2025
Procedure duration predicts outcomes more than prehospital delay in endovascular stroke treatment
Saad H, Koo A, Grossberg J, Tianwen M, Howard B, Sowlat M, Baba B, Chacon A, Jabbour P, Rai A, Dye J, Alaraj A, Cawley C, Tong F, Akbik F, Pabaney A, Ezzeldin M, Fiorella D, Yoshimura S, Kim J, Goyal N, Arthur A, Fragata I, Siddiqui F, Mascitelli J, Matouk C, Maier I, Park M, Levitt M, Grandhi R, Psychogios M, Wolfe S, Starke R, Shaban A, Samaniego E, Tanweer O, Romano D, Navia P, Cuellar H, Polifka A, Osbun J, Moss M, Limaye K, Mokin M, Brinjikji W, Daglioglu E, Williamson R, Altschul D, Ogilvy C, Crosa R, Gory B, Paul A, Kan P, Casagrande W, Chowdhry S, Stiefel M, Spiotta A, Alawieh A. Procedure duration predicts outcomes more than prehospital delay in endovascular stroke treatment. Journal Of NeuroInterventional Surgery 2025, jnis-2025-023906. PMID: 40973492, DOI: 10.1136/jnis-2025-023906.Peer-Reviewed Original ResearchAcute ischemic strokeModified Rankin ScaleStroke systemsEndovascular thrombectomyStroke systems of carePropensity score matchingSystems of careFunctional outcomesMarginal effects modelsSymptomatic intracranial hemorrhage rateRate of functional independencePrehospital delayIntracranial hemorrhage rateAssociated with functional outcomeInter-center differencesInternational stroke centersFunctional independenceHigher RatesEndovascular stroke treatmentHemorrhage ratePatient outcomesProcedure durationRetrospective analysisStroke centersRankin ScaleLuspatercept for Patients with Lower-Risk Myelodysplastic Syndromes/Neoplasms: A Systematic Review and Meta-Analysis.
Alhajahjeh A, Link Woite N, Rolles B, Stempel J, Mina A, Mendez L, Kewan T, Podoltsev N, Stahl M, Grimshaw A, Zeidan A, Bewersdorf J. Luspatercept for Patients with Lower-Risk Myelodysplastic Syndromes/Neoplasms: A Systematic Review and Meta-Analysis. Blood Advances 2025 PMID: 40966428, DOI: 10.1182/bloodadvances.2025017611.Peer-Reviewed Original ResearchLower-risk myelodysplastic syndromesLow transfusion burdenTransfusion independenceTransfusion-DependentAdverse eventsTI rateSystematic reviewHematological improvement-erythroidWell-tolerated treatmentFrequent adverse eventsMeta-analysisSerious adverse eventsMeta-analysis aimTransfusion burdenMyelodysplastic syndromeFrontline settingPeripheral edemaSafety profileLuspaterceptPatientsAnemiaHigher RatesEfficacyReviewTransfusionCharacterization of Postural Orthostatic Tachycardia Syndrome in Long COVID Self-reported Data From the LISTEN Study
AL Mouslmani M, Sawano M, Arun A, Wu Y, Shah R, Kaleem S, Zhou T, Murugiah K, Lu Y, Herrin J, Bishop P, Taub P, Peixoto A, Bhattacharjee B, Iwasaki A, Krumholz H. Characterization of Postural Orthostatic Tachycardia Syndrome in Long COVID Self-reported Data From the LISTEN Study. JACC Advances 2025, 4: 101873. PMID: 40883051, PMCID: PMC12399260, DOI: 10.1016/j.jacadv.2025.101873.Peer-Reviewed Original ResearchSelf-reported diagnosisPostural orthostatic tachycardia syndromeHealth statusSelf-reported long COVIDOrthostatic tachycardia syndromeHealth status of peopleEuroQol visual analog scaleDiagnosis of postural orthostatic tachycardia syndromeOnline observational studyExperiences of peopleStatus of peoplePostacute COVID-19 syndromeChest painVisual analog scaleHigher RatesExcessive fatigueHealth burdenMyalgic encephalomyelitis/chronic fatigue syndromeSocial isolationInternal tremorExercise intoleranceObservational studyFinancial difficultiesAnalog scaleSuicidal thoughtsPolygenic Resistance to Blood Pressure Treatment and Stroke Risk: Insights from the All of Us Research Program
Huo S, Rivier C, Clocchiatti‐Tuozzo S, Renedo D, Petersen N, de Havenon A, Meeker D, Zhao H, Ohno‐Machado L, Sheth K, Falcone G. Polygenic Resistance to Blood Pressure Treatment and Stroke Risk: Insights from the All of Us Research Program. Annals Of Neurology 2025 PMID: 40827941, DOI: 10.1002/ana.78009.Peer-Reviewed Original ResearchUs Research ProgramUncontrolled hypertensionSystolic BPGenetic riskSusceptibility to hypertensionRates of uncontrolled hypertensionPolygenic risk scoresAssociated with higher systolic BPOdds of uncontrolled hypertensionCox proportional hazards regressionUnited Kingdom BiobankGenetic association studiesHigh-risk individualsHigher systolic BPProportional hazards regressionBlood pressure treatmentIncident strokeStroke hazardBlood pressureHigher RatesSystolic blood pressureHypertensive adultsDiagnosed hypertensionBP medicationsHazards regressionBeyond smoking: A geospatial investigation of factors associated with lung and bronchus cancer risk in Pennsylvania
DuBois T, Wiese D, Henry K, Lynch S. Beyond smoking: A geospatial investigation of factors associated with lung and bronchus cancer risk in Pennsylvania. Social Science & Medicine 2025, 384: 118485. PMID: 40944988, DOI: 10.1016/j.socscimed.2025.118485.Peer-Reviewed Original ResearchSmoking ratesGeospatial investigationRisk factorsArea-level risk factorsHigher rates of smokingCancer registry dataRates of smokingTargeted prevention strategiesElevated incidence ratesCensus tract levelBronchus cancerSpatial scan statisticAssociated risk factorsCancer riskHigher RatesRegistry dataElevated ratesHigh-incidence areasTract levelIncidence ratePrevention strategiesNever-smokersGeographical areasSocioeconomic riskSmokingIs Gaining Housing Associated With Higher Rates of Cancer Screening Among US Veterans Experiencing Homelessness?
Decker H, Graham L, Titan A, Kanzaria H, Hawn M, Wick E, Tsai J, Kushel M. Is Gaining Housing Associated With Higher Rates of Cancer Screening Among US Veterans Experiencing Homelessness? The Annals Of Family Medicine 2025, 23: 330-336. PMID: 40721329, PMCID: PMC12306998, DOI: 10.1370/afm.240520.Peer-Reviewed Original ResearchConceptsRates of cancer screeningBreast cancer screeningColorectal cancer screeningCancer screeningHomeless veteransIndex clinic visitColorectal screeningFacility levelHealth outcomesRetrospective cohort studyTime-varying covariatesHigher RatesClinic visitsCancer diagnosisCohort studyBivariate analysisHomeless individualsCox proportional hazards analysisVeteransDemographic covariatesPrimary outcomeProportional hazards analysisHoused peopleVisitsHomelessnessPrevalence of Critical Congenital Heart Defects Among Neonates Born With Abdominal Wall Defects
Hellmann Z, Buu L, Rehman S, Thaxton C, Solomon D, Cowles R. Prevalence of Critical Congenital Heart Defects Among Neonates Born With Abdominal Wall Defects. Prenatal Diagnosis 2025, 45: 1115-1121. PMID: 40670328, DOI: 10.1002/pd.6861.Peer-Reviewed Original ResearchConceptsCritical congenital heart defectsNeonatal intensive care unitPediatric Health Information SystemNeonatal intensive care unit admissionCongenital heart defectsOpen cardiac surgeryCardiac surgeryHeart defectsConcomitant diagnosisNeonatal intensive care unit populationPediatric Health Information System hospitalsDiagnosis of gastroschisisGeneral populationIntensive care unitRate of gastroschisisAbdominal wall defectsIndex hospital admissionHigher RatesLive birthsGastroschisisCare unitNeonatesWall defectsHospital admissionAdmissionThe Epidemiology of Atopic Dermatitis Among Adults and Adolescents with Alopecia Areata in the United States
Bunick C, Armstrong A, Grada A, Soliman A, Li C, Bristow C, Khan I, Lipiszko D, Silverberg J, Issa N, Mostaghimi A. The Epidemiology of Atopic Dermatitis Among Adults and Adolescents with Alopecia Areata in the United States. Journal Of Investigative Dermatology 2025 PMID: 40581103, DOI: 10.1016/j.jid.2025.06.1578.Peer-Reviewed Original ResearchAlopecia areataAtopic dermatitisRelative riskAA disease severityComorbid atopic dermatitisModerate-to-severe ADDisease severityModerate-to-severe AAFollow-up periodMarketScan Research DatabasesModerate-to-severeAdjusted hazard ratiosEpidemiology of atopic dermatitisMild AAComorbid ADAA diagnosisHigher RatesEligible patientsMild diseaseSubgroup analysisAA severityHazard ratioTreatment decisionsPatientsHigh riskInvestigating the familiality of trichotillomania and excoriation disorder
Chen D, Farhat L, Lebowitz E, Silverman W, Bloch M, Fernandez T, Olfson E. Investigating the familiality of trichotillomania and excoriation disorder. Psychiatry Research 2025, 350: 116560. PMID: 40449230, PMCID: PMC12179820, DOI: 10.1016/j.psychres.2025.116560.Peer-Reviewed Original ResearchConceptsSelf-reported family historyFamily history of mental health disordersFirst-degreeHistory of mental health disordersFamily historyExcoriation disorderFamily history of individualsMental health historyMental health disordersFamily history of anxietyHistory of anxietyCross-sectional survey responsesFirst-degree relativesHigher RatesHealth historyHealth disordersSurvey responsesAged 4Genetic studiesEtiological underpinningsTrichotillomaniaSmall studyAnxietyDepressionIndividuals
2024
Measurement and Prevalence of Aggression
Iennaco J, Molle E, Lauvrud C, Palmstierna T, Nijman H, Almvik R. Measurement and Prevalence of Aggression. 2024, 93-123. DOI: 10.1007/978-3-031-61224-4_5.Peer-Reviewed Original ResearchQuality of carePatient safetyActivity programmeHealthcare workplaceHealthcare settingsPatient carePsychiatric settingsOverview of scalesImpact patientsTherapeutic relationshipClinical environmentCoercive interventionsPrevalence of aggressionClinical settingCareHealthcareSeverity of violenceHigher RatesPrevalenceViolenceCaregiversSetsPatientsComplex issuesInterventionComparative Outcomes of Unilateral vs Bilateral Revascularization in Moyamoya Disease: A Multicenter Retrospective Study
Musmar B, Roy J, Abdalrazeq H, Kaul A, Atallah E, Naamani K, Chen C, Jabre R, Saad H, Grossberg J, Dmytriw A, Patel A, Khorasanizadeh M, Ogilvy C, Thomas A, Monteiro A, Siddiqui A, Cortez G, Hanel R, Porto G, Spiotta A, Piscopo A, Hasan D, Ghorbani M, Weinberg J, Nimjee S, Bekelis K, Salem M, Burkhardt J, Zetchi A, Matouk C, Howard B, Lai R, Du R, Abbas R, Sioutas G, Amllay A, Munoz A, Herial N, Tjoumakaris S, Gooch M, Rosenwasser R, Jabbour P. Comparative Outcomes of Unilateral vs Bilateral Revascularization in Moyamoya Disease: A Multicenter Retrospective Study. Neurosurgery 2024, 96: 1364-1373. PMID: 39465938, DOI: 10.1227/neu.0000000000003243.Peer-Reviewed Original ResearchConceptsMulticenter retrospective studyBilateral revascularizationUnilateral revascularizationMoyamoya diseasePropensity score matchingRevascularization groupRetrospective studyModified Rankin scale 0 to 1Perioperative strokeCompare outcomesShort-term safety profileRate of excellent functional outcomeTreatment of moyamoya diseaseLength of hospital stayOptimal surgical approachScore matchingSignificant differenceExcellent functional outcomeNational Institutes of Health Stroke ScaleCollateral vessel formationInternal carotid arteryProgressive steno-occlusionHigher RatesStatistically significant differenceHealth Stroke ScaleInclusion of Veterans Health Administration hospitals in Centers for Medicare & Medicaid Services Overall Hospital Quality Star Ratings
Bagshaw K, Gettel C, Qin L, Lin Z, Suter L, Rothenberg E, Omotosho P, Duseja R, Krabacher J, Schreiber M, Nakashima T, Myers R, Venkatesh A. Inclusion of Veterans Health Administration hospitals in Centers for Medicare & Medicaid Services Overall Hospital Quality Star Ratings. Journal Of Hospital Medicine 2024, 20: 258-265. PMID: 39434547, PMCID: PMC11874188, DOI: 10.1002/jhm.13523.Peer-Reviewed Original ResearchVeterans Health Administration hospitalsNon-VHA hospitalsVeterans Health AdministrationCenters for Medicare & Medicaid ServicesQuality star ratingsStar ratingsQuality measure scoresAcute care hospitalsInformed healthcare decisionsOverall star ratingVHA hospitalsHealthcare decisionsRate hospitalsHealth AdministrationMedicaid ServicesMeasure scoresCare hospitalFive-star ratingAdministration HospitalMatching AnalysisQuality ratingsHospitalVeteransOverall analysisHigher RatesEndovascular thrombectomy versus medical management for acute basilar artery occlusion stroke in the elderly
Chen H, Colasurdo M, Khunte M, Malhotra A, Gandhi D. Endovascular thrombectomy versus medical management for acute basilar artery occlusion stroke in the elderly. American Journal Of Neuroradiology 2024, 46: ajnr.a8473. PMID: 39181691, PMCID: PMC11878975, DOI: 10.3174/ajnr.a8473.Peer-Reviewed Original ResearchPropensity score matchingBasilar artery occlusionIntracranial hemorrhageAssociated with higher ratesIn-Hospital MortalityEndovascular thrombectomyIntravenous thrombolysisMedical managementAssociated with increased risk of ICHTreated with medical managementPatients treated with endovascular thrombectomyRisk of intracranial hemorrhageSafety of endovascular thrombectomyBasilar artery occlusion strokeFavorable hospital outcomesTreated with intravenous thrombolysisHome dischargeAssociated with increased riskEndovascular thrombectomy groupArtery occlusion strokeNational Inpatient SampleNIH Stroke ScalePropensity score-matched controlsStroke patientsHigher RatesProgression of Gestational Subclinical Hypothyroidism and Hypothyroxinemia to Overt Hypothyroidism After Pregnancy: Pooled Analysis of Data from Two Randomized Controlled Trials
Varner M, Mele L, Casey B, Peaceman A, Reddy U, Wapner R, Thorp J, Saade G, Tita A, Rouse D, Sibai B, Costantine M, Mercer B, Caritis S, Bethesda. Progression of Gestational Subclinical Hypothyroidism and Hypothyroxinemia to Overt Hypothyroidism After Pregnancy: Pooled Analysis of Data from Two Randomized Controlled Trials. Thyroid 2024, 34: 1171-1176. PMID: 39028022, PMCID: PMC11563732, DOI: 10.1089/thy.2023.0616.Peer-Reviewed Original ResearchSubclinical hypothyroidismOvert hypothyroidismAssociated with higher ratesTPO levelsThyroid peroxidaseYear 5Gestational subclinical hypothyroidismNormal free T4Multicenter treatment trialThyroid replacement therapyYear of deliveryThyrotropin (TSHThyroid peroxidase levelsYear 1Randomized Controlled TrialsWeeks gestationPlacebo groupTSH valuesMaternal serumReplacement therapyFree T4Higher RatesHypothyroxinemiaThyroid functionHypothyroidismEndovascular thrombectomy versus medical management for moderate-to-severe anterior cerebral artery occlusion stroke
Chen H, Khunte M, Malhotra A, Gandhi D, Colasurdo M. Endovascular thrombectomy versus medical management for moderate-to-severe anterior cerebral artery occlusion stroke. Journal Of Neurology 2024, 271: 6247-6254. PMID: 39085619, DOI: 10.1007/s00415-024-12582-z.Peer-Reviewed Original ResearchAssociated with higher oddsAnterior cerebral arteryAssociated with higher ratesIntracranial hemorrhageEndovascular thrombectomyMedical managementHigher oddsEfficacy of endovascular thrombectomyFavorable short-term outcomesRetrospective cohort studyPatient selection criteriaShort-term outcomesEndovascular thrombectomy patientsIn-Hospital MortalityMultivariate logistic regressionHome dischargeArtery occlusion strokeNational Inpatient SampleHigher RatesNeurological outcomeCohort studyPrimary outcomeCerebral arterySecondary outcomesOcclusion strokeElectronic Patient-Reported Outcome-Driven Symptom Management by Oncology Pharmacists in a Majority-Minority Population: An Implementation Study
Chan A, Ng D, Arcos D, Heshmatipour M, Lee B, Chen A, Duong L, Van L, Nguyen T, Green V, Hoang D. Electronic Patient-Reported Outcome-Driven Symptom Management by Oncology Pharmacists in a Majority-Minority Population: An Implementation Study. JCO Oncology Practice 2024, 20: 1744-1754. PMID: 39008806, PMCID: PMC11649175, DOI: 10.1200/op.24.00050.Peer-Reviewed Original ResearchConceptsOncology pharmacistsRacial/Ethnic MinoritiesSymptom managementImplementation outcomesPatient-Reported Outcomes Measurement Information System measuresImplementation studyRE-AIM frameworkSymptom management toolSevere pain interferenceUrgent care utilizationNon-Hispanic whitesSupportive care issuesGeneralized Estimating EquationsRE-AIMHealth disparitiesMultilevel interventionsPain interferenceCare utilizationNon-HispanicCare issuesSymptom screeningHigher RatesTreatment counselingSymptom assessmentSymptom trajectoriesSocial Capital, Social Cohesion, and COVID-19
Kawachi I, Ransome Y. Social Capital, Social Cohesion, and COVID-19. 2024, 364-394. DOI: 10.1093/oso/9780197625217.003.0015.Peer-Reviewed Original ResearchSocial capitalPopulation health outcomesPopulation health impactSocial cohesionCohesive societyHealth outcomesCommunity—areMental illnessInformal socializingSocial distancing policiesSocial participationSocial isolationCOVID outcomesHealth impactsCapitalDistancing policiesIllustrative case studyCOVID-19 pandemicHigher RatesCase studyOutcomesMask-wearingPhysical distancePolicyCOVID-19Association of Preprocedural SYNTAX Score With Outcomes in Impella-Assisted High-Risk Percutaneous Coronary Intervention
Medranda G, Faraz H, Thompson J, Zhang Y, Bharadwaj A, Osborn E, Abu-Much A, Lansky A, Basir M, Moses J, O’Neill W, Grines C, Baron S. Association of Preprocedural SYNTAX Score With Outcomes in Impella-Assisted High-Risk Percutaneous Coronary Intervention. Journal Of The Society For Cardiovascular Angiography & Interventions 2024, 3: 101981. PMID: 39166169, PMCID: PMC11330901, DOI: 10.1016/j.jscai.2024.101981.Peer-Reviewed Original ResearchSYNTAX I scoreHigh-risk percutaneous coronary interventionPercutaneous coronary interventionCoronary interventionSYNTAX IIII studiesSYNTAX scoreI scoresAssociated with higher ratesComplex coronary artery diseaseCoronary artery diseaseMultivariate regression analysisMechanical circulatory supportInterventionClinical outcomesPoor outcomeCerebrovascular eventsRegression analysisArtery diseasePost-PCIPatientsCirculatory supportProcedural factorsHigher RatesOutcomesSystematic Review of Interventions with Some School Involvement for School Refusal in High School–Age Adolescents
Fernandes C, Kannoth S, Boomer T, Hieftje K, Fiellin L. Systematic Review of Interventions with Some School Involvement for School Refusal in High School–Age Adolescents. Children & Schools 2024, 46: 85-95. DOI: 10.1093/cs/cdae003.Peer-Reviewed Original ResearchSchool-based componentCognitive-behavioral therapySchool-aged adolescentsSystematic reviewSystematic Reviews of InterventionsQuality appraisal toolDevelopment of interventionsReviews of InterventionsRandomized Controlled TrialsChronic absenteeismPublic health concernAppraisal toolEmotional distressStudy designEligibility criteriaControlled TrialsHigh school-aged adolescentsHealth concernQuality studiesSchool settingsInterventionAbsenteeismHigher RatesDuplicate recordsAdolescents
2023
Heart Failure, Investigator-Reported Sleep Apnea and Dapagliflozin: A Patient-Level Pooled Meta-Analysis of DAPA-HF and DELIVER
Butt J, Jering K, DE Boer R, Claggett B, Desai A, Hernandez A, Inzucchi S, Jhund P, Køber L, Kosiborod M, Lam C, Martinez F, Ponikowski P, Sabatine M, Shah S, Vaduganathan M, Langkilde A, Bengtsson O, Petersson M, Sjöstrand M, Wilderäng U, Solomon S, McMurray J. Heart Failure, Investigator-Reported Sleep Apnea and Dapagliflozin: A Patient-Level Pooled Meta-Analysis of DAPA-HF and DELIVER. Journal Of Cardiac Failure 2023, 30: 436-448. PMID: 38104937, DOI: 10.1016/j.cardfail.2023.08.027.Peer-Reviewed Original ResearchConceptsHistory of sleep apneaPrevalence of sleep apneaEffects of dapagliflozinSleep apneaWorsening HF eventsDAPA-HFAssociated with higher ratesHeart failureClinical outcomesEjection fractionPooled analysisComposite of worsening HFEffects of HF therapiesPrimary outcomeHF eventsDELIVER trialBenefits of dapagliflozinDAPA-HF trialAssociated with outcomePrimary endpointHF therapyHigher RatesHF phenotypesApneaTreatment options
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