2025
Integrated Immune Landscape Analysis of RNA Splicing Factor-Mutant AML and Higher risk MDS Treated with Azacitidine ± Durvalumab
Bewersdorf J, Hasle V, Shallis R, Thompson E, de Menezes D, Rose S, Boss I, Mendez L, Podoltsev N, Stahl M, Kewan T, Halene S, Haferlach T, Fox B, Zeidan A. Integrated Immune Landscape Analysis of RNA Splicing Factor-Mutant AML and Higher risk MDS Treated with Azacitidine ± Durvalumab. Therapeutic Advances In Hematology 2025, 16: 20406207251347344. PMID: 40546817, PMCID: PMC12182606, DOI: 10.1177/20406207251347344.Peer-Reviewed Original ResearchThis study investigates the immune landscape of RNA splicing factor-mutant AML and MDS, showing no survival benefit from adding durvalumab to azacitidine treatment.Intravenous Glyburide in Medical and Endovascular‐Treated Large‐Core Stroke: A Subgroup Analysis of the CHARM Randomized Clinical Trial
Kimberly W, Saver J, Campbell B, Albers G, Molyneaux B, Hinson H, Rocha M, Mittal S, Bacchi S, Sharma G, Cordonnier C, Steiner T, Toyoda K, Wintermark M, Nogueira R, Jacobson S, Simard J, Sheth K. Intravenous Glyburide in Medical and Endovascular‐Treated Large‐Core Stroke: A Subgroup Analysis of the CHARM Randomized Clinical Trial. Annals Of Neurology 2025 PMID: 40476628, DOI: 10.1002/ana.27268.Peer-Reviewed Original ResearchRandomized clinical trialsIntravenous glyburideClinical trialsBaseline National Institutes of Health Stroke ScaleEndovascular thrombectomyNational Institutes of Health Stroke ScaleBaseline core volumeBaseline stroke volumeEfficacy of i.Health Stroke ScaleComputed tomography perfusionModified Rankin ScaleTissue plasminogen activatorPost-hocPost hoc studyPost Hoc AnalysisMagnetic resonance imagingPrimary endpointCHARM trialMidline shiftStroke ScaleFavorable outcomeTreatment armsSubgroup analysisRankin ScaleTowards Automating Risk Stratification of Intraductal Papillary Mucinous Neoplasms: Artificial Intelligence Advances Beyond Human Expertise with Confocal Laser Endomicroscopy
Krishna S, Abdelbaki A, Li Z, Culp S, Xiong X, Napoleon B, Mok S, Bertani H, Feng Y, Kongkam P, Luthra A, Machicado J, El-Dika S, Leblanc S, Tan D, Burlen J, Keane M, Keihanian T, Ladd A, Muniraj T, Visrodia K, Chen W, Esnakula A, Hart P, Chao W. Towards Automating Risk Stratification of Intraductal Papillary Mucinous Neoplasms: Artificial Intelligence Advances Beyond Human Expertise with Confocal Laser Endomicroscopy. Pancreatology 2025 PMID: 40447463, DOI: 10.1016/j.pan.2025.05.011.Peer-Reviewed Original ResearchNeedle-based confocal laser endomicroscopyIntraductal papillary mucinous neoplasmBD-IPMNInterobserver agreementArtificial intelligenceConfocal laser endomicroscopyLaser endomicroscopyBranch ductPapillary mucinous neoplasmPerformance of expertsHuman expertiseAI modelsPost Hoc AnalysisMucinous neoplasmsDysplasia gradeEndoscopic ultrasoundClinical criteriaInterobserver variabilityCyst epitheliumSuperior accuracyDysplasiaAUCPost-hocArtificialDiagnostic parametersStatus epilepticus in older adults: A critical review
Woodward M, Armahizer M, Wang T, Badjatia N, Johnson E, Gilmore E. Status epilepticus in older adults: A critical review. Epilepsia 2025 PMID: 40365943, DOI: 10.1111/epi.18453.Peer-Reviewed Original ResearchEstablished Status Epilepticus Treatment TrialStatus epilepticusOlder adultsTreatment trialsMortality associated with SEIncidence of status epilepticusAssociated with poor outcomesSensitivity to benzodiazepinesMen aged >Analysis of older adultsPhysiologic changes of agingAdults aged <Incidence of SERandomized clinical trialsEfficacy of treatmentPost Hoc AnalysisHigh morbidityPoor outcomeAntiseizure medicationsEstablished treatmentTreatment selectionChanges of agingOlder trialsHigher incidenceIncidence increasesImpact of Brain Frailty on Clinical Presentation and Neurologic Recovery in Acute Ischemic Stroke Patients Undergoing Thrombectomy
Fladt J, Benali F, Jaroenngarmsamer T, Bala F, Singh N, Nogueira R, McTaggart R, Demchuk A, Poppe A, Buck B, Tymianski M, Hill M, Goyal M, Ganesh A, Barber P, Smith E, Bal S, Subramanian S, Peters S, Couillard P, Klein G, Stys P, Coutts S, Wong J, Mitha A, Eesa M, Morrish W, Alqatani S, Alqatani S, Venkatesan P, Teleg E, Sitaram A, Graham B, van Gaal S, Moussaddy A, Chakraborty D, Maraj N, Lockey A, Chen S, Singh R, Alsultan A, Asunsian R, Tse D, Doshi D, Volny O, Ojha P, Wadhwa A, Marko M, Singh N, Wasyliw S, Ryckborst K, Kenney C, Save S, Jambula A, Newcommon N, Hull G, Blackstock D, Kiszczak S, Zimmel L, Wright M, Jahraus C, Andersen L, Bohn S, Paul J, Buck B, Butcher K, Shuaib A, Jeerakathil T, Jickling G, Emery D, Rempel J, Ower R, Ashforth R, Yeo T, Kotylak T, O'Kelly C, Chow M, Siddiqui M, Saqqur M, D'Souza A, Lloret M, Butt A, Nomani A, Kalashyan H, Thirunavukkarasu S, Jabs J, Fairall P, Piquette L, Phillips S, Green A, Gubitz G, Heidenreich J, Huynh T, Shankar J, Maloney W, Vandorpe R, Schmidt M, Pickett G, Weeks A, Jarrett J, MacDonald D, Arsenault J, Kinnear R, Mandzia J, Mayich M, Boulton M, Bullrich M, Fridman S, Kiwan R, Lee D, Lownie S, Khaw A, Pandey S, Sharma M, Sposato L, Wade K, Beauchamp B, Lambourn L, Amato-Marziali B, Roy D, Deneault N, Deschaintre Y, Gioia L, Jacquin G, Odier C, Stapf C, Iancu D, Raymond J, Weill A, Lapierre M, Jadil N, Jolteus J, Teitelbaum J, Angle M, Hannouche M, Badawy M, Letourneau J, Cortes M, Linnell G, Tampieri D, Vieira L, Moussaddy A, Legault C, Durcan L, Moore A, Cole E, Magnussen C, Salmon K, Khalil S, Desloges I, Waxman L, Abdon W, Lai S, Dowlatshahi D, Iancu D, Shamy M, Stotts G, Blacquiere D, Lesiuk H, Quateen A, Drake B, Dewar B, Daham Z, Kelly M, Hunter G, Peeling L, Graham B, Whelan R, Garner A, Urroz L, Maley S, Silver F, Casaubon L, Pikula A, del Campo M, Schaafsma J, Jaigobin C, Krings T, Pereira V, Agid R, Farb R, Kalman L, Cayley A, Williams J, Stewart T, Misquitta K, Bharatha A, Selchen D, Marotta T, Sarma D, Montanera W, Spears J, Saposnik G, Kostyrko P, Li Y, Parra-Farinas C, Bengzon Diestro J, Camden M, Verreault S, Mackey A, Audet M, Milot G, Lavoie P, Gariepy J, Collard K, Hache A, Sahlas D, Alshanbari A, Baldwin J, Catanese L, Chen B, de Sa Boasquevisque D, Deshmukh A, Knapman J, Lamers S, Larrazabal R, MacMillan S, Mai L, Mattai A, Nayar S, Ng K, Oczkowski W, Perera K, Shawawrah M, Shoamanesh A, Sobhi G, Syed N, Yaher N, Vandervelde C, Wang D, Field T, Van Gaal S, Teal P, Benavente O, Wilson L, Mann S, Yip S, Murphy C, Heran M, Rohr A, Settecase F, Redekop G, Haw C, Maclean G, Murray K, Chiu R, Flexman A, Strecha E, Gayton Y, Yip J, Swartz R, Boulos M, Gladstone D, Yu A, Hopyan J, Khosravani H, Manosalva Alzate H, Southwell A, Kamra M, Lopes K, Kapoor A, da Costa L, Yang V, Dyer E, Shah R, Knowles B, Nichols J, Patterson J, Cope K, Dickerson L, Barton K, Gray K, Massengale T, Miller M, Simpson C, Walker S, Tennyson-Yemm C, Frei D, on R, Atchie B, Kaminsky I, Wilson D, Schraeder N, Arias E, Kodis L, Talley M, Edinger A, Talley T, Dempsey I, Williams L, Williams S, Kupniewski S, Fasbinder B, Snead J, Choe H, Mackenzie L, Weisman D, Kozak O, Shah Q, Gzesh D, Kulandaivel K, Khoury J, Klein B, Bussinger P, Griffin L, DePalmo A, Oliva C, Jadhav A, Jovin T, Kenmuir C, Jankowitz B, Gross B, Rocha M, Starr M, Brown M, Hawkes C, Shah K, Tememe D, Walker G, Patel P, Klein B, Ziayee H, Limaye K, Baxendell L, Glichrist V, Feineigle P, Haibach K, Van Every C, Desai S, Zulfiqar M, Gibson L, Barrett S, Turkel-Parrella D, Arcot K, DiCrescento S, Farkas J, Filipowski G, Frontera J, Joset D, Liff J, Scher E, McDougall C, Kelly C, Patel A, Monteith S, Starkman S, Atchaneeyasakul K, Burgos A, Chua J, Gaines N, Grunberg I, Guzy J, Liu Z, Maluste N, Ramirez L, Sharma L, Heck D, Brown M, McDonald C, Calderon M, Hargis M, Roels C, Emmady P, Alvi T, Jayaraman M, Cutting S, Smith W, Foley S, Paolucci G, Haas R, Quinn K, Fuller L, Brierley R, Watkins C, Demir N, Lopez G, Vargas A, Osteraas N, Holtz B, Sauvageau E, Aghaebrahim A, Chmayssani M, Naval N, Day J, Dellorso S, Ludwig B, Schemmel D, Ebreo N, Bell K, Lewis L, Delucia M, Haussen D, Frankel M, Bhatt N, Bianchi N, Anderson A, Belagaje S, Liberato B, Rangaraju S, Al-Bayati A, Grossber J, Craft L, Schindler K, Schaad E, Schultz M, Sutherly L, Doppelheuer S, Charlton J, Faggard J, Barbret Z, DukSoo Han E, Walters R, Dolia J, El-Jamal S, Eby B, Saleem Y, Pearl H, Patel K, Rahman H, Butt R, English S, Puri A, Howk M, Singh J, Massari F, DeMacedo Rodrigues K, Kuhn A, English J, Barazangi N, Telischak N, Kim W, Ross J, DeVole N, Redford J, Ferreira M, Ponting K, Shen H, Bedenk A, Patel S, Fernandess J, Ke M, Spokoyny I, Gao B, Tong D, Chen C, Wong C, Choe J, Martin C, Summers D, Boutwell C, Olds K, Crandall S, Eatman J, Akhtar N, Holloway W, Halpin J, Donegan B, Schindler J, Hwang D, Gilmore E, Petersen N, Sheth K, Brown S, Beekman R, George B, Kaddouh F, Falcone G, Wira C, Matouk C, Loomis C, Amin H, Stretz H, Narula R, Jasne A, Sansing L, Agarwal T, Jasak S, Fontaine B, King Z, Kouhn L, Orgass H, Leary M, Nye J, Halbert K, Nystrom K, Neuschatz K, Petrucci D, Coppola A, Joyce T, Hou S, Umekubo M, Nakamura C, Ovando R, Zuniga D, Nien Y, Basto F, Arch A, Jong L, Conrad W, Abbott T, Yao J, Caganap S, Jordan J, Teitelbaum G, Darflinger R, Kelly D, Gupta R, Budzik R, Czerniak J, Groezinger K, Hicks W, Kaskar O, Katz B, Loochtan A, Pema P, Rai V, Vora N, Brown A, Goodman D, Danenbergs B, Gossett M, Bang O, Chung J, Jeon P, Kim K, Lim Y, Heo J, Nam H, Kim Y, Park H, Hwang I, Ha W, Choi J, Jeong K, Rha J, Park H, Yoon C, Kim B, Sohn S, Kim C, Yoo J, Hong J, Park H, Kim S, Choi M, Bae H, Lee J, Lee J, Jun G, Jeon S, Campbell B, Mitchell P, Yassi N, Davis S, Donnan G, Parsons M, Yan B, Dowling R, Bush S, Wu T, Shan D, Zhao H, Salvaris P, Alemseged F, Ng F, Williams C, Balabanski A, Santos A, Ng J, McDonald A, Jackson D, Tsoleridis J, Pesavento L, Kleinig T, Drew R, Cranefield J, Scroop R, Cagi L, Harvey J, Waters M, Thornton J, Brennan R, O'Hare A, Power S, Williams D, Boyle K, Moynihan B, Liddy A, Large M, Cullen A, Walsh R, Martin E, Lynch J, McElroy S, Murphy S, Coveney S, Deegan C, Horgan G, Kelly P, Laffan A, Llamas-Osorio Y, Lynch C, Mac Mahon P, Marnane M, McCabe J, Burns P, Tauro S, Cuddy S, Rennie I, Smyth G, Flynn P, Wiggam I, Kerr E, Gordon P, Fearon P, Roberts G, Patterson C, Adams K, Wells B, McFarland M, Moreira T, Sjostrand C, Mazya M, Almqvist H, Wahlgren N, Steinberg A, Cooray C, Eriksson E, Thoren M, Keselman B, Ahmed N, Holmberg A, Axelsson M, Berglund A, Golsari A, Hoppe J, Deb-Chatterji M, Cheng B, Barow E, Schlemm E, Lettow I, Jensen M, Otto D, Jaramillo K, Appelbohm H, Fiehler J, Bester M, Schönfeld M, Brekenfeld C, Holst B, Wortmann G, Koch F, Gerber J, Abramyuk A, Kaiser D, Winzer S, Prakapenia A, Pallesen L, Siepmann T, Barlinn K, Haase K, Sauer A, Psychogios M, Liman J, Brehm A, Maus V, Hollstein N, Reinke A, Neitz G, Schnieder M, Schwarz M, Ibrahim A, Muller J, Meister S, Bäumle B, Chapot R, Pilgram-Pastor S, Wallocha M, Stauder M, Celik E, Stracke P, Muller N, Weber R, Veltkamp R, Nagel S, Ringleb P, Heyse M, Amiri H, Mundiyanapurath S, Chen M, Beyrle E, Beck P, Mohlenbruch M. Impact of Brain Frailty on Clinical Presentation and Neurologic Recovery in Acute Ischemic Stroke Patients Undergoing Thrombectomy. Neurology 2025, 104: e213619. PMID: 40294371, DOI: 10.1212/wnl.0000000000213619.Peer-Reviewed Original ResearchConceptsAcute ischemic strokeRepeated-measures analysisNIHSS scoreEndovascular thrombectomyStroke severityBrain frailtyCortical atrophyChronic infarctionAssociated with NIHSS scoreIschemic strokeNoncontrast CT scanFollow-up periodWhite matter hyperintensity burdenMultivariable quantile regressionPost Hoc AnalysisAdmission stroke severityRandomized-controlled trialsClinical presentationESCAPE-NA1Brain dysfunctionCT scanSubcortical atrophyNeurological recoveryHyperintensity burdenAcute phaseDifferent Responses to Blood Pressure Reduction in Lobar and Deep Intracerebral Hemorrhage
Clocchiatti-Tuozzo S, Rivier C, Qureshi A, Renedo D, Huo S, Matouk C, Petersen N, de Havenon A, Sheth K, Rabinstein A, Falcone G, Hawkes M. Different Responses to Blood Pressure Reduction in Lobar and Deep Intracerebral Hemorrhage. Neurocritical Care 2025, 1-9. PMID: 40293696, DOI: 10.1007/s12028-025-02269-2.Peer-Reviewed Original ResearchRenal adverse eventsDeep intracerebral hemorrhageIntensive BP reductionRisk of renal adverse eventsRisk of HEHematoma expansionBP reductionATACH-2Intracerebral hemorrhageLobar intracerebral hemorrhageFunctional outcomesAntihypertensive Treatment of Acute Cerebral Hemorrhage IIAcute spontaneous intracerebral hemorrhageAcute intracerebral hemorrhageSpontaneous intracerebral hemorrhageAssociated with reduced riskUnfavorable functional outcomeBlood pressure reductionRandomized clinical trialsMultivariate logistic regression resultsPost Hoc AnalysisAntihypertensive treatmentAdverse eventsClinical trialsIncreased riskEffects of exercise versus usual care on older adults with amnestic mild cognitive impairment: EXERT versus ADNI
Shadyab A, Aslanyan V, Jacobs D, Salmon D, Morrison R, Katula J, Jin S, Thomas R, LaCroix A, Pa J, Cotman C, Feldman H, Baker L, Group F. Effects of exercise versus usual care on older adults with amnestic mild cognitive impairment: EXERT versus ADNI. Alzheimer's & Dementia 2025, 21: e70118. PMID: 40271887, PMCID: PMC12019695, DOI: 10.1002/alz.70118.Peer-Reviewed Original ResearchConceptsUsual careRandomized Controlled TrialsAmnestic mild cognitive impairmentOlder adultsMild cognitive impairmentADNI-1Multisite Randomized Controlled TrialNo interventionSedentary older adultsIntensity aerobic trainingAlzheimer's Disease Neuroimaging Initiative 1Moderate-high intensityEffects of exerciseCognitive declineCognitive impairmentFlexibility exercisesExercise armAerobic trainingAD-signature regionsExertion groupCognitive trajectoriesExertionCarePost Hoc AnalysisExerciseImpact of atopic status, prior omalizumab use and baseline blood eosinophil count alone and in combination with total serum IgE on maintenance OCS reduction outcomes in patients with severe asthma treated with mepolizumab in the REALITI-A study
Liu M, Chaudhuri R, Chupp G, Heaney L, Lee J, Pilette C, Brusselle G, Alfonso-Cristancho R, Zhang L, Howarth P, Kumar A. Impact of atopic status, prior omalizumab use and baseline blood eosinophil count alone and in combination with total serum IgE on maintenance OCS reduction outcomes in patients with severe asthma treated with mepolizumab in the REALITI-A study. Revue Française D'Allergologie Et D'Immunologie Clinique 2025, 65: 104319. DOI: 10.1016/j.reval.2025.104319.Peer-Reviewed Original ResearchBaseline blood eosinophil countBlood eosinophil countProportion of patientsAtopic statusDaily doseDose reductionOmalizumab useEosinophil countSevere asthmaDaily dose reductionSerum total IgEDaily dose dataReal-world treatmentReal-world studyPost Hoc AnalysisAdverse event riskSingle-armIL-5Total IgEDose dataOmalizumabClinical trialsMepolizumabPatientsEvent riskElevated inflammatory type 2 biomarkers at baseline predict multicomponent clinical remission following dupilumab treatment in patients with moderate-to-severe asthma
De Llano L, Guilleminault L, Canonica G, Pavord I, Couillard S, Porsbjerg C, Brusselle G, Castro M, Bourdin A, Altincatal A, Kwah J, Ledanois O. Elevated inflammatory type 2 biomarkers at baseline predict multicomponent clinical remission following dupilumab treatment in patients with moderate-to-severe asthma. Revue Française D'Allergologie Et D'Immunologie Clinique 2025, 65: 104323. DOI: 10.1016/j.reval.2025.104323.Peer-Reviewed Original ResearchModerate-to-severe asthmaClinical remissionDupilumab treatmentDrivers of type 2 inflammationType 2 biomarkersFractional exhaled nitric oxideOral corticosteroid useType 2 inflammationBaseline blood eosinophilsHuman monoclonal antibodyAdd-on dupilumabImprove lung functionExhaled Nitric OxidePost Hoc AnalysisPlacebo Q2WPlacebo recipientsBaseline FeNORemission rateCorticosteroid useDupilumabFeNO levelsRemissionBlood eosinophilsPlaceboLung functionTime saved in activities of daily living and whole‐brain volume: Post hoc analysis of a randomized feasibility trial of gamma oscillation treatment in participants with mild or moderate Alzheimer's disease
Kern R, Haaland B, Nicodemus‐Johnson J, Dickson S, Morgan M, Christensen J, Sabbagh M, Lee L, Hajós M, Riddle J, Seshagiri C, Howell C, Mallinckrodt C, Hendrix S. Time saved in activities of daily living and whole‐brain volume: Post hoc analysis of a randomized feasibility trial of gamma oscillation treatment in participants with mild or moderate Alzheimer's disease. Alzheimer's & Dementia: Translational Research & Clinical Interventions 2025, 11: e70118. PMID: 40501511, PMCID: PMC12152371, DOI: 10.1002/trc2.70118.Peer-Reviewed Original ResearchWhole-brain volumeMini-Mental State ExaminationOpen-label extensionMild to moderate ADEvoked gamma oscillationsGamma oscillationsADCS-ADLActivities of daily livingWhole-brain atrophyPost Hoc AnalysisMeasures of whole-brain volumeMini-MentalState ExaminationAlzheimer's Disease Cooperative Study-ActivitiesAlzheimer's diseaseMonths of active treatmentDaily livingActive treatmentRandomized controlled trial phaseOpen-label extension phaseModerate Alzheimer's diseaseWhole-brain volume changesEffect of active treatmentMonths of progressionMemory consolidationBPI25-014: Pacritinib in Patients With Intermediate-1 Risk Myelofibrosis: Outcomes From Post-Hoc Analysis of Two Phase 3 Studies.
Vachhani P, Podoltsev N, Kishtagari A, Suthar P, Vredenburg M, Roman-Torres K, Gerds A. BPI25-014: Pacritinib in Patients With Intermediate-1 Risk Myelofibrosis: Outcomes From Post-Hoc Analysis of Two Phase 3 Studies. Journal Of The National Comprehensive Cancer Network 2025, 23 PMID: 40154382, DOI: 10.6004/jnccn.2024.7162.Peer-Reviewed Original ResearchFactors Associated With Stroke Recurrence After Initial Diagnosis of Cervical Artery Dissection
Mandel D, Shu L, Chang C, Jack N, Guerrero C, Henninger N, Muppa J, Affan M, Lodhi O, Heldner M, Antonenko K, Seiffge D, Arnold M, Omran S, Crandall R, Lester E, Mena D, Arauz A, Nehme A, Boulanger M, Touzé E, Sousa J, Sargento-Freitas J, Barata V, Castro-Chaves P, Brito M, Khan M, Mallick D, Rothstein A, Khazaal O, Kaufman J, Engelter S, Traenka C, de Sousa D, Soares M, Rosa S, Zhou L, Gandhi P, Field T, Mancini S, Metanis I, Leker R, Pan K, Dantu V, Baumgartner K, Burton T, von Rennenberg R, Nolte C, Choi R, MacDonald J, Shahripour R, Guo X, Ghannam M, Almajali M, Samaniego E, Sanchez S, Rioux B, Zine-Eddine F, Poppe A, Fonseca A, Baptista M, Cruz D, Romoli M, De Marco G, Longoni M, Keser Z, Griffin K, Kuohn L, Frontera J, Amar J, Giles J, Zedde M, Pascarella R, Grisendi I, Nzwalo H, Liebeskind D, Molaie A, Cavalier A, Kam W, Mac Grory B, Al Kasab S, Anadani M, Kicielinski K, Eltatawy A, Chervak L, Rivas R, Aziz Y, Bakradze E, Tran T, Gisbert M, Requena M, Velez F, Garcia J, Muddasani V, de Havenon A, Vishnu V, Yaddanapudi S, Adams L, Browngoehl A, Ranasinghe T, Dunston R, Lynch Z, Penckofer M, Siegler J, Mayer S, Willey J, Zubair A, Cheng Y, Sharma R, Marto J, Ferreira V, Klein P, Nguyen T, Asad S, Sarwat Z, Balabhadra A, Patel S, Secchi T, Martins S, Mantovani G, Kim Y, Krishnaiah B, Elangovan C, Lingam S, Qureshi A, Fridman S, Alvarado-Bolanos A, Khasiyev F, Linares G, Mannino M, Terruso V, Vassilopoulou S, Tentolouris-Piperas V, Marino M, Wall V, Indraswari F, Jamal S, Liu S, Alvi M, Ali F, Sarvath M, Morsi R, Kass-Hout T, Shi F, Zhang J, Sokhi D, Said J, Mongare N, Simpkins A, Gomez R, Sen S, Ghani M, Elnazeir M, Xiao H, Kala N, Khan F, Stretz C, Mohammadzadeh N, Goldstein E, Furie K, Yaghi S. Factors Associated With Stroke Recurrence After Initial Diagnosis of Cervical Artery Dissection. Stroke 2025, 56: 1413-1421. PMID: 40143807, DOI: 10.1161/strokeaha.124.048215.Peer-Reviewed Original ResearchConceptsCervical artery dissectionCox regressionOcclusive dissectionIschemic strokeArtery dissectionAssociated with subsequent stroke riskDiagnosis of cervical artery dissectionFactors associated with increased riskAssociated with increased risk of ischemic strokeStroke riskTreated with anticoagulationAssociated with increased riskOptimal treatment strategyHistory of ischemic strokeRetrospective observational studyRisk of ischemic strokeBenefits of anticoagulationIschemic stroke riskFactors associated with stroke recurrenceHigh-risk individualsIdentified risk factorsPost Hoc AnalysisCAD subgroupAntiplatelet therapyInitial diagnosisMolecular residual disease analysis of adjuvant osimertinib in resected EGFR-mutated stage IB–IIIA non-small-cell lung cancer
Herbst R, John T, Grohé C, Goldman J, Kato T, Laktionov K, Bonanno L, Tiseo M, Majem M, Dómine M, Ahn M, Kowalski D, Pérol M, Sriuranpong V, Özgüroğlu M, Bhetariya P, Markovets A, Rukazenkov Y, Muldoon C, Robichaux J, Hartmaier R, Tsuboi M, Wu Y. Molecular residual disease analysis of adjuvant osimertinib in resected EGFR-mutated stage IB–IIIA non-small-cell lung cancer. Nature Medicine 2025, 31: 1958-1968. PMID: 40097663, PMCID: PMC12176615, DOI: 10.1038/s41591-025-03577-y.Peer-Reviewed Original ResearchConceptsMolecular residual diseaseDisease-free survivalNon-small-cell lung cancerDisease-free survival eventsEvent-free rateAdjuvant osimertinibOsimertinib treatmentStage IB-IIIA non-small-cell lung cancerLung cancerOverall survival improvementEvent-free statusPosttreatment Follow-upExploratory post hoc analysisYear adjuvant treatmentPost Hoc AnalysisDFS eventsOsimertinib groupResidual diseaseTreatment discontinuationPlacebo groupAdjuvant therapyAdjuvant treatmentSurvival improvementOsimertinibFollow-upInspired Oxygen Concentration During the Re-initiation of Two-Lung Ventilation in Thoracic Surgery: A Post Hoc Analysis of Data From the Multicenter Perioperative Outcomes Group.
Douville N, Mathis M, Smolkin M, Martin L, Popescu W, Blank R. Inspired Oxygen Concentration During the Re-initiation of Two-Lung Ventilation in Thoracic Surgery: A Post Hoc Analysis of Data From the Multicenter Perioperative Outcomes Group. Anesthesia & Analgesia 2025 PMID: 40063506, DOI: 10.1213/ane.0000000000007479.Peer-Reviewed Original ResearchPostoperative pulmonary complicationsSingle-lung ventilationInspired oxygen fractionPulmonary complicationsAssociated with postoperative pulmonary complicationsLung reinflationDevelopment of postoperative pulmonary complicationsMulticenter retrospective cohort studyTwo-lung ventilationRetrospective cohort studyAlveolar hyperoxiaMultivariate logistic regressionOxygen fractionPotential clinical implicationsInspired oxygen concentrationPost Hoc AnalysisThoracic surgeryMulticenter studyHyperoxic injuryRetrospective natureCohort studyMulticenter Perioperative Outcomes GroupOutcome groupComplicationsSecondary analysis of dataImpact of Transcatheter or Surgical Aortic Valve Performance on 5-Year Outcomes in Patients at ≥ Intermediate Risk
Yakubov S, Van Mieghem N, Oh J, Ito S, Grubb K, O'Hair D, Forrest J, Gada H, Mumtaz M, Deeb G, Tang G, Rovin J, Jain R, Windecker S, Skelding K, Kleiman N, Chetcuti S, Dedrick A, Boatman S, Popma J, Reardon M. Impact of Transcatheter or Surgical Aortic Valve Performance on 5-Year Outcomes in Patients at ≥ Intermediate Risk. Journal Of The American College Of Cardiology 2025, 85: 1419-1430. PMID: 40175015, DOI: 10.1016/j.jacc.2025.02.009.Peer-Reviewed Original ResearchBioprosthetic valve dysfunctionRandomized Controlled TrialsRandomized controlled trial patientsClinical outcomesAssociated with increased 5-year all-cause mortalityWorsening Heart FailureContinued Access StudyAll-Cause MortalityPost Hoc AnalysisPooled randomized controlled trialsIntermediate riskPivotal trialsPrimary endpointAortic valve performanceValve dysfunctionSurgery patientsHeart failureValve diseaseTAVI patientsSupra-annularSurgeryCardiovascular mortalityClinical importancePatientsControlled TrialsBASELINE PROGNOSTIC FACTORS OF BOWEL URGENCY IMPROVEMENT IN PATIENTS WITH ULCERATIVE COLITIS TREATED WITH MIRIKIZUMAB
Dubinsky M, Schreiber S, Matsuoka K, Jairath V, Al-Bawardy B, Pellanda P, Zhu B, Bleakman A, Redondo I, Owen C, Limdi J. BASELINE PROGNOSTIC FACTORS OF BOWEL URGENCY IMPROVEMENT IN PATIENTS WITH ULCERATIVE COLITIS TREATED WITH MIRIKIZUMAB. Inflammatory Bowel Diseases 2025, 31: s62-s63. DOI: 10.1093/ibd/izae282.147.Peer-Reviewed Original ResearchNumerical rating scalePain numerical rating scaleModified Mayo scoreMultivariate linear regression analysisInflammatory Bowel Disease QuestionnaireUnivariate analysisUlcerative colitisMayo scorePrognostic variablesAnti-IL-23p19 antibodyBaseline characteristics of patientsAnti-IL-23p19Linear regression analysisPhase 3 trialRegression analysisCharacteristics of patientsUrgency Numeric Rating ScaleBristol Stool ScaleMultivariate regression analysisPost Hoc AnalysisUnivariate analysis of associationPrognostic factorsDisease extentBaseline characteristicsMirikizumabUsing twin-pairs to assess potential bias in polygenic prediction of externalising behaviours across development
Bright J, Rayner C, Freeman Z, Zavos H, Ahmadzadeh Y, Viding E, McAdams T. Using twin-pairs to assess potential bias in polygenic prediction of externalising behaviours across development. Molecular Psychiatry 2025, 30: 3129-3137. PMID: 39972057, PMCID: PMC12185310, DOI: 10.1038/s41380-025-02920-6.Peer-Reviewed Original ResearchPolygenic scoresTwin pairsGenetic influencesPassive gene-environment correlationConduct problemsCallous-unemotional traitsGene-environment correlationADHD-related symptomsGenome-wide association studiesIndirect genetic effectsCU traitsADHD symptomologyExternalising behaviourPost Hoc AnalysisGenomic dataAssociation studiesPolygenic predictionEnvironmental influencesWithin-familyGenetic effectsPost-hocTraitsScoresADHDRGESalt repletion and diuretic response: The role of serum chloride. A post‐hoc analysis of the SALT‐HF trial on furosemide and hypertonic saline solution administration in ambulatory patients with worsening heart failure
Núñez J, Miñana G, de la Espriella R, Zegrí‐Reiriz I, Comín‐Colet J, Gracia J, Morales‐Rull J, Llàcer P, Diez‐Villanueva P, de Juan Bagudá J, Cortés C, Goirigolzarri‐Artaza J, García‐Pinilla J, Barrios E, del Prado Díaz S, Jiménez‐Marrero S, Restrepo‐Córdoba M, Testani J, Marcos M. Salt repletion and diuretic response: The role of serum chloride. A post‐hoc analysis of the SALT‐HF trial on furosemide and hypertonic saline solution administration in ambulatory patients with worsening heart failure. European Journal Of Heart Failure 2025 PMID: 39933832, DOI: 10.1002/ejhf.3597.Peer-Reviewed Original ResearchWorsening Heart FailureHypertonic saline solutionPost Hoc AnalysisAmbulatory patientsIV furosemideNatriuretic responseCongestion scoreDiuretic responseHeart failureBaseline serum chloride levelsSerum chlorideClinical congestion scoreOvercome diuretic resistanceUrinary sodium excretionHeart failure eventsSerum chloride levelsPost-hocBetween-treatment effectsDiuretic resistanceChloride levelsDouble-blindLoop diureticsDiuretic efficacyNatriuretic effectSodium excretionTargeting the SARS-CoV-2 reservoir in long COVID
Proal A, Aleman S, Bomsel M, Brodin P, Buggert M, Cherry S, Chertow D, Davies H, Dupont C, Deeks S, Ely E, Fasano A, Freire M, Geng L, Griffin D, Henrich T, Hewitt S, Iwasaki A, Krumholz H, Locci M, Marconi V, Mehandru S, Muller-Trutwin M, Painter M, Pretorius E, Price D, Putrino D, Qian Y, Roan N, Salmon D, Tan G, VanElzakker M, Wherry E, Van Weyenbergh J, Yonker L, Peluso M. Targeting the SARS-CoV-2 reservoir in long COVID. The Lancet Infectious Diseases 2025, 25: e294-e306. PMID: 39947217, PMCID: PMC12151306, DOI: 10.1016/s1473-3099(24)00769-2.Peer-Reviewed Original ResearchSARS-CoV-2Duration of treatmentPotential combination approachSARS-CoV-2 persistenceSARS-CoV-2 infectionPost Hoc AnalysisHIV reservoirHepatitis CMechanism of actionPatient subgroupsInterpretation of trialsDebilitating disease statesPrecision oncologyMonoclonal antibodiesGrowing body of evidenceBody of evidenceSilent Myocardial Infarction and Risk of Stroke Recurrence: A Post Hoc Analysis of the IRIS Trial
Ridha M, Zhang C, McCullough S, Viscoli C, Sharma R, Kamel H, Merkler A. Silent Myocardial Infarction and Risk of Stroke Recurrence: A Post Hoc Analysis of the IRIS Trial. Journal Of The American Heart Association 2025, 14: e037663. PMID: 39921499, PMCID: PMC12074768, DOI: 10.1161/jaha.124.037663.Peer-Reviewed Original ResearchConceptsSilent MISilent myocardial infarctionStroke recurrenceClinical MIAssociated with stroke recurrenceFirst-ever strokeMyocardial infarctionIschemic strokeTailored prevention strategiesRecurrent strokeVascular risk factorsHistory of hospitalizationRisk of stroke recurrenceEvidence of MIUnadjusted analysisPrevention strategiesInclusion criteriaSecondary outcomesECG evidence of MIPrimary outcomeRisk factorsMultivariate Cox regression analysisPost Hoc AnalysisStrokeRegression analysis
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