2025
Differences Among Veterans With Chronic Overlapping Pain Conditions and Other Chronic Pain: Baseline Results From the LAMP Pain Management Trial
Adamowicz J, Grant A, Calvert C, Elchert D, Hadlandsmyth K, Driscoll M, Taylor S, Allen K, Taylor B, Burgess D. Differences Among Veterans With Chronic Overlapping Pain Conditions and Other Chronic Pain: Baseline Results From the LAMP Pain Management Trial. European Journal Of Pain 2025, 29: e70125. PMID: 40948198, DOI: 10.1002/ejp.70125.Peer-Reviewed Original ResearchConceptsChronic overlapping pain conditionsPragmatic clinical trialsStudy baseline dataChronic painLower pain self-efficacyChronic low back painImpaired health-related quality of lifeHealth-related quality of lifePain self-efficacyLow back painElectronic health recordsMental health concernsPain conditionsSample of veteransQuality of lifeClinical researchPain catastrophisingHealth recordsBack painPain severityClinical trialsPain characteristicsU.S. veteransICD-10Self-EfficacyThe Church and Academia Model: New Paradigm for Spirituality and Mental Health Research
Illueca M, Meints S, Miller M, Osaji D, Doolittle B. The Church and Academia Model: New Paradigm for Spirituality and Mental Health Research. Religions 2025, 16: 998. DOI: 10.3390/rel16080998.Peer-Reviewed Original ResearchMental healthCoping skillsSpirituality-based interventionMental health researchSkills of patientsHealthcare providersChronic pain conditionsHealth researchPain psychologistDissemination strategiesClinical spaceStudy designClinical inquiryIntersection of spiritualityChronic painPain conditionsHealthProtocol writingPsychometric measuresSpiritualityJournal publicationsSkill setsTranslational platformHealthcareProvidersCannabis and Cannabinoids for Treating Pain: What Are the Data?
Khalsa J, Potenza M, Bunt G, DuPont R. Cannabis and Cannabinoids for Treating Pain: What Are the Data? Journal Of Addiction Medicine 2025 PMID: 40657749, DOI: 10.1097/adm.0000000000001537.Peer-Reviewed Original ResearchTreat painFederally illicit drugAssociated with serious health consequencesAdverse effectsClinical researchBody of clinical researchEvidence-informed discussionsChronic painPain conditionsPotential adverse effectsCannabis useClinical evidenceClinical conditionsPainSerious health consequencesCognitive dysfunctionMemory problemsCannabisHigh-potencyLack of evidenceHealth conditionsCannabinoidHealth consequencesIllicit drugsProduction of cannabisThe inflammatory and genetic mechanisms underlying the cumulative effect of co-occurring pain conditions on depression
Jiang R, Geha P, Rosenblatt M, Wang Y, Fu Z, Foster M, Dai W, Calhoun V, Sui J, Spann M, Scheinost D. The inflammatory and genetic mechanisms underlying the cumulative effect of co-occurring pain conditions on depression. Science Advances 2025, 11: eadt1083. PMID: 40173244, PMCID: PMC11964001, DOI: 10.1126/sciadv.adt1083.Peer-Reviewed Original ResearchConceptsDepression riskChronic pain conditionsPain conditionsPrevalence of comorbid depressionPain scoresUK Biobank participantsPain-free individualsComposite pain scoresHigh-risk individualsPain screeningMendelian randomizationBiobank participantsPain sitesDepression incidenceComorbid depressionIncreased riskBody sitesDepressionC-reactive proteinPainCausal inferenceFollow-upScoresRiskInflammatory markers221 The Impact of Gender on Co-Occurring Chronic Overlapping Pain Conditions and Pharmacotherapy in Veterans with Fibromyalgia
Adamowicz J, Lund B, Garvin L, Driscoll M, Hadlandsmyth K. 221 The Impact of Gender on Co-Occurring Chronic Overlapping Pain Conditions and Pharmacotherapy in Veterans with Fibromyalgia. Journal Of Pain 2025, 29: 105019. DOI: 10.1016/j.jpain.2025.105019.Peer-Reviewed Original ResearchRepetitive Transcranial Magnetic Stimulation for Substance Use Disorders and Chronic Pain: a Review of the Evidence and Call for Increased Mechanistic Understanding
Michel A, Kang D, Fillingim R, Balderston N, Bond D, Steele V. Repetitive Transcranial Magnetic Stimulation for Substance Use Disorders and Chronic Pain: a Review of the Evidence and Call for Increased Mechanistic Understanding. Current Addiction Reports 2025, 12: 14. PMID: 41019785, PMCID: PMC12467114, DOI: 10.1007/s40429-025-00620-3.Peer-Reviewed Original ResearchSubstance use disordersChronic painRepetitive transcranial magnetic stimulationTranscranial magnetic stimulationDiverse chronic pain conditionsChronic pain conditionsCo-occurring diseasesRTMS interventionMagnetic stimulationMagnetic resonance imagingEffective interventionsPain fieldPain conditionsSubstance use disorders fieldRepetitive transcranial magnetic stimulation applicationPainEffective treatmentUse disorderNarrative reviewClinical populationsSubstance useResonance imagingInterventionEvaluate relative efficacyClinical samples
2024
Pain can’t be carved at the joints: defining function-based pain profiles and their relevance to chronic disease management in healthcare delivery design
Barron D, Saltoun K, Kiesow H, Fu M, Cohen-Tanugi J, Geha P, Scheinost D, Isaac Z, Silbersweig D, Bzdok D. Pain can’t be carved at the joints: defining function-based pain profiles and their relevance to chronic disease management in healthcare delivery design. BMC Medicine 2024, 22: 594. PMID: 39696368, PMCID: PMC11656997, DOI: 10.1186/s12916-024-03807-z.Peer-Reviewed Original ResearchConceptsChronic diseasesPain ProfileChronic conditionsPatient functionPain conditionsManagement of chronic diseasesChronic disease managementContinuum of careHealthcare delivery systemImprove quality of lifeQuality of lifePainful body partPain interferenceAssociated with clinical variablesUK BiobankWhole-body perspectiveHealth strategiesTreatment of individual patientsPain intensityClinically relevant differencesPatient wellbeingPain managementTreat painful conditionsICD codesMedical specialtiesTranscutaneous Auricular Vagus Nerve Stimulation for Managing Pain: A Scoping Review
Chen J, Kuang H, Chen A, Dungan J, Cousin L, Cong X, Patel P, Starkweather A. Transcutaneous Auricular Vagus Nerve Stimulation for Managing Pain: A Scoping Review. Pain Management Nursing 2024, 26: 33-39. PMID: 39690039, DOI: 10.1016/j.pmn.2024.11.006.Peer-Reviewed Original ResearchConceptsScoping ReviewTranscutaneous auricular vagus nerve stimulationChronic low back painPain managementEvaluate intervention fidelityLow back painAuricular vagus nerve stimulationPain conditionsPreferred Reporting ItemsPeer-reviewed journalsTranscutaneous nerve stimulationIntervention fidelityHealthcare professionalsBack painManaging painNerve stimulationSociodemographic variablesReporting ItemsInclusion of measuresVagus nerve stimulationEfficacy of transcutaneous auricular vagus nerve stimulationSystematic reviewSystematic searchMeSH termsLiterature searchRelationship between diet and postoperative pain: A scoping review
Chowdhary H, Chow R, Li J, Rajput K. Relationship between diet and postoperative pain: A scoping review. Journal Of Anesthesia And Translational Medicine 2024, 3: 181-187. DOI: 10.1016/j.jatmed.2024.11.004.Peer-Reviewed Original ResearchPost-surgical painN-methyl-D-aspartateAcute postoperative painPostoperative painHigh-fat dietPain sensitivitySurgical populationImpact of dietIntermittent fastingPersistent post-surgical painAcute post-surgical painHuman studiesDiverse surgical populationResponse to morphinePost-operative painChronic pain conditionsHigh-fatReduction of inflammationPersistent painPain conditionsPainCochrane DatabaseRisk factorsCollate available evidenceInflammationChronic overlapping pain conditions and nociplastic pain
Johnston K, Signer R, Huckins L. Chronic overlapping pain conditions and nociplastic pain. Human Genetics And Genomics Advances 2024, 6: 100381. PMID: 39497418, PMCID: PMC11617767, DOI: 10.1016/j.xhgg.2024.100381.Peer-Reviewed Original ResearchGenome wide association studiesTranscriptome-wide associationChronic overlapping pain conditionsTissue enrichment analysisSingle nucleotide polymorphismsEnrichment analysisNociplastic painPain conditionsIndependent single nucleotide polymorphismsMultisite chronic painGene Set Enrichment AnalysisSNP heritabilityUnique genesNeuropathic pain phenotypesAssociation studiesPolygenic traitChronic pain conditionsGene setsNucleotide polymorphismsMetabolic traitsHeritable traitGenetic overlapPain phenotypesPain descriptorsPain experienceMultiple Pain Conditions: Overlap, Gender Differences, and Associations with Post-Traumatic Stress Disorder Among Veterans
Hadlandsmyth K, Driscoll M, Johnson N, Mares J, Mengeling M, Thomas E, Norman S, Lund B. Multiple Pain Conditions: Overlap, Gender Differences, and Associations with Post-Traumatic Stress Disorder Among Veterans. Journal Of Pain 2024, 25: 44-45. DOI: 10.1016/j.jpain.2024.01.207.Peer-Reviewed Original ResearchEstimate gender differencesTrajectory of chronic painVeterans Health Administration administrative dataPain typesVeterans with chronic painChronic painTrauma-sensitive careRisk factorsMultivariate logistic regression modelGender differencesLogistic regression modelsNegative binomial regressionStress disorderAssociated with post-traumatic stress disorderWomen veteransChronic pain typesPost-traumatic stress disorderIndependent risk factorAdministrative dataBinomial regressionPain subtypesPosttraumatic stress disorderVeteransPain conditionsRegression modelsVeterans with chronic pain: Examining gender differences in pain type, overlap, and the impact of post‐traumatic stress disorder
Hadlandsmyth K, Driscoll M, Johnson N, Mares J, Mengeling M, Thomas E, Norman S, Lund B. Veterans with chronic pain: Examining gender differences in pain type, overlap, and the impact of post‐traumatic stress disorder. European Journal Of Pain 2024, 28: 1311-1319. PMID: 38450917, DOI: 10.1002/ejp.2258.Peer-Reviewed Original ResearchPost-traumatic stress disorderChronic painPain typesTrajectory of chronic painVeterans Health Administration administrative dataVeterans with chronic painTrauma-sensitive careStress disorderRisk factorsMultivariate logistic regression modelImpact of post-traumatic stress disorderGender differencesLogistic regression modelsNegative binomial regressionWomen veteransChronic pain typesEstimate gender differencesIndependent risk factorAdministrative dataBinomial regressionPain subtypesVeteransPain conditionsRegression modelsPain
2023
Novel hippocampal genes involved in enhanced susceptibility to chronic pain-induced behavioral emotionality
Garman A, Ash A, Kokkinos E, Nerland D, Winter L, Langreck C, Forgette M, Girgenti M, Banasr M, Duric V. Novel hippocampal genes involved in enhanced susceptibility to chronic pain-induced behavioral emotionality. European Journal Of Pharmacology 2023, 964: 176273. PMID: 38135263, DOI: 10.1016/j.ejphar.2023.176273.Peer-Reviewed Original ResearchBlood-brain barrier integrityChronic pain statesBehavioral emotionalityHippocampal genesPain statesGenome-wide RNA-seq analysisStress responseBarrier integrityCommon stress responseRNA-seq analysisAurora kinase BChronic inflammatory painDepressive-like behaviorChronic pain conditionsRodent stress modelsLimbic brain regionsTight junction proteinsBioinformatics analysisInflammatory painAstrocyte activationPain groupPain conditionsTranscriptomic profilesAltered moodKinase BT70. A COMPUTATIONAL TRANSCRIPTOMICS APPROACH TO DRUG REPURPOSING IDENTIFIES NEW THERAPEUTIC CANDIDATES FOR TREATMENT OF CHRONIC PAIN
Cote A, Johnston K, Seah C, Young H, Charney A, Huckins L. T70. A COMPUTATIONAL TRANSCRIPTOMICS APPROACH TO DRUG REPURPOSING IDENTIFIES NEW THERAPEUTIC CANDIDATES FOR TREATMENT OF CHRONIC PAIN. European Neuropsychopharmacology 2023, 75: s199. DOI: 10.1016/j.euroneuro.2023.08.354.Peer-Reviewed Original ResearchResolution of acute painSeverity of chronic painChronic painAcute painExpression signaturesTreatment of chronic pain conditionsAcute low back painPresence of chronic painTreatment of chronic painChronic pain developmentChronic pain phenotypeChronic pain prevalenceChronic pain conditionsLow back painLong-term treatmentTherapeutic candidatePain symptom severityAnti-diabetic medicationsGene expression signaturesPain phenotypesDrug candidatesPain developmentBack painPain prevalencePain conditionsPeripheral Nerve Stimulation for Pain Management: A Review
Chow R, Lee R, Rajput K. Peripheral Nerve Stimulation for Pain Management: A Review. Current Pain And Headache Reports 2023, 27: 321-327. PMID: 37523121, DOI: 10.1007/s11916-023-01143-0.Peer-Reviewed Original ResearchConceptsPeripheral nerve stimulationNerve stimulationChronic painChronic low back painSingle peripheral nerveUse of PNSChronic pain conditionsPost-amputation painLong-term outcomesLow back painWidespread disease processNeuropathic etiologyUpcoming evidenceNeuropathic painPain reliefOccipital neuralgiaPain conditionsPain managementBack painPeripheral nervesPainRecent FindingsThereDisease processImproved functionAvailable evidence“It Made Me Not Want to See him…”: The Role of Patient-Provider Communication in Influencing Rural-Dwelling Women Veterans’ Motivation to Seek Health Care for Managing Chronic Pain
Johnson N, Steffensmeier K, Garvin L, Adamowicz J, Obrecht A, Rothmiller S, Sibenaller Z, Stout L, Driscoll M, Hadlandsmyth K. “It Made Me Not Want to See him…”: The Role of Patient-Provider Communication in Influencing Rural-Dwelling Women Veterans’ Motivation to Seek Health Care for Managing Chronic Pain. Health Communication 2023, 39: 1161-1174. PMID: 37161286, DOI: 10.1080/10410236.2023.2207280.Peer-Reviewed Original ResearchWomen veteransHealth careChronic painPatient-provider communication skillsHigher health care utilizationRural women veteransPatient-provider communicationSeeking health careHealth care utilizationPain treatment optionsChronic pain managementPatient-providerCare utilizationSeeking CareSource of motivationMotivational interviewingInterview participantsPain managementDecision-makingCareVeteransCommunication skillsProvidersPain conditionsHealthIncreasing risk of cannabis use disorder among U.S. veterans with chronic pain: 2005-2019
Mannes Z, Malte C, Olfson M, Wall M, Keyes K, Martins S, Cerdá M, Gradus J, Saxon A, Keyhani S, Maynard C, Livne O, Fink D, Gutkind S, Hasin D. Increasing risk of cannabis use disorder among U.S. veterans with chronic pain: 2005-2019. Pain 2023, 164: 2093-2103. PMID: 37159542, PMCID: PMC10524371, DOI: 10.1097/j.pain.0000000000002920.Peer-Reviewed Original ResearchConceptsCannabis use disorder prevalenceVeterans Health Administration patientsVeterans Health AdministrationCannabis use disorderRisk of cannabis use disorderChronic painPain conditionsVeterans Health Administration electronic health recordPrevalence of cannabis use disorderDiagnosis of cannabis use disorderSymptoms of cannabis use disorderUse disorderElectronic health recordsChronic pain conditionsChronic pain managementEffects of cannabisSymptom managementHealth recordsHealth AdministrationMonitor symptomsPatient agePain managementCannabis useAge-stratifiedU.S. veterans
2022
Chronic Pain and Psychiatric Conditions
Johnston K, Huckins L. Chronic Pain and Psychiatric Conditions. Complex Psychiatry 2022, 9: 24-43. PMID: 37034825, PMCID: PMC10080192, DOI: 10.1159/000527041.Peer-Reviewed Original ResearchChronic painLinkage disequilibrium score regression analysisPsychiatric conditionsPain comorbidityDSM-5 psychiatric diagnosisRates of chronic painGenetic overlapPublic health burdenDSM-5Chronic pain conditionsAssociated with increased ratesPotential mechanismsHealth burdenPsychiatric diagnosisPain conditionsTreatment strategiesDepressive disorderPainOverview of relationshipsComorbidityRegression analysisADHDDepressionImpact understandingDisordersAcute pain pathways: protocol for a prospective cohort study
Jeffery MM, Ahadpour M, Allen S, Araojo R, Bellolio F, Chang N, Ciaccio L, Emanuel L, Fillmore J, Gilbert GH, Koussis P, Lee C, Lipkind H, Mallama C, Meyer T, Moncur M, Nuckols T, Pacanowski MA, Page DB, Papadopoulos E, Ritchie JD, Ross JS, Shah ND, Soukup M, St. Clair CO, Tamang S, Torbati S, Wallace DW, Zhao Y, Heckmann R. Acute pain pathways: protocol for a prospective cohort study. BMJ Open 2022, 12: e058782. PMID: 35790333, PMCID: PMC9258513, DOI: 10.1136/bmjopen-2021-058782.Peer-Reviewed Original ResearchConceptsAcute painOpioid analgesicsMulticentre prospective observational studyLittle high-quality evidenceNon-cancer painOpioid analgesic useResolution of painProspective cohort studyProspective observational studyPatient-centered outcomesElectronic health record dataEvidence-based guidelinesHigh-quality evidenceHealth record dataDiverse clinical settingsLong-term useClinician prescribingLeftover opioidsAnalgesic usePain controlCohort studyPain conditionsPain managementPain treatmentCommon diagnosisTrends in Prescriptions for Non-opioid Pain Medications Among U.S. Adults With Moderate or Severe Pain, 2014-2018
Gorfinkel L, Hasin D, Saxon A, Wall M, Martins S, Cerdá M, Keyes K, Fink D, Keyhani S, Maynard C, Olfson M. Trends in Prescriptions for Non-opioid Pain Medications Among U.S. Adults With Moderate or Severe Pain, 2014-2018. Journal Of Pain 2022, 23: 1187-1195. PMID: 35143969, PMCID: PMC9271556, DOI: 10.1016/j.jpain.2022.01.006.Peer-Reviewed Original ResearchConceptsNon-opioid pain medicationsNon-steroidal anti-inflammatory drugsAnti-inflammatory drugsPain medicationNon-opioid medicationsLow back painSelf-reported painAcetaminophen prescriptionsBack painOpioid prescriptionsSevere painPain treatmentU.S. adultsOpioid prescribingPain conditionsPain managementGabapentinoidsAntidepressantsPainPercentage of participantsOpioidMedication efficacyMedicationNationally-representative dataSecondary analysis
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