2025
Ethical challenges and justice concerns for infants and children with life-limiting conditions and significant disability, including trisomy 13 and 18
Pyle A, Mercurio M. Ethical challenges and justice concerns for infants and children with life-limiting conditions and significant disability, including trisomy 13 and 18. Seminars In Perinatology 2025, 152101. PMID: 40517086, DOI: 10.1016/j.semperi.2025.152101.Peer-Reviewed Original ResearchShared Decision-Making ProcessPositive quality of lifeLife-limiting conditionsQuality of lifeComfort careImpact counselingSignificant neurodevelopmental impairmentMedical/surgical interventionDisabilityEthical frameworkEthical challengesNeurodevelopmental impairmentTrisomy 13Surgical treatmentLong-established practiceInterventionEarly deathTrisomyDecision-making processJustice concerns
2023
Neonatal Paenibacilliosis: Paenibacillus Infection as a Novel Cause of Sepsis in Term Neonates With High Risk of Sequelae in Uganda
Ericson J, Burgoine K, Kumbakumba E, Ochora M, Hehnly C, Bajunirwe F, Bazira J, Fronterre C, Hagmann C, Kulkarni A, Kumar M, Magombe J, Mbabazi-Kabachelor E, Morton S, Movassagh M, Mugamba J, Mulondo R, Natukwatsa D, Kaaya B, Olupot-Olupot P, Onen J, Sheldon K, Smith J, Ssentongo P, Ssenyonga P, Warf B, Wegoye E, Zhang L, Kiwanuka J, Paulson J, Broach J, Schiff S. Neonatal Paenibacilliosis: Paenibacillus Infection as a Novel Cause of Sepsis in Term Neonates With High Risk of Sequelae in Uganda. Clinical Infectious Diseases 2023, 77: 768-775. PMID: 37279589, PMCID: PMC10495130, DOI: 10.1093/cid/ciad337.Peer-Reviewed Original ResearchConceptsNeonatal sepsisPostinfectious hydrocephalusCerebrospinal fluidSigns of sepsisFull-term neonatesOptimal antibiotic treatmentUgandan referral hospitalQuantitative polymerase chain reactionNeonatal characteristicsClinical sepsisTerm neonatesUnderdiagnosed causeAntibiotic choiceMedian ageReferral hospitalUgandan hospitalNeurodevelopmental impairmentAdverse outcomesSpecimen typesAntibiotic treatmentPolymerase chain reactionClinical signsUnusual pathogensSepsisHigh riskHeterogeneity of Treatment Effects of Hydrocortisone by Risk of Bronchopulmonary Dysplasia or Death Among Extremely Preterm Infants in the National Institute of Child Health and Human Development Neonatal Research Network Trial
Gentle S, Rysavy M, Li L, Laughon M, Patel R, Jensen E, Hintz S, Ambalavanan N, Carlo W, Watterberg K, Laptook A, Keszler M, Vohr B, Hensman A, Vieira E, St. Pierre L, Burke R, Alksinis B, Caskey M, Hoffman L, Johnson K, Keszler M, Knoll A, Leach T, Little E, McGowan E, Stephens B, Watson V, Hibbs A, Walsh M, Wilson-Costello D, Newman N, Bhola M, Payne A, Siner B, Yalcinkaya G, Truog W, Kilbride H, Gauldin C, Pallotto E, Holmes A, Johnson K, Scott A, Poindexter B, Schibler K, Merhar S, Yolton K, Grisby C, Beiersdorfer T, Cahill T, Dudley J, Gratton T, Kirker K, Thompson J, Wuertz S, Polin R, Cotton M, Goldberg R, Malcolm W, Goldstein R, Finkle J, Ashley P, Fisher K, Gustafson K, Mago-Shah D, Warren M, Bose C, Bernhardt J, Bose G, Wereszczak J, Warner D, Clark C, Kicklighter S, Bentley A, Edwards L, Rhodes-Ryan G, White D, Carlton D, Stoll B, Hale E, Loggins Y, Bottcher D, Carter S, Kendrick-Allywood S, Mulligan LaRossa M, Mackie C, Smikle G, Comerford L, Laursen J, Sanders A, Maitre N, Adams-Chapman I, Bremer A, Wilson Archer S, Higgins R, Tyson J, Khan A, Kennedy K, Mosquera R, Duncan A, McDavid G, Alaniz N, Allain E, Arldt-McAlister J, Sana Boral D, Burson K, Dempsey A, Eason E, Evans P, Garcia C, Green C, Hall D, Jiminez M, John J, Jones P, Lillie M, Martin K, Martin S, Mason C, McKee S, Poe M, Rennie K, Rodgers S, Siddiki S, Sperry D, Stephens E, Pierce Tate P, Wright S, Sanchez P, Nelin L, Jadcherla S, Slaughter J, Luzader P, Burkhardt S, Carey H, Chao M, Clark E, Fearns E, Fortney C, Fowler A, Grothause J, Gutentag J, Hague C, McCool J, Nelin M, Park C, Pietruszewski L, Purnell J, Shadd J, Small K, Stein M, Sullivan M, Sullivan R, Timan C, Yeates K, Yoseff-Salameh L, Keim S, Newton J, Levengood K, Batterson N, Rice C, Moallem M, Harmon H, Das A, Wallace D, Banna C, Gantz M, O'Donnell Auman J, Crawford M, Gabrio J, Leblond D, Newman J, Petrie Huitema C, vonLehmden A, Zaterka-Baxter K, Li L, Van Meurs K, Stevenson D, Chock V, Ball M, Bentley B, Chitkara R, Davis A, DeAnda M, DeBattista A, Earhart B, Huffman L, Krueger C, Lucash R, Proud M, Hitchner Reichert E, Sivakumar D, Taylor H, Weiss H, Peralta-Carcelen M, Collins M, Cosby S, Biasini F, Domnanovich K, McNair T, Phillips V, Whitley S, York Chapman S, Devaskar U, Chanlaw T, Geller R, Garg M, Purdy I, Bell E, Colaizy T, Widness J, Brumbaugh J, Johnson K, Walker J, Goeke C, Schmelzel M, Eastman D, Baack M, Meyer L, Hogden L, Henning M, Elenkiwich C, Broadbent M, Van Muyden S, Ellsbury D, Campbell D, Tud T, Fuller J, Beauman S, Backstrom Lacy C, Ruffner Hanson M, Hartenberger C, Kuan E, Lowe S, Sokol G, Papile L, Harmon H, Hines A, Lytle C, Herron D, Gunn S, Smiley L, Dawn Wilson L, DeMauro S, Schmidt B, Eichenwald E, Kirpalani H, Abbasi S, Mancini T, Chaudhary A, Cucinotta D, Bernbaum J, Freeman Duncan A, Dysart K, Gerdes M, Hurt H, Snyder J, Ziolkowski K, D'Angio C, Guillet R, Myers G, Binion K, Chess P, Fallone C, Farooq O, Kent A, Maffett D, Merzbach J, Orme C, Sacilowski M, Sabaratnam P, Scorsone A, Wadkins H, Wynn K, Yost K, Reynolds A, Lakshminrusimha S, Chandrasekharan P, Guilford S, Hartley-McAndrews M, Williams A, Zorn W, Li E, Donato J, McKee K, Coleman K, Bean S, Coleman C, Horihan C, Wyckoff M, Brion L, Heyne R, Vasil D, Adams S, Chen L, De Leon M, Eubanks F, Guzman A, Heyne E, Lee L, Madden L, McDougald E, Pavageau L, Sepulveda P, Twell Boatman C, Tolentino-Plata K, Vera A, Waterbury J, Yoder B, Ohls R, Baserga M, Winter S, Minton S, Sheffield M, Rau C, Baker S, Burnett J, Christensen S, Cole Bledsoe L, Cunningham S, Davis B, Elmont J, Hall B, Loertscher M, Marchant T, Maxon E, McGrath K, Mickelsen H, Morshedzadeh G, Parry D, Reich B, Schaefer S, Stout K, Stuart A, Weaver-Lewis K, Woodbury K, Shankaran S, Chawla S, Natarajan G, Sood B, Bara R, Agarwal P, Bajaj M, Childs K, February M, Goldston L, Johnson M, Panaitescu B, Hinz Woldt E, Barks J, Carlson M, Christensen M, White D, Wiggins S. Heterogeneity of Treatment Effects of Hydrocortisone by Risk of Bronchopulmonary Dysplasia or Death Among Extremely Preterm Infants in the National Institute of Child Health and Human Development Neonatal Research Network Trial. JAMA Network Open 2023, 6: e2315315. PMID: 37256621, PMCID: PMC10233424, DOI: 10.1001/jamanetworkopen.2023.15315.Peer-Reviewed Original ResearchConceptsSevere neurodevelopmental impairmentExtremely preterm infantsEffect of hydrocortisoneBronchopulmonary dysplasiaNeurodevelopmental impairmentNational Institute of Child HealthInstitute of Child HealthRandomized clinical trialsBaseline riskPreterm infantsGestational ageFollow-upQuartile 4Reduced rates of bronchopulmonary dysplasiaHuman Development Neonatal Research NetworkQuartile 1Clinical trialsMonths of corrected ageRate of bronchopulmonary dysplasiaRate of neurodevelopmental impairmentRisk of bronchopulmonary dysplasiaRelative riskDay of hydrocortisoneNeonatal Research NetworkTreatment groups
2022
1328. Paenibacillosis: An Emerging Cause of Neonatal Sepsis and Postinfectious Hydrocephalus
Ericson J, Burgoine K, Hehnly C, Kumbakumba E, Ochora M, Bajunirwe F, Bazira J, Fronterre C, Hagmann C, Kulkarni A, Kumar M, Magombe J, Mbabazi-Kabachelor E, Morton S, Movassagh M, Mugamba J, Mulondo R, Muwanguzi A, Natukwatsa D, Kaaya B, Olupot-Olupot P, Onen J, Sheldon K, Smith J, Ssentongo P, Ssenyonga P, Warf B, Wegoye E, Zhang L, Broach J, Kiwanuka J, Paulson J, Schiff S. 1328. Paenibacillosis: An Emerging Cause of Neonatal Sepsis and Postinfectious Hydrocephalus. Open Forum Infectious Diseases 2022, 9: ofac492.1158. PMCID: PMC9752957, DOI: 10.1093/ofid/ofac492.1158.Peer-Reviewed Original ResearchNeonatal sepsisPostinfectious hydrocephalusPolymerase chain reactionSigns of sepsisCommon presenting signsAntibiotic susceptibility testingQuantitative polymerase chain reactionUnderrecognized causeIntravenous ampicillinMedian agePresenting signUgandan hospitalNeurodevelopmental impairmentBest regimenNeonatal mortalityRRNA sequencingAdverse outcomesBirth characteristicsMost neonatesOptimal treatmentClinical signsSepsisBeta-lactamase genesCerebrospinal fluidAdditional survivor
2021
Structural and functional connectivity in premature neonates
Brenner R, Wheelock M, Neil J, Smyser C. Structural and functional connectivity in premature neonates. Seminars In Perinatology 2021, 45: 151473. PMID: 34452753, DOI: 10.1016/j.semperi.2021.151473.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingRisk of long-term neurodevelopmental impairmentLong-term neurodevelopmental impairmentAdvanced magnetic resonance imagingHigh-risk populationPreterm brainPreterm infantsAbsence of brain injuryPremature neonatesNeonatal periodNeurodevelopmental impairmentResonance imagingBrain developmentPretermPsychiatric deficitsPsychiatric outcomesBrain injuryBrainFunctional connectivityNeuroimaging modalitiesNeonatesInfantsCohortConnectivity developmentInjuryMulti-Omics Analysis on Neurodevelopment in Preterm Neonates
Casavant S, Chen J, Xu W, Lainwala S, Matson A, Chen M, Starkweather A, Maas K, Cong X. Multi-Omics Analysis on Neurodevelopment in Preterm Neonates. Nursing Research 2021, 70: 462-468. PMID: 34380978, PMCID: PMC8563389, DOI: 10.1097/nnr.0000000000000548.Peer-Reviewed Original ResearchConceptsPreterm infantsIntensive care unitNecrotizing enterocolitisFeeding intoleranceNeurodevelopmental impairmentNeonatal intensive care unit periodAdverse outcomesHost genetic variationIntestinal microbiomePreterm infants born <Care unitNeonatal intensive care unitInfants born <Weeks gestational ageGut microbiomeIntensive care unit periodFollow-up visitRegulation of intestinal healthPreterm neonatesGestational agePotential adverse outcomesNeurodevelopmental outcomesPain sensitivityPretermMulti-omics analysisAn Initiative to Decrease Laboratory Testing in a NICU
Klunk CJ, Barrett RE, Peterec SM, Blythe E, Brockett R, Kenney M, Natusch A, Thursland C, Gallagher PG, Pando R, Bizzarro MJ. An Initiative to Decrease Laboratory Testing in a NICU. 2021, 148: e2020000570. PMID: 34088759, DOI: 10.1542/peds.2020-000570.Peer-Reviewed Original ResearchMeSH KeywordsBilirubinBlood GlucoseBlood VolumeCarbon DioxideConnecticutHemorrhageHospitals, PediatricHumansInfant, NewbornIntensive Care Units, NeonatalLaboratories, HospitalMonitoring, PhysiologicPainPoint-of-Care TestingProcedures and Techniques UtilizationQuality ImprovementUnnecessary ProceduresConceptsExtreme laboratory valuesPatient daysLaboratory valuesOutcome measuresMultifaceted quality improvement projectSerum bilirubin testSecondary outcome measuresPrimary outcome measureHealthcare Improvement's ModelNotable adverse effectsLaboratory testingQuality improvement projectOrder of interventionsBlood lossNeurodevelopmental impairmentBlood glucoseSecondary measuresSustained reductionBilirubin testBlood volumeGuideline developmentLaboratory testsUnnecessary testsNICUAdverse effects
2020
Pharmacological reversal of synaptic and network pathology in human MECP2‐KO neurons and cortical organoids
Trujillo CA, Adams JW, Negraes PD, Carromeu C, Tejwani L, Acab A, Tsuda B, Thomas CA, Sodhi N, Fichter KM, Romero S, Zanella F, Sejnowski TJ, Ulrich H, Muotri AR. Pharmacological reversal of synaptic and network pathology in human MECP2‐KO neurons and cortical organoids. EMBO Molecular Medicine 2020, 13: emmm202012523. PMID: 33501759, PMCID: PMC7799367, DOI: 10.15252/emmm.202012523.Peer-Reviewed Original ResearchConceptsRett syndromeCortical organoidsPredominant etiologyNeurodevelopmental impairmentPharmacological reversalPHA-543613Neuropathologic phenotypeSynaptic dysregulationClinical studiesHuman pluripotent stem cell technologySymptomatic severityHuman neuronsMeCP2 deficiencyCandidate therapeuticsBrain mosaicismNetwork pathologyPharmacological compoundsPluripotent stem cell (iPSC) technologyNeurodevelopmental disordersMECP2 mutationsNeuropathologyMECP2 geneNeuronsCellular mosaicismStem cell technologyAssociation of Antenatal Corticosteroids and Magnesium Sulfate Therapy With Neurodevelopmental Outcome in Extremely Preterm Children.
Gentle S, Carlo W, Tan S, Gargano M, Ambalavanan N, Chawla S, Bell E, Bann C, Hintz S, Heyne R, Tita A, Higgins R. Association of Antenatal Corticosteroids and Magnesium Sulfate Therapy With Neurodevelopmental Outcome in Extremely Preterm Children. Obstetrics And Gynecology 2020, 135: 1377-1386. PMID: 32459430, PMCID: PMC7278037, DOI: 10.1097/aog.0000000000003882.Peer-Reviewed Original ResearchMeSH KeywordsAdrenal Cortex HormonesChild, PreschoolDatabases, FactualFemaleGestational AgeHumansInfantInfant MortalityInfant, Extremely PrematureInfant, NewbornLogistic ModelsMagnesium SulfateMaleNeurodevelopmental DisordersPregnancyPregnancy OutcomePrenatal CarePrenatal Exposure Delayed EffectsProspective StudiesUnited StatesConceptsSevere neurodevelopmental impairmentExposed to antenatal corticosteroidsExposure to antenatal corticosteroidsAntenatal corticosteroidsWeeks of gestationNeurodevelopmental impairmentMagnesium sulfateAssociation of antenatal corticosteroidsEunice Kennedy Shriver National Institute of Child HealthMagnesium sulfate therapyNational Institute of Child HealthInstitute of Child HealthAssociated with lower ratesExposure groupRate of deathPreterm childrenNeurodevelopmental outcomesLogistic regression modelsCorticosteroidsFollow-upPrimary outcomeSecondary outcomesTherapyGestationNetwork hospitalsT67. TRAUMA IN AFFECTIVE AND NONAFFECTIVE PSYCHOSIS: ASSOCIATIONS AND DISSOCIATIONS WITH COGNITIVE FUNCTIONING IN CHILDHOOD AND ADULTHOOD
Mollon J, Knowles E, Mathias S, Rodrigue A, Koenis M, Pearlson G, Glahn D. T67. TRAUMA IN AFFECTIVE AND NONAFFECTIVE PSYCHOSIS: ASSOCIATIONS AND DISSOCIATIONS WITH COGNITIVE FUNCTIONING IN CHILDHOOD AND ADULTHOOD. Schizophrenia Bulletin 2020, 46: s256-s257. PMCID: PMC7234213, DOI: 10.1093/schbul/sbaa029.627.Peer-Reviewed Original ResearchAffective psychosis groupNon-psychotic psychiatric disordersPsychotic disordersAdult traumaPsychosis groupChildhood Trauma QuestionnaireChildhood traumaTrauma History QuestionnairePsychiatric disordersCognitive functioningLifetime traumaImportant risk factorCase-control studyNonaffective psychotic disordersNon-psychotic groupAffective psychotic disordersManifestation of psychosisChildhood neglectAfrican American adultsNeurodevelopmental impairmentMore lifetime traumasRisk factorsAffective psychosisNonaffective psychosisHistory questionnaire
2018
Caffeine controversies
Gentle S, Travers C, Carlo W. Caffeine controversies. Current Opinion In Pediatrics 2018, 30: 177-181. PMID: 29346141, DOI: 10.1097/mop.0000000000000588.Peer-Reviewed Original ResearchConceptsApnea of prematurityBronchopulmonary dysplasiaPreterm infantsEvidence of bronchopulmonary dysplasiaCaffeine usePatent ductus arteriosusRate of motor impairmentCaffeine therapyRate of deathRandomized Controlled TrialsDuctus arteriosusNeurodevelopmental impairmentTherapy initiationNeonatal careCaffeine groupFollow-upTiming of initiationInfantsPretermCaffeineDoseMotor impairmentRisk reductionImpairmentApneaOutcome of Preterm Infants with Transient Cystic Periventricular Leukomalacia on Serial Cranial Imaging Up to Term Equivalent Age
Sarkar S, Shankaran S, Barks J, T. B, Laptook R, Das A, Ambalavanan N, Van Meurs K, Bell E, Sanchez P, Hintz S, Wyckoff M, Stoll B, Carlo W, Jobe A, Caplan M, Polin R, Keszler M, Oh W, Vohr B, Hensman A, Alksninis B, Basso K, Burke R, Caskey M, Johnson K, Keszler M, Knoll A, Leach T, Little E, McGowan E, Vieira E, Watson V, Ventura S, Walsh M, Fanaroff A, Hibbs A, Wilson-Costello D, Newman N, Payne A, Siner B, Bhola M, Yalcinkaya G, Friedman H, Truog W, Pallotto E, Kilbride H, Gauldin C, Holmes A, Johnson K, Knutson A, Schibler K, Donovan E, Grisby C, Bridges K, Alexander B, Fischer E, Mincey H, Hessling J, Gratton T, Jackson L, Kirker K, Muthig G, Steichen J, Tepe S, Mersmann M, Yolton K, Goldberg R, Cotten C, Goldstein R, Ashley P, Malcolm W, Auten K, Fisher K, Grimes S, Gustafson K, Lohmeyer M, Finkle J, Laughon M, Bose C, Bernhardt J, Bose G, Warner D, Wereszczak J, Carlton D, Adams-Chapman I, Hale E, Loggins Y, Blackwelder A, Bottcher D, Mackie C, Higgins R, Archer S, Sokol G, Poindexter B, Lemons J, Dusick A, Papile L, Lytle C, Hines A, Minnich H, Herron D, Smiley L, Gunn S, Wilson L, Kennedy K, Tyson J, McDavid G, Akpa E, Arldt-McAlister J, Alaniz N, Burson K, Bradt P, Dieterich S, Dempsey A, Duncan A, Evans P, Franco C, Garcia C, Green C, Harris B, Jiminez M, John J, Jones P, Lillie L, Lis A, Major-Kincade T, Martin K, Martin S, Morris B, Orekoya P, Reddoch S, Rodgers S, Siddiki S, Simmons M, Sperry D, Tate P, Whitely L, Wright S, Nelin L, Jadcherla S, Luzader P, Fortney C, Besner G, Parikh N, Wallace D, Gantz M, Poole W, Crawford M, Gabrio J, Hastings B, Newman J, Auman J, Huitema C, Zaterka-Baxter K, Stevenson D, Ball M, Adams M, Davis A, Palmquist A, Proud M, Bentley B, Bruno E, DeAnda M, DeBattista A, Earhart B, Huffman L, Kohn J, Krueger C, Palmquist A, Weiss H, Frantz I, Fiascone J, MacKinnon B, Furey A, Nylen E, McGowan E, Peralta-Carcelen M, Collins M, Cosby S, Biasini F, Johnston K, Nelson K, Patterson C, Phillips V, Whitley S, Devaskar U, Garg M, Purdy I, Chanlaw T, Geller R, Finer N, Kaegi D, Rasmussen M, Wozniak P, Arnell K, Demetrio C, Fuller M, Henderson C, Rich W, Vaucher Y, Colaizy T, Acarregui M, Brumbaugh J, Ellsbury D, Widness J, Johnson K, Campbell D, Eastman D, Krutzfield N, Duara S, Bauer C, Everett-Thomas R, Fajardo-Hiriart S, Rigaud A, Calejo M, Eguaras S, Berkowits M, Garcia A, Pierre H, Stoerger A, Watterberg K, Papile L, Lowe J, Dupont T, Fuller J, Ohls R, Lacy C, Duncan A, Montman R, Schmidt B, Kirpalani H, DeMauro S, Chaudhary A, Abbasi S, Mancini T, Cucinotta D, Bernbaum J, Gerdes M, Hurt H, Cook N, D'Angio C, Phelps D, Guillet R, Lakshminrusimha S, Johnson J, Burnell E, Reubens L, Horihan C, Jensen R, Kushner E, Merzbach J, Myers G, Rowan M, Wadkins H, Scorsone A, Bowman M, Hunn J, Guilford S, Maffett D, Farooq O, Prinzing D, Reynolds A, Sacilowski M, Williams A, Wynn K, Yost K, Zorn W, Zwetsch L, Brion L, Broyles R, Heyne R, Ipson M, Salhab W, Rosenfeld C, Vasil D, Chen L, Guzman A, Hensley G, Hickman J, Leps M, Madison S, Miller N, Morgan J, Pavageau L, Adams S, Dooley C, Heyne E, Lee L, Madden L, Boatman C, Faix R, Yoder B, Osborne K, Spencer C, Weaver-Lewis K, Baker S, Bird K, Burnett J, Steffen M, Jensen J, Winter S, Zanetti K, O'Shea T, Dillard R, Washburn L, Jackson B, Peters N, Chiu K, Allred D, Goldstein D, Halfond R, Peterson C, Waldrep E, Welch C, Morris M, Hounshell G, Pappas A, Bara R, Goldston L, Muran G, Natarajan G, Christensen M, Wiggins S, White D, Ehrenkranz R, Jacobs H, Butler C, Cervone P, Gettner P, Greisman S, Konstantino M, Poulsen J, Romano E, Taft J, Williams J. Outcome of Preterm Infants with Transient Cystic Periventricular Leukomalacia on Serial Cranial Imaging Up to Term Equivalent Age. The Journal Of Pediatrics 2018, 195: 59-65.e3. PMID: 29398046, PMCID: PMC6407628, DOI: 10.1016/j.jpeds.2017.12.010.Peer-Reviewed Original ResearchConceptsCystic periventricular leukomalaciaPeriventricular leukomalaciaCranial imaging studiesNeurodevelopmental impairmentPreterm infantsImaging studiesTerm-equivalent ageWeeks of gestationDays of ageEligible infantsSerial cranialLate deathsAbnormal studiesAdverse outcomesLeukomalaciaInfantsLogistic regressionOutcomesAgeEquivalent ageWeeksDeathGestationStudyImpairment
2017
Co-occurrence and Severity of Neurodevelopmental Burden (Cognitive Impairment, Cerebral Palsy, Autism Spectrum Disorder, and Epilepsy) at Age Ten Years in Children Born Extremely Preterm
Hirschberger R, Kuban K, O'Shea T, Joseph R, Heeren T, Douglass L, Stafstrom C, Jara H, Frazier J, Hirtz D, Rollins J, Paneth N, Investigators E, Ware J, Coster T, Hanson B, Wilson R, McGhee K, Lee P, Asgarian A, Sadhwani A, Perrin E, Neger E, Mattern K, Walkowiak J, Barron S, Shah B, Singh R, Smith A, Klein D, McQuiston S, Venuti L, Powers B, Foley A, Dessureau B, Wood M, Damon-Minow J, Ehrenkranz R, Benjamin J, Romano E, Tsatsanis K, Chawarska K, Kim S, Dieterich S, Bearrs K, Peters N, Brown P, Ansusinha E, Waldrep E, Friedman J, Hounshell G, Allred D, Engelke S, Darden-Saad N, Stainback G, Warner D, Wereszczak J, Bernhardt J, McKeeman J, Meyer E, Pastyrnak S, Rathbun J, Nota S, Crumb T, Lenski M, Weiland D, Lloyd M, Hunter S, Msall M, Ramoskaite R, Wiggins S, Washington K, Martin R, Prendergast B, Scott M, Klarr J, Kring B, DeRidder J, Vogt K. Co-occurrence and Severity of Neurodevelopmental Burden (Cognitive Impairment, Cerebral Palsy, Autism Spectrum Disorder, and Epilepsy) at Age Ten Years in Children Born Extremely Preterm. Pediatric Neurology 2017, 79: 45-52. PMID: 29310907, PMCID: PMC5803305, DOI: 10.1016/j.pediatrneurol.2017.11.002.Peer-Reviewed Original ResearchConceptsCerebral palsyAge ten yearsNeurodevelopmental impairmentCognitive impairmentProspective cohort followAutism spectrum disorderMajor neurodevelopmental impairmentPercent of childrenThird of childrenQuarter of childrenCategory ICohort followGestational ageTen yearsNumber of impairmentsChildren BornImpairment severityMultiple diagnosesIII childrenEpilepsyNormal intellectImpairmentDiagnosisCategory IIITen-year-old childrenApparent Diffusion Coefficient Value Changes and Clinical Correlation in 90 Cases of Cytomegalovirus-Infected Fetuses with Unremarkable Fetal MRI Results
Kotovich D, Guedalia JSB, Hoffmann C, Sze G, Eisenkraft A, Yaniv G. Apparent Diffusion Coefficient Value Changes and Clinical Correlation in 90 Cases of Cytomegalovirus-Infected Fetuses with Unremarkable Fetal MRI Results. American Journal Of Neuroradiology 2017, 38: 1443-1448. PMID: 28522662, PMCID: PMC7959907, DOI: 10.3174/ajnr.a5222.Peer-Reviewed Original ResearchConceptsCytomegalovirus-infected fetusesFetal MRVABS-II scoresADC valuesCytomegalovirus infectionFetal brainApparent diffusion coefficient (ADC) value changesNeurocognitive assessmentIntrauterine cytomegalovirus infectionCase of cytomegalovirusMost brain areasFetal MR imagingVABS-IIDiffuse reductionIntrauterine infectionNeurodevelopmental impairmentClinical findingsBasal gangliaUnremarkable findingsClinical correlationBrain evaluationRetrospective analysisAge control groupTemporal lobeMRI resultsFKBP5 genotype and early life stress exposure predict neurobehavioral outcomes for preterm infants
D'Agata A, Walsh S, Vittner D, Cong X, McGrath J, Young E. FKBP5 genotype and early life stress exposure predict neurobehavioral outcomes for preterm infants. Developmental Psychobiology 2017, 59: 410-418. PMID: 28247564, DOI: 10.1002/dev.21507.Peer-Reviewed Original ResearchConceptsNeonatal intensive care unitNeurobehavioral outcomesNeonatal intensive care unit stressNeonatal intensive care unit careFKBP5 genotypeIntensive care unitEarly life stress exposureStress response-associated genesGenetic susceptibility to stressInfant neurobehavioral developmentPreterm infantsImpact of genetic variationNeurodevelopmental impairmentResponse-associated genesLife stress exposureNeurobehavioral developmentCare unitEnvironmental risk factorsRisk factorsInfant problemsAssociated with neurobehavioral outcomesStatistical analysisPretermSusceptibility to stressStress exposureMRI Differences Associated with Intrauterine Growth Restriction in Preterm Infants
Bruno CJ, Bengani S, Gomes WA, Brewer M, Vega M, Xie X, Kim M, Fuloria M. MRI Differences Associated with Intrauterine Growth Restriction in Preterm Infants. Neonatology 2017, 111: 317-323. PMID: 28076856, DOI: 10.1159/000453576.Peer-Reviewed Original ResearchConceptsIntrauterine growth restrictionPreterm infantsTerm-equivalent ageBrain volumeIUGR infantsGestational ageGrowth restrictionMRI scansAcademic neonatal intensive care unitGrowth-restricted preterm infantsRetrospective case-control studyNeonatal intensive care unitGestational age infantsBasal ganglia volumesIntensive care unitCase-control studyBrain volumetric differencesRegional brain volumesBrain imaging studiesAGA infantsGanglia volumesNeurodevelopmental outcomesPostconceptual ageLate prognosisNeurodevelopmental impairment
2016
H19 long noncoding RNA alters trophoblast cell migration and invasion by regulating TβR3 in placentae with fetal growth restriction
Zuckerwise L, Li J, Lu L, Men Y, Geng T, Buhimschi CS, Buhimschi IA, Bukowski R, Guller S, Paidas M, Huang Y. H19 long noncoding RNA alters trophoblast cell migration and invasion by regulating TβR3 in placentae with fetal growth restriction. Oncotarget 2016, 7: 38398-38407. PMID: 27223264, PMCID: PMC5122399, DOI: 10.18632/oncotarget.9534.Peer-Reviewed Original ResearchConceptsFetal growth restrictionGrowth restrictionExtravillous trophoblastsDownregulation of H19Type III TGF-β receptorCell migrationEVT cell migrationNon-canonical TGFTGF-β receptorFGR placentasNeurodevelopmental impairmentPerinatal mortalityRisk factorsTherapeutic modalitiesEVT cellsH19 knockdownOnset disordersPlacentaInvasionMolecular mechanismsH19Let-7Novel regulatory targetMorbidityRegulatory pathways
2011
Microstructural and Functional Connectivity in the Developing Preterm Brain
Lubsen J, Vohr B, Myers E, Hampson M, Lacadie C, Schneider KC, Katz KH, Constable RT, Ment LR. Microstructural and Functional Connectivity in the Developing Preterm Brain. Seminars In Perinatology 2011, 35: 34-43. PMID: 21255705, PMCID: PMC3063450, DOI: 10.1053/j.semperi.2010.10.006.Peer-Reviewed Original ResearchConceptsPreterm birthPreterm brainTerm control subjectsDiffusion tensor imaging studyFunctional connectivity studiesPreterm neonatesNeurodevelopmental impairmentControl subjectsAxonal integrityImaging studiesCognitive deficitsFunctional connectivityNeural circuitryFractional anisotropyTask-based connectivityNeural connectivityBrainExhibit alterationsNeurobiological basisConnectivity studiesWidespread alterationsMicrostructural connectivityBirthChildrenAlterations
2000
Premorbid Speech and Language Impairments in Childhood-Onset Schizophrenia: Association With Risk Factors
Nicolson R, Lenane M, Singaracharlu S, Malaspina D, Giedd JN, Hamburger SD, Gochman P, Bedwell J, Thaker GK, Fernandez T, Wudarsky M, Hommer DW, Rapoport JL. Premorbid Speech and Language Impairments in Childhood-Onset Schizophrenia: Association With Risk Factors. American Journal Of Psychiatry 2000, 157: 794-800. PMID: 10784474, DOI: 10.1176/appi.ajp.157.5.794.Peer-Reviewed Original ResearchConceptsChildhood-onset schizophreniaRisk factorsSchizophrenia spectrum disordersObstetrical complicationsMotor abnormalitiesDevelopmental impairmentMore obstetrical complicationsSmooth pursuit eye movementsChildhood-onset casesPathophysiology of schizophreniaEye-tracking dysfunctionLanguage-related brain regionsFamilial loading scoresFamilial risk factorsSocial impairmentNeurodevelopmental impairmentPremorbid abnormalitiesSpectrum disorderFamilial loadingPatientsLanguage impairmentBrain regionsSchizophreniaImpairmentAbnormalities
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