2025
Analysis of Calcium Patterns in the Thoracic Aorta and Clinical Outcomes of TAVR Patients Presenting with Porcelain Aorta
Campanella C, Voss S, Schreyer J, Puluca N, Amabile A, Wirth F, Krane M, Ruge H. Analysis of Calcium Patterns in the Thoracic Aorta and Clinical Outcomes of TAVR Patients Presenting with Porcelain Aorta. Journal Of Clinical Medicine 2025, 14: 503. PMID: 39860509, PMCID: PMC11766034, DOI: 10.3390/jcm14020503.Peer-Reviewed Original ResearchPresence of porcelain aortaTranscatheter aortic valve replacementMulti-slice CTClinical outcomesPorcelain aortaPA patientsClinical outcomes of transcatheter aortic valve replacementThoracic aortaOutcomes of transcatheter aortic valve replacementTranscatheter aortic valve replacement patientsTreatment of severe aortic valve stenosisSevere aortic valve stenosisTranscatheter aortic valve replacement procedureMedian EuroSCORE IIOutcomes of TAVR patientsAortic valve replacementPre-operative CTAortic valve stenosisIschemic stroke rateThoracic aortic segmentsShort-term mortalityRisk of mortalityEuroSCORE IISuperior quadrantTAVR patients
2024
Vγ6/Vδ1+ γδ T cells protect from angiotensin II effects on blood pressure and endothelial function in mice
Mahmoud A, Caillon A, Shokoples B, Ferreira N, Comeau K, Hatano S, Yoshikai Y, Lewis J, Tigelaar R, Paradis P, Schiffrin E. Vγ6/Vδ1+ γδ T cells protect from angiotensin II effects on blood pressure and endothelial function in mice. Journal Of Hypertension 2024, 43: 109-119. PMID: 39248136, DOI: 10.1097/hjh.0000000000003871.Peer-Reviewed Original ResearchGd T cellsT cellsBlood pressureAngII infusionEndothelial dysfunctionBP elevationPerivascular tissueAngiotensin II (AngII)-induced hypertensionSpecific T cell receptorMesenteric arterial functionArtery endothelial dysfunctionAngiotensin II effectsDescending Thoracic AortaT cell receptorAngII-infused micePerivascular adipose tissuePressure myographyHypertensive effectEndothelial functionThoracic aortaII effectsMale miceVascular injuryArterial functionFlow cytometryThe Predictive Value of Aortic Calcification on Computed Tomography for Major Cardiovascular Events
Chlorogiannis D, Pargaonkar S, Apostolos A, Vythoulkas-Biotis N, Kokkinidis D, Nagraj S. The Predictive Value of Aortic Calcification on Computed Tomography for Major Cardiovascular Events. Journal Of Clinical Medicine 2024, 13: 4019. PMID: 39064058, PMCID: PMC11277087, DOI: 10.3390/jcm13144019.Peer-Reviewed Original ResearchTranscatheter aortic valve implantationPrediction of MACEAortic calcificationComputed tomographyPredictive valueCardiovascular diseaseAbdominal aortic calcificationTranscatheter aortic valve implantation proceduresDescending Thoracic AortaAdverse cardiovascular eventsIdentification of patientsPrevalence of cardiovascular diseaseExtra-coronary calcificationAortic valve implantationAtherosclerotic cardiovascular diseaseMinimally invasive percutaneous proceduresInvasive percutaneous proceduresThoracic calcificationDiagnostic modalitiesAortic archRisk stratificationAortic valveCardiovascular eventsCoronary calcificationThoracic aortaCentral Artery Hemodynamics in Angiotensin II-Induced Hypertension and Effects of Anesthesia
Hopper S, Weiss D, Mikush N, Jiang B, Spronck B, Cavinato C, Humphrey J, Figueroa C. Central Artery Hemodynamics in Angiotensin II-Induced Hypertension and Effects of Anesthesia. Annals Of Biomedical Engineering 2024, 52: 1051-1066. PMID: 38383871, PMCID: PMC11418744, DOI: 10.1007/s10439-024-03440-0.Peer-Reviewed Original ResearchEffects of angiotensin II infusionMouse-to-mouse variationAngiotensin II-induced hypertensionRegional vascular structuresII-induced hypertensionAngiotensin II-infused miceAngiotensin II infusionWild-type miceDescending Thoracic AortaGroups of miceSuprarenal abdominal aortaEffects of hypertensionCentral arterial stiffnessDepressed hemodynamicsII infusionIndicator of hypertensionSystemic hypertensionRenovascular diseaseCardiac functionInduced hypertensionDistal aortaThoracic aortaEffects of anesthesiaMouse modelAbdominal aortaA Systematic Comparison of Normal Structure and Function of the Greater Thoracic Vessels
Ramachandra A, Cavinato C, Humphrey J. A Systematic Comparison of Normal Structure and Function of the Greater Thoracic Vessels. Annals Of Biomedical Engineering 2024, 52: 958-966. PMID: 38227167, DOI: 10.1007/s10439-023-03432-6.Peer-Reviewed Original ResearchThoracic vesselsVena cavaThoracic aortaCongenital heart surgeryRight pulmonary arterySuperior vena cavaInferior vena cavaRight subclavian arteryThoracic inferior vena cavaWild-type miceAscending thoracic aortaDescending Thoracic AortaPulmonary arterySubclavian arteryHeart surgerySurgical interventionVasoactive responsesVenous circulationThoracicCavaNormal structureAortaArteryBiomechanical propertiesVascular system
2023
Association of simple renal cysts to aneurysm sac shrinkage in true thoracic aortic aneurysms after thoracic endovascular aortic repair
Kano M, Nishibe T, Iwahashi T, Maekawa K, Nakano Y, Matsumoto R, Fujiyoshi T, Ogino H, Kato N, Dardik A. Association of simple renal cysts to aneurysm sac shrinkage in true thoracic aortic aneurysms after thoracic endovascular aortic repair. Journal Of Vascular Surgery 2023, 78: 624-632. PMID: 37116594, DOI: 10.1016/j.jvs.2023.02.031.Peer-Reviewed Original ResearchConceptsAneurysm sac shrinkageTrue thoracic aortic aneurysmSimple renal cystsThoracic aortic aneurysmSac shrinkageAneurysm sac sizeEndovascular aortic repairAortic repairAortic aneurysmRenal cystsPresence of SRCSac sizePostoperative computed tomography scansPreoperative computed tomographyComputed tomography scanMultivariable analysisTrue aneurysmUniversity HospitalThoracic aortaSac diameterTomography scanComputed tomographyTEVARPatientsAortic wallAortic Size at the Time of Type A and Type B Dissections
Perez Z, Zafar M, Velasco J, Sonsino A, Ellauzi H, John C, Kalyanasundaram A, Ziganshin B, Elefteriades J. Aortic Size at the Time of Type A and Type B Dissections. The Annals Of Thoracic Surgery 2023, 116: 262-268. PMID: 37062339, DOI: 10.1016/j.athoracsur.2023.03.037.Peer-Reviewed Original ResearchConceptsType B dissectionTime of dissectionB dissectionAortic sizeAortic diameterBicuspid aortic valveThoracic aortic aneurysmAortic interventionAortic dissectionSurgical interventionAortic aneurysmFemale sexAortic valveThoracic aortaProphylactic repairUnadjusted regressionLeft shiftLogistic regressionDissectionNew guidelinesType ASize criteriaOddsInterventionTime of types
2021
A Comparison of Clinical Outcomes of Endovascular Repair Versus Open Surgery for Ruptured Descending Thoracic Aorta
Xie X, Shu X, Zhang W, Guo D, Zhang W, Wang L, Fu W. A Comparison of Clinical Outcomes of Endovascular Repair Versus Open Surgery for Ruptured Descending Thoracic Aorta. Journal Of Endovascular Therapy 2021, 29: 307-318. PMID: 34779300, DOI: 10.1177/15266028211057087.Peer-Reviewed Original ResearchConceptsRe-intervention rateDescending Thoracic AortaOpen surgeryThoracic aortaRe-interventionPulmonary complicationsCardiac complicationsPerioperative mortalityPulmonary embolismAssociated with lower perioperative mortalityOdds ratioThoracic endovascular aortic repairYear mortalityEarly postoperative complicationsEndovascular aortic repairLow perioperative mortalityMeta-analysisRuptured thoracic aortaCochrane Library databasesAssociated with lower ratesConfidence intervalsTEVAR groupOS outcomesAortic repairPerioperative morbidityDevelopment and Validation of a Predictive Model to Identify Patients With an Ascending Thoracic Aortic Aneurysm
Mori M, Gan G, Deng Y, Yousef S, Weininger G, Daggula KR, Agarwal R, Shang M, Assi R, Geirsson A, Vallabhajosyula P. Development and Validation of a Predictive Model to Identify Patients With an Ascending Thoracic Aortic Aneurysm. Journal Of The American Heart Association 2021, 10: e022102. PMID: 34743563, PMCID: PMC8751931, DOI: 10.1161/jaha.121.022102.Peer-Reviewed Original ResearchConceptsThoracic aortic aneurysmAortic aneurysmPatient riskTomography scanHigher body surface areaTertiary care centerAortic valve diseaseHistory of arrhythmiaAvailable clinical informationBody surface areaScreening of patientsCross-sectional studyRisk prediction algorithmAscending Thoracic Aortic AneurysmsLogistic regression modelsClinical characteristicsAortic dissectionUnique patientsValve diseaseC-statisticFemale sexThoracic aortaCare centerComorbidity variablesMultivariable modelExcessive adventitial stress drives inflammation-mediated fibrosis in hypertensive aortic remodelling in mice
Spronck B, Latorre M, Wang M, Mehta S, Caulk AW, Ren P, Ramachandra AB, Murtada SI, Rojas A, He CS, Jiang B, Bersi MR, Tellides G, Humphrey JD. Excessive adventitial stress drives inflammation-mediated fibrosis in hypertensive aortic remodelling in mice. Journal Of The Royal Society Interface 2021, 18: 20210336. PMID: 34314650, PMCID: PMC8315831, DOI: 10.1098/rsif.2021.0336.Peer-Reviewed Original ResearchConceptsAortic remodellingWall stressAngiotensin II infusionInflammatory cell infiltrationC57BL/6 J miceSmooth muscle contractile processHigh wall stressVasoconstrictive capacityII infusionBlood pressureInflammatory cellsCell infiltrationMean wall stressJ miceThoracic aortaMaladaptive remodellingImmune processesAortaBulk RNA sequencingBiomechanical assessmentAdaptive remodellingContractile processMarked increaseRemodellingVasoconstriction
2020
Thoracic Aorta and Its Variants
Madou I, Ziganshin B, Elefteriades J, Erben Y. Thoracic Aorta and Its Variants. 2020, 123-141. DOI: 10.1007/978-3-030-55660-0_7.Peer-Reviewed Original ResearchAortic Arch Aneurysms
Imran M, Zafar M, Chkhikvadze T, Ziganshin B, Elefteriades J. Aortic Arch Aneurysms. 2020, 529-544. DOI: 10.1007/978-3-030-24174-2_57.Peer-Reviewed Original Research
2019
Oral Resolvin D1 attenuates early inflammation but not intimal hyperplasia in a rat carotid angioplasty model
Mottola G, Werlin EC, Wu B, Chen M, Chatterjee A, Schaller MS, Conte MS. Oral Resolvin D1 attenuates early inflammation but not intimal hyperplasia in a rat carotid angioplasty model. Prostaglandins And Other Lipid Mediators 2019, 146: 106401. PMID: 31841663, PMCID: PMC7265259, DOI: 10.1016/j.prostaglandins.2019.106401.Peer-Reviewed Original ResearchConceptsIntimal hyperplasiaResolvin D1Post-operative day 3Phagocytosis activityRat carotid angioplasty modelCAMP levelsLocal inflammatory responsePro-inflammatory genesArterial inflammationCarotid angioplastyOral gavageAcute inflammationVascular injuryThoracic aortaAngioplasty modelEarly inflammationInflammatory responseOral administrationPlasma concentrationsCarotid arteryRvD1Lipid mediatorsAnimal modelsDay 3InflammationComplex two-stage open surgical repair of an aortoesophageal fistula after thoracic endovascular aortic repair
Chaar C, Zafar MA, Velasquez C, Saeyeldin A, Elefteriades JA. Complex two-stage open surgical repair of an aortoesophageal fistula after thoracic endovascular aortic repair. Journal Of Vascular Surgery Cases And Innovative Techniques 2019, 5: 261-263. PMID: 31304437, PMCID: PMC6601018, DOI: 10.1016/j.jvscit.2019.02.011.Peer-Reviewed Original ResearchThoracic endovascular aortic repairEndovascular aortic repairAortoesophageal fistulaInfected endograftAortic repairExtra-anatomic aortic bypassOpen surgical repairOpen surgical approachFocus of infectionVisceral ischemia timesAortic bypassFatal complicationSurgical repairIschemia timeThoracic endograftSurgical approachThoracic aortaOptimal managementEndograftFistulaAortaClear guidelinesRepairComplex casesComplicationsMechanics of the Thoracic Aortic Wall
Ziganshin B, Elefteriades J. Mechanics of the Thoracic Aortic Wall. 2019, 149-162. DOI: 10.1007/978-3-7091-4874-7_10.Peer-Reviewed Original ResearchDilation of the Proximal Thoracic Aorta in an Asymptomatic Primary Prevention Population Undergoing Noncontrast Chest Computed Tomography
Alashi A, Lang R, Seballos R, Feinleib S, Sukol R, Roselli EE, Svensson LG, Kalahasti V, Schoenhagen P, Flamm SD, Griffin BP, Desai MY. Dilation of the Proximal Thoracic Aorta in an Asymptomatic Primary Prevention Population Undergoing Noncontrast Chest Computed Tomography. Circulation 2019, 139: 557-558. PMID: 30586688, DOI: 10.1161/circulationaha.118.036191.Peer-Reviewed Original ResearchMeSH KeywordsAgedAortic Aneurysm, ThoracicAortographyAsymptomatic DiseasesComputed Tomography AngiographyCoronary AngiographyCoronary Artery DiseaseDilatation, PathologicEarly DiagnosisHumansIncidental FindingsMaleMiddle AgedPredictive Value of TestsPrimary PreventionUnited StatesVascular CalcificationConceptsAortic aneurysmDissection/rupturePrimary prevention populationCoronary artery calciumProximal thoracic aortaThoracic aortic aneurysmNoncontrast chestPrevention populationArtery calciumThoracic aortaSurgical techniqueSudden deathProximal ascendingTrue prevalenceImproved surveillanceAneurysmsEarly detectionDevastating diseaseDeathAortaChestMortalityPrevalenceDiseaseExsanguination
2018
Central artery stiffness and thoracic aortopathy
Humphrey J, Tellides G. Central artery stiffness and thoracic aortopathy. AJP Heart And Circulatory Physiology 2018, 316: h169-h182. PMID: 30412443, PMCID: PMC6880196, DOI: 10.1152/ajpheart.00205.2018.Peer-Reviewed Original ResearchConceptsCentral arteriesEnd-organ diseaseProximal thoracic aortaCentral artery stiffnessPrimary risk factorUncontrolled hypertensionAntihypertensive medicationsNonsurgical treatmentSignificant morbidityArtery stiffnessAortic aneurysmPulse pressureRisk factorsThoracic aortaDisease progressionStrenuous exerciseMouse modelMarfan syndromeWeight liftingGlobal hemodynamicsDysfunctional mechanosensingLethal conditionAortaGenetic mutationsArteryCompromised mechanical homeostasis in arterial aging and associated cardiovascular consequences
Ferruzzi J, Madziva D, Caulk AW, Tellides G, Humphrey JD. Compromised mechanical homeostasis in arterial aging and associated cardiovascular consequences. Biomechanics And Modeling In Mechanobiology 2018, 17: 1281-1295. PMID: 29754316, PMCID: PMC8344131, DOI: 10.1007/s10237-018-1026-7.Peer-Reviewed Original ResearchMeSH KeywordsAgingAnimalsAorta, AbdominalAorta, ThoracicBiomechanical PhenomenaCardiovascular DiseasesCardiovascular SystemCarotid ArteriesCarotid Artery, CommonDiastoleDisease Models, AnimalElastinExtracellular Matrix ProteinsHemodynamicsHomeostasisHumansMaleMiceModels, CardiovascularPressureRecombinant ProteinsStress, MechanicalTime FactorsVascular StiffnessConceptsCentral arteriesMale wild-type miceArterial wallAberrant matrix remodelingCentral pulse pressureInfrarenal abdominal aortaCommon carotid arteryWild-type miceDiastolic functionCardiovascular consequencesCardiac massHemodynamic sequelaePulse pressureAbdominal aortaThoracic aortaArterial agingVascular agingCommon findingTreatment strategiesCarotid arteryArteryLeft ventricleCarotid vesselsCentral vesselsVivo axial stretchTime to Move to Earlier Intervention for Thoracic Aortic Aneurysm?
Gryaznov A, Ziganshin B, Elefteriades J. Time to Move to Earlier Intervention for Thoracic Aortic Aneurysm? Structural Heart 2018, 2: 10-22. DOI: 10.1080/24748706.2017.1404664.Peer-Reviewed Original ResearchThoracic aortic aneurysmBody surface areaAortic aneurysmMost life-threatening complicationsAortic growth rateEarly prophylactic interventionAcute aortic dissectionLife-threatening complicationsPatient/yearProphylactic surgical interventionSpecific genetic aberrationsAortic dissectionAortic sizeAortic diseaseCurrent gold standardSurgical interventionPatient heightProphylactic interventionsThoracic aortaAneurysm diseaseCommon causeFamily historyEarly diagnosisEarly interventionGenetic aberrations
2017
Concomitant antegrade stent grafting of the descending thoracic aorta during transverse hemiarch reconstruction for acute DeBakey I aortic dissection repair improves aortic remodeling
Sultan I, Wallen TJ, Habertheuer A, Siki M, Arnaoutakis GJ, Bavaria J, Szeto WY, Milewski R, Vallabhajosyula P. Concomitant antegrade stent grafting of the descending thoracic aorta during transverse hemiarch reconstruction for acute DeBakey I aortic dissection repair improves aortic remodeling. Journal Of Cardiac Surgery 2017, 32: 581-592. PMID: 28795434, DOI: 10.1111/jocs.13192.Peer-Reviewed Original ResearchConceptsTrue lumen diameterTEVAR groupTrue lumenThoracic aortaLumen diameterHemiarch reconstructionAortic remodelingStent graftingOpen repairAortic diameterAcute DeBakey I aortic dissectionDeBakey I aortic dissectionFalse lumen thrombosis rateThree-dimensional computed tomography scansAortic dissection repairDeBakey I dissectionsDistal aortic remodelingTotal aortic diameterFalse lumen thrombosisAbdominal aortic diameterEndovascular stent graftingEndovascular aortic repairComputed tomography scanArch tearDeBakey I
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