternsDifferencesTestStatisticallySignificant advantageThe Cost of Medications at a Student-Run Free Clinic in New Haven, Connecticut, 2021–2023
See C, Hegde K, Reid L, Shi R, Luthra R, Dong W, Lee V, Kang-Giaimo A. The Cost of Medications at a Student-Run Free Clinic in New Haven, Connecticut, 2021–2023. Preventing Chronic Disease 2024, 21: e34. PMID: 38753526, PMCID: PMC11155686, DOI: 10.5888/pcd21.230277.Peer-Reviewed Original ResearchConceptsStudent-run free clinicFree clinicExpensive medicationsLocal pharmaciesFederal poverty levelIn-house pharmaciesNew HavenHousehold annual incomeCost of medicationsPatient's homeStudent-runHealth insurancePharmacy departmentAnnual incomePoverty levelFluticasone propionate/salmeterolMedical suppliesMedroxyprogesterone acetateRespiratory conditionsPharmacyMedicationDeliver medicationsPrescriptionAlbuterol sulfatePatientsClients’ experiences and satisfaction with produce prescription programs in California: a qualitative evaluation to inform person-centered and respectful program models
Rhodes E, Pérez-Escamilla R, Okoli N, Hromi-Fiedler A, Foster J, McAndrew J, Duran-Becerra B, Duffany K. Clients’ experiences and satisfaction with produce prescription programs in California: a qualitative evaluation to inform person-centered and respectful program models. Frontiers In Public Health 2024, 12: 1295291. PMID: 38572012, PMCID: PMC10990041, DOI: 10.3389/fpubh.2024.1295291.Peer-Reviewed Original ResearchPrescription programClient experiencePerson-centeredFederally Qualified Health CentersFramework analysis approachQualified health centersImprove client experienceFocus group discussionsTreated with respectVegetable consumptionPerson-centrednessProgram usabilityHealth centersParticipants' program experiencesPositive experiencesGroup discussionsLife courseGift cardsPrescriptionParticipantsProgram designSatisfactionThemesProgram demandsFresh fruitsDevelopment and validation of an indicator to identify prescriptions as non-opioid pharmacological therapies used for pain management through the use of electronic health record data
Lane R, Tomedi L, Takeda M, Hood N, Katzman J. Development and validation of an indicator to identify prescriptions as non-opioid pharmacological therapies used for pain management through the use of electronic health record data. Pain Medicine 2024, 25: 416-418. PMID: 38400762, PMCID: PMC11145446, DOI: 10.1093/pm/pnae011.Peer-Reviewed Original ResearchPsychotropic prescribing after hospital discharge in survivors of critical illness, a retrospective cohort study (2012–2019)
Mansi E, Rentsch C, Bourne R, Guthrie B, Lone N. Psychotropic prescribing after hospital discharge in survivors of critical illness, a retrospective cohort study (2012–2019). Journal Of The Intensive Care Society 2024, 25: 171-180. PMID: 38737305, PMCID: PMC11081855, DOI: 10.1177/17511437231223470.Peer-Reviewed Original ResearchPsychotropic prescriptionsSurvivors of critical illnessCritical care survivorsPsychotropic prescribingCare groupHospital dischargeRetrospective cohort studyCritical careCritical illnessCohort studyHazard ratioMental health issuesCritical care groupHospitalised survivorsPsychotropic medicinesPotential confoundersSleep disturbanceHospitalised adultsHealth issuesHospitalised patientsIllnessSurvivorsPrescriptionClinical practiceCare
2023
Is hospitalization a missed opportunity to intervene on tobacco cessation?
Nielsen E, Zhang J, Marsden J, Bays C, Moran W, Mauldin P, Lenert L, Toll B, Schreiner A, Heincelman M. Is hospitalization a missed opportunity to intervene on tobacco cessation? The American Journal Of The Medical Sciences 2023, 367: 89-94. PMID: 38043793, DOI: 10.1016/j.amjms.2023.11.024.Peer-Reviewed Original ResearchTobacco cessationNRT prescriptionCurrent smokersTobacco usePatient-centered medical homeStudy periodNicotine replacement therapy productsRetrospective cohort studyPrimary care physiciansLogistic regression modelsProportion of adultsHealth-related changesAdult patientsCohort studyHospital dischargeMost patientsCare physiciansElevated morbidityMedical homeHospitalizationSmokersPatientsCessationPrescriptionTeachable momentHealth policy considerations for combining exercise prescription into noncommunicable diseases treatment: a narrative literature review
Tao D, Awan-Scully R, Ash G, Gu Y, Pei Z, Gao Y, Cole A, Supriya R, Sun Y, Xu R, Baker J. Health policy considerations for combining exercise prescription into noncommunicable diseases treatment: a narrative literature review. Frontiers In Public Health 2023, 11: 1219676. PMID: 37849722, PMCID: PMC10577435, DOI: 10.3389/fpubh.2023.1219676.Peer-Reviewed Original ResearchConceptsExercise prescriptionNoncommunicable diseasesNoncommunicable disease preventionBenefits of exerciseHealth policy considerationsDisease treatmentPatients' life qualityLife qualityPopulation health statusRoutine careOutpatient settingHealth statusDisease preventionHealthy lifestyleEvidence baseLiterature reviewHealth policyNarrative literature reviewFitness levelHealthcare systemPrescriptionTreatmentFramework analysisExerciseReviewIntegration of exercise prescription into medical provision as a treatment for non-communicable diseases: A scoping review
Tao D, Awan-Scully R, Cole A, Gao Y, Ash G, Gu Y, Dutheil F, Sun Y, Baker J. Integration of exercise prescription into medical provision as a treatment for non-communicable diseases: A scoping review. Frontiers In Public Health 2023, 11: 1126244. PMID: 37501942, PMCID: PMC10369190, DOI: 10.3389/fpubh.2023.1126244.Peer-Reviewed Original ResearchConceptsNon-communicable diseasesExercise prescriptionInclusion criteriaEffectiveness of exerciseOutpatient healthcare servicesPRISMA extension guidelinesWeb of ScienceExercise interventionMixed study designOutpatient settingPICO toolCurrent evidenceReference listsTreatment settingsLiterature searchDiseaseSystematic searchHealthcare policymakersHealthcare practitionersHealthcare servicesPrescriptionCurrent scientific literatureInpatientsScoping ReviewTreatmentPatterns of Digoxin Prescribing for Medicare Beneficiaries in the United States 2013-2019
See C, Wheelock K, Caraballo C, Khera R, Annapureddy A, Mahajan S, Lu Y, Krumholz H, Murugiah K. Patterns of Digoxin Prescribing for Medicare Beneficiaries in the United States 2013-2019. American Journal Of Medicine Open 2023, 10: 100048. PMID: 38213879, PMCID: PMC10783702, DOI: 10.1016/j.ajmo.2023.100048.Peer-Reviewed Original ResearchDigoxin prescriptionDigoxin useNew heart failure therapiesGeneral medicine physiciansHeart failure therapyMedicare Part D dataPart D dataDigoxin prescribingFailure therapyPrescriber characteristicsMedicine physiciansMedicare beneficiariesPrescribersLikely maleLogistic regressionDigoxinNew prescribersPrescriptionRecent dataCardiologyReal-World Observational Evaluation of Common Interventions to Reduce Emergency Department Prescribing of Opioid Medications
Sangal R, Rothenberg C, Hawk K, D'Onofrio G, Hsiao A, Solad Y, Venkatesh A. Real-World Observational Evaluation of Common Interventions to Reduce Emergency Department Prescribing of Opioid Medications. The Joint Commission Journal On Quality And Patient Safety 2023, 49: 239-246. PMID: 36914528, DOI: 10.1016/j.jcjq.2023.01.013.Peer-Reviewed Original ResearchConceptsOpioid prescribingED visitsElectronic health recordsOpioid prescriptionsEmergency department opioid prescriptionsAnalgesia prescriptionOpioid stewardshipOpioid medicationsSecondary outcomesPrimary outcomePreintervention periodInterruptive alertsCommon interventionPrescribingAlert fatigueElectronic prescribingPrevious interventionsHospital systemObservational evaluationHealth recordsVisitsStewardship policiesInterventionOutcomesPrescription
2022
Granular analysis of pathways to care and durations of untreated psychosis: A marginal delay model
Mathis W, Ferrara M, Burke S, Hyun E, Li F, Zhou B, Cahill J, Kline E, Keshavan M, Srihari V. Granular analysis of pathways to care and durations of untreated psychosis: A marginal delay model. PLOS ONE 2022, 17: e0270234. PMID: 36472968, PMCID: PMC9725156, DOI: 10.1371/journal.pone.0270234.Peer-Reviewed Original ResearchUntreated psychosisAntipsychotic prescriptionsEarly detection campaignsPatient characteristics influencesEarly detection effortsPatient characteristicsClinical nodesLonger DUPFunctional declineOutpatient programPsychosis onsetSpecialized treatmentPsychosisNumber of daysDetection campaignsNetworks of careHigh functioningPrescriptionEnrollmentPTCDurationStart dateHospital Variation of Spironolactone Use in Patients Hospitalized for Heart Failure in China—The China PEACE Retrospective Heart Failure Study
Yu Y, Guan W, Masoudi FA, Wang B, He G, Spertus JA, Lu Y, Krumholz HM, Li J. Hospital Variation of Spironolactone Use in Patients Hospitalized for Heart Failure in China—The China PEACE Retrospective Heart Failure Study. Journal Of The American Heart Association 2022, 11: e026300. PMID: 36172964, PMCID: PMC9673705, DOI: 10.1161/jaha.122.026300.Peer-Reviewed Original ResearchConceptsSpironolactone prescriptionSpironolactone useHeart failureMedian odds ratioIdeal patientAldosterone antagonistsHospital variationMedian rateReduced ejection fractionUse of spironolactoneMultivariable linear regression modelsHeart Failure StudyEjection fractionHospital characteristicsOdds ratioRepresentative cohortPatientsHospitalChinese hospitalsInappropriate usePrescriptionSpironolactoneSelect individualsAntagonistHigh rateJoint longitudinal trajectories of pain intensity and opioid prescription in veterans with back pain
Buta E, Gordon KS, Gueorguieva R, Becker WC, Heapy A, Bathulapalli H, Zeng Q, Redd D, Brandt C, Goulet J. Joint longitudinal trajectories of pain intensity and opioid prescription in veterans with back pain. Pharmacoepidemiology And Drug Safety 2022, 31: 1262-1271. PMID: 35996825, DOI: 10.1002/pds.5531.Peer-Reviewed Original ResearchConceptsBack painOpioid prescriptionsPain/Pain intensityRetrospective cohort studyTrajectories of painElectronic health record dataMental health diagnosesHealth record dataHigh opioidCohort studyClinical predictorsHigher oddsPainLatent class growth analysisOpioidsPain classesHealth diagnosisRecord dataVeteransLongitudinal trajectoriesPrescriptionOddsTrajectory classesDistinct patterns
2021
National Trends in the Use of Sacubitril/Valsartan
Ozaki AF, Krumholz HM, Mody FV, Jackevicius CA. National Trends in the Use of Sacubitril/Valsartan. Journal Of Cardiac Failure 2021, 27: 839-847. PMID: 34364661, DOI: 10.1016/j.cardfail.2021.05.015.Peer-Reviewed Original ResearchConceptsSacubitril/valsartanSacubitril/valsartan useReduced ejection fractionValsartan useEjection fractionHeart failurePopulation-level cohort studyNational Prescription AuditEligible patientsCohort studyPrescription patternsYounger patientsPrescription auditDosage patternClinical implicationsFurther evaluationValsartanPatientsSubstantial proportionNational trendsPrescriptionGreater increaseRecent useGreater proportionUnited StatesPain intensity and pain medication prescription patterns in Veterans with heart failure and back pain
Cavanagh CE, Rosman L, Chui PW, DeRycke E, Bathulapalli H, Gandhi P, Bastian LA, Burg MM, Brandt C, Goulet JL. Pain intensity and pain medication prescription patterns in Veterans with heart failure and back pain. Heart & Lung 2021, 50: 770-774. PMID: 34225088, DOI: 10.1016/j.hrtlng.2021.04.016.Peer-Reviewed Original ResearchConceptsComorbid heart failureHeart failureBack painPain intensityMedication prescription patternsPain medication prescriptionsHigher likelihoodGabapentin prescriptionsNSAID prescriptionsPrescription patternsSevere painPain conditionsMedication prescriptionsClinical managementPainMusculoskeletal disordersDisorder cohortLower likelihoodVeteransFurther studiesPrescriptionFailureOpioidsCardiovascularCohort
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