2025
Effects of Centro-Median Nucleus Stimulation on Interictal scalp EEG burden in LGS.
Sivaraju A, Poe J, Blumenfed H, Cukiert A. Effects of Centro-Median Nucleus Stimulation on Interictal scalp EEG burden in LGS. Stereotactic And Functional Neurosurgery 2025, 1-9. PMID: 40889229, DOI: 10.1159/000548242.Peer-Reviewed Original ResearchInterictal dischargesDeep brain stimulationAcute EEG changesDuration of EEG recordingSeizure reduction rateLennox-Gastaut syndromeOne-month post-surgeryExpert human readersShort durationCM-DBSLGS patientsLennox-GastautPredictive biomarkersBaseline EEGEEG changesTreatment optionsNon-respondersPost-surgeryInterictal activityThalamic nucleiClinical utilityPatientsEEG recordingsNucleus stimulationHypothesis-generatingPreoperative Radiation Boost Results in Low Rates of Re-excision and Reduced Locoregional Treatment Time in Breast Cancer Patients
Chakraborty M, Sherwani Z, Narra L, Abou Yehia Z, Ohri N, Cui T, Eladoumikdachi F, Kowzun M, Kumar S, Potdevin L, Toppmeyer D, Haffty B. Preoperative Radiation Boost Results in Low Rates of Re-excision and Reduced Locoregional Treatment Time in Breast Cancer Patients. Annals Of Surgical Oncology 2025, 1-7. PMID: 40836156, PMCID: PMC12373021, DOI: 10.1245/s10434-025-18089-9.Peer-Reviewed Original ResearchRate of re-excisionRe-excision ratesPhase II trialRe-ExcisionBreast cancer patientsContemporary cohortII trialCancer patientsInitiation of systemic therapyRisk of wound complicationsStandard postoperative approachTumor bed boostWhole breast radiotherapyCompletion of radiotherapyInadequate surgical marginsMedian treatment timeShort durationPostoperative boostLocoregional therapyPostoperative approachDiagnostic biopsySurgical marginsSystemic therapyProspective trialsWound complications
2024
Trends in management of patients with new‐onset refractory status epilepticus (NORSE) from 2016 to 2023: An interim analysis
Hanin A, Jimenez A, Gopaul M, Asbell H, Aydemir S, Basha M, Batra A, Damien C, Day G, Eka O, Eschbach K, Fatima S, Fields M, Foreman B, Gerard E, Gofton T, Haider H, Hantus S, Hocker S, Jongeling A, Aparicio M, Kandula P, Kang P, Kazazian K, Kellogg M, Kim M, Lee J, Marcuse L, McGraw C, Mohamed W, Orozco J, Pimentel C, Punia V, Ramirez A, Steriade C, Struck A, Taraschenko O, Treister A, Wainwright M, Yoo J, Zafar S, Zhou D, Zutshi D, Gaspard N, Hirsch L. Trends in management of patients with new‐onset refractory status epilepticus (NORSE) from 2016 to 2023: An interim analysis. Epilepsia 2024, 65: e148-e155. PMID: 38837761, DOI: 10.1111/epi.18014.Peer-Reviewed Original ResearchNew-onset refractory status epilepticusSecond-line immunotherapyKetogenic dietStatus epilepticusDuration of status epilepticusRefractory status epilepticusStatus epilepticus onsetManagement of patientsEvolving treatment landscapeTreatment landscapeImmunotherapyConsensus recommendationsInterim analysisPatientsPatient outcomesAnakinraEpilepticusShort durationMedianORCIDietDaysTocilizumabIncreased useImmune and behavioral correlates of protection against symptomatic post-vaccination SARS-CoV-2 infection
Goguet E, Olsen C, Meyer W, Ansari S, Powers J, Conner T, Coggins S, Wang W, Wang R, Illinik L, Edwards M, Jackson-Thompson B, Hollis-Perry M, Wang G, Alcorta Y, Wong M, Saunders D, Mohammed R, Balogun B, Kobi P, Kosh L, Bishop-Lilly K, Cer R, Arnold C, Voegtly L, Fitzpatrick M, Luquette A, Malagon F, Ortega O, Parmelee E, Davies J, Lindrose A, Haines-Hull H, Moser M, Samuels E, Rekedal M, Graydon E, Malloy A, Tribble D, Burgess T, Campbell W, Robinson S, Broder C, O’Connell R, Weiss C, Pollett S, Laing E, Mitre E. Immune and behavioral correlates of protection against symptomatic post-vaccination SARS-CoV-2 infection. Frontiers In Immunology 2024, 15: 1287504. PMID: 38566991, PMCID: PMC10985347, DOI: 10.3389/fimmu.2024.1287504.Peer-Reviewed Original ResearchConceptsResearch assaySARS-CoV-2Commercial assaysIgA binding antibodiesCorrelates of protectionAnti-spike IgG levelsSpike-specific IgGShorter duration of illnessDuration of illnessMultivariate regression analysisSARS-CoV-2 infectionShort durationSARS-CoV-2 variantsNeutralization titersPost-vaccination SARS-CoV-2 infectionIgG levelsNeutralizing activityOmicron waveBehavioral correlatesRisk scoreDisease severityBinding antibodiesSerumSaliva samplesOmicron subvariants
2023
Triglyceride Clearance in Hypertriglyceridemic Pancreatitis: Time Course and Its Implications for Management
Majumdar S. Triglyceride Clearance in Hypertriglyceridemic Pancreatitis: Time Course and Its Implications for Management. Endocrine Practice 2023, 29: 971-979. PMID: 37714331, DOI: 10.1016/j.eprac.2023.09.002.Peer-Reviewed Original ResearchInitial TG levelsTG levelsInsulin therapyMedical record reviewDiagnosis of pancreatitisTime courseHypertriglyceridemic pancreatitisIntravenous insulinRecord reviewTime-course evaluationTriglyceride clearanceInsulin treatmentNutritional intakeSeparate patientsTG loweringDlPatientsLonger durationPancreatitisShort durationHTGTherapyCauseClearanceDaysCharacterization of the extracellular free water signal in schizophrenia using multi-site diffusion MRI harmonization
Cetin-Karayumak S, Lyall A, Di Biase M, Seitz-Holland J, Zhang F, Kelly S, Elad D, Pearlson G, Tamminga C, Sweeney J, Clementz B, Schretlen D, Stegmayer K, Walther S, Lee J, Crow T, James A, Voineskos A, Buchanan R, Szeszko P, Malhotra A, Keshavan M, Shenton M, Rathi Y, Pasternak O, Kubicki M. Characterization of the extracellular free water signal in schizophrenia using multi-site diffusion MRI harmonization. Molecular Psychiatry 2023, 28: 2030-2038. PMID: 37095352, PMCID: PMC11146151, DOI: 10.1038/s41380-023-02068-1.Peer-Reviewed Original ResearchDuration of illnessIllness stageHealthy controlsWhole brain white matterDifferent illness stagesFree-water imagingSchizophrenia spectrum disordersYounger patientsBrain white matterExtracellular free waterProlonged illnessEarly psychosisDiffusion magnetic resonanceWhite matterDemographic dataIllnessSchizophreniaSmall effect sizesShort durationTime courseAgeEffect sizeSignificant global increaseInternational sitesDisordersQualitative exploration of longer versus shorter quit attempts among adults using E-Cigarettes for combustible cigarette cessation
Suttiratana S, Morean M, Krishnan-Sarin S, Bold K. Qualitative exploration of longer versus shorter quit attempts among adults using E-Cigarettes for combustible cigarette cessation. Addictive Behaviors 2023, 143: 107710. PMID: 37015170, PMCID: PMC10165882, DOI: 10.1016/j.addbeh.2023.107710.Peer-Reviewed Original ResearchConceptsQuit attemptsE-cigarettesSmoking cigarettesHealth-related harmsShort durationCombustible cigarette useAttempt durationSmoking cessationCigarette cessationMajority of participantsCigarette useCombustible cigarettesE-cigarette devicesHealth concernLonger durationCigarettesMost participantsCessationDurationSocial stigmaAdditional researchAdult experienceAdultsQualitative explorationInterview transcriptsIt is strongly recommended to not conduct, fund, or publish research studies that use spot urine samples with estimating equations to assess individuals’ sodium (salt) intake in association with health outcomes: a policy statement of the World Hypertension League, International Society of Hypertension and Resolve to Save Lives
Campbell N, Whelton P, Orias M, Cobb L, Jones E, Garg R, Willliams B, Khan N, Chia Y, Jafar T, Ide N. It is strongly recommended to not conduct, fund, or publish research studies that use spot urine samples with estimating equations to assess individuals’ sodium (salt) intake in association with health outcomes: a policy statement of the World Hypertension League, International Society of Hypertension and Resolve to Save Lives. Journal Of Hypertension 2023, 41: 683-686. PMID: 36723484, PMCID: PMC10090307, DOI: 10.1097/hjh.0000000000003385.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsSpot urine samplesSodium intakeIndividual sodium intakeWorld Hypertension LeagueHealth outcomesUrine samplesHealth outcome associationsOutcome associationsInternational SocietyDietary sodiumHealth OrganizationIntakeHypertensionHealth impactsShort durationOutcomesAssociationSubstantial controversyLiterature reviewPolicy statements
2022
Warm Blood Meal Increases Digestion Rate and Milk Protein Production to Maximize Reproductive Output for the Tsetse Fly, Glossina morsitans
Benoit J, Lahondère C, Attardo G, Michalkova V, Oyen K, Xiao Y, Aksoy S. Warm Blood Meal Increases Digestion Rate and Milk Protein Production to Maximize Reproductive Output for the Tsetse Fly, Glossina morsitans. Insects 2022, 13: 997. PMID: 36354821, PMCID: PMC9695897, DOI: 10.3390/insects13110997.Peer-Reviewed Original ResearchBurnout Among US Gastroenterologists and Fellows in Training
Anderson J, Bilal M, Burke C, Gaidos J, Lopez R, Oxentenko A, Surawicz C. Burnout Among US Gastroenterologists and Fellows in Training. Journal Of Clinical Gastroenterology 2022, 57: 1063-1069. PMID: 36477385, DOI: 10.1097/mcg.0000000000001781.Peer-Reviewed Original ResearchPatient-related workPrevalence of burnoutElectronic health recordsOutpatient timeProcedure 10More hoursHigh burnoutLifestyle factorsMaslach Burnout Inventory SurveyFemale sexPatient satisfactionUS gastroenterologistsAmerican CollegeInpatient consultsGastroenterologistsGastroenterology fellowsYounger ageSurvey of fellowsHealth recordsSpecific contributing factorsLevel of burnoutPhysician burnoutMedical errorsCOVID-19 pandemicShort durationBreastmilk pumping experiences of physician mothers: quantitative and qualitative findings from a nationwide survey study
Jain S, Neaves S, Royston A, Huang I, Juengst S. Breastmilk pumping experiences of physician mothers: quantitative and qualitative findings from a nationwide survey study. Journal Of General Internal Medicine 2022, 37: 3411-3418. PMID: 35060006, PMCID: PMC9550890, DOI: 10.1007/s11606-021-07388-y.Peer-Reviewed Original ResearchConceptsNationwide survey studyPhysician mothersFree-text response optionsBreast milkFree-text responsesSurvey studyBreastmilkSurvey response optionsCommon barriersMothersMothers' experiencesShort durationInfantsMedical students todayResponse optionsFamily leaveOpen-ended questionMaternity leaveLack of supportQualitative findingsBackgroundNearlyResultsLackBreastfeedGreater supportOptions
2021
Prognostic value of vascular inflammation biomarkers over clinical risk factors for cardiovascular risk : a meta-analysis
Simantiris S, Antonopoulos A, Angelopoulos A, Papanikolaou P, Oikonomou E, Vamvakaris K, Koumpoura A, Farmaki M, Trivella M, Vlachopoulos C, Tsioufis K, Antoniades C, Tousoulis D. Prognostic value of vascular inflammation biomarkers over clinical risk factors for cardiovascular risk : a meta-analysis. European Journal Of Preventive Cardiology 2021, 28: zwab061.243. DOI: 10.1093/eurjpc/zwab061.243.Peer-Reviewed Original ResearchBiomarkers of vascular inflammationFat attenuation indexVascular inflammation biomarkersResidual inflammatory riskIncremental prognostic valuePrognostic valuePrimary outcomeVascular inflammationImaging biomarkersSecondary outcomesRisk stratificationComposite endpointCardiovascular eventsInflammation biomarkersInflammatory riskMeta-analysisHigh-risk plaque featuresDuration of follow-upShort duration of follow-upCCTA imagesProspective cohort studyClinical risk factorsRandom-effects modelCardiovascular risk stratificationShort durationNoninvasive preimplantation genetic testing for aneuploidy exhibits high rates of deoxyribonucleic acid amplification failure and poor correlation with results obtained using trophectoderm biopsy
Hanson BM, Tao X, Hong KH, Comito CE, Pangasnan R, Seli E, Jalas C, Scott RT. Noninvasive preimplantation genetic testing for aneuploidy exhibits high rates of deoxyribonucleic acid amplification failure and poor correlation with results obtained using trophectoderm biopsy. Fertility And Sterility 2021, 115: 1461-1470. PMID: 33745720, DOI: 10.1016/j.fertnstert.2021.01.028.Peer-Reviewed Original ResearchMeSH KeywordsAneuploidyBlastocystCulture MediaEmbryo Culture TechniquesEmbryo ImplantationEmbryo TransferFemaleFertilityHigh-Throughput Nucleotide SequencingHumansInfertilityLive BirthMaleNoninvasive Prenatal TestingNucleic Acid Amplification TechniquesPredictive Value of TestsPregnancyPregnancy RatePreimplantation DiagnosisReproducibility of ResultsSperm Injections, IntracytoplasmicTime FactorsTreatment OutcomeWhole Genome SequencingConceptsPreimplantation genetic testingGenetic testingBiopsy resultsProspective cohort study SETTINGTrophectoderm biopsyTE biopsyNoninvasive preimplantation genetic testingCohort study SETTINGNext-generation sequencingHigh ratePrimary outcomeClinical outcomesMAIN OUTCOMEBiopsyStudy settingAmplification failureDiscordant resultsClinical applicabilityPrivate practiceNiPGTAvailable kitsCulture mediumShort durationOutcomesCulture medium samplesPreferred practices for rescue treatment of seizure clusters: A consensus-driven, multi-stakeholder approach
Buchhalter J, Shafer PO, Buelow JM, French JA, Gilchrist B, Hirsch LJ, Nasuta M, Santilli N. Preferred practices for rescue treatment of seizure clusters: A consensus-driven, multi-stakeholder approach. Epilepsy & Behavior 2021, 117: 107836. PMID: 33640567, DOI: 10.1016/j.yebeh.2021.107836.Peer-Reviewed Original ResearchConceptsSeizure action planRescue therapySeizure clustersConsensus-derived recommendationsCare of peoplePreferred termPhase 2Seizure frequencyPreferred practicesRescue treatmentEpilepsy expertsRescue medicineSpecialist physiciansTreatment interventionsEpilepsyHealthcare professionalsEpilepsy FoundationPWEIndividualized mannerShort durationTherapyFinal consensusPhase 1Education/communicationCaregiversComparison of imaging vs. plasma biomarkers of vascular inflammation for cardiovascular prognostication: a meta-analysis
Antonopoulos A, Angelopoulos A, Papanikolaou P, Simantiris S, Oikonomou E, Vamvakaris K, Koumpoura A, Farmaki M, Trivella M, Vlachopoulos C, Antoniades C, Tousoulis D. Comparison of imaging vs. plasma biomarkers of vascular inflammation for cardiovascular prognostication: a meta-analysis. European Heart Journal - Cardiovascular Imaging 2021, 22: jeaa356.242. DOI: 10.1093/ehjci/jeaa356.242.Peer-Reviewed Original ResearchBiomarkers of vascular inflammationIncremental prognostic valuePrognostic valueVascular inflammationPrimary outcomePlasma biomarkersImaging biomarkersInflammatory biomarkersC-indexSecondary outcomesDuration of follow-upShort duration of follow-upMeasurement of inflammatory biomarkersClinical modelMeta-analysisProspective cohort studyCardiovascular disease burdenMedian C-indexCardiovascular risk stratificationRandom-effects modelShort durationStable patientsRisk stratificationComposite endpointRisk prognostication
2020
Herbal Medicines in Glaucoma Treatment.
Ige M, Liu J. Herbal Medicines in Glaucoma Treatment. The Yale Journal Of Biology And Medicine 2020, 93: 347-353. PMID: 32607093, PMCID: PMC7309662.Peer-Reviewed Original ResearchConceptsCourse of glaucomaIntraocular pressureGlaucoma patientsGlaucoma treatmentRetinal ganglion cell deathHerbal medicineMedical marijuanaGanglion cell deathStandard therapeutic agentsSignificant adverse effectsCurrent standardGinkgo bilobaSurgical therapyGlaucoma managementIrreversible blindnessGlaucomaAlternative medicineLarger studyHerbal remediesTherapeutic agentsAddictive potentialAdverse effectsLonger durationPatientsShort durationEarly tracheostomy in patients with cervical spine injury reduces morbidity and improves resource utilization
Khan M, Prabhakaran K, Jehan F, Anderson P, Con J, Lombardo G, Rhee P, Latifi R. Early tracheostomy in patients with cervical spine injury reduces morbidity and improves resource utilization. The American Journal Of Surgery 2020, 220: 773-777. PMID: 32057414, DOI: 10.1016/j.amjsurg.2020.01.054.Peer-Reviewed Original ResearchConceptsShorter duration of mechanical ventilationDuration of mechanical ventilationC-spine injuriesEarly tracheostomyC-spineMechanical ventilationAssociated with shorter durationVentilator-associated pneumoniaAssociated with shorter duration of mechanical ventilationVentilator-associated-pneumoniaTiming of tracheostomyAssociated with lower ratesImpact of early tracheostomyRegression analysisCervical-spineMedian ISSMean ageTrauma patientsPatientsTracheostomyMortality rateICUHospitalShort durationInjury
2019
Antiplatelet therapy for tibial balloon angioplasty: A clinical perspective
Ionescu CN, Altin SE, Mena-Hurtado C. Antiplatelet therapy for tibial balloon angioplasty: A clinical perspective. SAGE Open Medicine 2019, 7: 2050312119854579. PMID: 31210934, PMCID: PMC6545680, DOI: 10.1177/2050312119854579.Peer-Reviewed Original ResearchTibial balloon angioplastyCritical limb ischaemiaBalloon angioplastyAntiplatelet therapyLimb ischaemiaCritical limb ischaemia patientsNumber of patientsMultiple comorbiditiesPreclinical dataAngioplasty techniquesTherapeutic approachesHigh riskPost interventionAngioplastyClinical perspectiveTherapyIschaemiaPatientsShort durationComorbiditiesTrialsImportant role
2018
New England BK consortium: Regional survey of BK screening and management protocols in comparison to published consensus guidelines
Gabardi S, Pavlakis M, Tan C, Francis J, Cardarelli F, Asch W, Bodziak K, Chobanian M, Gilligan H, Gohh R, Kung S, Inker L, Martin S, Rodig N, Rossi A, Chandraker A. New England BK consortium: Regional survey of BK screening and management protocols in comparison to published consensus guidelines. Transplant Infectious Disease 2018, 20: e12985. PMID: 30175491, DOI: 10.1111/tid.12985.Peer-Reviewed Original ResearchConceptsRenal transplant recipientsConsensus guidelinesBKPyV-associated nephropathyCNI dose reductionPlasma viral loadUse of leflunomideCopies/mLHalf of centersMajority of centersManagement protocolCause biopsiesImmunosuppression reductionIntravenous immunoglobulinTransplant recipientsRenal biopsyViral loadBK polyomavirusPrimary treatmentDose reductionBiopsyUniform screeningNephropathyBKPyVShort durationScreening
2017
Distressing Symptoms, Disability, and Hospice Services at the End of Life: Prospective Cohort Study
Gill TM, Han L, Leo‐Summers L, Gahbauer EA, Allore HG. Distressing Symptoms, Disability, and Hospice Services at the End of Life: Prospective Cohort Study. Journal Of The American Geriatrics Society 2017, 66: 41-47. PMID: 28895118, PMCID: PMC5777867, DOI: 10.1111/jgs.15041.Peer-Reviewed Original ResearchConceptsProspective cohort studyEnd of lifeHospice admissionCohort studyDistressing symptomsHospice servicesMonths of lifeNumber of disabilitiesMedian durationSubsequent admissionHigh burdenMedicare claimsAdditional disabilitiesAdmissionAdditional monthsSymptomsOlder personsHospiceMonthly interviewsMonthsDisabilityShort durationAdditional strategiesDurationNew Haven
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