2025
The prognostic impact of MLH1 promoter hypermethylation in stage I–II endometrial cancer treated with adjuvant radiotherapy: a multi-institutional retrospective study MLH1ph status in stage I-II endometrial cancer
Sherwani Z, Damast S, Fields E, Beriwal S, Horne Z, Kidd E, Leung E, Taunk N, Chino J, Russo A, Dyer M, Albuquerque K, Hathout L. The prognostic impact of MLH1 promoter hypermethylation in stage I–II endometrial cancer treated with adjuvant radiotherapy: a multi-institutional retrospective study MLH1ph status in stage I-II endometrial cancer. International Journal Of Radiation Oncology • Biology • Physics 2025 PMID: 40379143, DOI: 10.1016/j.ijrobp.2025.05.004.Peer-Reviewed Original ResearchRecurrence-free survivalExternal beam radiationVaginal brachytherapyEndometrial cancerAssociated with decreased RFSAbsence of lymphovascular space invasionTreated with adjuvant radiation therapyPromoter hypermethylationStage I-II endometrial cancerProportion of locoregional recurrenceStage IMulti-institutional cohort studyAdjuvant radiation therapyLymphovascular space invasionInstitutional review board approvalPatterns of recurrenceKaplan-Meier methodReview board approvalDeficient mismatch repairMismatch repair statusAdjuvant radiotherapyCox proportional hazardsDistant recurrenceLocoregional recurrenceMyometrial invasionPreoperative submaximal cardiopulmonary exercise testing and its association with early postoperative complications
Carr Z, Charchaflieh J, Brenes-Bastos A, He H, Lin H, Jankelovits A, Gu E, Zafar J, Ghali F, Tan W, Heerdt P. Preoperative submaximal cardiopulmonary exercise testing and its association with early postoperative complications. BJA Open 2025, 14: 100407. PMID: 40421445, PMCID: PMC12105740, DOI: 10.1016/j.bjao.2025.100407.Peer-Reviewed Original ResearchLength of staySubmaximal cardiopulmonary exercise testingInstitutional review board approvalPostoperative complication riskReview board approvalDuke Activity Status IndexCardiopulmonary exercise testingIncreased length of stayAdjusted multivariable regression modelsPostoperative complications predictionPulmonary capacitanceOpen-labelPeak oxygen uptakePerioperative surveillancePrimary endpointNoncardiac surgeryPostoperative complicationsSecondary endpointsSingle-centreComplication riskMET assessmentPeak VOBoard approvalMultivariate regression modelMetabolic equivalents
2024
Cryoablation Without Excision for Early-Stage Breast Cancer: ICE3 Trial 5-Year Follow-Up on Ipsilateral Breast Tumor Recurrence
Fine R, Gilmore R, Tomkovich K, Dietz J, Berry M, Hernandez L, Columbus K, Seedman S, Fisher C, Han L, Manahan E, Hicks R, Vaidya R, Curcio L, Sevrukov A, Kenler A, Taback B, Chen M, Miller M, Gold L, Anglin B, Aoun H, Simmons R, Feldman S, Boolbol S. Cryoablation Without Excision for Early-Stage Breast Cancer: ICE3 Trial 5-Year Follow-Up on Ipsilateral Breast Tumor Recurrence. Annals Of Surgical Oncology 2024, 31: 7273-7283. PMID: 39283572, PMCID: PMC11452421, DOI: 10.1245/s10434-024-16181-0.Peer-Reviewed Original ResearchIpsilateral breast tumor recurrenceEarly-stage breast cancerBreast tumor recurrenceTumor recurrenceAdverse eventsBreast cancerEpidermal growth factor receptor 2 (HER2)-negativeHuman epidermal growth factor receptor 2 (HER2)-negativeIpsilateral breast tumor recurrence ratesHormone receptor (HR)-positivePatients meeting eligibilityDevice-related adverse eventsNon-operative treatment optionsHistological grade 1Institutional review board approvalPotential surgical risksEfficacy of cryoablationInvasive ductal carcinomaAlternative to surgeryLow-risk patientsPrimary study endpointFollow-up periodMinimally invasive procedureQuality-of-life scoresReview board approvalLong‐term outcomes of bladder‐sparing therapy vs radical cystectomy in BCG‐unresponsive non‐muscle‐invasive bladder cancer
Taylor J, Kamat A, O'Donnell M, Annapureddy D, Howard J, Tan W, McElree I, Davaro F, Yim K, Harrington S, Dyer E, Black A, Kanabur P, Roumiguié M, Lerner S, Black P, Raman J, Preston M, Steinberg G, Huang W, Li R, Packiam V, Woldu S, Lotan Y. Long‐term outcomes of bladder‐sparing therapy vs radical cystectomy in BCG‐unresponsive non‐muscle‐invasive bladder cancer. BJU International 2024, 135: 260-268. PMID: 39183466, PMCID: PMC11745998, DOI: 10.1111/bju.16509.Peer-Reviewed Original ResearchNon-muscle-invasive bladder cancerBladder-sparing therapyUpfront RCRadical cystectomyCohort of patientsBladder cancerBCG-unresponsive NMIBCRetrospective cohort of patientsProgression to MIBCUpfront radical cystectomyCancer-specific survivalInstitutional review board approvalMetastasis-free survivalFood and Drug Administration criteriaRate of recurrenceReview board approvalLong-term outcomesStatistically significant differenceNodal diseaseRe-resectionSystemic immunotherapyIntravesical chemotherapyOncological outcomesOverall survivalOncological riskRecurrence-free survival after curative resection of non-small cell lung cancer between inhalational gas anesthesia and propofol-based total intravenous anesthesia: a multicenter, randomized, clinical trial (GAS TIVA trial): protocol description
Kim J, Yoon S, Song I, Lee K, Hwang W, Kim H, Lee D, Lim H, Kim S, Lee J, Hong B, Blank R, Pedoto A, Popescu W, Theresa G, Martin A, Patteril M, Pathanasethpong A, Thongsuk Y, Pisitpitayasaree T, Huang A, Yu H, Kapoor P, Kim K, Chi S, Ahn H. Recurrence-free survival after curative resection of non-small cell lung cancer between inhalational gas anesthesia and propofol-based total intravenous anesthesia: a multicenter, randomized, clinical trial (GAS TIVA trial): protocol description. Perioperative Medicine 2024, 13: 79. PMID: 39039548, PMCID: PMC11264408, DOI: 10.1186/s13741-024-00436-1.Peer-Reviewed Original ResearchNon-small cell lung cancerRecurrence-free survivalCurative resection of non-small cell lung cancerResection of non-small cell lung cancerCell lung cancerCurative resectionTotal intravenous anesthesiaPropofol-based total intravenous anesthesiaLung cancerRandomized trialsClinical trialsAnesthetic managementReducing cancer recurrence riskAmerican Society of Anesthesiologists physical statusPatient's written informed consentMicroscopic residual diseaseInstitutional review board approvalReduce tumor recurrenceLung resection surgeryMethodsThis double-blindInhibit tumor angiogenesisMulticenter randomized trialCancer recurrence riskCell-mediated immunityIntravenous anesthesiaP-438 Association of uterine cavity immune cells at the time of frozen embryo transfer with live birth
Rodriguez S, Ibrahim M, Padula L, Fisher E, Rivas K, Paidas M, Strbo N, Attia G. P-438 Association of uterine cavity immune cells at the time of frozen embryo transfer with live birth. Human Reproduction 2024, 39: deae108.787. DOI: 10.1093/humrep/deae108.787.Peer-Reviewed Original ResearchTiming of frozen embryo transferFrozen embryo transferImprove pregnancy ratesT regulatory cellsLive birthsEmbryo transferImmune cellsPregnancy rateUterine segmentInfluence implantationUltrasound guidanceUterine milieuEndometrial receptivityElective single embryo transferFc receptor-positive cellsUpper uterusTotal immune cellsLower uterine segmentInstitutional review board approvalLive-born infantsSingle embryo transferImmune cell profilesLive birth rateGamma delta TCRImmune cell subsetsMulticenter early United States feasibility study and periprocedural safety of LVIS EVO for the treatment of unruptured intracranial aneurysms
Kayan Y, Almandoz J, Copelan A, Matouk C, Chaudry M, Altschul D, Essibayi M, Goren O, Yim B, Tsappidi S, Zhang Y, Hui F, Samaniego E, Gudino A, Siddiqui A, Jaikumar V, Puri A, Kühn A, Singh J, Ringer A, Hanel R, De Toledo O, Dabus G, Gooch M, Sizdahkhani S, Field N, Paul A. Multicenter early United States feasibility study and periprocedural safety of LVIS EVO for the treatment of unruptured intracranial aneurysms. Journal Of NeuroInterventional Surgery 2024, 17: jnis-2024-021900. PMID: 38906689, DOI: 10.1136/jnis-2024-021900.Peer-Reviewed Original ResearchConceptsLow-profile visualized intraluminal supportIntracranial aneurysmsHemorrhagic complicationsTreatment of unruptured intracranial aneurysmsComplete neck coverageAverage aneurysm sizeInstitutional review board approvalClass I occlusionReview board approvalAnterior communicating arteryTreatment of intracranial aneurysmsMiddle cerebral artery bifurcationUnruptured intracranial aneurysmsSelf-expanding stentsCerebral artery bifurcationLength of stayParent vessel sizePatient agePeriprocedural complicationsPeriprocedural safetyAneurysm locationAneurysm sizeAntiplatelet therapyBoard approvalIntraluminal supportJoint bleeds in mild hemophilia: Prevalence and clinical characteristics
Chiari J, Prozora S, Feinn R, Louizos E, Gallagher P, Bona R. Joint bleeds in mild hemophilia: Prevalence and clinical characteristics. Haemophilia 2024, 30: 331-335. PMID: 38240020, DOI: 10.1111/hae.14939.Peer-Reviewed Original ResearchMild haemophiliaJoint bleedsJoint range of motionHepatitis CRange of motionMild diseaseHistory of joint bleedsInstitutional review board approvalJoint rangeRetrospective chart reviewHemophilia treatment centersReview board approvalJoint healthHistory of traumaDisease burdenMedical recordsChart reviewClinical characteristicsMitigate disease burdenRisk factorsBoard approvalBleedingTraumatic bleedingAverage ageHemophilic arthropathy
2023
Cohort profile: Epidemiologic Questionnaire (EPI-Q) – a scalable, app-based health survey linked to electronic health record and genotype data
Salvatore M, Clark-Boucher D, Fritsche L, Ortlieb J, Houghtby J, Driscoll A, Caldwell-Larkins B, Smith J, Brummett C, Kheterpal S, Lisabeth L, Mukherjee B. Cohort profile: Epidemiologic Questionnaire (EPI-Q) – a scalable, app-based health survey linked to electronic health record and genotype data. Epidemiology And Health 2023, 45: e2023074. PMID: 37591787, PMCID: PMC10867525, DOI: 10.4178/epih.e2023074.Peer-Reviewed Original ResearchConceptsElectronic health recordsHealth recordsSelf-reported health dataFamily health historyEpidemiological questionnaireCancer screeningHealth cohortHealth SurveyHealth historyFinancial toxicityBaseline surveyEHR dataHealth dataCohort dataEPI-QAverage ageOccupational exposureGenotype dataParticipantsGenotype informationInstitutional review board approvalResponse rateCohortLife meaningQuestionnaireImproving Care After Sexual Assault: A Needs Assessment for a Standardized, Patient-Centered Educational Resource [ID: 1377465]
Lepore C, Bechtel K, Choi J, Gawel M, Griggs S, Pathy S. Improving Care After Sexual Assault: A Needs Assessment for a Standardized, Patient-Centered Educational Resource [ID: 1377465]. Obstetrics And Gynecology 2023, 141: 91s-91s. DOI: 10.1097/01.aog.0000931112.50405.07.Peer-Reviewed Original ResearchDischarge paperworkTertiary care emergency departmentRetrospective chart reviewInstitutional review board approvalLong-term followReview board approvalWorld Health Organization guidelinesMental health resourcesHealth Organization guidelinesOne-thirdElectronic medical record systemCommunity resourcesChart reviewMedical record systemSSA patientsEmergency departmentPatient morbidityAcute traumaPatient educationAmerican CollegeBoard approvalSuch careMedical followHealth resourcesFollowLung Cancer Screening Penetration in an Urban Underserved County
Lee K, Haramati L, Ye K, Lin J, Mardakhaev E, Gohari A. Lung Cancer Screening Penetration in an Urban Underserved County. Lung 2023, 201: 243-249. PMID: 36892635, DOI: 10.1007/s00408-023-00609-7.Peer-Reviewed Original ResearchConceptsLung cancer screening programsCancer screening programsRace/ethnicityLung cancerScreening programSocioeconomic statusMethodsThis retrospective cohort studyRetrospective cohort studyInstitutional review board approvalLung cancer screeningUrban medical centerReview board approvalSignificant differencesTwo-sample t-testLower SES neighborhoodsCohort studyMore patientsHispanic patientsCancer screeningCancer cohortUnderserved countiesInclusion criteriaMedical CenterBoard approvalPatientsNon-Invasive Imaging Biomarkers to Predict the Hepatopulmonary Shunt Fraction Before Transarterial Radioembolization in Patients with Hepatocellular Carcinoma
Hamm C, Busch F, Pöhlmann A, Shewarega A, He Y, Schmidt R, Xu H, Wieners G, Gebauer B, Savic L. Non-Invasive Imaging Biomarkers to Predict the Hepatopulmonary Shunt Fraction Before Transarterial Radioembolization in Patients with Hepatocellular Carcinoma. Journal Of Hepatocellular Carcinoma 2023, 10: 27-42. PMID: 36660411, PMCID: PMC9842483, DOI: 10.2147/jhc.s391537.Peer-Reviewed Original ResearchHepatopulmonary shunt fractionArterial phase enhancementTransarterial radioembolizationHepatocellular carcinomaOverall survivalCE-CTShunt fractionTechnetium-99m macroaggregated albuminImaging biomarkersInstitutional review board approvalM macroaggregated albuminIndependent risk factorClinically applicable risk scoreDisease-specific clinical parametersNon-invasive predictorPoor overall survivalReview board approvalNon-invasive imaging biomarkerTumor diameterNon-invasive predictionPoor OSTumor extentVenous invasionClinical parametersRetrospective study
2022
Prospective analysis of home narcotic consumption and management of excess narcotic prescription following adolescent idiopathic scoliosis surgery
Garcia-Muñoz J, Elblein C, David W, Elaydi A, Tuason D. Prospective analysis of home narcotic consumption and management of excess narcotic prescription following adolescent idiopathic scoliosis surgery. Spine Deformity 2022, 11: 651-656. PMID: 36583832, DOI: 10.1007/s43390-022-00637-y.Peer-Reviewed Original ResearchConceptsPosterior spinal fusionAdolescent idiopathic scoliosisNarcotic useSpinal fusionIdiopathic scoliosisLow-use groupAdolescent idiopathic scoliosis surgeryMethodsFollowing institutional review board approvalIntraoperative blood lossPostoperative clinic visitsLength of surgeryInstitutional review board approvalLength of hospitalizationIdiopathic scoliosis surgeryPatient demographic dataReview board approvalHigh-use groupNarcotic dosesNarcotic intakeUnused narcoticsNarcotic usagePain scoresNarcotic prescriptionsBlood lossChart reviewDisparities and implicit bias in the management of low-risk febrile infants: a mixed methods study protocol
Gutman C, Lion K, Aronson P, Fisher C, Bylund C, McFarlane A, Lou X, Patterson M, Lababidi A, Fernandez R. Disparities and implicit bias in the management of low-risk febrile infants: a mixed methods study protocol. BMJ Open 2022, 12: e063611. PMID: 36127098, PMCID: PMC9490627, DOI: 10.1136/bmjopen-2022-063611.Peer-Reviewed Original ResearchConceptsLow-risk febrile infantsFebrile infantsEmergency departmentClinical carePediatric Emergency Medicine Collaborative Research CommitteeFlorida Institutional Review BoardLocal institutional review board approvalPediatric ED physiciansInstitutional review board approvalMultivariable logistic regressionCross-sectional studyPhysician-patient communicationReview board approvalClinical guideline implementationMethods study protocolInstitutional review boardMulticenter analysisPrimary outcomeED physiciansPhysician assessmentRecommended careGuideline implementationLumbar punctureStudy protocolEmergency settingDiverting Ileostomy in Children With Functional Constipation
Rodriguez L, Colliard K, Nurko S, Flores A, Buchmiller TL. Diverting Ileostomy in Children With Functional Constipation. Journal Of Pediatric Gastroenterology And Nutrition 2022, 75: 578-583. PMID: 35897140, DOI: 10.1097/mpg.0000000000003579.Peer-Reviewed Original ResearchConceptsFunctional constipationOstomy closurePediatric functional constipationInstitutional review board approvalReview board approvalEnema failureColon motilityFurther surgeryInvasive evaluationRetrospective studySurgical interventionOstomyBoard approvalUseful interventionLarger studyConstipationSuccessful responsePatientsSurgeryChildrenRole of CMDemographicsAssociationInterventionIndicationsRationale and design of the SARCoidosis Outcomes in all respiratory Viral Infectious Diseases (SARCOVID) Study
Strykowski R, Patel DC, Neto MR, Hena KM, Gulati M, Maier LA, Patterson K. Rationale and design of the SARCoidosis Outcomes in all respiratory Viral Infectious Diseases (SARCOVID) Study. BMJ Open Respiratory Research 2022, 9: e001254. PMID: 35882424, PMCID: PMC9329732, DOI: 10.1136/bmjresp-2022-001254.Peer-Reviewed Original ResearchConceptsLung functionRespiratory infectionsLocal institutional review board approvalFibrotic pulmonary sarcoidosisInstitutional review board approvalNon-infected patientsInterstitial lung diseaseRespiratory viral illnessReview board approvalViral infectious diseasesImpact of infectionPulmonary sarcoidosisViral illnessClinical courseInfectious eventsStudy entryStudy cohortPoor outcomeProspective studyLung diseaseLong-term impactLife measuresSarcoidosisHigh riskGeneral populationDiabetes mellitus is associated with increased risk of positive qSOFA score but not with increased ICU admission in patients undergoing ureteral stent placement for ureteral stone and suspected infection
Lee J, Kottooran C, Hinojosa-González D, Yaghoubian A, Uppuluri N, Hanson K, Borofsky M, Eisner B. Diabetes mellitus is associated with increased risk of positive qSOFA score but not with increased ICU admission in patients undergoing ureteral stent placement for ureteral stone and suspected infection. Canadian Urological Association Journal 2022, 16: 430-434. PMID: 36656692, PMCID: PMC9851227, DOI: 10.5489/cuaj.7896.Peer-Reviewed Original ResearchUrinary tract infectionUreteral stent placementQuick Sequential Organ Failure AssessmentDevelopment of septic shockPostoperative septic shockObstructing ureteral stonesSeptic shockUreteral stonesDiabetes mellitusPositive qSOFA scoreIntensive care unitStent placementQSOFA scoreNon-DMIncreased riskMulticenter study of patientsSequential Organ Failure AssessmentSevere infectious complicationsInstitutional review board approvalAssociated with increased riskOrgan Failure AssessmentStudy of patientsReview board approvalRisk of septic shockIncreased ICU admissionReflecting on Plastic Surgery Training During Early COVID-19 Pandemic: Resident Exposure and Telemedicine
Epstein A, Jabori S, Wo L, Huberman M, Samaha G, Ovadia S, Thaller S. Reflecting on Plastic Surgery Training During Early COVID-19 Pandemic: Resident Exposure and Telemedicine. Journal Of Craniofacial Surgery 2022, 33: 1820-1824. PMID: 35762598, PMCID: PMC9432419, DOI: 10.1097/scs.0000000000008471.Peer-Reviewed Original ResearchConceptsPlastic surgery residentsPlastic surgery traineesPlastic surgery programsBoard approvalReconstructive surgeryExposure to COVID-19COVID-19 statusSurgery traineesSurgery programsSurgery residentsPlastic surgery program directorsInstitutional review board approvalEmergency departmentYears of trainingHigh-risk patientsNon-COVID-19Follow-up visitReview board approvalPlastic surgery consultationIntensive care unitSurgery program directorsPlastic surgery trainingCOVID-19 patientsPersonal protective equipmentN95 masksCardiac Magnetic Resonance to Predict Coronary Artery Compression in Transcatheter Pulmonary Valve Implantation Into Conduits
Romans RA, Lu JC, Balasubramanian S, Whiteside W, Yu S, Aldoss OT, Armstrong AK, Boe BA, Balzer DT, Christensen JT, Jones TK, Keeshan B, McLennan D, Nicholson GT, Patel N, Salavitabar A, Shahanavaz S, Sullivan PM, Turner ME, Zampi JD. Cardiac Magnetic Resonance to Predict Coronary Artery Compression in Transcatheter Pulmonary Valve Implantation Into Conduits. JACC Cardiovascular Interventions 2022, 15: 979-988. PMID: 35512922, DOI: 10.1016/j.jcin.2022.02.047.Peer-Reviewed Original ResearchConceptsTranscatheter pulmonary valve implantationCardiac magnetic resonanceRV-PA conduitCA compressionCoronary artery compressionPulmonary valve implantationArtery compressionValve implantationCoronary anatomyBalloon testingStenotic areaAbnormal coronary anatomyPulmonary artery conduitInstitutional review board approvalDysfunctional right ventricleReview board approvalNegative predictive valueConduit calcificationArtery conduitAbsolute contraindicationPatient selectionRight ventricleSubjective assessmentCMR studiesBoard approvalSignificance of KRAS mutation testing in biliary brushing cytology specimens: A 10‐year retrospective review
Sun T, Zuo T, Hui P, Cai G. Significance of KRAS mutation testing in biliary brushing cytology specimens: A 10‐year retrospective review. Cancer Cytopathology 2022, 130: 558-565. PMID: 35417072, DOI: 10.1002/cncy.22579.Peer-Reviewed Original ResearchConceptsExtrahepatic biliary stenosisKRAS mutation testingKRAS mutational analysisKRAS mutationsBiliary stenosisBiliary ductsInstitutional review board approvalResults of cytologyPancreatic duct adenocarcinomaBiliary brushing cytologyReview board approvalCytological diagnostic categoriesRetrospective reviewBiliary stricturesDuct adenocarcinomaAbsolute riskCytology examinationDuct brushingsBiliary brushingsBrushing cytologyMalignant conditionsCytological diagnosisBoard approvalClinical practiceCytology specimens
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