2025
Effect modification by cardiovascular and metabolic disease onset on long-term PM2.5 exposure and mortality: a nationwide cohort study
Jang H, Park J, Lee E, Kang D, Moon J, Song I, Ahn S, Kim A, Kang C, Oh J, Kwon D, Min J, Kim E, Bell M, Kim H, Lee W. Effect modification by cardiovascular and metabolic disease onset on long-term PM2.5 exposure and mortality: a nationwide cohort study. Scientific Reports 2025, 15: 19570. PMID: 40467860, PMCID: PMC12137577, DOI: 10.1038/s41598-025-04498-z.Peer-Reviewed Original ResearchConceptsLong-term PM2.5 exposureEffect modificationPM2.5 exposureEstimate effect modificationPM2.5-mortality associationsPopulation-representative cohortTarget specific interventionsMyocardial infarctionNationwide cohort studyNon-accidental deathsEffects of PM2.5PM2.5-mortalityRisk of PM2.5Preemptive careCox regression modelsHTN/DMCohort studyHazard ratioDisease onsetCerebrovascular diseaseRegression modelsMetabolic disease onsetCohortRenal diseaseMortality
2024
Endovascular arterial embolization versus conservative management with nasal packing alone for severe epistaxis: a nationwide cohort study
Chen H, Khunte M, Colasurdo M, Gunawardane S, Malhotra A, Gandhi D. Endovascular arterial embolization versus conservative management with nasal packing alone for severe epistaxis: a nationwide cohort study. Journal Of NeuroInterventional Surgery 2024, jnis-2024-022790. PMID: 39715667, DOI: 10.1136/jnis-2024-022790.Peer-Reviewed Original ResearchEndovascular arterial embolizationNasal packingSevere epistaxisPropensity score matchingNationwide Readmissions DatabaseArtery embolizationIschemic strokeCohort studyRates of patient morbidityHemorrhage risk factorsConservative management groupConservative managementRetrospective cohort studyNationwide cohort studyRate of ischemic strokeBalance patient characteristicsContemporary real-world dataAssociated with lower ratesPatients admitted to hospitalNon-routine dischargeRisk of ischemic strokeRecurrent epistaxisRecurrence ratePatient morbidityPatient characteristicsAssociation between dietary diversity changes and frailty among Chinese older adults: findings from a nationwide cohort study
Wang X, Zhong W, Zhang Y, Xiang J, Chen H, Li Z, Shen Q, Shen D, Song W, Fu Q, Gao J, Chen Z, Li C, Xie J, Liu D, Lv Y, Shi X, Mao C. Association between dietary diversity changes and frailty among Chinese older adults: findings from a nationwide cohort study. Nutrition Journal 2024, 23: 91. PMID: 39138490, PMCID: PMC11320915, DOI: 10.1186/s12937-024-00997-3.Peer-Reviewed Original ResearchConceptsDietary diversity scoreRisk of frailtyChinese older adultsOlder adultsSelf-reported health itemsChinese Longitudinal Healthy Longevity SurveyHigher risk of frailtyIncreased risk of frailtyOlder Chinese adultsFollow-up surveyNationwide cohort studyCox proportional hazards modelsHealth itemsLongevity SurveyFrailty incidencePrevent frailtyProportional hazards modelBackgroundDietary diversityChinese adultsFood groupsAssess frailtyPotential preventive measuresDiversity scoreComparing scoresCohort studyA Nationwide Analysis of Complications, Reoperations, and Cost of Wide-Awake Flexor Tendon Repairs
Kammien A, Rancu A, Kim S, Parikh N, Grauer J, Colen D. A Nationwide Analysis of Complications, Reoperations, and Cost of Wide-Awake Flexor Tendon Repairs. Plastic & Reconstructive Surgery 2024, 155: 301-307. PMID: 39026384, DOI: 10.1097/prs.0000000000011651.Peer-Reviewed Original ResearchElixhauser Comorbidity IndexWound complicationsTraditional anesthesiaEmergency department visitsYears of follow-upTendon repairAnalysis of complicationsRate of tendon ruptureNationwide cohort studyDepartment visitsWide-awake surgeryFlexor tendon repairConcomitant treatmentMatched CohortFollow-upZone II flexor tendon repairCohort studyMultivariate linear regressionAnesthesia techniquesComorbidity indexVascular injuryIntraoperative testingReoperationNerve repairPatientsAnalysis of changes in social isolation, loneliness, or both, and subsequent cognitive function among older adults: Findings from a nationwide cohort study
Huang Q, Zhang P, Shen D, Gao J, Li Z, Lv Y, Shi X, Mao C. Analysis of changes in social isolation, loneliness, or both, and subsequent cognitive function among older adults: Findings from a nationwide cohort study. Alzheimer's & Dementia 2024, 20: 5674-5683. PMID: 38946708, PMCID: PMC11350036, DOI: 10.1002/alz.14080.Peer-Reviewed Original ResearchAssociated with accelerated cognitive declineCognitive impairment riskPersistent lonelinessSocial isolationCognitive declineOlder adultsImpairment riskChinese Longitudinal Healthy Longevity SurveyIncident cognitive impairmentCognitive impairmentAssociation of changesNationwide cohort studyAccelerated cognitive declineCognitive functionLongevity SurveyCohort studyChanging statusLonelinessRisk factorsRegression modelsTobit regression modelCox modelShort-termRiskAdultsLong-term exposure to PM2.5 and mortality in a national cohort in South Korea: effect modification by community deprivation, medical infrastructure, and greenness
Byun G, Kim S, Choi Y, Kim A, Team A, Lee J, Bell M. Long-term exposure to PM2.5 and mortality in a national cohort in South Korea: effect modification by community deprivation, medical infrastructure, and greenness. BMC Public Health 2024, 24: 1266. PMID: 38720292, PMCID: PMC11080206, DOI: 10.1186/s12889-024-18752-y.Peer-Reviewed Original ResearchConceptsLong-term exposure to PM2.5Exposure to PM2.5Respiratory mortalityCirculatory mortalityEffect of long-term exposure to PM2.5National Health Insurance Service-National Sample CohortLong-term PM2.5 exposureAssociated with respiratory mortalityReduce health disparitiesMedical infrastructureNon-accidentalCommunity-level deprivationCommunity-level factorsCommunity-level characteristicsPotential modifying effectPublic health outcomesNationwide cohort studyIncreased mortality riskCox proportional-hazards modelDeprivation indexHealth disparitiesCommunity deprivationHigh deprivationHealth outcomesEffect modification
2023
Comparative Safety Analysis of Oral Antipsychotics for In-Hospital Adverse Clinical Events in Older Adults After Major Surgery : A Nationwide Cohort Study.
Kim D, Lee S, Park C, Levin R, Metzger E, Bateman B, Ely E, Pandharipande P, Pisani M, Jones R, Marcantonio E, Inouye S. Comparative Safety Analysis of Oral Antipsychotics for In-Hospital Adverse Clinical Events in Older Adults After Major Surgery : A Nationwide Cohort Study. Annals Of Internal Medicine 2023, 176: 1153-1162. PMID: 37665998, PMCID: PMC10625498, DOI: 10.7326/m22-3021.Peer-Reviewed Original ResearchConceptsTransient ischemic attackAdverse clinical eventsHospital deathMajor surgeryClinical eventsPostoperative deliriumCohort studyOlder patientsAntipsychotic drugsArrhythmia eventsCardiac arrhythmia eventsHospital adverse clinical eventsModerate-dose treatmentPremier Healthcare DatabaseHospital adverse eventsNationwide cohort studyRetrospective cohort studyAtypical antipsychotic useOral antipsychotic drugsSignificant differencesHaloperidol useIschemic attackOral antipsychoticsAdverse eventsOral haloperidolEffectiveness of famotidine on the risk of poor prognosis in patients with COVID-19: A nationwide cohort study in Korea
Kwon R, Kim H, Lee S, Koyanagi A, Shin J, Song T, Yon D, Smith L. Effectiveness of famotidine on the risk of poor prognosis in patients with COVID-19: A nationwide cohort study in Korea. Heliyon 2023, 9: e16171. PMID: 37287614, PMCID: PMC10232936, DOI: 10.1016/j.heliyon.2023.e16171.Peer-Reviewed Original ResearchFamotidine useComposite outcomePoor prognosisAdministration of mechanical ventilationRisk of poor prognosisPoor prognosis of COVID-19Intensive care unit admissionHigh oxygen therapyEffect of famotidinePrognosis of COVID-19Nationwide cohort studyKorean nationwide cohortPoorer COVID-19-related outcomesTreatment of coronavirus disease 2019Unit admissionH2 blockersMatched CohortMechanical ventilationSevere acute respiratory syndrome coronavirus 2Oxygen therapyAcute respiratory syndrome coronavirus 2Nationwide cohortCohort studyRespiratory syndrome coronavirus 2Multivariate analysis
2022
Rebleeding in peptic ulcer bleeding – a nationwide cohort study of 19,537 patients
Laursen S, Stanley A, Laine L, de Muckadell O. Rebleeding in peptic ulcer bleeding – a nationwide cohort study of 19,537 patients. Scandinavian Journal Of Gastroenterology 2022, 57: 1423-1429. PMID: 35853234, DOI: 10.1080/00365521.2022.2098050.Peer-Reviewed Original ResearchConceptsPeptic ulcer bleedingNationwide cohort studyUlcer bleedingHemodynamic instabilityCohort studyDuodenal ulcerHigh-risk endoscopic stigmataNon-ulcer lesionsHigh-risk stigmataLogistic regression analysisEndoscopic stigmataPersistent bleedingEndoscopic therapyFrequent complicationConsecutive patientsSuch patientsPrognostic consequencesHigh riskPatientsInterventional radiologyBleedingTwo-fold increaseMortalityUlcersStrongest predictorAssociation of Alzheimer’s Disease with COVID-19 Susceptibility and Severe Complications: A Nationwide Cohort Study
Chung S, Chang Y, Jeon J, Shin J, Song T, Kim J. Association of Alzheimer’s Disease with COVID-19 Susceptibility and Severe Complications: A Nationwide Cohort Study. Journal Of Alzheimer’s Disease 2022, 87: 701-710. PMID: 35275548, DOI: 10.3233/jad-220031.Peer-Reviewed Original ResearchConceptsSevere COVID-19 complicationsCOVID-19 infectionCOVID-19 complicationsSusceptibility to COVID-19 infectionSevere complicationsIncreased riskRatio propensity score matchingAssociation of Alzheimer's diseasePrevalence of participantsRisk of severe COVID-19 complicationsReal-time reverse transcription polymerase chain reaction assayIdentification of patientsNationwide cohort studyBinary logistic regression analysisLogistic regression analysisReverse transcription polymerase chain reaction assaySecondary outcome analysisPolymerase chain reaction assayAlzheimer's diseaseActivity interventionsPropensity score matchingMechanical ventilationCohort studyStudy participantsComplicationsPrescribing of antipsychotics among people with recorded personality disorder in primary care: a retrospective nationwide cohort study using The Health Improvement Network primary care database
Hardoon S, Hayes J, Viding E, McCrory E, Walters K, Osborn D. Prescribing of antipsychotics among people with recorded personality disorder in primary care: a retrospective nationwide cohort study using The Health Improvement Network primary care database. BMJ Open 2022, 12: e053943. PMID: 35264346, PMCID: PMC8968526, DOI: 10.1136/bmjopen-2021-053943.Peer-Reviewed Original ResearchConceptsSevere mental illnessPrimary care databasePersonality disorderSuch prescribingCohort studyCare databasePrimary careGeneral practiceHealth Improvement Network primary care databaseRetrospective nationwide cohort studyGeneral practice notesNationwide cohort studyRetrospective cohort studyGeneral practice recordsUK primary careCurrent UK guidelinesAdverse childhood experiencesMetabolic complicationsAntipsychotic prescribingAntipsychotic prescriptionsMedian timePractice recordsAntipsychoticsUK guidelinesClinical practiceAssociation of atrial fibrillation with infectivity and severe complications of COVID‐19: A nationwide cohort study
Park J, Shin J, Kim D, Park J, Jeon J, Kim J, Song T. Association of atrial fibrillation with infectivity and severe complications of COVID‐19: A nationwide cohort study. Journal Of Medical Virology 2022, 94: 2422-2430. PMID: 35130367, PMCID: PMC9088370, DOI: 10.1002/jmv.27647.Peer-Reviewed Original ResearchConceptsHistory of AFSevere complications of COVID-19Complications of COVID-19Propensity score matchingSevere complicationsAtrial fibrillationCOVID-19 patientsComposite outcome of mechanical ventilationIncreased risk of severe complicationsRatio propensity score matchingDevelopment of severe complicationsRisk of severe complicationsIntensive care unit admissionProgression of atrial fibrillationOutcome of mechanical ventilationCOVID-19 PCR positivitySeverity of complicationsNationwide cohort studyPresence of AFAssociation of atrial fibrillationCOVID-19 positive patientsAssociation of AFCOVID-19 infected patientsPositive patientsUnit admission
2021
Associations of heart failure with susceptibility and severe complications of COVID‐19: A nationwide cohort study
Kim H, Park M, Shin J, Park J, Kim D, Jeon J, Kim J, Song T. Associations of heart failure with susceptibility and severe complications of COVID‐19: A nationwide cohort study. Journal Of Medical Virology 2021, 94: 1138-1145. PMID: 34738248, PMCID: PMC8661586, DOI: 10.1002/jmv.27435.Peer-Reviewed Original ResearchConceptsSevere complications of COVID-19HF historyComplications of COVID-19Severe complicationsPropensity score matchingHeart failureIntensive care unitPrimary outcomeMechanical ventilationComposite outcome of mechanical ventilationRatio propensity score matchingWorsening of heart failureAssociation of heart failureOutcome of mechanical ventilationComplication of coronavirus disease 2019COVID-19 PCR positivityMultivariate logistic analysisNationwide cohort studyLogistic regression analysisCases of mechanical ventilationAssociated with occurrenceReverse transcription polymerase chain reactionTranscription polymerase chain reactionCOVID-19 infectionAssociation of HFHIV care using differentiated service delivery during the COVID‐19 pandemic: a nationwide cohort study in the US Department of Veterans Affairs
McGinnis KA, Skanderson M, Justice AC, Akgün KM, Tate JP, King JT, Rentsch CT, Marconi VC, Hsieh E, Ruser C, Kidwai‐Khan F, Yousefzadeh R, Erdos J, Park LS. HIV care using differentiated service delivery during the COVID‐19 pandemic: a nationwide cohort study in the US Department of Veterans Affairs. Journal Of The International AIDS Society 2021, 24: e25810. PMID: 34713585, PMCID: PMC8554215, DOI: 10.1002/jia2.25810.Peer-Reviewed Original ResearchConceptsVeterans AffairsClinic visitsCohort studyVL testARV coverageCOVID-19 pandemicVeterans Aging Cohort StudyHIV healthcare deliveryNationwide cohort studyAging Cohort StudyViral load testsDifferentiated service deliveryHealthcare deliveryHIV careMost patientsPharmacy recordsVL testingCalendar periodHealthcare encountersOverall healthARVVirtual healthcareVirtual visitsVisitsService deliveryStatin Use and COVID-19 Infectivity and Severity in South Korea: Two Population-Based Nationwide Cohort Studies
Lee S, Kim S, Moon S, Yoo I, Yoo E, Eom G, Kim J, Shin J, Jeong M, Yang J, Yon D. Statin Use and COVID-19 Infectivity and Severity in South Korea: Two Population-Based Nationwide Cohort Studies. JMIR Public Health And Surveillance 2021, 7: e29379. PMID: 34623311, PMCID: PMC8510150, DOI: 10.2196/29379.Peer-Reviewed Original ResearchConceptsClinical outcomes of COVID-19Outcomes of COVID-19Length of hospital stayStatin usersSevere clinical outcomesStatin useSARS-CoV-2 test positivitySARS-CoV-2Hospital stayClinical outcomesSARS-CoV-2 testingPopulation-based nationwide cohort studyAssociated with statin useAdd-on therapyTest positivityNationwide cohort studySevere clinical outcomes of COVID-19Intensive care unitPopulation-based cohortSARS-CoV-2 infectionPropensity score matchingInvasive ventilationSARS-CoV-2 test positivity rateCOVID-19 infectionTest positivity rateCOVID-19 Morbidity and Severity in Patients With Nonalcoholic Fatty Liver Disease in South Korea: A Nationwide Cohort Study
Yoo H, Shin J, Yon D, Lee S. COVID-19 Morbidity and Severity in Patients With Nonalcoholic Fatty Liver Disease in South Korea: A Nationwide Cohort Study. Clinical Gastroenterology And Hepatology 2021, 20: e1217-e1218. PMID: 34311112, PMCID: PMC8302822, DOI: 10.1016/j.cgh.2021.07.031.Peer-Reviewed Original ResearchPhysical activity and the risk of SARS-CoV-2 infection, severe COVID-19 illness and COVID-19 related mortality in South Korea: a nationwide cohort study
Lee S, Lee J, Moon S, Jin H, Yang J, Ogino S, Song M, Hong S, Ghayda R, Kronbichler A, Koyanagi A, Jacob L, Dragioti E, Smith L, Giovannucci E, Lee I, Lee D, Lee K, Shin Y, Kim S, Kim M, Won H, Ekelund U, Shin J, Yon D. Physical activity and the risk of SARS-CoV-2 infection, severe COVID-19 illness and COVID-19 related mortality in South Korea: a nationwide cohort study. British Journal Of Sports Medicine 2021, 56: 901-912. PMID: 34301715, DOI: 10.1136/bjsports-2021-104203.Peer-Reviewed Original ResearchConceptsMuscle strengthening activitiesPhysical activityCOVID-19 related deathsRisk of SARS-CoV-2 infectionGeneral health examinationCOVID-19 illnessStrengthening activitiesRecommended levels of physical activityHealth examinationLevels of physical activityNational Health Insurance Service of South KoreaPhysical activity guidelinesPhysical activity levelsMetabolic equivalent taskNational Health Insurance ServiceLikelihood of SARS-CoV-2 infectionRelated deathsNationwide cohort studyPublic health valueActivity guidelinesReduced risk of SARS-CoV-2 infectionEquivalent taskPatterns of associationKorean adultsSARS-CoV-2 positivityAutoimmune inflammatory rheumatic diseases and COVID-19 outcomes in South Korea: a nationwide cohort study
Shin Y, Shin J, Moon S, Jin H, Kim S, Yang J, Cho S, Kim S, Lee M, Park Y, Kim M, Won H, Hong S, Kronbichler A, Koyanagi A, Jacob L, Smith L, Lee K, Suh D, Lee S, Yon D. Autoimmune inflammatory rheumatic diseases and COVID-19 outcomes in South Korea: a nationwide cohort study. The Lancet Rheumatology 2021, 3: e698-e706. PMID: 34179832, PMCID: PMC8213376, DOI: 10.1016/s2665-9913(21)00151-x.Peer-Reviewed Original ResearchCOVID-19-related deathsGeneral health examinationAutoimmune inflammatory rheumatic diseasesCOVID-19 outcomesHealth examinationDisease-modifying antirheumatic drugsIncreased likelihoodOdds ratioInflammatory rheumatic diseasesKorean National Health Insurance ServiceNational Health Insurance ServiceDoses of systemic corticosteroidsSARS-CoV-2 RT-PCR testAdjusted odds ratiosPositive SARS-CoV-2 testHealth Insurance ServiceICD-10 codesNationwide cohort studyHealth examination recordsSystemic corticosteroidsPositive SARS-CoV-2 PCR testCOVID-19 pandemicKorean nationwide cohortRheumatic diseasesPositive SARS-CoV-2 RT-PCR testEstimating COVID-19 Infection and Severity Risks in Patients with Chronic Rhinosinusitis: A Korean Nationwide Cohort Study
Lee S, Kim S, Moon S, Yang J, Ha E, Jee H, Shin J, Cho S, Yon D, Suh D. Estimating COVID-19 Infection and Severity Risks in Patients with Chronic Rhinosinusitis: A Korean Nationwide Cohort Study. The Journal Of Allergy And Clinical Immunology In Practice 2021, 9: 2262-2271.e2. PMID: 33931377, PMCID: PMC8079802, DOI: 10.1016/j.jaip.2021.03.044.Peer-Reviewed Original ResearchConceptsAbsence of nasal polypsSARS-CoV-2 infectionChronic rhinosinusitisAssociated with increased riskIntranasal corticosteroid useSevere COVID-19Severe COVID-19 outcomesNonatopic typeCorticosteroid useSARS-CoV-2Nasal polypsCOVID-19 outcomesHealth Insurance Review and Assessment Service of KoreaHealth Insurance Review and Assessment ServiceNested Case-Control StudyChronic rhinosinusitis patientsSevere coronavirus disease 19SARS-CoV-2 test resultsNationwide cohort studyKorean nationwide cohortCase-control studyCOVID-19 patientsPropensity score matchingSelf-referralAdult patients
2020
Patterns of COVID-19 testing and mortality by race and ethnicity among United States veterans: A nationwide cohort study
Rentsch CT, Kidwai-Khan F, Tate JP, Park LS, King JT, Skanderson M, Hauser RG, Schultze A, Jarvis CI, Holodniy M, Re V, Akgün KM, Crothers K, Taddei TH, Freiberg MS, Justice AC. Patterns of COVID-19 testing and mortality by race and ethnicity among United States veterans: A nationwide cohort study. PLOS Medicine 2020, 17: e1003379. PMID: 32960880, PMCID: PMC7508372, DOI: 10.1371/journal.pmed.1003379.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBetacoronavirusBlack or African AmericanClinical Laboratory TechniquesCohort StudiesCoronavirus InfectionsCOVID-19COVID-19 TestingEthnicityFemaleHispanic or LatinoHumansMaleMiddle AgedPandemicsPneumonia, ViralRetrospective StudiesSARS-CoV-2United StatesVeteransWhite PeopleYoung AdultConceptsCOVID-19 testingRace/ethnicityCohort studyWhite individualsSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infectionAcute respiratory syndrome coronavirus 2 infectionSyndrome coronavirus 2 infectionSARS-CoV-2 infectionCOVID-19Large integrated healthcare systemCoronavirus 2 infectionNationwide cohort studyRetrospective cohort studyCoronavirus disease 2019Site of careIntegrated healthcare systemNon-Hispanic blacksPositive test resultsNon-Hispanic whitesClinical characteristicsMultivariable adjustmentComorbid conditionsMedication historyEthnic minority communitiesDisease 2019
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